期刊
CURRENT DIABETES REPORTS
卷 13, 期 3, 页码 411-418出版社
CURRENT MEDICINE GROUP
DOI: 10.1007/s11892-013-0376-x
关键词
Diabetes mellitus; Type 1 diabetes mellitus; Type 2 diabetes mellitus; Osteoporosis; Fracture; Obesity; Bone mineral density; Dual energy X-ray absorptiometry; Osteocalcin
资金
- Merck
- Eli Lily
- Novartis
- Genentech
- Amgen
Diabetes mellitus (particularly type 2) and osteoporosis are two very common disorders, and both are increasing in prevalence. Adolescents with type 1 diabetes mellitus may not reach potential peak bone mass, putting them at greater fracture risk. In adults with type 2 diabetes, fracture risk is increased and is not explained by the bone mineral density measured by dual-energy X-ray absorptiometry, still considered the gold standard predictor of fracture. In this review, we explore potential mechanisms behind the increased fracture risk that occurs in patients with diabetes, even those with increased bone mineral density. One potential link between diabetes and bone is the osteoblast-produced factor, osteocalcin. It remains to be established whether osteocalcin reflects or affects the connection between bone and glucose metabolism. Several other potential mediators of the effects of diabetes on bone are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据