期刊
CURRENT DIABETES REPORTS
卷 12, 期 5, 页码 604-611出版社
CURRENT MEDICINE GROUP
DOI: 10.1007/s11892-012-0309-0
关键词
Type 1 diabetes; Stem cell; Hematopoietic; Cure; Diabetes; Immunosuppression; Autologous transplantation; Autoimmune diabetes
Type 1 diabetes mellitus is a chronic disease that results from the autoimmune response against pancreatic insulin producing beta cells. Apart of several insulin regimens, since the decade of 80s various immunomodulatory regimens were tested aiming at blocking some steps of the autoimmune process against beta cell mass and at promoting beta cell preservation. In the last years, some independent research groups tried to cure type 1 diabetes with an immunologic reset provided by autologous hematopoietic stem cell transplantation in newly diagnosed patients, and the majority of patients became free form insulin with increasing levels of C-peptide along the time. In this review, we discuss the biology of hematopoietic stem cells and the possible advantages and disadvantages related to the high dose immunosuppression followed by autologous hematopoietic stem cell transplantation.
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