期刊
CURRENT DIABETES REPORTS
卷 11, 期 5, 页码 434-444出版社
CURRENT MEDICINE GROUP
DOI: 10.1007/s11892-011-0210-2
关键词
Type 1 diabetes; Islet transplantation; Islet niche; Biomaterial; Encapsulation
资金
- DFG-Center for Regenerative Therapies Dresden, Cluster of Excellence [FZT 111]
- Federal Ministry of Education and Research, Germany [01GN0945]
Pancreatic islet transplantation is a therapeutic option to replace destroyed beta cells in autoimmune diabetes. Islets are transplanted into the liver via the portal vein; however, inflammation, the required immunosuppression, and lack of vasculature decrease early islet viability and function. Therefore, the use of accessory therapy and biomaterials to protect islets and improve islet function has definite therapeutic potential. Here we review the application of niche accessory cells and factors, as well as the use of biomaterials as carriers or capsules, for pancreatic islet transplantation.
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