Article
Chemistry, Multidisciplinary
Elisa Hernandez Becerra, Jennifer Quinchia, Cristina Castro, Jahir Orozco
Summary: Polymersomes are biomimetic cell membrane-like model structures that have gained attention for their biocompatibility, versatility, and tunable properties. They can encapsulate cargoes and be triggered to disassemble in response to stimuli, making them suitable for photodynamic therapy. This review explores the current advances and applications of light-responsive polymersomes in anticancer therapy.
Review
Polymer Science
Chao-Ping Fu, Xing-Yu Cai, Si-Lin Chen, Hong-Wei Yu, Ying Fang, Xiao-Chen Feng, Li-Ming Zhang, Chang-Yong Li
Summary: Hyaluronic acid (HA) is extensively used as a carrier for anticancer drugs due to its biocompatibility and ability to target cancer cells. This article comprehensively reviews the fabrication of HA-based nanocarriers for drug delivery, including prodrugs, organic carrier materials, and inorganic composite nanocarriers. The progress, design, and optimization of these nanocarriers and their impact on cancer therapy are discussed, as well as future perspectives in this field.
Article
Polymer Science
Arjaree Jobdeedamrong, Man Theerasilp, Nutthanit Thumrongsiri, Paweena Dana, Nattika Saengkrit, Daniel Crespy
Summary: In this study, GSH-responsive and self-immolative polyprodrug nanoparticles were prepared for cancer treatment. These nanoparticles showed high drug loading and efficient redox-responsive release, displaying high cytotoxicity against cancer cells and low cytotoxicity against cancer cells treated with GSH scavenger or normal cells.
Review
Oncology
Andy Guzman Rodriguez, Marquiza Sablon Carrazana, Chrislayne Rodriguez Tanty, Martijn J. A. Malessy, Gaston Fuentes, Luis J. Cruz
Summary: Cancer has been a lethal disease with high incidence and invasive treatments. Nanotechnology provides a promising alternative for cancer treatment by using nanocarriers to transport anticancer drugs. This study aims to explore different nanocarriers and new routes to reduce the incidence of cancer to very low levels in humans.
Article
Biochemistry & Molecular Biology
Idowu Kehinde, Pritika Ramharack, Manimbulu Nlooto, Michelle Gordon
Summary: This study used computational tools to analyze the inhibitory potential of four phytochemical compounds against drug-metabolizing proteins. The study found that epigallocatechin gallate and kaempferol-7-glucoside showed strong inhibitory activities and could potentially increase the concentration of drugs in patients.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Pharmacology & Pharmacy
Rodrigo dos A. Miguel, Amanda S. Hirata, Paula C. Jimenez, Luciana B. Lopes, Leticia V. Costa-Lotufo
Summary: Nature is a rich source of medicinal compounds like doxorubicin (DOX) and paclitaxel (PTX). Nanoformulations of these drugs are cost-effective and offer improved pharmacokinetic properties and targeted delivery, resulting in reduced side effects. They can also overcome drug resistance and allow for multi-drug encapsulation for combined chemotherapy.
Review
Pharmacology & Pharmacy
Hussein Sabit, Mohamed Abdel-Hakeem, Tahsin Shoala, Shaimaa Abdel-Ghany, Mokhtar Mamdouh Abdel-Latif, Jawaher Almulhim, Mohamed Mansy
Summary: Nanomedicine has gained popularity in cancer treatment due to its advanced targeting and multifunctionality. Nanoparticles can deliver drugs directly to cancer cells, reducing off-target toxicity and increasing efficacy. However, translating nanomedicine from the lab to clinical settings remains challenging.
Review
Chemistry, Multidisciplinary
Helena I. O. Gomes, Catarina S. M. Martins, Joao A. Prior
Summary: Nanotechnology has rapidly evolved over the last decade and has found applications in various fields, with nanoparticles being explored as drug carriers with controlled and targeted release advantages. Silver nanoparticles, with unique properties, are increasingly being studied for drug transport, particularly in cancer treatment where conventional chemotherapy has limitations in bioavailability and adverse effects. Strategies utilizing silver nanoparticles as anticancer drug carriers show promise in overcoming these challenges.
Article
Polymer Science
Chao Lv, Jia Gao, Kun An, Jingjing Nie, Junting Xu, Binyang Du
Summary: A series of pH-sensitive and thermosensitive amphiphilic pentablock copolymers were self-assembled into micelles with different morphologies and structures, exhibiting varying thermosensitive behavior and nanostructures under different pH conditions.
Article
Chemistry, Medicinal
Xinguang Cao, Rui Li, Huihua Xiong, Jinfang Su, Changqing Guo, Tianqi An, Hong Zong, Ruihua Zhao
Summary: Among the four Pt(IV) complexes, complex 14 shows promising potential in reversing cisplatin resistance and enhancing anticancer efficiency through multiple mechanisms. Its low systematic toxicity makes it a potential novel P-gp-mediated MDR modulator with increased tumor inhibition compared to cisplatin and oxaliplatin.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Polymer Science
Anastasia Balafouti, Stergios Pispas
Summary: We report the synthesis of novel amphiphilic hyperbranched copolymers and investigate their self-assembly behavior and drug encapsulation ability.
JOURNAL OF POLYMER SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Niloufar Rezaei, Mandana Kazem Arki, Zohre Miri-Lavasani, Roya Solhi, Mahsa Khoramipour, Hamid Rashedi, Hamid Asadzadeh Aghdaei, Nikoo Hossein-Khannazer, Ebrahim Mostafavi, Massoud Vosough
Summary: This study aims to optimize treatment doses and overcome multidrug resistance in gastric cancer by developing an optimal niosomal formulation for doxorubicin and paclitaxel delivery. The results show that the drug-loaded niosomes have a higher release rate and can effectively inhibit tumor cell proliferation.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Oncology
Oezkan Yalkinoglu, Andreas Becker, Axel Krebs-Brown, Claudia Vetter, Christian Luepfert, Dominique Perrin, Juergen Heuer, Herlind Biedert, Stefan Hirt, Afrim Bytyqi, Angelika Bachmann, Rainer Strotmann
Summary: Tepotinib is a MET inhibitor approved for treating non-small cell lung cancer. This study investigated its potential for drug-drug interactions and found that tepotinib showed little evidence of inhibiting CYP3A4/5 or inducing its activity. Clinical studies showed that tepotinib had no impact on the pharmacokinetics of a CYP3A4 substrate and had a minimal effect on a P-gp substrate. Tepotinib was considered safe and well tolerated.
INVESTIGATIONAL NEW DRUGS
(2023)
Review
Pharmacology & Pharmacy
Sachin Rathod, Heta Desai, Rahul Patil, Jayant Sarolia
Summary: This article discusses the significance of studying P-glycoprotein in drug delivery and highlights the effective reversal of P-gp inhibition using nonionic surfactants. Nonionic surfactants, being inert, non-toxic, and efficient, show potential as P-gp inhibitors and improve drug absorption and bioavailability through various mechanisms.
Article
Engineering, Chemical
Mohamed Abbas, Mohammed S. Alqahtani
Summary: Nanotechnology is increasingly being applied in the field of colorectal cancer treatment, with nano drug delivery systems showing promise in delivering pharmaceutical drugs more effectively. Research indicates that nanoscale drugs may be more efficient in preventing disease progression compared to conventional drugs.