期刊
CURRENT CANCER DRUG TARGETS
卷 14, 期 6, 页码 549-556出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568009614666140725092430
关键词
Cancer; E3 ligase; NEDD4; oncogene; target; therapy; ubiquitination
类别
资金
- NSFC [81172087]
- NIH [GM089763, GM094777, CA177910]
The Neuronally expressed developmentally downregulated 4 (NEDD4), functioning largely as an E3 ubiquitin ligase, has been demonstrated to play a critical role in the development and progression of human cancers. In this review, to understand the regulatory mechanism(s) of NEDD4 as well as the signaling pathways controlled by NEDD4, we briefly describe the NEDD4 upstream regulators and its downstream ubiquitin substrates. Moreover, we further discuss its oncogenic roles in human malignancies. Therefore, targeting NEDD4 could be a potential therapeutic strategy for treatment of human cancers.
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