期刊
CURRENT CANCER DRUG TARGETS
卷 12, 期 6, 页码 640-657出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156800912801784866
关键词
Cigarette smoke; cytokines; in vitro studies; in vivo studies; lycopene; redox-sensitive molecular pathways; ROS
类别
资金
- LYCOCARD, European Integrated Project [016213]
Increasing evidence indicates that tomato lycopene may be an ideal candidate in protecting from cancer risk related to smoking exposure. The carotenoid shows potent redox-properties by which it decreases the reactive oxygen species (ROS) generated by smoke and modulates redox-sensitive cell targets, including protein tyrosine phosphatases, protein kinases, MAPKs and transcription factors. Moreover, it counteracts the effects of smoke on carcinogen-bioactivating enzymes and on molecular pathways involved in cell proliferation, apoptosis and inflammation. Lycopene also inhibits smoke-stimulated IGF-signalling and smoke-induced DNA adducts. Some of these actions may be mediated by its oxidative metabolites and may be synergistically enhanced by the presence of other antioxidant nutrients. This review summarizes the background information about the interactions of lycopene with smoke in experimental models and presents the most current knowledge with respect to lycopene role in smoke-related diseases.
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