Article
Cell Biology
Kai Weissenbruch, Magdalena Fladung, Justin Grewe, Laurent Baulesch, Ulrich S. Schwarz, Martin Bastmeyer
Summary: Nonmuscle myosin II minifilaments are important for force generation and mechanosensing in mammalian cells. Different minifilaments have different compositions and activities, with a strong asymmetry between paralogs A and B. NM IIA is responsible for the formation of new minifilaments, while NM IIB acts as a regulator to prevent excessive activity. These two paralogs work together to form a balanced system.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Article
Cell Biology
Alexandre Bergeron, Andra Brezai, Rami Shukr, Louis Villeneuve, Bruce G. Allen, Wasay M. S. Qureshi, Kathryn E. Hentges, Angelino Calderone
Summary: The study found that the appearance of nestin in neonatal rat ventricular cardiomyocytes was associated with a migratory phenotype, and the cotreatment with p38 mitogen-activated protein kinase inhibitor promoted the synthesis of nestin. Additionally, the reorganization of nonmuscle myosin IIB and its physical interaction with nestin may act together to facilitate the migratory phenotype in cardiomyocytes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Clinical Neurology
Shuaishuai Gong, Guosheng Cao, Fang Li, Zhuo Chen, Xuewei Pan, Huifen Ma, Yuanyuan Zhang, Boyang Yu, Junping Kou
Summary: The study suggests that NMMHC IIA plays a crucial role in ischemic stroke by maintaining the integrity of the cerebral endothelial barrier, making it a potential therapeutic target for ischemic stroke.
Article
Cell Biology
Amlan Barai, Abhishek Mukherjee, Alakesh Das, Neha Saxena, Shamik Sen
Summary: ACTN4 regulates cancer invasion by controlling the expression and localization of non-muscle myosin, with protrusion forces depending on confinement and nucleus to matrix stiffness ratio as predicted by experimental observations.
JOURNAL OF CELL SCIENCE
(2021)
Article
Cell Biology
Wencan Ke, Bingjin Wang, Wenbin Hua, Yu Song, Saideng Lu, Rongjin Luo, Gaocai Li, Kun Wang, Zhiwei Liao, Qian Xiang, Shuai Li, Xinghuo Wu, Yukun Zhang, Cao Yang
Summary: The study found that compression stress increased the interaction between myosin IIA and actin, while decreasing the interaction between myosin IIB and actin. Remodeling of the actomyosin cytoskeleton was involved in the fibrotic phenotype induced by compression stress, mediated by MRTF-A nuclear translocation and proliferation inhibition in NP cells. Activation of the RhoA/ROCK1 pathway mediated compression stress-induced senescence in human NP cells by regulating the interaction between myosin IIA and IIB with actin.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Fang Zhang, Yong Li, Lipeng Gan, Xiaomei Tong, Dandan Qi, Qihui Wang, Xin Ye
Summary: The study identified lncRNA MAFG-AS1 as upregulated in HBV-related HCC tissues, leading to enhanced proliferation and migration of HCC cells, suggesting its potential oncogenic role in HBV-related HCC development.
Article
Virology
Jian Chen, Jian Liu, Zhilu Chen, Daobin Feng, Cuisong Zhu, Jun Fan, Shuye Zhang, Xiaoyan Zhang, Jianqing Xu
Summary: This study reveals the crucial role of nonmuscle myosin IIA (MYH9) in regulating influenza A virus (IAV) infection and replication. MYH9 can interact with the viral nucleoprotein (NP) and interrupt the formation of viral ribonucleoprotein (vRNP) complexes, leading to a suppression of viral RNA transcription and replication. These findings shed new light on the complicated interactions between IAV and its host, making MYH9 a potential target for antiviral drug development.
Article
Cell Biology
Maria S. Shutova, Sreeja B. Asokan, Shefali Talwar, Richard K. Assoian, James E. Bear, Tatyana M. Svitkina
JOURNAL OF CELL BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Maria S. Shutova, Tatyana M. Svitkina
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Maria Shutova, Changsong Yang, Jury M. Vasiliev, Tatyana Svitkina
Article
Cell Biology
Maria S. Shutova, Antonina Y. Alexandrova, Jury M. Vasiliev
CELL MOTILITY AND THE CYTOSKELETON
(2008)
Article
Cell Biology
Abhishek Kumar, Maria S. Shutova, Keiichiro Tanaka, Daniel Iwamoto, David A. Calderwood, Tatyana M. Svitkina, Martin A. Schwartz
JOURNAL OF CELL BIOLOGY
(2019)
Review
Allergy
Julia Borowczyk, Maria Shutova, Nicolo Costantino Brembilla, Wolf-Henning Boehncke
Summary: IL-25, a unique cytokine of the IL-17 family, predominantly derived from epithelial cells, plays a significant role in various organ systems' physiology and pathology. It may lead to inflammatory disorders and helps maintain the balance in regulating immune responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Dermatology
Loic Mermoud, Maria Shutova, Alejandro Diaz-Barreiro, Dominique Talabot-Ayer, Justyna Drukala, Michal Wolnicki, Guerkan Kaya, Wolf-Henning Boehncke, Gaby Palmer, Julia Borowczyk
Summary: IL-38, a member of the IL-1 cytokine family, is involved in skin physiology by regulating keratinocyte differentiation, proliferation, and epidermal alterations. It has anti-inflammatory activity, mainly expressed by keratinocytes, dermal fibroblasts, and epithelial cells of skin appendages. IL-38 can shuttle between the nucleus and the cytoplasm and modulate the activity of transcription regulators YAP and ID1.
EXPERIMENTAL DERMATOLOGY
(2022)
Review
Cell Biology
Maria S. Shutova, Wolf-Henning Boehncke
Summary: This review discusses the role of mechanotransduction in skin inflammation, focusing on psoriasis and skin fibrosis. It emphasizes the need for more attention to mechanoregulation in the stratified epidermis of the skin.
Article
Multidisciplinary Sciences
Maria S. Shutova, Julia Borowczyk, Barbara Russo, Sihem Sellami, Justyna Drukala, Michal Wolnicki, Nicolo C. Brembilla, Gurkan Kaya, Andrei I. Ivanov, Wolf-Henning Boehncke
Summary: Abnormal mechanotransduction and compromised epithelial barrier function are observed in various human pathologies, including inflammatory skin disorders. This study investigates the cytoskeletal mechanisms involved in the regulation of inflammatory responses in the epidermis. The results suggest that inflammation up-regulates the Rho-myosin II pathway and disrupts adherens junctions, leading to YAP nuclear entry. The disruption of adherens junctions, increased paracellular permeability, and YAP nuclear translocation are regulated by ROCK2 independently of myosin II activation. The inhibitor KD025 demonstrates the effects of ROCK2 on the inflammatory response in the epidermis through cytoskeletal and transcription-dependent mechanisms.
Article
Multidisciplinary Sciences
Sarah R. Barger, Nicholas S. Reilly, Maria S. Shutova, Qingsen Li, Paolo Maiuri, John M. Heddleston, Mark S. Mooseker, Richard A. Flavell, Tatyana Svitkina, Patrick W. Oakes, Mira Krendel, Nils C. Gauthier
NATURE COMMUNICATIONS
(2019)
Review
Biochemistry & Molecular Biology
M. S. Shutova, T. M. Svitkina
BIOCHEMISTRY-MOSCOW
(2018)
Article
Cell Biology
M. E. Lomakina, M. S. Shutova, A. Y. Zhurayskaya, A. Y. Alexandrova
BIOLOGICHESKIE MEMBRANY
(2017)
Article
Cell Biology
M. E. Lomakina, M. S. Shutova, A. Y. Zhuravskaya, A. Y. Alexandrova
BIOCHEMISTRY MOSCOW SUPPLEMENT SERIES A-MEMBRANE AND CELL BIOLOGY
(2017)