Article
Multidisciplinary Sciences
Avishag Yehuda, Einav Malach, Shahar Vanunu Ofri, Leyla Slamti, Shanny Hsuan Kuo, Jonathan Z. Lau, Myung Whan Oh, John Adeoye, Neta Shlezinger, Didier Lereclus, Gee W. Lau, Zvi Hayouka
Summary: This study reports on how interception of quorum sensing communication in Bacillus cereus (Bc) eliminates its ability to affect the host immune system. A peptide-based quorum sensing inhibitor was designed, which attenuated Bc infectivity in mouse models by suppressing virulence factor expression. These findings reveal a novel strategy to limit Bc virulence and enhance host defense.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Bianca Striednig, Ulrike Lanner, Selina Niggli, Ana Katic, Simone Vormittag, Sabrina Brulisauer, Ramon Hochstrasser, Andres Kaech, Amanda Welin, Antje Flieger, Urs Ziegler, Alexander Schmidt, Hubert Hilbi, Nicolas Personnic
Summary: Legionella pneumophila, the causative agent of Legionnaires' disease, replicates in a distinct compartment within amoebae and macrophages. The pathogen switches between replicative, non-virulent and non-replicating, virulent/transmissive phases. Individual motile and virulent L. pneumophila cells emerge in the cluster of non-growing bacteria within the Legionella-containing vacuole at late stages of infection, with distinct proteomes and phenotypic heterogeneity. The emergence and spreading of a subpopulation of transmissive L. pneumophila at the LCV periphery at the end of an infection cycle are regulated by the Legionella quorum sensing system.
Review
Biotechnology & Applied Microbiology
Pengfei Gu, Qianqian Ma, Shuo Zhao, Juan Gao, Changtao Li, Hao Zhou, Shuixing Jiang, Qiang Li
Summary: This review summarizes the recent progress in using quorum sensing systems for dynamic regulation in microorganisms and highlights its applications and challenges in the field of metabolic engineering.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Justin E. Silpe, Olivia P. Duddy, Bonnie L. Bassler
Summary: This study reveals that bacteriophages can manipulate the bacterial cell-to-cell communication process and trigger the death of host bacteria. The activity of a specific phage receptor is modulated by noncognate signaling molecules and synthetic inhibitors. The findings suggest that the density and species composition of bacterial communities can influence the outcome of bacterial-phage interactions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Parasitology
Victoria L. Pike, Emily J. Stevens, Ashleigh S. Griffin, Kayla C. King
Summary: In order for infections to persist in a population, pathogens need to compete for host colonization and transmission. A study using Pseudomonas aeruginosa and Caenorhabditis elegans as models found that producer pathogens were more successful at colonizing hosts and transmitting between them compared to non-producers, even when co-infecting. Understanding these dynamics can help predict and control the spread of infections and explain the persistence of cooperative genotypes in natural populations.
Article
Microbiology
Alejandro Vasquez-Rifo, Jamie Cook, Deborah L. McEwan, Dania Shikara, Frederick M. Ausubel, Francesca Di Cara, Zhenyu Cheng
Summary: This study systematically compares the virulence of wild-type P. aeruginosa and QS mutants in selected hosts and conditions. It contributes to the long-term goal of understanding the intricate roles of different branches of the P. aeruginosa QS network in different hosts, and serves as a valuable resource for the field of host-pathogen interactions.
Article
Multidisciplinary Sciences
Aishan Zhao, Steven P. Bodine, Qian Xie, Boyuan Wang, Geeta Ram, Richard P. Novick, Tom W. Muir
Summary: This study reveals the involvement of membrane protease regulator of agr QS (MroQ) in the production of autoinducing peptide (AIP) in Staphylococcus aureus. It also uncovers the different roles of MroQ in different agr specificity groups, enhancing our understanding of the agr response and Staphylococcus aureus virulence.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Ann T. Tate, Nora K. E. Schulz
Summary: The article discusses the complex relationship between hosts and their microbes within hosts and the role of mathematical models in disease biology. Insect hosts provide strong support for integrating experiments and theory in research. Studies on fruit flies, moths, beetles, and other insects have inspired important mathematical models and raised questions that are ripe for further testing in insects.
CURRENT OPINION IN INSECT SCIENCE
(2022)
Review
Microbiology
Lei Yang, Tian-jie Yuan, Yue Wan, Wen-wen Li, Chen Liu, Shu Jiang, Jin-ao Duan
Summary: Quorum sensing is a chemical communication process between bacteria that synchronizes gene expression and promotes cooperation and competitiveness. Further research is needed to investigate bacterial quorum sensing in natural conditions, particularly in the intestinal flora and its relation to health.
FUTURE MICROBIOLOGY
(2022)
Article
Plant Sciences
Biswajit Samal, Subhadeep Chatterjee
Summary: The study revealed the important role of quorum sensing in phytopathogens, facilitating Xanthomonas campestris colonization in cabbage leaves and triggering chlorosis, promoting systemic infection. The quorum sensing response in the Xanthomonas group maximizes population fitness, triggering host chlorophagy at specific stages and establishing systemic infection.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Biology
Bingqian Xue, Yamin Shen, Jing Zuo, Dong Song, Qingying Fan, Xiaoling Zhang, Li Yi, Yang Wang
Summary: Streptococcus suis relies on quorum sensing to adapt to its surroundings, and inhibiting AI-2 production, targeting LuxS protein, and blocking luxs gene expression can control its system. Quorum sensing inhibitors offer hope for the development of new antibacterial drugs in the face of antibiotic resistance.
Review
Polymer Science
Moupriya Nag, Dibyajit Lahiri, Dipro Mukherjee, Ritwik Banerjee, Sayantani Garai, Tanmay Sarkar, Sujay Ghosh, Ankita Dey, Sougata Ghosh, Smaranika Pattnaik, Hisham Atan Edinur, Zulhisyam Abdul Kari, Siddhartha Pati, Rina Rani Ray
Summary: Chitosan and its nano materials show potential in combating drug resistance by disrupting quorum sensing in microbial biofilms, offering a solution for treating chronic infections and preparing medical devices. Through interaction with amino groups on microorganisms, they disrupt membrane permeability and induce cell death.
Review
Food Science & Technology
Yucheng Zhang, Ning Ma, Peng Tan, Xi Ma
Summary: This review provides an overview of how gut bacteria use quorum sensing (QS) to communicate and coordinate their activities, and the role of QS in the interaction between the gut host and microbiota. Understanding the communication network of gut microbiota is crucial for developing strategies against bacterial illnesses and improving gut health.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Ecology
Charles Bernard, Yanyan Li, Philippe Lopez, Eric Bapteste
Summary: The phi3T phage utilizes both the arbitrium quorum sensing system and the host-derived Rap phi-Phr phi system to communicate and coordinate lytic-to-lysogeny transitions based on population density and stress levels of the bacterial hosts. This novel QS system not only regulates host defense mechanisms during viral infection, but also provides lysogenized bacteria with a fitness advantage and delays costly production of public goods. Ultimately, this discovery sheds light on how phage communication systems contribute to phage-host evolutionary stability.
Review
Gastroenterology & Hepatology
Garance Coquant, Doriane Aguanno, Sandrine Pham, Nathan Grellier, Sophie Thenet, Veronique Carriere, Jean-Pierre Grill, Philippe Seksik
Summary: Bacteria communicate and regulate activities through quorum sensing, impacting gut health. Various QS systems may play a crucial role in intestinal disorders. Understanding the role of bacterial social networks in gut physiology can lead to the development of new therapeutic strategies.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Genetics & Heredity
Priscilla de F. Cardoso, Stephane Perchat, Laurival A. Vilas-Boas, Didier Lereclus, Gislayne T. Vilas-Boas
Article
Microbiology
Monika Ehling-Schulz, Didier Lereclus, Theresa M. Koehler
MICROBIOLOGY SPECTRUM
(2019)
Article
Microbiology
Leyla Slamti, Didier Lereclus
RESEARCH IN MICROBIOLOGY
(2019)
Article
Microbiology
Eugenie Huillet, Ludovic Bridoux, Isabelle Barboza, Christelle Lemy, Gwenaelle Andre-Leroux, Didier Lereclus
Article
Biochemistry & Molecular Biology
Ruibin Zhang, Leyla Slamti, Lei Tong, Emilie Verplaetse, Lixia Ma, Christelle Lemy, Qi Peng, Shuyuan Guo, Jie Zhang, Fuping Song, Didier Lereclus
MOLECULAR MICROBIOLOGY
(2020)
Article
Microbiology
Liqin Zhou, Leyla Slamti, Didier Lereclus, Ben Raymond
Article
Biotechnology & Applied Microbiology
Priscilla Cardoso, Fernanda Fazion, Stephane Perchat, Christophe Buisson, Gislayne Vilas-Boas, Didier Lereclus
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2020)
Article
Microbiology
Stephanie Henry, Didier Lereclus, Leyla Slamti
JOURNAL OF BACTERIOLOGY
(2020)
Article
Genetics & Heredity
Alexander Bolotin, Benoit Quinquis, Hugo Roume, Michel Gohar, Didier Lereclus, Alexei Sorokin
MICROBIAL GENOMICS
(2020)
Article
Microbiology
Nay El-Khoury, Imene Bennaceur, Emilie Verplaetse, Stephane Aymerich, Didier Lereclus, Mireille Kallassy, Michel Gohar
Summary: During biofilm growth, dynamic exchanges occur between planktonic and sessile cells. The planktonic population grows until the biofilm forms, then rapidly decreases to zero, while recruited planktonic cells are found in specific areas with low sessile cell density within the biofilm, indicating spatial heterogeneity.
Article
Immunology
Erin T. Livingston, Md Huzzatul Mursalin, Phillip S. Coburn, Roger Astley, Frederick C. Miller, Omar Amayem, Didier Lereclus, Michelle C. Callegan
Summary: The InhA metalloproteases of Bacillus contribute to the severity of infection and inflammation in endophthalmitis.
INFECTION AND IMMUNITY
(2021)
Article
Ecology
Haibo Chen, Emilie Verplaetse, Tania Jauslin, Pierre Cosson, Leyla Slamti, Didier Lereclus
Summary: This study reveals that amoebas can phagocytose and digest vegetative Bacillus cells, prevent the formation of cysts, and promote spore germination and completion of their developmental cycle in their environment. The interaction between amoebas and Bacillus creates a virtuous circle where each protagonist helps the other to develop.
Article
Microbiology
Haibo Chen, Emilie Verplaetse, Leyla Slamti, Didier Lereclus
Summary: This study identified a novel regulator called VipR that activates vip3A gene expression at the onset of the stationary phase. Additionally, the study found a highly conserved DNA sequence in the promoter regions of vip3A and vipR genes, which is also present upstream of the cry2A and cry1I genes, suggesting that Cry toxins may be produced before sporulation. This result helps to better understand the role of Cry and Vip3A toxins during the infectious cycle of Bacillus thuringiensis in insects, in addition to the primary role of Cry toxins in toxemia caused by crystal ingestion.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Hasna Toukabri, Didier Lereclus, Leyla Slamti
Summary: Bacillus thuringiensis can persist in the host cadaver in a nonsporulated form for at least 14 days and engages in a profound adaptation process.
Article
Multidisciplinary Sciences
Avishag Yehuda, Einav Malach, Shahar Vanunu Ofri, Leyla Slamti, Shanny Hsuan Kuo, Jonathan Z. Lau, Myung Whan Oh, John Adeoye, Neta Shlezinger, Didier Lereclus, Gee W. Lau, Zvi Hayouka
Summary: This study reports on how interception of quorum sensing communication in Bacillus cereus (Bc) eliminates its ability to affect the host immune system. A peptide-based quorum sensing inhibitor was designed, which attenuated Bc infectivity in mouse models by suppressing virulence factor expression. These findings reveal a novel strategy to limit Bc virulence and enhance host defense.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)