Article
Engineering, Environmental
Yibo Jia, Yumin Zhu, Dashan Xu, Xuemin Feng, Xiaoyong Yu, Guoqiang Shan, Lingyan Zhu
Summary: It has been found that some PFASs tend to accumulate in the liver and cause hepatotoxicity. Experimental results indicate that there is a competition between liver and blood for the partitioning of PFSAs, which is mainly determined by the competitive binding between hL-FABP and HSA. Therefore, the liver concentrations of PFASs in humans can be predicted from the available serum concentrations, which is important for assessing hepatotoxicity.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Multidisciplinary Sciences
Sujay Raghavendra Naganna, Hussein Adebayo Ibrahim, Soon Poh Yap, Chee Ghuan Tan, Kim Hung Mo, Ahmed El-Shafie
Summary: Architectural concrete, coined in 1924, enhances the visual aspect of structures through the application of color, form and texture. It is suitable for both structural and veneer applications, providing economic and environmental benefits, as well as a wide range of structural appearance options.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Cheng-Yi Yen, Min-Guan Lin, Bo-Wei Chen, Irene W. Ng, Nicholas Read, Azhar F. Kabli, Che-Ting Wu, Yo-You Shen, Chen-Hao Chen, Daniela Barilla, Yuh-Ju Sun, Chwan-Deng Hsiao
Summary: The SegAB system in Sulfolobus solfataricus consists of SegA, a ParA Walker-type ATPase, and SegB, a site-specific DNA-binding protein. Both proteins form higher order chromatin-like structures with DNA, contributing to chromosome segregation in archaea.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yi Zhou, Panayiotis E. Stevis, Jing Cao, Kei Saotome, Jiaxi Wu, Arielle Glatman Zaretsky, Sokol Haxhinasto, George D. Yancopoulos, Andrew J. Murphy, Mark W. Sleeman, William C. Olson, Matthew C. Franklin
Summary: This article presents the cryo-electron microscopy structures of five signaling complexes of the IL-6 family cytokines, revealing their assembly and molecular interactions. The structures provide insights for therapeutic targeting of gp130-mediated signaling.
Article
Cell Biology
Yanhe Zhao, Justine Pinskey, Jianfeng Lin, Weining Yin, Patrick R. Sears, Leigh A. Daniels, Maimoona A. Zariwala, Michael R. Knowles, Lawrence E. Ostrowski, Daniela Nicastro
Summary: The study provides insights into the potential structural basis for primary ciliary dyskinesia by examining the structure of RSPH4A(-/-) human respiratory cilia, highlighting the benefits of using cryo-electron tomography directly on patient samples for molecular structure determination.
MOLECULAR BIOLOGY OF THE CELL
(2021)
Review
Pharmacology & Pharmacy
Pronalis Tapfumaneyi, Mohammad Imran, Seyed Ebrahim Alavi, Yousuf Mohammed
Summary: Studies have shown that the thermodynamic activity of drugs plays a significant role in skin drug delivery by increasing drug absorption. This activity can be altered based on the physicochemical parameters of the drug in the vehicle. Thermodynamic principles have been utilized to develop novel delivery systems and enhance drug permeation through the skin. This review provides insights into the importance of thermodynamic principles in optimizing topical and transdermal drug delivery systems.
DRUG DISCOVERY TODAY
(2023)
Article
Engineering, Electrical & Electronic
Randall Balestriero, Richard G. Baraniuk
Summary: The study establishes a rigorous connection between deep networks and approximation theory using spline functions and operators, introducing the concept of max-affine spline operators (MASOs). By analyzing the inner workings of DNs, exploring signal comparison, optimal classification theory, and data memorization effects, the research provides insights into the organization of signals in a hierarchical manner. Additionally, a penalty term is proposed to enhance classification performance by forcing templates to be orthogonal, without altering the DN architecture.
PROCEEDINGS OF THE IEEE
(2021)
Article
Biology
Andrea Volante, Juan Carlos Alonso, Kiyoshi Mizuuchi
Summary: This study focuses on the unique architecture of the pSM19035 partition complex and its interaction with nucleoid-bound ParA(pSM)-ATP. It reveals that the presence of four or more contiguous ParB(pSM)-binding sequence repeats in the parS(pSM) is required for the assembly of a stable ParA(pSM)-ParB(pSM) complex and efficient activation of ParA(pSM)-ATPase.
Article
Management
Flavio K. Miyazawa, Phablo F. S. Moura, Matheus J. Ota, Yoshiko Wakabayashi
Summary: This work addresses the balanced connected k-partition problem and proposes three linear programming formulations for modeling practical applications. The computational experiments showed that the exact algorithms based on these formulations outperform other approaches presented in the literature.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2021)
Article
Geosciences, Multidisciplinary
Guilherme Bozetti, Xiangbo Li, Zhanlong Yang, Huaqing Liu, Junping Huang, Zhiyong Li, Jingping Xu
Summary: Deep-lacustrine systems have been less studied compared to marine systems due to the scarcity of large and continuous outcrops globally. This study examines outcrops and cores from the Ordos Basin in China, revealing the presence of deep-lacustrine slope channels and levee deposits composed of interbedded sandstones and mudstones. The re-interpretation of sandstone-prone deposits in the Yanchang Formation provides insights into the architectural elements in intracratonic lacustrine basins, with implications for hydrocarbon exploration and production.
JOURNAL OF ASIAN EARTH SCIENCES
(2023)
Article
Construction & Building Technology
Lin Li, Xiaolong Yang, Xingwei Xiang, Luyi Kong, Jiner Dai, Qingyong Zeng
Summary: By incorporating architectural design competitions in architectural design teaching, students can gain a more comprehensive understanding of sustainable manufacturing by considering elements beyond traditional architectural design.
Article
Agricultural Engineering
Hong Wang, Min Yang, Ke Liu, Enzhe Yang, Jing Chen, Sha Wu, Min Xie, Dongbo Wang, Hengwei Deng, Hong Chen
Summary: Through an integrated investigation, it was found that stable dissolved oxygen partition and granular sludge cultivation can significantly enhance the activity and abundance of functional microbes, thereby enhancing the synergy of autotrophic nitrogen removal.
BIORESOURCE TECHNOLOGY
(2022)
Article
Chemistry, Physical
Luis A. Zepeda-Ruiz, Alexander Stukowski, Tomas Oppelstrup, Nicolas Bertin, Nathan R. Barton, Rodrigo Freitas, Vasily V. Bulatov
Summary: We demonstrated that crystal rotation leads to the staged hardening of metals, while the basic mechanisms of dislocation behavior remain consistent across all stages of metal hardening.
Review
Pharmacology & Pharmacy
Xifeng Xiong, Nan Tang, Xudong Lai, Jinli Zhang, Weilun Wen, Xiaojian Li, Aiguo Li, Yanhua Wu, Zhihe Liu
Summary: Amentoflavone is an active phenolic compound with multifunctional biological activities, including anti-cancer and anti-SARS-CoV-2 effects, making it a promising therapeutic agent for clinical research.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
K. Bouhouche, M. S. Valentine, P. Le Borgne, M. Lemullois, J. Yano, S. Lodh, A. Nabi, A. M. Tassin, J. L. Van Houten
Summary: Cilia are ubiquitous and highly conserved extensions that endow the cell with motility and sensory functions. Paramecium, a ciliated organism, is a suitable model for studying cilia assembly and function, and can be used to validate candidate genes for ciliopathies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)