Article
Biochemistry & Molecular Biology
Valentina Tosato, Beatrice Rossi, Jason Sims, Carlo V. Bruschi
Summary: This study investigates the cell uptake and genomic integration of exogenous linear DNA in the model organism Saccharomyces cerevisiae throughout the cell cycle. The researchers found that transformability increases in S phase regardless of sequence homologies, and the efficiency of chromosomal integration depends on the genomic targets during a specific phase. The Pol32 polymerase was found to control a specific translocation between chromosomes XV and VIII during DNA synthesis. The cell-cycle dependent regulation of DNA repair pathways under stress and the increase of ROS levels following translocation events were also discovered.
Article
Transplantation
Marja Puurunen, Caroline Kurtz, Alistair Wheeler, Kyra Mulder, Kyle Wood, Anna Swenson, Gary Curhan
Summary: This study aimed to assess whether 24-hour urine oxalate excretion is associated with the risk of chronic kidney disease (CKD). The results showed that as the urine oxalate excretion increased, the risk of developing CKD also increased. Therefore, future studies should investigate whether reducing urine oxalate can decrease the risk of CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Clinical Neurology
Michele Terzaghi, Laura Pilati, Natascia Ghiotto, Dario Arnaldi, Maurizio Versino, Valter Rustioni, Gianluca Rustioni, Ivana Sartori, Raffaele Manni
Summary: The study aimed to investigate the impact of autonomic dysfunction in idiopathic REM sleep behavior disorder (iRBD) on circadian blood pressure profile. Results showed that iRBD patients had impaired 24-hour blood pressure control, characterized by reduced nocturnal dipping and increased frequency of nondipping status, similar to patterns seen in de novo PD patients. These findings may have implications for cardiovascular morbidity and mortality in iRBD.
Article
Biology
Florent Gobert, Alexandra Corneyllie, Helene Bastuji, Christian Berthomier, Marc Thevenet, Jonas Abernot, Veronique Raverot, Frederic Dailler, Claude Guerin, Claude Gronfier, Jacques Luaute, Fabien Perrin
Summary: This study examined the fluctuations of consciousness in patients with acute brain injuries and their association with EEG patterns and circadian rhythms. The results suggested that more physiological and favorable patterns of fluctuations were associated with higher predictability and distinct up-and-down shape of EEG switches. Patients with simultaneous circadian rhythmicity for brain, behavior, and hormones had a better outcome. This study highlights the importance of predictable long-term generation of brain rhythms and circadian body-brain rhythms in awakening.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cell Biology
Airong Qian, Tzu-Bou Hsieh, M. Moazzem Hossain, Jim J-C Lin, J-P Jin
Summary: Calponin 2 is a crucial protein regulating cell motility-related functions and cell division. Proper expression levels and degradation of calponin 2 play essential roles in normal cytokinesis. PKC phosphorylation-triggered degradation of calponin 2 may determine the rate of cell division.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Neurosciences
Maddison L. Mellow, Dorothea Dumuid, Alexandra T. Wade, Ty Stanford, Timothy S. Olds, Frini Karayanidis, Montana Hunter, Hannah A. D. Keage, Jillian Dorrian, Mitchell R. Goldsworthy, Ashleigh E. Smith
Summary: This study aimed to investigate the association between 24-h time-use composition and cognitive function in healthy older adults. The results showed no significant associations between time-use composition and global cognition, long-term memory, short-term memory, executive function, or processing speed outcomes, highlighting the need for longitudinal studies to uncover temporal effects.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Fei Ma, Yating Yang, Jingwen Tao, Xiaoyan Deng, Xufeng Chen, Jingjing Fan, Xuelei Bai, Tongyu Dai, Sheng Li, Xiaoyun Yang, Fan Lin
Summary: The characteristics of inverted T-waves in patients with apical hypertrophic cardiomyopathy (ApHCM) over a 24-hour period were studied. Inverted T-waves in ApHCM showed notable variations and were strongly correlated with heart rate and circadian rhythm. Conducting electrocardiogram (ECG) examinations during states of inactivity, comparable to sleep, improved the sensitivity of the diagnosis of ApHCM. Detecting T-wave amplitudes greater than 10 mm effectively improved the diagnostic rate of ApHCM, especially in patients under 50 years of age.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Chemistry, Analytical
Katrina Hinde, Graham White, Nicola Armstrong
Summary: Heart rate variability (HRV) measurements provide insights into the autonomic nervous system and sympathetic activity balance. High HRV indicates good adaptability, while low HRV may signal fatigue, overtraining, or health issues. The Polar H10 stands out as the most accurate wearable device currently available, although it requires additional cost for data extraction without using an app.
Article
Neurosciences
Rachel C. Williams, Wendy W. Harrison, Andrew Carkeet, Lisa A. Ostrin
Summary: Retinal oxygen saturation undergoes diurnal variations and is influenced by systemic and local vasculature, intraocular pressure, and cellular function. This study investigated the relationship between diurnal variations in retinal oximetry measures and other ocular and systemic physiological processes. The findings contribute to a better understanding of factors influencing oxygenation of the area surrounding the fovea.
Article
Peripheral Vascular Disease
Thomas Weber, Athanase D. Protogerou, Mohsen Agharazii, Antonis Argyris, Sola Aoun Bahous, Jose R. Banegas, Ronald K. Binder, Jacques Blacher, Andrea Araujo Brandao, Juan J. Cruz, Kathrin Danninger, Cristina Giannatasio, Auxiliadora Graciani, Bernhard Hametner, Piotr Jankowski, Yan Li, Alessandro Maloberti, Christopher C. Mayer, Barry J. McDonnell, Carmel M. McEniery, Marco Antonio Mota Gomes, Annelise Machado Gomes, Maria Lorenza Muiesan, Janos Nemcsik, Anna Paini, Enrique Rodilla, Aletta E. Schutte, Petros P. Sfikakis, Dimitrios Terentes-Printzios, Alexandre Vallee, Charalambos Vlachopoulos, Lisa Ware, Ian Wilkinson, Robert Zweiker, James E. Sharman, Siegfried Wassertheurer
Summary: Central systolic blood pressure (cSBP) is more closely associated with hypertension-mediated organ damage and prognosis than brachial systolic blood pressure. This study investigated the 24-hour profiles of brachial and central SBP in untreated adults, providing reference values and analyzing daytime-nighttime variability. The findings have potential implications for refining hypertension diagnosis and management.
Article
Endocrinology & Metabolism
Anne Gemmink, Sabine Daemen, Jakob Wefers, Jan Hansen, Dirk van Moorsel, Puji Astuti, Johanna A. Jorgensen, Esther Kornips, Gert Schaart, Joris Hoeks, Patrick Schrauwen, Matthijs K. C. Hesselink
Summary: The morphology of the mitochondrial network and its respiratory capacity exhibit day-night rhythmicity in young healthy lean individuals but not in older individuals with obesity.
MOLECULAR METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Bashaaer Sharad, Giulia Rivasi, Viktor Hamrefors, Madeleine Johansson, Andrea Ungar, Richard Sutton, Michele Brignole, Gianfranco Parati, Artur Fedorowski
Summary: This study compared ambulatory blood pressure monitoring data between patients with reflex syncope and a control group. The findings showed that patients with reflex syncope had lower 24-hour systolic blood pressure, higher 24-hour diastolic blood pressure, and more frequent daytime drops in systolic blood pressure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Urology & Nephrology
Zheng Li, Shi Chen, Ying Tan, Jicheng Lv, Minghui Zhao, Qian Chen, Yingdong He
Summary: This study analyzed the association between proteinuria levels and adverse pregnancy outcomes among CKD patients treated with or without steroids/immunosuppressive therapy in early pregnancy. The study found that higher levels of proteinuria were associated with adverse pregnancy outcomes, and the impact differed based on whether patients received treatment.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Anne Zanchi, Menno Pruijm, Marie-Eve Muller, Arlene Ghajarzadeh-Wurzner, Marc Maillard, Nathalie Dufour, Olivier Bonny, Gregoire Wuerzner, Michel Burnier
Summary: This study found that SGLT2 inhibitors can lower daytime and nighttime ambulatory blood pressure in normotensive non-diabetic subjects, with effects comparable to those seen in diabetic or hypertensive patients. Baseline ambulatory blood pressure levels were identified as a significant determinant of blood pressure response.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Clinical Neurology
Solveig Vieluf, Marta Amengual-Gual, Bo Zhang, Rima El Atrache, Claire Ufongene, Michele C. Jackson, Sarah Branch, Claus Reinsberger, Tobias Loddenkemper
Summary: Objective: Daytime and nighttime patterns affect brain and body functions, influencing autonomic nervous system response to seizures. Methods: 24-hour electrodermal activity (EDA) patterns were evaluated in pediatric patients with and without seizures, revealing lower EDA levels in patients with recorded seizures. Significance: Continuous EDA monitoring offers a noninvasive tool for sympathetic activity monitoring, with potential applications in seizure detection and prediction, as well as in estimating risk of sudden unexpected death in epilepsy (SUDEP).
Article
Computer Science, Theory & Methods
Ricardo Honorato-Zimmer, Andrew J. Millar, Gordon D. Plotkin, Argyris Zardilis
THEORETICAL COMPUTER SCIENCE
(2019)
Article
Plant Sciences
Anna Flis, Virginie Mengin, Alexander A. Ivakov, Sam T. Mugford, Hans-Michael Hubberten, Beatrice Encke, Nicole Krohn, Melanie Hoehne, Regina Feil, Rainer Hoefgen, John E. Lunn, Andrew J. Millar, Alison M. Smith, Ronan Sulpice, Mark Stitt
PLANT CELL AND ENVIRONMENT
(2019)
Article
Plant Sciences
Argyris Zardilis, Alastair Hume, Andrew J. Millar
JOURNAL OF EXPERIMENTAL BOTANY
(2019)
Review
Plant Sciences
Andrew J. Millar, Uriel Urquiza, Peter L. Freeman, Alastair Hume, Gordon D. Plotkin, Oxana Sorokina, Argyris Zardilis, Tomasz Zielinski
JOURNAL OF EXPERIMENTAL BOTANY
(2019)
Article
Genetics & Heredity
Helen K. Feord, Frederick E. G. Dear, Darren J. Obbard, Gerben van Ooijen
Article
Biology
Jean-Michel Fustin, Shiqi Ye, Christin Rakers, Kensuke Kaneko, Kazuki Fukumoto, Mayu Yamano, Marijke Versteven, Ellen Grunewald, Samantha J. Cargill, T. Katherine Tamai, Yao Xu, Maria Luisa Jabbur, Rika Kojima, Melisa L. Lamberti, Kumiko Yoshioka-Kobayashi, David Whitmore, Stephanie Tammam, P. Lynne Howell, Ryoichiro Kageyama, Takuya Matsuo, Ralf Stanewsky, Diego A. Golombek, Carl Hirschie Johnson, Hideaki Kakeya, Gerben van Ooijen, Hitoshi Okamura
COMMUNICATIONS BIOLOGY
(2020)
Correction
Biology
Jean-Michel Fustin, Shiqi Ye, Christin Rakers, Kensuke Kaneko, Kazuki Fukumoto, Mayu Yamano, Marijke Versteven, Ellen Grunewald, Samantha J. Cargill, T. Katherine Tamai, Yao Xu, Maria Luisa Jabbur, Rika Kojima, Melisa L. Lamberti, Kumiko Yoshioka-Kobayashi, David Whitmore, Stephanie Tammam, P. Lynne Howell, Ryoichiro Kageyama, Takuya Matsuo, Ralf Stanewsky, Diego A. Golombek, Carl Hirschie Johnson, Hideaki Kakeya, Gerben van Ooijen, Hitoshi Okamura
COMMUNICATIONS BIOLOGY
(2020)
Article
Biochemical Research Methods
Johanna Krahmer, Matthew Hindle, Laura K. Perby, Helle K. Mogensen, Tom H. Nielsen, Karen J. Halliday, Gerben van Ooijen, Thierry Le Bihan, Andrew J. Millar
Summary: This study observed the proteomic and phosphoproteomic time series of Arabidopsis thaliana plants under constant light conditions. It found that only a small percentage of proteins and a larger proportion of phospho-sites exhibited rhythmic changes. Furthermore, half of the rhythmic phospho-sites showed the highest phosphorylation levels at subjective dawn. The clock gene circuit plays a crucial role in most protein phosphorylation rhythms, but not necessarily in all of them.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Article
Multidisciplinary Sciences
Alessandra Stangherlin, Joseph L. Watson, David C. S. Wong, Silvia Barbiero, Aiwei Zeng, Estere Seinkmane, Sew Peak Chew, Andrew D. Beale, Edward A. Hayter, Alina Guna, Alison J. Inglis, Marrit Putker, Eline Bartolami, Stefan Matile, Nicolas Lequeux, Thomas Pons, Jason Day, Gerben van Ooijen, Rebecca M. Voorhees, David A. Bechtold, Emmanuel Derivery, Rachel S. Edgar, Peter Newham, John S. O'Neill
Summary: This study reveals that circadian control of the proteome impacts ion homeostasis in cells, especially cardiomyocytes, through mechanisms involving osmotic compensation via electroneutral ion transport. Changes in ion content due to perturbation of soluble protein abundance drive daily rhythms in cardiomyocyte electrical activity, with substantial consequences for cell physiology.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Holly Kay, Harry Taylor, Gerben van Ooijen
Summary: This study reveals how environmental and endogenous circadian rhythms regulate the selenoproteome in a model eukaryotic cell. The expression of selenoproteins is influenced by rhythmicity under constant circadian conditions, while selenium uptake shows high-amplitude rhythms under environmentally rhythmic conditions. Additionally, selenium deprivation leads to clock gene expression defects under the light/dark cycle.
Article
Biology
Holly Kay, Ellen Grunewald, Helen K. Feord, Sergio Gil, Sew Y. Peak-Chew, Alessandra Stangherlin, John S. O'Neill, Gerben van Ooijen
Summary: The cellular landscape undergoes significant changes over a 24-hour period, with the proteome responding directly to daily environmental cycles and being regulated by the circadian clock. Research suggests that transcript oscillations are not strong predictors of protein oscillations, indicating that the cellular spatiotemporal proteome is shaped by rhythmic regulation at various stages of transcription and translation.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Livia C. T. Scorza, Graeme J. Cameron, Roisin Murray-Williams, David Findlay, Julie Bolland, Brindusa Cerghizan, Kirsty Campbell, David Thomson, Alexander Corbishley, David Gally, Stephen Fitzgerald, Alison Low, Sean McAteer, Adrian M. I. Roberts, Zhou Fang, Claus-Dieter Mayer, Anastasia Frantsuzova, Sumy V. Baby, Tomasz Zielinski, Andrew J. Millar
Summary: Wastewater-based monitoring was established in Scotland to track SARS-CoV-2 viral RNA levels in the sewage network during the COVID-19 pandemic. A curated dataset from May 2020 to February 2022 was presented, with viral levels analyzed using RT-qPCR assays. The wastewater data contribute to estimates of disease prevalence and the viral reproduction number in Scotland and the UK.
Article
Biochemical Research Methods
Tomasz Zielinski, Johnny Hay, Andrew Romanowski, Anja Nenninger, Alistair McCormick, Andrew J. Millar
Summary: Practical delivery of Findable, Accessible, Reusable and Interoperable principles for research data management requires expertise, time resource, (meta)data standards and formats, software tools and public repositories. SynBio2Easy, a tool presented in this paper, streamlines and automates operations on Synthetic Biology Open Language (SBOL) designs using Microsoft Excel(R) tables as metadata inputs.
Article
Biochemical Research Methods
Uriel Urquiza-Garcia, Tomasz Zielinski, Andrew J. Millar
Meeting Abstract
Biochemistry & Molecular Biology
S. J. Cargill, S. H. Spoel, G. van Ooijen
MOLECULAR PLANT-MICROBE INTERACTIONS
(2019)