Article
Biochemistry & Molecular Biology
Huibo Ren, Jinqiu Rao, Min Tang, Yaxing Li, Xie Dang, Deshu Lin
Summary: This study identified PP2A as a regulator of conical cell shape and suggested that it mediates the phospho-regulation of KATANIN during plant cell morphogenesis.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu Chen, Xiayan Liu, Wenjing Zhang, Jie Li, Haofeng Liu, Lan Yang, Pei Lei, Hongchang Zhang, Fei Yu
Summary: This study identifies the interaction between two important microtubule (MT)-associated proteins, MOR1/MAP215 and KTN1, which play a crucial role in regulating MT dynamics and development in plants.
Article
Biochemistry & Molecular Biology
Emmanuel Panteris, Anna Kouskouveli, Dimitris Pappas, Ioannis-Dimosthenis S. Adamakis
Summary: The malfunction of p60-katanin in cell plate/daughter wall formation in the fra2 Arabidopsis thaliana loss-of-function mutant was investigated. Deviations in the chemical composition of cell plate/new cell wall were identified by transmission electron microscopy (TEM), immunolabeling, and confocal microscopy. Delayed cytokinesis in the mutant results in a loss of synchronization between cell plate growth and chemical maturation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Landi Sun, Lihong Cui, Zhen Liu, Qixuan Wang, Zhaoyu Xue, Menghua Wu, Tianhui Sun, Decai Mao, Jianquan Ni, Jose Carlos Pastor-Pareja, Xin Liang
Summary: The study reveals the dual functions of the neuronal microtubule-severing enzyme kat60L1 in constructing the cytoskeleton in fly campaniform mechanosensory cilia. It amplifies the mass of microtubules to form dense arrays and generates short microtubules required for building the nanoscopic cytoskeleton. Additionally, Patronin and other potential factors play functional roles in the local regulatory network.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mariya Genova, Lenka Grycova, Verena Puttrich, Maria M. Magiera, Zdenek Lansky, Carsten Janke, Marcus Braun
Summary: By using in-vitro reconstitution, this study reveals that the polyglutamylation generated by TTLL1 and TTLL7 differentially modulates the activities of Tau, katanin, and kinesin-1, providing mechanistic insight into how polyglutamylation selectively controls microtubule interactions in neurons.
Article
Multidisciplinary Sciences
Stefan Baar, Masahiro Kuragano, Kiyotaka Tokuraku, Shinya Watanabe
Summary: This study aims to define a comprehensive approach to quantitatively estimate the physical cell activity based on migration and morphology using statistical analysis. The researchers present quantitative measurements of the influence of drugs on cell populations and have developed a customized deep learning cell detection and tracking procedure.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Aglaja Kopf, Eva Kiermaier
Summary: The organization of microtubule arrays in immune cells is crucial for their effector functions in immune responses. Leukocytes mainly use centrosomes for microtubule nucleation, allowing for plastic MTOC localization and dynamics to adapt to different environmental conditions, highlighting the importance of microtubule involvement in cell shape maintenance and physical coherence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kirstine Lavrsen, Girish Rajendraprasad, Marcin Leda, Susana Eibes, Elisa Vitiello, Vasileios Katopodis, Andrew B. Goryachev, Marin Barisic
Summary: Cell polarization and symmetry breaking are crucial for directed cell migration. The study reveals that microtubule detyrosination drives cell polarization by transporting APC protein to cortical sites through kinesin-1-based transport, supporting the formation of leading edge and directed cell migration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Narendra Thapa, Tianmu Wen, Vincent L. Cryns, Richard A. Anderson
Summary: This article focuses on the processes of cell adhesion and migration in cancer cells, specifically discussing the reorganization of microtubule cytoskeleton, cell polarity, and phosphoinositide signaling and their impact on adhesion and migration.
Article
Cell Biology
Fabiola Mascanzoni, Roberta Iannitti, Antonino Colanzi
Summary: The dynamic association between the Golgi complex and the centrosome plays a crucial role in cellular processes such as cell polarization and division.
Review
Cell Biology
Martina Mascaro, Ines Lages, Germana Meroni
Summary: TRIM36 is a microtubule-associated E3 ubiquitin ligase that plays a crucial role in cytoskeletal organization and cell cycle progression. It is also important for dorso-ventral axis formation in early development. Mutations in the TRIM36 gene can cause severe neural tube closure defects in humans.
Editorial Material
Cell Biology
Jonathan S. Bogan
Summary: The study used advanced technology to investigate the structure of pancreatic beta cells and found that glucose stimulation can alter microtubule structure to control insulin secretion.
JOURNAL OF CELL BIOLOGY
(2021)
Review
Oncology
Josephine A. A. Hinneh, Joanna L. L. Gillis, Nicole L. L. Moore, Lisa M. M. Butler, Margaret M. M. Centenera
Summary: Receptor for hyaluronic acid-mediated motility (RHAMM) is a critical cell surface receptor involved in cell migration, cell cycle, and microtubule assembly. It is exploited by tumor cells to promote malignant progression and metastasis. Inhibition of RHAMM can suppress tumor invasiveness and metastatic spread and is considered a potential therapeutic target. However, the complexity of RHAMM's subcellular distribution complicates the design of targeted therapies. Identifying downstream signaling pathways of RHAMM may provide alternative strategies to control tumor aggressiveness.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Pooja Suresh, Vahe Galstyan, Rob Phillips, Sophie Dumont
Summary: This study reveals how spatially regulated anchorage gives rise to spatially distinct mechanics in the mammalian spindle.
Article
Genetics & Heredity
Tammy Lu, Ryan B. Smit, Hanifa Soueid, Paul E. Mains
Summary: Microtubule severing plays a crucial role in cell structure and division. The protein katanin, composed of MEI-1/MEI-2 subunits, is required for oocyte meiotic spindle formation but must be inactivated for mitosis to proceed. Katanin activity is regulated by two ubiquitin-based protein degradation pathways, as well as by the ubiquitin ligase HECD-1. In C. elegans, components of the striatin-interacting kinase phosphatase complex also affect katanin function, with some acting as inhibitors in mitosis and activators in meiosis. These findings suggest that different subunits of the complex have diverse functions in regulating cell proliferation and signaling pathways.
