Article
Cell Biology
Lisa Dobson, William B. Barrell, Zahra Seraj, Steven Lynham, Sheng-Yuan Wu, Matthias Krause, Karen J. Liu
Summary: This study demonstrates that murine neural crest cells display actin-based lamellipodia and filopodia in vivo. Serine-threonine kinase GSK3 and cytoskeletal regulator Lpd are found to be required for lamellipodia formation while preventing focal adhesion maturation. These findings improve the understanding of cytoskeletal regulation in mammalian neural crest migration and have implications for neural crest anomalies and cancer.
Article
Cell Biology
Fernando Montano-Rendon, Glenn F. W. Walpole, Matthias Krause, Gerald R. V. Hammond, Sergio Grinstein, Gregory D. Fairn
Summary: PI 3-kinase is crucial for phagocytosis, with PI3,4P2, Lamellipodin, and VASP playing essential roles in actin-driven pseudopod extension and particle engulfment. Phosphoinositides are key regulators of vesicular traffic and signaling during phagocytosis, with locally generated PtdIns(3,4)P-2 influencing pseudopod progression and phagocytosis. Lamellipodin and VASP are important actin-regulatory proteins involved in phagosome formation downstream of PtdIns(3,4)P-2.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Cell Biology
Hsiao Yu Fang, Rameen Forghani, Akanni Clarke, Philip G. McQueen, Aravind Chandrasekaran, Kate M. O'Neill, Wolfgang Losert, Garegin A. Papoian, Edward Giniger
Summary: Ena/VASP proteins play a crucial role in various morphogenetic processes, including axon growth and guidance. Live imaging of the TSM1 axon in Drosophila wing reveals that Ena promotes axon growth by linking actin to the morphogenetic processes of the plasma membrane, rather than directly regulating actin distribution.
MOLECULAR BIOLOGY OF THE CELL
(2023)
Article
Cell Biology
Evelyn C. Aviles, Alexandra Krol, Steven J. Henle, Jessica Burroughs-Garcia, Michael R. Deans, Lisa Goodrich
Summary: The polarized flow of information in neural circuits relies on the organization of neurons, their processes, and their synapses. Fat3, a protein similar to Fat cadherins, plays a crucial role in the development of polarized circuits in the mouse retina. It binds to cytoskeletal regulators and synaptic proteins, coordinating different cell behaviors and regulating synapse localization.
Article
Developmental Biology
Rebecca Shi, Daniel A. Kramer, Baoyu Chen, Kang Shen
Summary: This study investigated the morphological events during dendrite outgrowth in the PVD neuron in C. elegans, identifying that swellings and filopodia formation are essential for dendrite growth. It was also found that UNC-34 can bind to the WRC, suggesting a cooperative mechanism between regulators of branched and linear F-actin in dendritic branching.
NEURAL DEVELOPMENT
(2021)
Letter
Dermatology
John Y. W. Lee, Assem Farag, Amira Tawdy, Lu Liu, Magdalene Michael, Ellie Rashidghamat, Sophia Aristodemou, Chao-Kai Hsu, Michael A. Simpson, Maddy Parsons, John A. McGrath
JOURNAL OF DERMATOLOGICAL SCIENCE
(2018)
Article
Multidisciplinary Sciences
Sandra G. Gonzalez Malagon, Anna M. Lopez Munoz, Daniel Doro, Triona G. Bolger, Evon Poon, Elizabeth R. Tucker, Hadeel Adel Al-Lami, Matthias Krause, Christopher J. Phiel, Louis Chesler, Karen J. Liu
NATURE COMMUNICATIONS
(2018)
Article
Dermatology
Magdalene Michael, Rumena Begum, Grace K. Chan, Austin J. Whitewood, Daniel R. Matthews, Benjamin T. Goult, John A. McGrath, Maddy Parsons
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Cell Biology
Laura Chan Wah Hak, Shaheen Khan, Ilaria Di Meglio, Ah-Lai Law, Safa Lucken-Ardjomande Hasler, Leonor M. Quintaneiro, Antonio P. A. Ferreira, Matthias Krause, Harvey T. McMahon, Emmanuel Boucrot
NATURE CELL BIOLOGY
(2018)
Correction
Cell Biology
Laura Chan Wah Hak, Shaheen Khan, Ilaria Di Meglio, Ah-Lai Law, Safa Lucken-Ardjomande Hasler, Leonor M. Quintaneiro, Antonio P. A. Ferreira, Matthias Krause, Harvey T. McMahon, Emmanuel Boucrot
NATURE CELL BIOLOGY
(2018)
Article
Dermatology
Chavalit Supsrisunjai, Chao-Kai Hsu, Magdalene Michael, Cedric Duval, John Y. W. Lee, Hsing-San Yang, Hsin-Yu Huang, Thitiwat Chaikul, Alexandros Onoufriadis, Roberto A. Steiner, Robert A. S. Ariens, Ofer Sarig, Eli Sprecher, Marina Eskin-Schwartz, Curt Samlaska, Michael A. Simpson, Eduardo Calonje, Maddy Parsons, John A. McGrath
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Article
Multidisciplinary Sciences
Sandra Guadalupe Gonzalez Malagon, Lisa Dobson, Anna M. Lopez Munoz, Marcus Dawson, William Barrell, Petros Marangos, Matthias Krause, Karen J. Liu
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Cell Biology
Georgi Dimchev, Behman Amiri, Ashley C. Humphries, Matthias Schaks, Vanessa Dimchev, Theresia E. B. Stradal, Jan Faix, Matthias Krause, Michael Way, Martin Falcke, Klemens Rottner
JOURNAL OF CELL SCIENCE
(2020)
Review
Cell Biology
Magdalene Michael, Maddy Parsons
CURRENT OPINION IN CELL BIOLOGY
(2020)
Article
Cell Biology
Joseph A. Brazzo, John C. Biber, Erik Nimmer, Yuna Heo, Linxuan Ying, Ruogang Zhao, Kwonmoo Lee, Matthias Krause, Yongho Bae
Summary: The stiffness of the extracellular matrix plays a critical role in regulating cell cycle progression and proliferation. Lamellipodin, previously known for its role in cell migration, is shown to stimulate cyclin expression and intracellular stiffening in response to ECM stiffness, suggesting its importance in controlling cell proliferation.
JOURNAL OF CELL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Ah-Lai Law, Shamsinar Jalal, Tommy Pallett, Fuad Mosis, Ahmad Guni, Simon Brayford, Lawrence Yolland, Stefania Marcotti, James A. Levitt, Simon P. Poland, Maia Rowe-Sampson, Anett Jandke, Robert Kochl, Giordano Pula, Simon M. Ameer-Beg, Brian Marc Stramer, Matthias Krause
Summary: NHSL1 interacts with the Scar/WAVE complex to inhibit cell migration by potentially reducing Arp2/3 activity, leading to decreased F-actin density in lamellipodia and impairing protrusion stability.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Stefanie Moritz, Matthias Krause, Jessica Schlatter, Nils Cordes, Anne Vehlow
Summary: Glioblastoma patients face poor prognosis due to aggressive invasion and therapy resistance, with Lamellipodin playing a key role in mediating these processes. The study highlights a novel Lamellipodin-RICTOR-EGFR signaling axis contributing to glioblastoma radiation survival, adding a critical facet to the complex resistance network in glioblastoma.
Article
Cell Biology
Fernando Montano-Rendon, Glenn F. W. Walpole, Matthias Krause, Gerald R. V. Hammond, Sergio Grinstein, Gregory D. Fairn
Summary: PI 3-kinase is crucial for phagocytosis, with PI3,4P2, Lamellipodin, and VASP playing essential roles in actin-driven pseudopod extension and particle engulfment. Phosphoinositides are key regulators of vesicular traffic and signaling during phagocytosis, with locally generated PtdIns(3,4)P-2 influencing pseudopod progression and phagocytosis. Lamellipodin and VASP are important actin-regulatory proteins involved in phagosome formation downstream of PtdIns(3,4)P-2.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Biology
Flavia Rosianu, Simeon R. Mihaylov, Noreen Eder, Antonie Martiniuc, Suzanne Claxton, Helen R. Flynn, Shamsinar Jalal, Marie-Charlotte Domart, Lucy Collinson, Mark Skehel, Ambrosius P. Snijders, Matthias Krause, Sharon A. Tooze, Sila K. Ultanir
Summary: This study reveals the importance of NDR1/2 kinases in maintaining neuronal health by regulating endocytosis, protein homeostasis, and autophagy. The loss of NDR1/2 results in neurodegeneration, accumulation of cellular components, and impaired autophagy efficiency.
LIFE SCIENCE ALLIANCE
(2022)
Article
Developmental Biology
Yushi Redhead, Dorota Gibbins, Eva Lana-Elola, Sheona Watson-Scales, Lisa Dobson, Matthias Krause, Karen J. Liu, Elizabeth M. C. Fisher, Jeremy B. A. Green, Victor L. J. Tybulewicz
Summary: Down syndrome (DS) is a common human chromosomal abnormality that leads to various phenotypic features, including craniofacial dysmorphology. Through analysis of a DS mouse model and genetic mapping, it was found that four regions on mouse chromosome 16, which correspond to Hsa21 in humans, contain dosage-sensitive genes that contribute to DS craniofacial abnormalities, with Dyrk1a identified as one of the causative genes. The study revealed that the earliest and most severe defects in the DS mouse skulls occur in bones of neural crest origin, and that abnormal mineralization of the skull base synchondroses is present. Additionally, increased dosage of Dyrk1a was found to result in decreased proliferation of neural crest cells and a reduction in size and cellularity of the frontal bone primordia.