Article
Chemistry, Analytical
James J. W. Hucklesby, Akshata Anchan, Simon J. O'Carroll, Charles P. Unsworth, E. Scott Graham, Catherine E. Angel
Summary: Commercially available instruments ECIS, xCELLigence, and cellZscope can measure the impedance of cellular monolayers, with ECIS showing the highest sensitivity and resolution when compared simultaneously.
Article
Biochemistry & Molecular Biology
Jihye Yoo, Jiyoung Park, Darong Kim, Yeonjoo Huh, Hea-Young Park Choo, Hyun Ae Woo
Summary: By synthesizing 12 novel compounds and evaluating their biological activities, it was found that 4 compounds exhibited strong inhibitory activities on IL-1 beta and IL-6 mRNA expression. Further in vivo activity evaluation indicated that 2 compounds significantly decreased mRNA levels of IL-1 beta, IL-6, and TNF-alpha.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Alvaro Nobrega de Melo Madureira, Joao Ricardhis Saturnino de Oliveira, Vera Lucia de Menezes Lima
Summary: Interleulcin-6 (IL-6) is a myokine that can be released by exercising skeletal muscle. It activates the PI3K-Akt pathway to enhance insulin signaling and glycogen synthesis. IL-6 also increases GLUT-4 vesicle mobilization and may contribute to muscle hypertrophy by activating mTORC1 and promoting contractile protein synthesis.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Medicine, General & Internal
Peng Deng, Nana Tang, Lin Li, Guohui Zou, Yang Xu, Zhongyong Liu
Summary: The combined detection of IL-1 beta, IL-6, and TNF-alpha shows better diagnostic value for sepsis-induced cardiomyopathy (SIC) and is closely related to the prognoses of patients.
Article
Cell Biology
Areej Al-Roub, Ashraf Al Madhoun, Nadeem Akhter, Reeby Thomas, Lavina Miranda, Texy Jacob, Ebaa Al-Ozairi, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Summary: The overexpression of IL-6 in the adipose tissue of obese individuals may lead to insulin resistance. IL-1 beta and TNF alpha, which are increased in obese adipose tissue, cooperate to enhance the production of IL-6 in adipocytes. This cooperative interaction depends on CREB binding and H3K14 acetylation and provides an interesting pathophysiological connection among IL-1 beta, TNF alpha, and IL-6 in obesity settings.
Article
Immunology
Yusha Wang, Jun Wang, Wenjie Zheng, Jiahui Zhang, Jinbo Wang, Taijie Jin, Panfeng Tao, Yibo Wang, Chenlu Liu, Jiqian Huang, Pui Y. Lee, Xiaomin Yu, Qing Zhou
Summary: A novel missense variant in IL-1R1 was identified in a patient with CRMO, leading to unopposed IL-1 signaling. Researchers designed an IL-1 therapeutic that effectively targets IL-1-driven diseases.
Review
Medicine, Research & Experimental
Parnian Shobeiri, Homa Seyedmirzaei, Nastaran Karimi, Fatemeh Rashidi, Antonio L. Teixeira, Serge Brand, Dena Sadeghi-Bahmani, Nima Rezaei
Summary: Physical exercise has a positive impact on the mental well-being of people with multiple sclerosis (PwMS). However, exercise does not result in significant changes in IL-6 levels in PwMS, unlike the response observed in healthy subjects and other medical contexts. Regular exercise, on the other hand, has a specific anti-inflammatory effect on blood TNF-alpha levels in PwMS.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Dermatology
Xiuju Dai, Ryo Utsunomiya, Ken Shiraishi, Hideki Mori, Jun Muto, Masamoto Murakami, Koji Sayama
Summary: IL-33 is highly expressed in atopic dermatitis (AD) lesions, potentially participating in the pathogenesis of AD by inhibiting keratinocyte differentiation and skin barrier function.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Psychiatry
Hannah E. Specht, Nina Mannig, Meriem Belheouane, Nadia Andrea Andreani, Klaus Tenbrock, Ronald Biemann, Katrin Borucki, Brigitte Dahmen, Astrid Dempfle, John F. Baines, Beate Herpertz-Dahlmann, Jochen Seitz
Summary: This study aimed to explore the role of inflammation in patients with anorexia nervosa (AN). The results showed that the inflammatory response was higher in adolescent patients at admission, but differed from adults as the levels of interleukin-1 beta (IL-1 beta) and IL-6 were lower. Additionally, the gut microbiota may play a regulatory role in the inflammatory processes of AN.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Immunology
Chunyun Fang, Lixia Wang, Jingting Qiao, Lina Chang, Qing He, Xiaona Zhang, Ming Liu
Summary: This study investigated the mechanism of impaired immune response in diabetic patients. By studying the production of cytokines in macrophages induced by LPS, it was found that pretreatment with palmitic acid (PA) can differentially regulate the production of TNF-alpha and IL-1 beta, and this effect is associated with the cellular metabolism of PA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olivier Escaffre, Peter Szaniszlo, Gabor Toro, Caitlyn L. L. Vilas, Brenna J. J. Servantes, Ernesto Lopez, Terry L. L. Juelich, Corri B. B. Levine, Susan L. F. McLellan, Jessica C. C. Cardenas, Alexander N. N. Freiberg, Katalin Modis
Summary: Recent studies have found that lung microvascular endothelial injury plays a crucial role in the development of COVID-19. This study explored the effects of H2S on the barrier function of lung endothelial cells and its potential therapeutic implications for COVID-19. The researchers observed that treatment with GYY4137, a slow-releasing H2S donor, reduced endothelial barrier permeability after exposure to plasma samples from COVID-19 patients or inactivated SARS-CoV-2 virus. These findings suggest that H2S-releasing compounds have the potential to ameliorate lung endothelial barrier disruption caused by SARS-CoV-2.
Article
Immunology
Alexandria Lozowchuk, Judith E. Carroll, Calvin Hobel, Mary Coussons-Read, Christine Dunkel Schetter, Kharah M. Ross
Summary: This study explored the relationship between partner relationship quality and inflammatory markers IL-6, IL-10, and TNF-alpha during pregnancy and the postpartum period. The findings suggest that lower partner support may be associated with reduced inflammation regulation, with potential consequences for maternal health and well-being.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Biochemistry & Molecular Biology
Katrin Witte, Robert Sabat, Ellen Witte-Haendel, Kamran Ghoreschi, Kerstin Wolk
Summary: Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory disease characterized by painful skin lesions in various areas of the body. It affects about 1% of the population and is associated with comorbidities such as metabolic syndrome. Current therapeutic options for HS are limited, and novel treatment options are needed. Recent research suggests that immune mediators IL-1 beta, IL-17A, and G-CSF play a key role in the development of HS. Phytomedical drugs, which have potent immunoregulatory properties, have not been considered as a treatment for HS. This review explores the potential of targeting the IL-1/IL-17/G-CSF axis for an integrated phytomedical treatment of HS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Chin-Horng Su, Chih-Yang Lin, Chun-Hao Tsai, Hsiang-Ping Lee, Lun-Chien Lo, Wei-Chien Huang, Yang-Chang Wu, Ching-Liang Hsieh, Chih-Hsin Tang
Summary: Betulin has shown potential for the treatment of osteoarthritis by suppressing the production of inflammatory cytokines in synovial tissue through inhibition of MEK, ERK, and NF-κ B signaling cascades.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Infectious Diseases
Catalina Tovar Acero, Javier Ramirez-Montoya, Maria Camila Velasco, Paula A. Aviles-Vergara, Dina Ricardo-Caldera, Miquel Duran-Frigola, Gustavo Quintero, Myriam Elena Cantero, Juan Rivera-Correa, Ana Rodriguez, Maria Fernanda Yasnot-Acosta
Summary: This study evaluated the cytokine profile of P. vivax malaria patients and identified several cytokines and chemokines that are associated with disease severity. These molecules could potentially serve as biomarkers for severity in P. vivax malaria.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Endocrinology & Metabolism
Charisse Kuo, Colin R. Green, Ilva D. Rupenthal, Odunayo O. Mugisho
ACTA DIABETOLOGICA
(2020)
Article
Cell Biology
Odunayo O. Mugisho, Laverne D. Robilliard, Louise F. B. Nicholson, E. Scott Graham, Simon J. O'Carroll
CELL BIOLOGY INTERNATIONAL
(2020)
Article
Oncology
Jennifer Eom, Saem Mul Park, Vaughan Feisst, Chun-Jen J. Chen, Joanna E. Mathy, Julie D. McIntosh, Catherine E. Angel, Adam Bartlett, Richard Martin, Jon A. Mathy, Jonathan S. Cebon, Michael A. Black, Anna E. S. Brooks, P. Rod Dunbar
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Cell Biology
Heather Kang, Naibo Yin, Heather Lyon, Ilva D. Rupenthal, Sachin S. Thakur, Odunayo O. Mugisho
Summary: The study evaluated the safety of ultrasound (US) administration in retinal pigment epithelial cells, indicating that under high glucose conditions, cell damage may occur but can be restored within 24 hours; within the safety parameters, US did not induce cell damage or inflammation.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Ophthalmology
Henry H. Louie, Avik Shome, Charisse Y. J. Kuo, Ilva D. Rupenthal, Colin R. Green, Odunayo O. Mugisho
Summary: Recent research has shown that connexin43 hemichannel blockers can inhibit activation of the inflammasome pathway in diabetic retinopathy. The development of an ex vivo human retinal organotypic culture model provides a more accurate representation of the inflammatory process in diabetic retinopathy, supporting the potential use of connexin43 hemichannel blockers as new therapies for the disease.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Cell Biology
Laverne D. Robilliard, Jane Yu, Akshata Anchan, Wayne Joseph, Graeme Finlay, Catherine E. Angel, E. Scott Graham
Summary: Glioblastoma cells express a wide range of inhibitory checkpoint ligands that control effector T cell responses, and glioblastoma stem-like cells with an enhanced phenotype express these ligands at significant levels. Understanding the extensive repertoire of immune checkpoint ligands and their functional consequence on immune evasion in glioblastoma is crucial for developing effective immunotherapeutics.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Heather Lyon, Avik Shome, Ilva D. Rupenthal, Colin R. Green, Odunayo O. Mugisho
Summary: The study demonstrated that tonabersat can inhibit inflammasome activation and proinflammatory cytokine release in diabetic retinopathy, showing potential for reducing inflammation in this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Sanjay Marasini, Odunayo O. Mugisho, Simon Swift, Hannah Read, Ilva D. Rupenthal, Simon J. Dean, Jennifer P. Craig
Summary: The study found that a single 15-second UVC exposure did not significantly induce CPD formation in vitro on human corneal epithelial cells, but continuous exposure for 3 days resulted in more CPD formation. In vivo experiments showed that three consecutive daily doses of 15-second UVC exposure were safe with respect to CPD formation, whereas a single 300-second exposure caused extensive CPD formation.
Article
Chemistry, Analytical
Laverne Diana Robilliard, Jane Yu, Sung-Min Jun, Akshata Anchan, Graeme Finlay, Catherine E. Angel, Euan Scott Graham
Summary: Glioblastoma is known as the most aggressive and lethal form of brain cancer, comprising differentiated cells and stem cells. ECIS shows reliable measurement of adhesion for differentiated glioblastoma cells and their migratory behavior post-ablation, but is less capable for weakly adherent stem cell counterparts.
Article
Chemistry, Analytical
Akshata Anchan, Graeme Finlay, Catherine E. Angel, James J. W. Hucklesby, Scott E. Graham
Summary: Previous studies have shown that human melanoma cells can weaken the brain endothelial barrier, but the expression of MMPs and proteases released by melanoma cells may not directly contribute to the initial disruption of the brain endothelium.
Article
Biochemistry & Molecular Biology
Dayna Spurling, Akshata Anchan, James Hucklesby, Graeme Finlay, Catherine E. Angel, E. Scott Graham
Summary: This study investigates the effects of large vesicles produced by melanoma cells on the barrier integrity of brain endothelial cells. The results demonstrate that these vesicles can rapidly disrupt the barrier integrity of the endothelial cells through transcellular uptake. The disruption occurs in a manner that is faster and completely distinct from invasion by intact melanoma cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Laverne D. Robilliard, Jane Yu, Akshata Anchan, Graeme Finlay, Catherine E. Angel, E. Scott Graham
Summary: Glioblastoma is a challenging cancer due to its resistance to therapy and suppressive effects on the immune system. This study investigated the different phenotypes of glioblastoma cells and their secretion patterns of cytokines. The results showed heterogeneity in secretion patterns between serum-derived and glioblastoma stem-like cells, with the serum-derived cells being the primary producers of cytokines associated with immune cell recruitment. These findings highlight the importance of targeting these cells in glioblastoma therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Monica L. Acosta, Mohd N. Mat Nor, Cindy X. Guo, Odunayo O. Mugisho, Frazer P. Coutinho, Ilva D. Rupenthal, Colin R. Green
Summary: Compounds that block the function of connexin and pannexin protein channels have shown potential as valuable therapeutics for diseases, but the current literature on their molecular effects on tissues is inconclusive. This review discusses the distinct physiological and pathological implications of blocking different channel types, as well as the contribution of connexins and pannexins to excessive ATP release linked to disease onset and progression.
NEURAL REGENERATION RESEARCH
(2021)
Article
Polymer Science
Yosra Agban, Odunayo O. Mugisho, Sachin S. Thakur, Ilva D. Rupenthal
Article
Biochemistry & Molecular Biology
Akshata Anchan, Olivia Martin, James J. W. Hucklesby, Graeme Finlay, Rebecca H. Johnson, Laverne D. Robilliard, Simon J. O'Carroll, Catherine E. Angel, Scott Graham
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)