Article
Biochemistry & Molecular Biology
Tapas Paul, Wilson Liou, Xinyi Cai, Patricia L. Opresko, Sua Myong
Summary: Research has found that POT1 has an unexpected activity in imparting dynamic structure to the telomere overhang, especially when interacting with TRF2. TRF2 can recruit POT1-bound overhangs to the telomere ds/ss junction and induce stepwise movement along the axis of the telomere duplex, with the same steps observed regardless of overhang length, implying a tightly regulated conformational dynamic coordinated by TRF2 and POT1.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Neurosciences
Katherine T. Baldwin, Christabel X. Tan, Samuel T. Strader, Changyu Jiang, Justin T. Savage, Xabier Elorza-Vidal, Ximena Contreras, Thomas Ruelicke, Simon Hippenmeyer, Raul Estevez, Ru-Rong Ji, Cagla Eroglu
Summary: This study identifies a molecular mechanism by which astrocytes coordinate morphogenesis and gap junction coupling during development. Conditional deletion of Hepacam disrupts gap junction coupling between astrocytes and affects the balance between synaptic excitation and inhibition. Mutations in HEPACAM are associated with megalencephalic leukoencephalopathy with subcortical cysts, suggesting that disruption of astrocyte self-organization mechanisms could be an underlying cause of neural pathology.
Article
Energy & Fuels
Sonu Kumar, Pinak Mohapatra, Rushikesh K. Joshi, Matthew Warburton, Liang-Shih Fan
Summary: We propose a new low-temperature chemical looping combustion scheme for natural gas conversion into CO2 and NOx purification. The process utilizes NiO/ZrO2 as the oxygen carrier and operates at temperatures close to the flue gas temperature of 400-500 degrees C. Thermodynamic studies show that the presence of CO2 does not significantly affect NOx purification performance. Comparative analyses indicate improvements in exergy efficiency and effective thermal efficiency compared to conventional NOx selective catalytic reduction (SCR) processes.
Article
Cardiac & Cardiovascular Systems
Michael M. Orlich, Rodrigo Dieguez-Hurtado, Regine Muehlfriedel, Vithiyanjali Sothilingam, Hartwig Wolburg, Cansu Ebru Oender, Pascal Woelffing, Christer Betsholtz, Konstantin Gaengel, Mathias Seeliger, Ralf H. Adams, Alfred Nordheim
Summary: This study reveals the crucial role of the transcription factor SRF in pericytes and vascular smooth muscle cells, which is essential for maintaining vascular integrity and tone.
CIRCULATION RESEARCH
(2022)
Article
Plant Sciences
Kaori Sakai, Sylvie Citerne, Sebastien Antelme, Philippe Le Bris, Sylviane Daniel, Axelle Bouder, Angelina D'Orlando, Amy Cartwright, Frederique Tellier, Stephanie Pateyron, Etienne Delannoy, Debbie Laudencia-Chingcuanco, Gregory Mouille, Jean Christophe Palauqui, John Vogel, Richard Sibout
Summary: The vascular system of plants consists of xylem and phloem tissues organized into vascular bundles. A mutation in the ERECTA gene severely affected vascular tissue organization in the model grass Brachypodium, indicating a pleiotropic role in plant development. The mutation led to defects in vasculature anastomosis, suggesting a major role of ERECTA in vascular tissue organization.
Article
Chemistry, Physical
Jiawei Hu, Vladimir V. Galvita, Hilde Poelman, Zhigang Wang, Guy B. Marin, Sibudjing Kawi
Summary: By utilizing carbon's reductive power, this study integrates dry reforming of methane and selective reduction of nitric oxide in a chemical looping process, achieving stable CO2 utilization and NO reduction with cyclic catalyst regeneration. The temporal-spatial separation of reactions in chemical looping allows for complete conversion of carbon and NO, ensuring a higher exergetic efficiency. Additionally, adapting the relative duration of the DRM and SRN steps to industrial point sources offers an attractive strategy for selective catalytic reduction of NO with greenhouse gases.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2021)
Article
Energy & Fuels
Zhuang Sun, Muhammad Aziz
Summary: This study presents a new configuration of solar-assisted biomass chemical looping gasification (CLG), which indirectly stores solar heat as sensible heat in solid particles. A steam Rankine cycle is integrated to recover thermal energy from high-temperature solid particles. Compared with direct solar energy utilization, this configuration can avoid the fluctuating working conditions of CLG and downstream processes, and achieve efficient thermal integration.
Article
Nanoscience & Nanotechnology
Hamidreza Daghigh Shirazi, Yujiao Dong, Jukka Niskanen, Chiara Fedele, Arri Priimagi, Ville P. Jokinen, Jaana Vapaavuori
Summary: A simple hierarchical surface patterning method is proposed by combining buckling instability and azopolymer-based surface relief grating inscription, allowing for the fabrication of surfaces with different length scales and the tuning of wetting properties. The demonstrated fine-tuning of the surface patterns may be useful in optimizing material properties related to surfaces and producing substrates of potential interest in mechanobiology and tissue engineering.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Cell Biology
Sara Simonini, Marian Bemer, Stefano Bencivenga, Valeria Gagliardini, Nuno D. Pires, Benedicte Desvoyes, Eric van der Graaff, Crisanto Gutierrez, Ueli Grossniklaus
Summary: This study reveals that the MEDEA protein, a subunit of the Polycomb Repressive Complex 2 (PRC2), is essential for embryonic patterning and cell lineage determination in Arabidopsis. MEDEA regulates cell-cycle progression by repressing the expression of CYCD1;1, impacting embryonic growth and development. This suggests that PcG proteins play a crucial role in epigenetically regulating embryogenesis in plants.
DEVELOPMENTAL CELL
(2021)
Article
Chemistry, Physical
Sitaram Ramakrishnan, Jinke Bao, Claudio Eisele, Bikash Patra, Minoru Nohara, Biplab Bag, Leila Noohinejad, Martin Tolkiehn, Carsten Paulmann, Achim M. Schaller, Toms Rekis, Surya Rohith Kotla, Andreas Schoenleber, Arumugam Thamizhavel, Bahadur Singh, Srinivasan Ramakrishnan, Sander van Smaalen
Summary: Ho2Ir3Si5 belongs to the family of 3D R2Ir3Si5 compounds. It exhibits a first-order charge-density-wave (CDW) transition accompanied by lattice distortion and superlattice reflections. The CDW is caused by Ir-Ir zigzag chains along c. Replacing Lu with magnetic Er or Ho decreases the CDW transition temperature. Ho2Ir3Si5 shows second-order superlattice reflections, indicating an anharmonic modulation wave. The CDW transition affects the magnetic moments of Ho3+ even in the paramagnetic state, and antiferromagnetic (AFM) ordering is suppressed in the single crystal.
CHEMISTRY OF MATERIALS
(2023)
Article
Multidisciplinary Sciences
Alexandre Prola, Jordan Blondelle, Aymeline Vandestienne, Jerome Piquereau, Raphael G. P. Denis, Stephane Guyot, Hadrien Chauvin, Arnaud Mourier, Marie Maurer, Celine Henry, Nahed Khadhraoui, Cindy Gallerne, Thibaut Molinie, Guillaume Courtin, Laurent Guillaud, Melanie Gressette, Audrey Solgadi, Florent Dumont, Julien Castel, Julien Ternacle, Jean Demarquoy, Alexandra Malgoyre, Nathalie Koulmann, Genevieve Derumeaux, Marie-France Giraud, Frederic Joubert, Vladimir Veksler, Serge Luquet, Frederic Relaix, Laurent Tiret, Fanny Pilot-Storck
Summary: Mice deficient for a muscle-specific enzyme of very-long-chain fatty acid synthesis displayed increased basal energy expenditure and protection against high-fat diet-induced obesity. Muscle-specific modulation of the very-long-chain fatty acid pathway was associated with a reduced content of inner mitochondrial membrane phospholipid cardiolipin and a blunted coupling efficiency between the respiratory chain and ATP synthase, which was restored by cardiolipin enrichment. Selective increase of lipid oxidative capacities in skeletal muscle, through the cardiolipin-dependent lowering of mitochondrial ATP production, provides an effective option against obesity at the whole-body level.
Article
Multidisciplinary Sciences
Caiqi Cheng, Qian Cong, Yuchen Liu, Yizhong Hu, Guoyan Liang, Kevin Marc Manquiquis Dioneda, Yingzi Yang
Summary: Correct formation of the notochord and neural tube is crucial for the development of the central nervous system. The mechanosensor and mechanotransducer Yap plays a necessary and sufficient role in the biochemical signaling activation during formation of the notochord and floor plate. Yap activation induces the expression of FoxA2 for notochord formation and Shh for the induction of the floor plate.
Article
Cell Biology
Xionghui Lie, Benjamin Swedlund, Mai-Linh N. Ton, Shila Ghazanfar, Carolina Guibentif, Catherine Paulissen, Elodie Baudelet, Elise Plaindoux, Younes Achouri, Emilie Calonne, Christine Dubois, William Mansfield, Stephane Zaffran, John C. Marioni, Francois Fuks, Berthold Goettgens, Fabienne Lescroart, Cedric Blanpain
Summary: In this study, we investigated the dynamic chromatin remodeling mediated by Mesp1 during mouse pluripotent stem cell differentiation. We identified temporally regulated enhancers that specify distinct populations of cardiovascular progenitors (CPs) involved in heart development. We also discovered Zic2 and Zic3 as key cofactors that regulate the transcription-factor activity of Mesp1 at mesodermal enhancers.
NATURE CELL BIOLOGY
(2022)
Article
Mathematics
Nicolas A. Barnafi, Luis Miguel De Oliveira Vilaca, Michel C. Milinkovitch, Ricardo Ruiz-Baier
Summary: In this paper, a mathematical model is proposed to describe the complex interaction between skin cell populations, fibroblast growth factors, and bone morphogenetic proteins occurring in deformable porous media during feather primordia patterning. The model considers tissue growth and the transport of morphogens through various mechanisms such as mechanical stress and mass supply. The study utilizes linear stability analysis to determine the conditions under which the system produces spatially heterogeneous solutions. Additionally, the mechanical model is extended to include anisotropic solid growth and feedback. Numerical methods are employed to solve the coupled system of nonlinear partial differential equations. Computational examples are presented to demonstrate the spatio-temporal patterns and solid response scenarios. The results show qualitative agreement with experimental observations and provide insights into the biomechanical properties of primordia patterning.
Article
Zoology
Rui Wang, April L. Bialas, Tapan Goel, Eva-Maria S. Collins
Summary: The freshwater cnidarian Hydra has the ability to regenerate from various sources, and its simple body plan makes it an ideal model to study developmental patterning. The Gierer-Meinhardt model has successfully explained patterning in adult Hydra, but the predicted inhibitor is still unknown. Additionally, the model cannot explain de novo axis formation in cellular aggregates. This review aims to synthesize current knowledge on Hydra symmetry breaking and patterning, and propose new experiments and ideas for future research.
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2023)
Article
Cell Biology
Emmanuel Martin, Sophie Theis, Guillaume Gay, Bruno Monier, Christian Rouviere, Magali Suzanne
Summary: The study reveals that a bias in force propagation ensures stereotyped morphogenesis in the developing leg of Drosophila, even in the presence of mechanical noise. Knockdown of the specific gene Arpc5 affects fold directionality without altering developmental or force generation patterns.
DEVELOPMENTAL CELL
(2021)
Review
Biochemistry & Molecular Biology
Bruno Monier, Magali Suzanne
Summary: Apoptosis, a crucial form of cell suicide, plays important roles in eliminating unnecessary cells, protecting the body against harmful cells, and promoting tissue morphogenesis during animal development. This process involves activation of dedicated enzymes called caspases, as well as mechanical forces and nuclear coupling for nucleus destruction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Bente Winkler, Dominik Funke, Billel Benmimoun, Pauline Speder, Simone Rey, Mary A. Logan, Christian Klaembt
Summary: The study reveals that macrophages can enter the brain during infections and autoimmune diseases, participating in pathogen elimination but also potentially causing tissue damage. Through a Drosophila model, it was found that the immune deficiency pathway plays a role in attracting and invading macrophages into the brain.
Article
Cell Biology
Daniela Roellig, Sophie Theis, Amsha Proag, Guillaume Allio, Bertrand Benazeraf, Jerome Gros, Magali Suzanne
Summary: Apoptotic cells play an important role in vertebrate morphogenesis by exerting apico-basal force on surrounding tissues, which contributes to neural tube closure.
DEVELOPMENTAL CELL
(2022)
Review
Cell Biology
Emmanuel Martin, Magali Suzanne
Summary: This review discusses the role of the actin nucleation complex Arp2/3 in epithelial tissue, including its influence on cell-cell cooperation and tissue morphogenesis. It plays a significant role in regulating cell-cell adhesion, intracellular trafficking, and protrusion formation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Cell Biology
Magali Suzanne, Miguel Torres Sanchez
CURRENT OPINION IN GENETICS & DEVELOPMENT
(2022)
Review
Biochemistry & Molecular Biology
Gabriel Ichim, Benjamin Gibert, Sahil Adriouch, Catherine Brenner, Nathalie Davoust, Solange Desagher, David Devos, Svetlana Dokudovskaya, Laurence Dubrez, Jerome Estaquier, Germain Gillet, Isabelle Guenal, Philippe P. Juin, Guido Kroemer, Patrick Legembre, Romain Levayer, Stephen Manon, Patrick Mehlen, Olivier Meurette, Olivier Micheau, Bernar Mignotte, Florence Nguyen-Khac, Nikolay Popgeorgiev, Jean-Lu Poyet, Muriel Priault, Jean-Ehrlan Ricci, Franck B. Riquet, Santos A. Susin, Magal Suzanne, Pierre Vacher, Ludivine Walter, Bertran Mollereau
Summary: Since the Nobel Prize was awarded more than twenty years ago for discovering the core apoptotic pathway in C. elegans, researchers around the world have conducted extensive research on apoptosis and various other forms of regulated cell death. Although there are still many aspects of regulated cell death that need to be clarified in specific cell subtypes and disease conditions, the last decade has seen the description of multiple cell death modalities, some of which have been successfully used in clinical therapy. To keep research into cell death alive, francophone researchers from several institutions in France and Belgium established the French Cell Death Research Network (FCDRN), which is at the forefront of emerging topics in cell death research. These research efforts will enhance our mechanistic knowledge of regulated cell death and its therapeutic applications in the coming years.
Article
Developmental Biology
Emmanuel Martin, Magali Suzanne
Summary: Live imaging of protein dynamics is crucial for cell and developmental biology research. Multicolor live imaging, however, remains challenging. The development of long Stokes shift red fluorescent proteins offers new possibilities to overcome this limitation. This article provides a detailed characterization of mBeRFP for in vivo live imaging and demonstrates its applications in Drosophila. It shows that mBeRFP can be combined with other fluorescent proteins without crosstalk and is suitable for quantitative analysis.
Article
Multidisciplinary Sciences
Maria Alexandra Rujano, David Briand, Bojana Delic, Julie Marc, Pauline Speder
Summary: This study reveals that the development of the neural stem cell niche in Drosophila involves complex proliferative strategies and atypical cell-cell fusion, providing insights into the architectural complexity and organization of the niche.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Cell Biology
Christa Rhiner, Magali Suzanne, Guang-Hui Liu, Stephen W. G. Tait, Keiko U. Torii, Takafumi Ichikawa, Hui Ting Zhang, Wen-Cheng Liu, Ning Sun
DEVELOPMENTAL CELL
(2022)
Editorial Material
Physics, Multidisciplinary
Tatiana Merle, Magali Suzanne
Summary: Epithelial tissues act as protective barriers for our organs. The factors causing spontaneous hole formation in monolayer epithelia, which compromises epithelial integrity, have been uncovered.
Article
Cell Biology
Tatiana Merle, Sophie Theis, Alain Kamgoue, Emmanuel Martin, Florian Sarron, Guillaume Gay, Emmanuel Farge, Magali Suzanne
Summary: Understanding morphogenesis relies on characterizing tissue topology and mechanical properties from imaging data. New imaging techniques allow analysis of complex tissue organization beyond flat surfaces. However, automated analysis of imaging datasets to extract morphology and cytoskeletal network organization remains a bottleneck. In this study, a method called DISSECT was developed to automatically extract spatial organization and morphological quantifications from deformed epithelia, with potential applications in the field of morphogenesis and tissue biomechanics.
DEVELOPMENTAL CELL
(2023)
Article
Biology
Audrey Barbaste, Sonia Schott, Corinne Benassayag, Magali Suzanne
Summary: This study identified 41 potential apoptosis-related genes involved in specific aspects of morphogenetic apoptosis in Drosophila legs through an unbiased RNAi-based genetic screen, shedding light on the nonautonomous aspect of the apoptotic pathway.
LIFE SCIENCE ALLIANCE
(2023)
Article
Developmental Biology
Meritxell Font-Noguera, Marianne Montemurro, Corinne Benassayag, Bruno Monier, Magali Suzanne
Summary: The process of EMT is reversible and plays a critical role in animal development, but in pathological conditions such as cancer, it is often associated with increased drug resistance, motility, and invasiveness. The upstream signals and main decision makers, such as EMT-transcription factors, have been identified, but the cellular execution steps of this fundamental shift are poorly described, particularly in cancerous cells.
CELLS & DEVELOPMENT
(2021)
Article
Biochemical Research Methods
Thomas Mangeat, Simon Labouesse, Marc Allain, Awoke Negash, Emmanuel Martin, Aude Guenole, Renaud Poincloux, Claire Estibal, Anais Bouissou, Sylvain Cantaloube, Elodie Vega, Tong Li, Christian Rouviere, Sophie Allart, Debora Keller, Valentin Debarnot, Xia Bo Wang, Gregoire Michaux, Mathieu Pinot, Roland Le Borgne, Sylvie Tournier, Magali Suzanne, Jerome Idier, Anne Sentenac
Summary: The study introduces a super-resolution microscopy method called random illumination microscopy (RIM), which is suitable for live-cell imaging and easy to implement. RIM's simplicity and extended biological applicability can help biology laboratories to more easily utilize super-resolution microscopy.
CELL REPORTS METHODS
(2021)