Article
Biochemistry & Molecular Biology
Amanda B. Abildgaard, Vasileios Voutsinos, Soren D. Petersen, Fia B. Larsen, Caroline Kampmeyer, Kristoffer E. Johansson, Amelie Stein, Tommer Ravid, Claes Andreasson, Michael K. Jensen, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
Summary: Protein quality control (PQC) degrons are short protein segments that target misfolded proteins for proteasomal degradation, and chaperone-binding regions may function as PQC degrons. A canonical Hsp70-binding motif, the APPY peptide, functions as a dose-dependent PQC degron in yeast and human cells. The number of exposed Hsp70-binding sites in the yeast proteome correlates with reduced protein abundance and half-life.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Joanna R. Kovalski, Duygu Kuzuoglu-Ozturk, Davide Ruggero
Summary: This review discusses how cancer cells regulate protein expression through translational control and highlights the clinical potential of targeting translation factors as anti-cancer therapies. It also details the interaction between RNA sequence and structural elements, the translational machinery, and RNA-binding proteins in coordinating specific pro-survival and pro-growth programs. Additionally, the review provides an overview of current and emerging technologies for studying selective translational control in cancer cells and the tumor microenvironment.
Review
Cell Biology
Fabian den Brave, Arushi Gupta, Thomas Becker
Summary: Mitochondria contain two membranes, the outer and inner membrane. The outer membrane plays crucial roles in communication with the cellular environment, and surveillance of outer membrane proteins is essential for mitochondrial functions. Quality control mechanisms remove defective and mistargeted proteins, as well as precursors that block the entry gate.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Carolyn Allain Breckel, Mark Hochstrasser
Summary: The proper folding of proteins is vital for their diverse functions, and misfolded proteins can potentially harm cells by forming aggregates. Protein quality control pathways are responsible for repairing or degrading abnormal proteins, with the ubiquitin-proteasome system being commonly employed.
Review
Biochemistry & Molecular Biology
Jing-Liang Sun, Jin-Yu Li, Mei-Jing Wang, Ze-Ting Song, Jian-Xiang Liu
Summary: Protein homeostasis in plant organelles is crucial for cell functions during growth and stress responses; a balance between protein synthesis and degradation is required to maintain this stability. Various mechanisms have evolved in plants to ensure efficient import, correct folding, and maturation of proteins within organelles, influenced by developmental signals and environmental cues.
Review
Cell Biology
Guofang Chen, Tingyi Wei, Furong Ju, Haisen Li
Summary: Endoplasmic reticulum (ER) is an essential cellular compartment involved in protein synthesis, lipid metabolism, and calcium balance. Dysfunction in the ER quality control system can lead to the accumulation and aggregation of misfolded proteins, resulting in various human disorders. Understanding the ER quality control network and protein aggregation will have significant implications for the diagnosis and treatment of ER storage diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kristoffer E. Johansson, Bayan Mashahreh, Rasmus Hartmann-Petersen, Tommer Ravid, Kresten Lindorff-Larsen
Summary: Effective proteome homeostasis is crucial for cell and organism survival. Cells have efficient quality control systems to monitor and remove misfolded proteins. The nature and sequence properties of quality-control degrons are still unknown.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Review
Food Science & Technology
Zhiliang Huang, Qi Wang, Jun Cao, Dayong Zhou, Chuan Li
Summary: Aquatic products are prone to spoilage during storage due to oxidation, endogenous enzymes, and bacteria. Consumers prefer natural, non-toxic, low-temperature, and more effective green biological preservatives based on the antibacterial and antioxidant mechanisms of biological agents compared to synthetic antioxidants. The effectiveness of polyphenols in oxidative and antibacterial processes is influenced by their type and molecular structure. This review provides an updated and summarized literature on the mechanism and application of polyphenols in preserving aquatic products. The conclusion is that polyphenols alleviate lipid oxidation, protein degradation, and inhibit the growth and reproduction of microorganisms in aquatic products, thereby achieving storage quality control, and suggestions for the application of research results in aquatic products are proposed. The aim is to provide theoretical support for better exploration of the application of polyphenols in aquatic product storage.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Physiology
Mohamed A. Eldeeb, Rhalena A. Thomas, Mohamed A. Ragheb, Armaan Fallahi, Edward A. Fon
Summary: Mitochondria, as a central hub for cellular metabolism and signaling, play a crucial role in human diseases. Eukaryotic cells have developed sophisticated quality control mechanisms to monitor and repair/mitophagy abnormal proteins and dysfunctional mitochondria. Chaperones help refold unstable proteins, which are selectively degraded if repair is not possible. Autophagy-lysosomal and ubiquitin-proteasome systems mediate the degradation of abnormal proteins. Mitophagy is responsible for eliminating dysfunctional mitochondria to protect cells from damage.
PHYSIOLOGICAL REVIEWS
(2022)
Article
Oncology
Ka-Yiu Edwin Kong, Joao P. L. Coelho, Matthias J. Feige, Anton Khmelinskii
Summary: A healthy and functional proteome is crucial for cell physiology, but errors in protein metabolism and changes in the environment can disrupt proteome homeostasis. Mislocalized and orphan proteins can form due to targeting errors or improper assembly, impacting cellular functions. Quality control mechanisms play a role in minimizing the detrimental effects of these aberrant proteins, which are associated with aging and disease.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Lion Borgert, Swadha Mishra, Fabian den Brave
Summary: The nucleus plays an emerging role in cellular quality control by degrading or sequestering aberrant proteins, thus protecting the cellular environment.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Yunting Fu, Xifeng Li, Baofang Fan, Cheng Zhu, Zhixiang Chen
Summary: Maintaining functional protein homeostasis in chloroplasts is crucial for plant fitness and survival. Research has uncovered various mechanisms involved in chloroplast protein quality control and turnover, such as endosymbiotically-derived proteases, ubiquitin-dependent turnover, chloroplast-associated degradation, chloroplast unfolded protein response, and vesicle-mediated degradation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Donghee Kang, Yurim Baek, Jae-Seon Lee
Summary: Cellular senescence, a key feature of aging, has both beneficial and detrimental effects on cellular homeostasis and diseases. Quality control (QC) mechanisms are dysregulated during cellular senescence, causing damage to RNA and protein integrity. This dysregulation is also implicated in age-related diseases. Further research on QC in cellular senescence and aging is needed for the development of new strategies to tackle age-related diseases.
Review
Biochemistry & Molecular Biology
Chen Jiang, Max Wynne, Damon Huber
Summary: The Sec machinery in bacteria is responsible for transporting proteins across the cytoplasmic membrane, requiring the substrates to be in an unfolded conformation. To prevent folding in the cytoplasm, bacteria have evolved a complex quality control network consisting of three branches: avoidance of cytoplasmic intermediates, inhibition of folding Sec substrate proteins, and destruction of potential translocation inhibitors. Stress response pathways also help restore protein-folding homeostasis when environmental conditions inhibit translocation.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Food Science & Technology
Yixing Sui, Patricia J. Harvey
Summary: This study optimized the production of biomass, protein, amino acids, and carotenoids from Dunaliella salina using a two-stage cultivation approach with different LED light intensities. The results showed that under red LED light, the biomass productivity of D. salina increased significantly, along with an increase in protein concentration and productivity. This indicates that red light has a positive impact on the growth and nutritional yield of D. salina.
Article
Gastroenterology & Hepatology
Tobias Schwerd, Sumeet Pandey, Huei-Ting Yang, Katrin Bagola, Elisabeth Jameson, Jonathan Jung, Robin H. Lachmann, Neil Shah, Smita Y. Patel, Claire Booth, Heiko Runz, Gesche Dueker, Ruth Bettels, Marianne Rohrbach, Subra Kugathasan, Helen Chapel, Satish Keshav, Abdul Elkadri, Nick Platt, Alexio M. Muise, Sibylle Koletzko, Ramnik J. Xavier, Thorsten Marquardt, Fiona Powrie, James E. Wraith, Mads Gyrd-Hansen, Frances M. Platt, Holm H. Uhlig
Article
Biochemistry & Molecular Biology
Maximilian von Delbrueck, Andreas Kniss, Vladimir V. Rogov, Lukas Pluska, Katrin Bagola, Frank Loehr, Peter Guentert, Thomas Sommer, Volker Doetsch
Article
Biochemistry & Molecular Biology
Paul R. Elliott, Derek Leske, Matous Hrdinka, Katrin Bagola, Berthe K. Fiil, Stephen H. McLaughlin, Jane Wagstaff, Norbert Volkmar, John C. Christianson, Benedikt M. Kessler, Stefan M. V. Freund, David Komander, Mads Gyrd-Hansen
Article
Cell Biology
Matous Hrdinka, Berthe Katrine Fiil, Mattia Zucca, Derek Leske, Katrin Bagola, Monica Yabal, Paul R. Elliott, Rune Busk Damgaard, David Komander, Philipp J. Jost, Mads Gyrd-Hansen
Article
Microbiology
Stefan Schille, Peter Crauwels, Rebecca Bohn, Katrin Bagola, Paul Walther, Ger van Zandbergen
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Katrin Bagola, Martin Mehnert, Ernst Jarosch, Thomas Sommer
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2011)
Article
Biochemistry & Molecular Biology
Katrin Bagola, Maximilian von Delbrueck, Gunnar Dittmar, Martin Scheffner, Inbal Ziv, Michael H. Glickman, Aaron Ciechanover, Thomas Sommer
Article
Immunology
Katharina Arens, Christodoulos Filippis, Helen Kleinfelder, Arthur Goetzee, Gabriele Reichmann, Peter Crauwels, Zoe Waibler, Katrin Bagola, Ger van Zandbergen
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Biology
Emma J. Fenech, Federica Lari, Philip D. Charles, Roman Fischer, Marie Laetitia-Thezenas, Katrin Bagola, Adrienne W. Paton, James C. Paton, Mads Gyrd-Hansen, Benedikt M. Kessler, John C. Christianson
Article
Multidisciplinary Sciences
Beata Turonova, Mateusz Sikora, Christoph Schuermann, Wim J. H. Hagen, Sonja Welsch, Florian E. C. Blanc, Soeren von Buelow, Michael Gecht, Katrin Bagola, Cindy Hoerner, Ger van Zandbergen, Jonathan Landry, Nayara Trevisan Doimo de Azevedo, Shyamal Mosalaganti, Andre Schwarz, Roberto Covino, Michael D. Muehlebach, Gerhard Hummer, Jacomine Krijnse Locker, Martin Beck
Article
Biochemistry & Molecular Biology
Lukas Pluska, Ernst Jarosch, Henrik Zauber, Andreas Kniss, Anita Waltho, Katrin Bagola, Maximilian von Delbrueck, Frank Loehr, Brenda A. Schulman, Matthias Selbach, Volker Doetsch, Thomas Sommer
Summary: The assembly of specific polymeric ubiquitin chains on target proteins is crucial for regulating cellular processes, but the mechanisms behind selective synthesis of these chains remain unclear. The E2 enzymes Ubc1 and Ube2K interact preferentially with ubiquitin chains linked through lysine 63 (K63), facilitating the selective assembly of K48/K63-branched ubiquitin conjugates. The activity of the UBA domain in these enzymes is linked to cellular proteostasis maintenance.
Article
Multidisciplinary Sciences
Laura Rossmann, Katrin Bagola, Tharshana Stephen, Anna-Lisa Gerards, Bianca Walber, Anja Ullrich, Stefan Schulke, Christel Kamp, Ingo Spreitzer, Milena Hasan, Brigitte David-Watine, Spencer L. Shorte, Max Bastian, Ger van Zandbergen
Summary: Efficient and safe vaccine development is crucial during the COVID-19 pandemic, with the use of appropriate adjuvants being essential to boost and tailor the immune response. Toll-like receptor agonists activate dendritic cells and induce immune responses, while TLR7/8 agonists have a strong impact on antiviral immune responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
