Article
Multidisciplinary Sciences
Phillip A. Frankino, Talha F. Siddiqi, Theodore Bolas, Raz Bar-Ziv, Holly K. Gildea, Hanlin Zhang, Ryo Higuchi-Sanabria, Andrew Dillin
Summary: The transcription factor SKN-1/NRF2 can sense and respond to changes in metabolic state. Knockdown of the amidohydrolase T12A2.1/amdh-1 activates a unique subset of SKN-1 regulated genes, independent of P38-MAPK signaling components. Histidine catabolism genes are required for this activation, possibly through accumulation of a specific catabolite. Activating SKN-1 results in increased oxidative stress resistance but decreased survival to heat stress.
Article
Biology
Isabelle Schiffer, Birgit Gerisch, Kazuto Kawamura, Raymond Laboy, Jennifer Hewitt, Martin Sebastian Denzel, Marcelo A. Mori, Siva Vanapalli, Yidong Shen, Orsolya Symmons, Adam Antebi
Summary: This study reveals that miR-1 in Caenorhabditis elegans plays a role in muscle function by regulating vacuolar ATPase subunits and lysosomal biogenesis, impacting muscle function and health by coordinating lysosomal v-ATPase and biogenesis. Deletion of mir-1 can improve mid-life muscle motility, pharyngeal pumping, and organismal longevity.
Article
Biochemistry & Molecular Biology
Shiling Feng, Chunyan Zhang, Tao Chen, Lijun Zhou, Yan Huang, Ming Yuan, Tian Li, Chunbang Ding
Summary: The study found that OLE significantly prolongs the lifespan of Caenorhabditis elegans and increases their resistance to lethal heat shock and oxidative stress. OLE regulates stress resistance and lifespan extension in nematodes through the activation of the IIS and SKN-1/Nrf2 signaling pathways.
Article
Cell Biology
Lei Sang, Rui Dong, Rui Liu, Qinggang Hao, Weiyu Bai, Jianwei Sun
Summary: Our study reveals that NHR-14/HNF4 alpha cooperates with CEP-1/p53 to regulate DNA damage-induced apoptosis.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Siqi Jiang, Na Deng, Bisheng Zheng, Tong Li, Rui Hai Liu
Summary: Rhodiola extract was found to significantly extend the lifespan of C. elegans and enhance its stress resistance by regulating gene expression and promoting protein translocation.
Article
Neurosciences
Yoshiki Sakai, Hiroshi Hanafusa, Tatsuhiro Shimizu, Strahil I. Pastuhov, Naoki Hisamoto, Kunihiro Matsumoto
Summary: This study reveals a novel role for BRCA1 and its partner BARD1 in neuronal cells, showing their involvement in regulating axon regeneration through the Gq alpha-DAG signaling network.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Xinwei Yu, Matthew S. Creamer, Francesco Randi, Anuj K. Sharma, Scott W. Linderman, Andrew M. Leifer
Summary: A method called fDNC, based on the transformer network architecture, is proposed for automated tracking and identifying neurons in C. elegans. This method predicts neural correspondence quickly without requiring straightening or transforming the animal into a canonical coordinate system, making it suitable for future real-time applications.
Article
Multidisciplinary Sciences
Cheng-Rung Huang, Cheng-Ju Kuo, Chih-Wen Huang, Yu-Ting Chen, Bang-Yu Liu, Chung-Ta Lee, Po-Lin Chen, Wen-Tsan Chang, Yun-Wen Chen, Tzer-Min Lee, Hui-Chen Hsieh, Chang-Shi Chen
Summary: Enterohemorrhagic Escherichia coli (EHEC) induces attaching and effacing lesions in the intestine through a host signaling pathway involving cyclin-dependent kinase CDK1 and formin CYK1, as demonstrated using human intestinal cells and a C. elegans model of infection.
NATURE COMMUNICATIONS
(2021)
Article
Biochemical Research Methods
Omer Yuval, Yael Iosilevskii, Anna Meledin, Benjamin Podbilewicz, Tom Shemesh
Summary: Complex dendritic trees are a distinctive feature of neurons, and alterations in dendritic morphology are associated with developmental, behavioral, and neurodegenerative changes. Using deep-learning and fitting algorithms, a method for neuronal feature extraction was presented, revealing uneven distribution of dendritic junctions and three-way-symmetrical junctions on average in the PVD neuron of C. elegans. Further analysis showed localized reduction in junctions due to mutations, shedding new light on PVD architecture and suggesting molecular control mechanisms.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Cell Biology
Phillip Wibisono, Shawndra Wibisono, Jan Watteyne, Chia-Hui Chen, Durai Sellegounder, Isabel Beets, Yiyong Liu, Jingru Sun
Summary: This study demonstrates that NMUR-1 regulates the expression of immune genes in C. elegans by modulating the activity of transcription factors involved in binding to RNA polymerase II regulatory regions. This finding provides a molecular basis for the specificity of C. elegans innate immunity and could potentially shed light on the specificity of innate immunity in other animals, including mammals.
Article
Infectious Diseases
Swarupa Mallick, Neha Mishra, Bedanta Kumar Barik, Vidya Devi Negi
Summary: This study aims to explore the development of C. elegans dauer larvae upon Salmonella Typhimurium infection and investigate the role of bacterial genes in regulating the worm's behavioral plasticity. The results revealed that the deletion of the fepB gene in the Salmonella strain reduced pathogenicity and bacterial burden in the worm's gut without damaging the pharynx. The fepB mutant strain enhanced the worm's immune responses and activated dauer signaling via the TGF-beta pathway, leading to increased dauer formation.
JOURNAL OF INFECTION
(2022)
Article
Multidisciplinary Sciences
Carla E. Cadena del Castillo, J. Thomas Hannich, Andres Kaech, Hirohisa Chiyoda, Jonathan Brewer, Masamitsu Fukuyama, Nils J. Faergeman, Howard Riezman, Anne Spang
Summary: The study reveals that the hedgehog signaling receptor PTCH functions as a cholesterol transporter. Reduction in PTCH activity leads to cellular cholesterol accumulation, resulting in changes in nuclear hormone receptor activity and fatty acid metabolism. This sheds light on the role of PTCH in maintaining organelle structure and fat metabolism.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Mengzhou Zhou, Xiaozhen Liu, Hai Yu, Joshua Gong
Summary: The study revealed that Lactobacillus zeae LB1 can regulate the cell signaling of Caenorhabditis elegans, including the p38 MAPK pathway, and the production of antimicrobial peptides and defense molecules to combat Salmonella infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Yuanyuan Liu, Qiuchen Zhao, Hui Nie, Fengguo Zhang, Tingting Fu, Zhenguo Zhang, Feifei Qi, Ruoxi Wang, Jun Zhou, Jinmin Gao
Summary: The SYP-5 protein is identified as a critical regulator of meiotic thermotolerance, affecting crossover designation and bivalent formation. Homolog segregation errors become more severe at elevated temperature, with defects during the pachytene stage responsible for reduced viability in syp-5 mutants. These findings reveal a novel molecular mechanism for regulating meiotic thermotolerance.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Article
Cell Biology
Chayki Charar, Sally Metsuyanim-Cohen, Daniel Z. Bar
Summary: Dietary restriction in animals is regulated by lamin, affecting body size and fat content. The LMN-1 protein plays a crucial role in the mTOR pathway.
JOURNAL OF CELL SCIENCE
(2021)
Article
Microbiology
Philip M. Armstrong, Hanna Y. Ehrlich, Tereza Magalhaes, Megan R. Miller, Patrick J. Conway, Angela Bransfield, Michael J. Misencik, Andrea Gloria-Soria, Joshua L. Warren, Theodore G. Andreadis, John J. Shepard, Brian D. Foy, Virginia E. Pitzer, Doug E. Brackney
NATURE MICROBIOLOGY
(2020)
Article
Ecology
Andrea Gloria-Soria, Sandra Y. Mendiola, Valerie J. Morley, Barry W. Alto, Paul E. Turner
ECOLOGY AND EVOLUTION
(2020)
Article
Infectious Diseases
Luciano Veiga Cosme, Andrea Gloria-Soria, Adalgisa Caccone, Jeffrey Robert Powell, Ademir Jesus Martins
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Noah H. Rose, Massamba Sylla, Athanase Badolo, Joel Lutomiah, Diego Ayala, Ogechukwu B. Aribodor, Nnenna Ibe, Jewelna Akorli, Sampson Otoo, John-Paul Mutebi, Alexis L. Kriete, Eliza G. Ewing, Rosemary Sang, Andrea Gloria-Soria, Jeffrey R. Powell, Rachel E. Baker, Bradley J. White, Jacob E. Crawford, Carolyn S. McBride
Article
Biochemistry & Molecular Biology
John Soghigian, Andrea Gloria-Soria, Vincent Robert, Gilbert Le Goff, Anna-Bella Failloux, Jeffrey R. Powell
Article
Public, Environmental & Occupational Health
Andrea Gloria-Soria, Anne F. Payne, Sean M. Bialosuknia, Jessica Stout, Nicholas Mathias, Gillian Eastwood, Alexander T. Ciota, Laura D. Kramer, Philip M. Armstrong
Summary: The Asian tiger mosquito has expanded its range in the eastern United States and poses a public health risk by transmitting Zika, dengue, and chikungunya viruses. Research shows that local populations of this mosquito species are susceptible to infection by these viruses, with a particular capability to transmit chikungunya. Maintaining mosquito surveillance and control programs is crucial to suppress populations and limit further range expansion.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Biology
Ricardo B. R. Azevedo, Peter Olofsson
Summary: Evolutionary rescue refers to the process in which a declining population may start growing again by increasing the frequency of fitter genotypes, thus avoiding extinction. This study presents a model to analyze the probability of rescue, the population growth curve of a rescued population, and the time until the first rescuing mutation occurs, under conditions of small mutation rate and selective advantage.
MATHEMATICAL BIOSCIENCES
(2021)
Article
Genetics & Heredity
Mohammed-Ahmed B. Elnour, Andrea Gloria-Soria, Rasha S. Azrag, Abeer M. Alkhaibari, Jeffrey R. Powell, Bashir Salim
Summary: Through genetic studies of Aedes aegypti in Sudan, two genetically distinct subspecies were identified in the country, located in Eastern and Western Sudan respectively. The research findings suggest that populations in Eastern Sudan are genetically closer to Asian and American populations, while populations in Western Sudan are more related to populations in East and West Africa.
FRONTIERS IN GENETICS
(2022)
Article
Parasitology
A. Gloria-Soria, D. E. Brackney, P. M. Armstrong
Summary: This study compared the accuracy of detecting virus infection in mosquito legs and salivary glands, and found that virus detection in mosquito legs was more accurate. Forced salivation methods tended to underestimate virus transmission.
PARASITES & VECTORS
(2022)
Article
Ecology
Evlyn Pless, Jeffrey R. Powell, Krystal R. Seger, Brett Ellis, Andrea Gloria-Soria
Summary: The study suggests that the colonization of Ae. aegypti in North America occurred through a series of founder events, with Florida as the potential source for westward invasions. However, some populations on the west coast do not follow the general trend, likely due to a distinct invasion history.
ECOLOGY AND EVOLUTION
(2022)
Editorial Material
Entomology
A. Gloria-Soria
Summary: This article compares the control of Covid-19 and vector-borne diseases, examines the advantages and caveats of using new genotyping technologies for studying invasive species, and highlights relevant papers published between 2020 and 2021 in the field of mosquito surveillance and mosquito vector population genetics.
JOURNAL OF MEDICAL ENTOMOLOGY
(2022)
Article
Biodiversity Conservation
Andrea Gloria-Soria, Talya Shragai, Alexander Ciota, Todd B. Duval, Barry W. Alto, Ademir J. Martins, Kathleen M. Westby, Kim A. Medley, Isik Unlu, Scott R. Campbell, Malgorzata Kawalkowski, Yoshio Tsuda, Yukiko Higa, Nicholas Indelicato, Paul T. Leisnham, Adalgisa Caccone, Philip M. Armstrong
Summary: The research found that the Asian tiger mosquito populations along the East Coast of the USA exhibit high levels of genetic diversity and connectivity, suggesting that they have successfully overwintered and migrated in large numbers in states like New York, Connecticut, and Massachusetts. The populations in Connecticut showed consistent genetic structure over three consecutive years.
Article
Biology
Peter Olofsson, Logan Chipkin, Ryan C. Daileda, Ricardo B. R. Azevedo
Summary: In this study, the phenomenon of mutational meltdown is analyzed using a multi-type branching process model, where populations are doomed to extinction due to the accumulation of mutations.
JOURNAL OF MATHEMATICAL BIOLOGY
(2023)
Article
Parasitology
Charles Jeannin, Yvon Perrin, Sylvie Cornelie, Andrea Gloria-Soria, Jean-Daniel Gauchet, Vincent Robert
Summary: Control of invasive species relies on surveillance at international entry points. In July 2018, a female Aedes aegypti mosquito, absent from Europe for 70 years, was captured in Marseille, France. Genetic analysis indicated that the mosquito originated from Cameroon, and it is believed to have arrived on a merchant ship from Douala to Marseille. This interception highlights the importance of preventing the establishment of invasive species.
Meeting Abstract
Public, Environmental & Occupational Health
I'ah Donovan-Banfield, Andrea Gloria-Soria, Jeffrey R. Powell, Seth N. Redmond
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)