Article
Multidisciplinary Sciences
Fuyuki Asano, Staci J. Kim, Tomoyuki Fujiyama, Chika Miyoshi, Noriko Hotta-Hirashima, Nodoka Asama, Kanako Iwasaki, Miyo Kakizaki, Seiya Mizuno, Michihiro Mieda, Fumihiro Sugiyama, Satoru Takahashi, Shoi Shi, Arisa Hirano, Hiromasa Funato, Masashi Yanagisawa
Summary: Deficiency of SIK3 in GABAergic neurons or NMS-producing neurons delays the arousal peak phase, while a gain-of-function mutant allele of Sik3 in GABAergic neurons advances the activity onset. Furthermore, HDAC4 deficiency shortens the circadian cycle.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Neurosciences
Harry A. Smith, James A. Betts
Summary: Daily rhythms and the timing of meals play a crucial role in coordinating metabolism and health. Experimental manipulation of feeding-fasting cycles can provide insights into the effects of meal timing on metabolism and health.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Editorial Material
Biochemistry & Molecular Biology
Christine Merlin
Summary: The molecular mechanism behind organisms' ability to anticipate variations in environmental conditions caused by tides in the intertidal zone has been unknown. A recent study shows that the circadian clock gene bmal1 is necessary for circatidal rhythms.
Review
Plant Sciences
Kanjana Laosuntisuk, Estefania Elorriaga, Colleen J. Doherty
Summary: Recurring patterns are essential for life on Earth, and plants have developed systems to coordinate with these patterns. The plant circadian clock plays a crucial role in this coordination, but our understanding is limited to a few species in controlled environments. This review explores the circadian clock in diverse plant species, the challenges of extrapolating data, and the importance of anticipating plant responses to climate change.
ANNUAL REVIEW OF PLANT BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sandrine Dulong, Lucas Eduardo Botelho de Souza, Jean Machowiak, Benoit Peuteman, Gaelle Duvallet, Deborah Boyenval, Elise Roth, Afag Asgarova, Yunhua Chang, Xiao-Mei Li, Adlen Foudi, Annabelle Ballesta
Summary: This study investigated the sex- and timing-related factors of hematopoietic toxicities induced by oxaliplatin in mice. The results showed that there were significant circadian rhythms in the counts of white blood cells and bone marrow cellularity in both sexes at different time points.
Review
Cell Biology
Raymond E. A. Sanchez, Franck Kalume, Horacio O. de la Iglesia
Summary: Nearly all mammals have robust daily rhythms called circadian rhythms, which are controlled by a master clock in the hypothalamus and affect various biological processes. This review summarizes the current understanding of circadian regulation of sleep, including neural circuitry, molecular mechanisms, and developmental regulation.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Janina Hesse, Julien Martinelli, Ouda Aboumanify, Annabelle Ballesta, Angela Relogio
Summary: This study introduces a novel mathematical model linking irinotecan cellular pharmacokinetics and dynamics to the core clock, successfully predicting treatment toxicity in a colorectal cancer cellular model. The model reveals the potential for personalized treatment timing optimization based on cellular clock characteristics.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Endocrinology & Metabolism
Gideon P. Dunster, Isabelle Hua, Alex Grahe, Jason G. Fleischer, Satchidananda Panda, Kenneth P. P. Wright Jr, Celine Vetter, Jennifer H. Doherty, Horacio O. de la Iglesia
Summary: Despite the availability of electric light, sleep timing is delayed during the winter. However, daily exposure to daylight can prevent this delayed phase of the circadian clock.
JOURNAL OF PINEAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Paula M. Wagner, Cesar G. Prucca, Beatriz L. Caputto, Mario E. Guido
Summary: Gliomas are solid tumors of the central nervous system classified into four groups by malignancy, with GBM being the most common and aggressive type. Current therapies for GBM have limited efficacy, prompting exploration of the potential role of the circadian clock in tumor cell modulation as a new target for novel treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Frank A. J. L. Scheer, Michael F. Hilton, Heather L. Evoniuk, Sally A. Shiels, Atul Malhotra, Rena Sugarbaker, R. Timothy Ayers, Elliot Israel, Anthony F. Massaro, Steven A. Shea
Summary: The study found that asthma patients experience worsened lung function and exacerbation of symptoms at night, often masked by sleep. Asthma patients exhibit significant circadian rhythms throughout the day and are more likely to use bronchodilators during the night.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Soo Ji Kim, Chris Chi, Gopal Pattanayak, Aaron R. Dinner, Michael J. Rust
Summary: By studying the cyanobacterial clock, a new protein called KidA was discovered to interact with the clock and shorten its period. It was also found that KidA alters the clock's ability to entrain to light-dark cycles. These findings reveal that the period and amplitude of the clock can be modulated by regulating the access of KaiB to the fold-switched form.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Surgery
Marine Cossec, Florian Atger, Claire Blanchard, David Jacobi
Summary: The timing of food intake can affect circadian rhythms and metabolism, potentially impacting obesity. Studies suggest a correlation between meal timing and weight loss after bariatric surgery in adults, with evidence pointing towards late-night food consumption hindering weight loss progress.
Review
Pharmacology & Pharmacy
Shuhui Jia, Xuantong Guo, Zuxin Chen, Shupeng Li, Xin-an Liu
Summary: Given the devastating social and health consequences of drug addiction and the limitations of current treatments, a new strategy involving correcting abnormal circadian rhythms and improving sleep quality may be beneficial in the treatment of drug addiction. Melatonin, a circadian hormone with various neuroprotective and pharmacological effects, has shown potential as an intervention for substance use disorders. This review discusses the roles of melatonin at different levels and its potential applications in drug addiction.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Clinical Neurology
Chooza Moon, Karin F. Hoth, Yelena Perkounkova, Meina Zhang, Jihye Lee, Maria Hein, Lauren Hopkins, Vincent Magnotta, Helen J. Burgess
Summary: This study aimed to investigate the association between circadian rhythms and hippocampal volume. The findings suggest that later circadian timing and reduced melatonin levels may be associated with reduced hippocampal volume in older adults.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Cell Biology
Namasthee Harris-Gauthier, Shashank Bangalore Srikanta, Nicolas Cermakian
Summary: Living organisms have evolved to synchronize and adapt to daily environmental cycles through circadian rhythms. These rhythms are driven by a molecular clock composed of clock genes and proteins, which regulate the expression of numerous genes. Ubiquitination and deubiquitination play important roles in the regulation of clock proteins and their functions within the circadian clock.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Genetics & Heredity
Navonil Banerjee, Raja Bhattacharya, Michael Gorczyca, Kevin M. Collins, Michael M. Francis
Article
Biochemistry & Molecular Biology
Michael Jensen, Frederic J. Hoerndli, Penelope J. Brockie, Rui Wang, Erica Johnson, Dane Maxfield, Michael M. Francis, David M. Madsen, Andres V. Maricq
Article
Neurosciences
Belinda Barbagallo, Hilary A. Prescott, Patrick Boyle, Jason Climer, Michael M. Francis
JOURNAL OF NEUROSCIENCE
(2010)
Article
Neurosciences
Rui Wang, Craig S. Walker, Penelope J. Brockie, Michael M. Francis, Jerry E. Mellem, David M. Madsen, Andres V. Maricq
Article
Neurosciences
Jennifer K. Pirri, Adam D. McPherson, Jamie L. Donnelly, Michael M. Francis, Mark J. Alkema
Article
Genetics & Heredity
Raja Bhattacharya, Denis Touroutine, Belinda Barbagallo, Jason Climer, Christopher M. Lambert, Christopher M. Clark, Mark J. Alkema, Michael M. Francis
Article
Biology
Alison Philbrook, Shankar Ramachandran, Christopher M. Lambert, Devyn Oliver, Jeremy Florman, Mark J. Alkema, Michele Lemons, Michael M. Francis
Article
Developmental Biology
Devyn Oliver, Emily Norman, Heather Bates, Rachel Avard, Monika Rettler, Claire Y. Benard, Michael M. Francis, Michele L. Lemons
JOURNAL OF DEVELOPMENTAL BIOLOGY
(2019)
Article
Developmental Biology
Belinda Barbagallo, Alison Philbrook, Denis Touroutine, Navonil Banerjee, Devyn Oliver, Christopher M. Lambert, Michael M. Francis
Article
Multidisciplinary Sciences
Craig S. Walker, Penelope J. Brockie, David M. Madsen, Michael M. Francis, Yi Zheng, Sri Koduri, Jerry E. Mellem, Nathalie Strutz-Seebohm, Andres V. Maricq
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2006)
Article
Multidisciplinary Sciences
Craig S. Walker, Michael M. Francis, Penelope J. Brockie, David M. Madsen, Yi Zheng, Andres V. Maricq
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2006)
Article
Multidisciplinary Sciences
Y Zheng, PJ Brockie, JE Mellem, DM Madsen, CS Walker, MM Francis, AV Maricq
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2006)
Article
Pharmacology & Pharmacy
RL Papke, JD Buhr, MM Francis, KI Choi, JS Thinschmidt, NA Horenstein
MOLECULAR PHARMACOLOGY
(2005)
Article
Neurosciences
MM Francis, SP Evans, M Jensen, DM Madsen, J Mancuso, KR Norman, AV Maricq
