期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 280, 期 -, 页码 49-55出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2015.02.002
关键词
Fibromyalgia; Rheumatoid arthritis; Cytokines; Chemokines; Cerebrospinal fluid; Glia cells; Heart rate variability
资金
- Swedish Research Council [K2009-53X-21070-01-3, 2009-3808]
- Swedish Rheumatism Association
- Karolinska Institute Foundations
- Stockholm County Council [20090060, 20100126]
- Swedish Foundation for Strategic Research
- EU [FP7-Health-2013-Innovation-1602919-2]
The purpose of this study was to relate central inflammation to autonomic activity (heart rate variability (HRV)) in patients with rheumatoid arthritis (RA) and fibromyalgia (FM). RA patients had reduced parasympathetic activity and FM patients had increased sympathetic activity compared to healthy controls. Comparisons between RA and FM showed higher cerebrospinal fluid (CSF) interleukin (1)-1 beta inversely correlated to parasympathetic activity in RA. The FM patients had higher concentrations of CSF IL-8, IL-1Ra, IL-4 and IL-10, but none of these cytokines correlated with HRV. In conclusion, we found different profiles of central cytokines, i.e., elevated IL-1 beta in inflammatory pain (RA) and elevated IL-8 in dysfunctional pain (FM). (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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