Article
Clinical Neurology
Q. Lisan, P. Marques-Vidal, N. Hausler, N. Danchin, P. Boutouyrie, A. Asselin, X. Jouven, R. Heinzer, J. P. Empana
Summary: This study aimed to compare the patterns of microRNAs expression between OSA and control patients with and without incident CVD. The results showed that there was no association between a large panel of microRNAs and OSA patients with and without incident CVD.
Article
Medicine, General & Internal
Benjamin K. Petrie, Tudor Sturzoiu, Julie Shulman, Saleh Abbas, Hesham Masoud, Jose Rafael Romero, Tatiana Filina, Thanh N. Nguyen, Helena Lau, Judith Clark, Sanford Auerbach, Yelena G. Pyatkevich, Hugo J. Aparicio
Summary: Sleep disordered breathing (SDB) is common but often undiagnosed in stroke patients. Screening questionnaires and portable sleep testing (PST) can help expedite the diagnosis and management of SDB in acute stroke, subarachnoid hemorrhage, or transient ischemic attack patients. The STOP-BANG questionnaire showed the highest sensitivity for at least mild SDB, but with low specificity, and overall discrimination of the questionnaires was poor. Inpatient PSTs were found useful for early screening and further outpatient evaluations of SDB.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
Yi Cai, Hailey M. Juszczak, Emily K. Cope, Andrew N. Goldberg
Summary: Recent evidence suggests a bidirectional relationship between obstructive sleep apnea and microbiota composition, where sleep quality and microbiota alterations influence each other. Animal model studies support the idea that the microbiome mediates disease states associated with obstructive sleep apnea, and potential treatment options include probiotics, prebiotics, and microbiota transplantation.
Article
Medicine, General & Internal
Andras Bikov, Martina Meszaros, Laszlo Kunos, Alina Gabriela Negru, Stefan Marian Frent, Stefan Mihaicuta
Summary: Patients with OSA had higher AIP and triglyceride, and lower HDL-C levels. AIP was significantly correlated with the Epworth Sleepiness Scale score, the apnoea-hypopnoea index, and oxygen desaturation index, but not with markers of sleep quality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Respiratory System
Pablo Catalan Serra, Xavier Soler
Summary: This article reviews the association between obstructive sleep apnea (OSA) and cardiovascular events (CVE) in the elderly, as well as the impact of continuous positive airway pressure (CPAP) treatment on CVE. Although the positive association between OSA and cardiovascular disease in the elderly has been established, the role of OSA in certain cardiovascular events remains controversial.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2022)
Article
Health Care Sciences & Services
Valerio Brunetti, Elisa Testani, Anna Losurdo, Catello Vollono, Aldobrando Broccolini, Riccardo Di Iorio, Giovanni Frisullo, Fabio Pilato, Paolo Profice, Jessica Marotta, Eleonora Rollo, Irene Scala, Paolo Calabresi, Giacomo Della Marca
Summary: This study aimed to evaluate the association between obstructive sleep apnea (OSA) and atrial fibrillation (AF) in acute ischemic stroke. The results showed that OSA and AF are highly prevalent but not associated in acute stroke. Furthermore, OSA acts as an independent risk factor for stroke.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Jacqueline H. Geer, Guido J. Falcone, Kevin N. Vanent, Audrey C. Leasure, Daniel Woo, Jennifer R. Molano, Lauren H. Sansing, Carl D. Langefeld, Margaret A. Pisani, Henry K. Yaggi, Kevin N. Sheth
Summary: The study found that obstructive sleep apnea (OSA) is associated with the risk of intracerebral hemorrhage (ICH). Cases with OSA were more likely to be male and have hypertension, heart disease, hyperlipidemia, and higher body mass index compared to those without OSA. Logistic regression analysis showed that OSA is a risk factor for ICH.
Article
Clinical Neurology
Andras Bikov, Sebastien Bailly, Dries Testelmans, Francesco Fanfulla, Athanasia Pataka, Izolde Bouloukaki, Holger Hein, Zoran K. Dogas, Ozen Basoglu, Richard Staats, Gianfranco Parati, Carolina Lombardi, Ludger Grote, Stefan Mihaicuta, ESADA Study Grp
Summary: Periodic limb movements during sleep may be an additional risk factor for cardiovascular disease in patients with obstructive sleep apnea, as it is associated with dyslipidemia. This study aimed to determine the impact of periodic limb movements during sleep on serum lipid levels in obstructive sleep apnea patients.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Endocrinology & Metabolism
Emily Jane Meyer, Gary Allen Wittert
Summary: Obstructive sleep apnea (OSA) and obesity are closely associated; OSA is often unrecognized in women; OSA increases the risk of developing comorbid chronic disorders and impairs quality of life; appropriate treatment can improve symptoms and related diseases.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Mohammad Badran, Shawn B. Bender, David Gozal
Summary: Obstructive sleep apnea (OSA) is associated with oxidative stress, inflammation, and fibrosis, leading to cardiovascular complications. Current treatments for OSA are not effective in improving cardiovascular outcomes. Inappropriate activation of mineralocorticoid receptor (MR) in cardiovascular tissues is implicated in various cardiovascular diseases. However, the causal involvement of MR signaling in OSA-related cardiovascular disease has not been studied extensively. This article suggests MR-targeted therapy as a potential approach to mitigate the adverse cardiovascular consequences of OSA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaoguang Yao, Nanfang Li, Mulalibieke Heizhati, Yingchun Wang, Yue Ma, Run Wang, Delian Zhang, Qin Luo, Junli Hu, Menghui Wang, Qing Zhu
Summary: This study investigates the association between blood pressure control and major adverse cardiovascular and cerebrovascular events in hypertensive patients with obstructive sleep apnea (OSA).
BMC CARDIOVASCULAR DISORDERS
(2023)
Review
Clinical Neurology
Nader Salari, Habibolah Khazaie, Maryam Abolfathi, Hooman Ghasemi, Shervin Shabani, Shna Rasoulpoor, Masoud Mohammadi, Shabnam Rasoulpoor, Behnam Khaledi-Paveh
Summary: This study conducted a meta-analysis to investigate the association between obstructive sleep apnea (OSA) and cardiovascular disease (CVD) risk. The results showed that OSA is considered a cardiovascular risk factor, with a significant relationship between the severity of OSA and the risk of CVD. Patients with OSA have increased risk of heart attack, CHD, and mortality from cardiovascular disease.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Kate Sutherland, Nadi Sadr, Yu Sun Bin, Kristina Cook, Hasthi U. Dissanayake, Peter A. Cistulli, Philip de Chazal
Summary: This study compared associations of different oximetry patterns with incident cardiovascular disease (CVD) in individuals with obstructive sleep apnea (OSA). The results showed that none of the oxygenation patterns were related to the development of CVD in OSA patients. However, there were some associations between certain oxygenation patterns and CVD risk in women. Further research is needed to determine if OSA phenotypes can be used to predict susceptibility to cardiovascular disease.
Article
Cardiac & Cardiovascular Systems
Adriana Lebkuchen, Lunara S. Freitas, Karina H. M. Cardozo, Luciano F. Drager
Summary: The impact of obstructive sleep apnea (OSA) on cardiovascular function presents several challenges due to unclear mechanisms, prompting the need for the development of biomarkers to reveal potential risks.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Clinical Neurology
Sonja G. Schutz, Lynda D. Lisabeth, River Gibbs, Xu Shi, Erin Case, Ronald D. Chervin, Devin L. Brown
Summary: This study found that although obstructive sleep apnea (OSA) is a risk factor for stroke, the onset of stroke during sleep is not significantly associated with OSA in this large, population-based stroke cohort.
