☆ 4.4 Article

Genetic Profiles in Ischaemic Stroke

CURRENT ATHEROSCLEROSIS REPORTS (2013)

期刊

CURRENT ATHEROSCLEROSIS REPORTS

卷 15, 期 8, 页码 -

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CURRENT MEDICINE GROUP

DOI: 10.1007/s11883-013-0342-8

关键词

Stroke; Ischaemic stroke; Genetics; Genetic risk; GWAS; HDAC9

类别

Peripheral Vascular Disease

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Reagent

摘要

Stroke represents a clinical syndrome rather than a single disease. A number of stroke subtypes can be distinguished based on careful phenotyping, with each of these having distinct and overlapping risk factor profiles. Recent evidence has suggested that genetics plays an important part in stroke risk, with at least 2 genes specific to stroke risk directly now having been identified. This review will explore our current understanding of the genetics underlying stroke risk and whether this information is currently useful in a clinical setting for patient benefit.

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Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2

Yu-Ching Cheng, Tara M. Stanne, Anne-Katrin Giese, Weang Kee Ho, Matthew Traylor, Philippe Amouyel, Elizabeth G. Holliday, Rainer Malik, Huichun Xu, Steven J. Kittner, John W. Cole, Jeffrey R. O'Connell, John Danesh, Asif Rasheed, Wei Zhao, Stefan Engelter, Caspar Grond-Ginsbach, Yoichiro Kamatani, Mark Lathrop, Didier Leys, Vincent Thijs, Tiina M. Metso, Turgut Tatlisumak, Alessandro Pezzini, Eugenio A. Parati, Bo Norrving, Steve Bevan, Peter M. Rothwell, Cathie Sudlow, Agnieszka Slowik, Arne Lindgren, Matthew R. Walters, Jim Jannes, Jess Shen, David Crosslin, Kimberly Doheny, Cathy C. Laurie, Sandip M. Kanse, Joshua C. Bis, Myriam Fornage, Thomas H. Mosley, Jemma C. Hopewell, Konstantin Strauch, Martina Mueller-Nurasyid, Christian Gieger, Melanie Waldenberger, Annette Peters, Christine Meisinger, M. Arfan Ikram, W. T. Longstreth, James F. Meschia, Sudha Seshadri, Pankaj Sharma, Bradford Worrall, Christina Jern, Christopher Levi, Martin Dichgans, Giorgio B. Boncoraglio, Hugh S. Markus, Stephanie Debette, Arndt Rolfs, Danish Saleheen, Braxton D. Mitchell

STROKE (2016)

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Article Clinical Neurology

Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype

Loes C. A. Rutten-Jacobs, Matthew Traylor, Poneh Adib-Samii, Vincent Thijs, Cathie Sudlow, Peter M. Rothwell, Giorgio Boncoraglio, Martin Dichgans, James Meschia, Jane Maguire, Christopher Levi, Natalia S. Rost, Jonathan Rosand, Ahamad Hassan, Steve Bevan, Hugh S. Markus

STROKE (2016)

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Article Clinical Neurology

Genetic Associations With White Matter Hyperintensities Confer Risk of Lacunar Stroke

Matthew Traylor, Loes C. A. Rutten-Jacobs, Vincent Thijs, Elizabeth G. Holliday, Chris Levi, Steve Bevan, Rainer Malik, Giorgio Boncoraglio, Cathie Sudlow, Peter M. Rothwell, Martin Dichgans, Hugh S. Markus

STROKE (2016)

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Article Multidisciplinary Sciences

Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke

Ilkka Seppala, Marcus E. Kleber, Steve Bevan, Leo-Pekka Lyytikainen, Niku Oksala, Jussi A. Hernesniemi, Kari-Matti Makela, Peter M. Rothwell, Cathie Sudlow, Martin Dichgans, Nina Mononen, Efthymia Vlachopoulou, Juha Sinisalo, Graciela E. Delgado, Reijo Laaksonen, Tuomas Koskinen, Hubert Scharnagl, Mika Kahonen, Hugh S. Markus, Winfried Marz, Terho Lehtimaki

SCIENTIFIC REPORTS (2016)

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Article Medicine, General & Internal

Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study

Bram. P. Prins, Ali Abbasi, Anson Wong, Ahmad Vaez, Ilja Nolte, Nora Franceschini, Philip E. Stuart, Javier Guterriez Achury, Vanisha Mistry, Jonathan P. Bradfield, Ana M. Valdes, Jose Bras, Aleksey Shatunov, Chen Lu, Buhm Han, Soumya Raychaudhuri, Steve Bevan, Maureen D. Mayes, Lam C. Tsoi, Evangelos Evangelou, Rajan P. Nair, Struan F. A. Grant, Constantin Polychronakos, Timothy R. D. Radstake, David A. van Heel, Melanie L. Dunstan, Nicholas W. Wood, Ammar Al-Chalabi, Abbas Dehghan, Hakon Hakonarson, Hugh S. Markus, James T. Elder, Jo Knight, Dan E. Arking, Timothy D. Spector, Bobby P. C. Koeleman, Cornelia M. van Duijn, Javier Martin, Andrew P. Morris, Rinse K. Weersma, Cisca Wijmenga, Patricia B. Munroe, John R. B. Perry, Jennie G. Pouget, Yalda Jamshidi, Harold Snieder, Behrooz Z. Alizadeh

PLOS MEDICINE (2016)

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Article Rheumatology

Nociceptive Sensitizers Are Regulated in Damaged Joint Tissues, Including Articular Cartilage, When Osteoarthritic Mice Display Pain Behavior

Clare Driscoll, Anastasios Chanalaris, Chancie Knights, Heba Ismail, Pradeep K. Sacitharan, Clive Gentry, Stuart Bevan, Tonia L. Vincent

ARTHRITIS & RHEUMATOLOGY (2016)

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Article Multidisciplinary Sciences

Prevalence of CADASIL and Fabry Disease in a Cohort of MRI Defined Younger Onset Lacunar Stroke

Laura L. Kilarski, Loes C. A. Rutten-Jacobs, Steve Bevan, Rob Baker, Ahamad Hassan, Derralynn A. Hughes, Hugh S. Markus

PLOS ONE (2015)

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