Review
Biochemistry & Molecular Biology
Armin Zittermann, Christian Trummer, Verena Theiler-Schwetz, Elisabeth Lerchbaum, Winfried Maerz, Stefan Pilz
Summary: Research on the potential impact of vitamin D on cardiovascular disease risk has yielded contradictory results, with no strong evidence for its beneficial effects. Further studies are needed to determine if specific subgroups may benefit from vitamin D supplementation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Cristian Sandoval, Jorge Farias, Mauricio Zamorano, Christian Herrera
Summary: The present review examined the relationship between vitamin deficiency and chronic liver disease. It was found that alcohol patients have low blood vitamin levels and that antioxidant mechanisms can prevent alcohol-induced liver damage. However, the effectiveness of antioxidants remains uncertain. Deficiencies in nutritional vitamins can rapidly develop during chronic liver disease.
Review
Chemistry, Analytical
Widson Michael dos Santos, Myla Lobo de Souza, Fernanda Pontes Nobrega, Andre Luiz Moreira Domingues de Sousa, Elvis Joacir De Franca, Larissa Araujo Rolim, Pedro Jose Rolim Neto
Summary: Dietary supplements containing calcium salts and cholecalciferol may have inconsistent levels and deviate from label claims, requiring accurate analysis and detection. Analyzing these compounds is challenging due to the inorganic nature of calcium and the organic nature of cholecalciferol, necessitating specific pretreatment procedures and multiple analytical methods.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Review
Endocrinology & Metabolism
Fatima Zarzour, Ahmad Didi, Mohammed Almohaya, David Kendler
Summary: Calcium and vitamin D play important roles in mineral homeostasis and skeletal health. The effectiveness and cardiovascular safety of their supplementation have been studied in various trials, yielding inconsistent results. Current guidelines recommend up to 1,200 mg of calcium intake from the diet without concern for cardiovascular risk. Recommendations for vitamin D supplementation vary widely, but well-conducted randomized trials suggest that modest supplementation is safe but does not provide cardiovascular benefits or harms.
ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Nutrition & Dietetics
Man Hung, Wendy C. Birmingham, Monica Ocampo, Amir Mohajeri
Summary: Cardiovascular diseases (CVD) are the leading cause of death in the United States. This study aimed to determine the association between reported CVD and serum 25-hydroxyvitamin D [25(OH)D]. Using data from the National Health and Nutrition Examination Survey, the study found that deficiency and insufficiency of 25(OH)D were associated with CVD, while adequacy of 25(OH)D was not. Healthcare professionals may consider vitamin D supplementation to improve cardiovascular health in adults for CVD prevention.
Article
Nutrition & Dietetics
Matteo Bargagli, Pietro Manuel Ferraro, Matteo Vittori, Gianmarco Lombardi, Giovanni Gambaro, Bhaskar Somani
Summary: Kidney stone disease is a multifactorial condition influenced by genetic predisposition and environmental factors. Dietary advice for kidney stone formers includes elevated fluid intake, dietary restriction, normal body mass index, and increased intake of vegetables and fibers. Calcium consumption plays a role in reducing the risk for kidney stones by affecting oxalate availability, while the impact of vitamin D supplements on stone formation risk remains unclear.
Review
Nutrition & Dietetics
Seung-Kwon Myung, Hong-Bae Kim, Yong-Jae Lee, Yoon-Jung Choi, Seung-Won Oh
Summary: This meta-analysis found that calcium supplements significantly increased the risk of cardiovascular disease in healthy postmenopausal women by about 15%, particularly with dietary calcium intake of 700-1000 mg or supplementary calcium intake of 1000 mg per day.
Review
Biochemistry & Molecular Biology
Francesco Visioli
Summary: There is a heated debate about the usefulness of food bioactives as dietary supplements, which often overlooks scientific evidence and proper research outcomes. Some argue that health claims should be based on pharmacological parameters, while others believe that botanical history and basic biological evidence should be sufficient for marketing. The current regulatory impasse does not help resolve this issue.
Article
Biochemistry & Molecular Biology
Malihe Aghasizadeh, Mahmoud Ghanei, Sahar Ghoflchi, Parisa Asadian-sohan, Mohammad Haghani, Tooba Kazemi, Habibollah Esmaily, Amir Avan, Gordon A. Ferns, Ebrahim Miri-Moghaddam, Majid Ghayour-Mobarhan
Summary: This study investigates the relationship between ANGPTL3 gene polymorphisms and calcium and vitamin D levels in cardiovascular disease patients. The findings suggest that certain genotypes are associated with vitamin D levels, indicating that individuals with cardiovascular disease may benefit from vitamin D and calcium supplementation to reduce their risk.
BIOCHEMICAL GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Fulvia Zappulo, Maria Cappuccilli, Alessandra Cingolani, Anna Scrivo, Anna Laura Croci Chiocchini, Miriam Di Nunzio, Chiara Donadei, Marianna Napoli, Francesco Tondolo, Giuseppe Cianciolo, Gaetano La Manna
Summary: Vitamin D plays a crucial role in bone metabolism, as well as having important extra-bone effects such as glucose homeostasis and cardiovascular protection. This narrative review provides an overview of the role of vitamin D in different settings, with a special focus on chronic kidney disease and kidney transplant.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Yi-Yan Pei, Yu Zhang, Xing-Chen Peng, Zhe-Ran Liu, Ping Xu, Fang Fang
Summary: This systematic review and meta-analysis found that vitamin D supplementation was not associated with a lower risk of cardiovascular events or mortality. These findings do not support the routine use of vitamin D supplementation.
Article
Cardiac & Cardiovascular Systems
Kyoung Jin Kim, Min Sun Kim, Namki Hong, Jae Hyun Bae, Kyeong Jin Kim, Nam Hoon Kim, Yumie Rhee, Juneyoung Lee, Sin Gon Kim
Summary: This population-based study aimed to evaluate the real effects of calcium supplementation on cardiovascular outcomes. The study found that calcium supplementation without vitamin D was associated with an increased risk of cardiovascular diseases.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Erika Rimondi, Annalisa Marcuzzi, Fabio Casciano, Gianluca Tornese, Agnese Pellati, Barbara Toffoli, Paola Secchiero, Elisabetta Melloni
Summary: This study demonstrates that vitamin D deficiency may contribute to the formation and instability of atheromatous plaques in mice, suggesting a potential role for vitamin D in preventing or delaying atheromatous disease in cardiovascular disorders. Further research is needed to fully understand the impact of vitamin D in cardiovascular diseases.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Cardiac & Cardiovascular Systems
Rati Jani, Kshemina Mhaskar, Thomas Tsiampalis, Nigussie A. Kassaw, Miguel A. M. Gonzalez, Demosthenes B. Panagiotakos
Summary: The circulating level of vitamin D is associated with the risk of cardiovascular disease, with lower levels of 25(OH)D being linked to increased risk of both CVD incidence and recurrent events. An inverse linear association was found between 25(OH)D levels and non-fatal CVD incidence events, while a non-linear association was observed with fatal and combined CVD events.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Nutrition & Dietetics
Zeyad Khalil, Benyamin Alam, Amir Reza Akbari, Harbans Sharma
Summary: Vitamin K-2 plays a crucial role in calcium metabolism and shows potential benefits for osteoporosis, cardiovascular disease, parathyroid disorders, cerebral palsy, and sperm motility. Further research is needed to confirm the reproducibility of these positive effects and evaluate the feasibility of using vitamin K-2 as a treatment for these conditions.
Article
Critical Care Medicine
Romil R. Parikh, Faye L. Norby, Wendy Wang, Thenappan Thenappan, Kurt W. Prins, Jeremy R. Van't Hof, Pamela L. Lutsey, Scott D. Solomon, Amil M. Shah, Lin Yee Chen
Summary: This study found that higher right ventricular afterload in older adults is associated with a greater risk of atrial fibrillation (AF), independent of left atrium and left ventricular remodeling. This suggests that changes in the right heart may be an important factor in the development of AF, in addition to the structural changes in the left heart.
Article
Biochemistry & Molecular Biology
Brian T. Steffen, James S. Pankow, Pamela L. Lutsey, Ryan T. Demmer, Jeffrey R. Misialek, Weihua Guan, Logan T. Cowan, Josef Coresh, Faye L. Norby, Weihong Tang
Summary: This study identified novel proteomic signatures and pathways associated with COVID-19 risk variants. Some of these proteins were associated with increased risk of incident hospitalized pneumonia and respiratory infections.
HUMAN MOLECULAR GENETICS
(2022)
Article
Neurosciences
Wendy Wang, Rebecca F. Gottesman, Michelle L. Meyer, Timothy M. Hughes, Kevin J. Sullivan, Dean F. Wong, Kamakshi Lakshminarayan, Pamela L. Lutsey
Summary: This study aimed to assess the association between carotid intima-media thickness (cIMT) and amyloid-beta (Aβ) deposition. The results showed that greater cIMT was associated with Aβ deposition among individuals with APOE ε4 genotype, but not in those without.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Kelsie M. Full, Snigdha Pusalavidyasagar, Priya Palta, Kevin J. Sullivan, Jung-Im Shin, Rebecca F. Gottesman, Adam P. Spira, Matthew P. Pase, Pamela L. Lutsey
Summary: This study aimed to examine the association between the use of sleep medications and incident dementia in a community-based cohort of older adults. The results showed that sleep medication use was associated with a 48% greater risk of dementia compared to nonuse.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Sanaz Sedaghat, Pamela L. Lutsey, Yuekai Ji, Jean-Philippe Empana, Farzaneh Sorond, Timothy M. Hughes, Thomas H. Mosley, Rebecca F. Gottesman, David S. Knopman, Keenan A. Walker, Vilmundur Gudnason, Lenore J. Launer, Thomas T. van Sloten
Summary: Better cardiovascular health at midlife and improvement of cardiovascular health within midlife are associated with lower dementia risk.
ALZHEIMERS & DEMENTIA
(2023)
Article
Endocrinology & Metabolism
Brian T. Steffen, Weihong Tang, Pamela L. Lutsey, Ryan T. Demmer, Elizabeth Selvin, Kunihiro Matsushita, Alanna C. Morrison, Weihua Guan, Mary R. Rooney, Faye L. Norby, Nathan Pankratz, David Couper, James S. Pankow
Summary: Proteomics analysis identified plasma proteins associated with the risk of type 2 diabetes. These proteins may serve as potential targets for intervention or pharmacological approaches to prevent, reverse, or slow down the progression of type 2 diabetes.
Review
Cardiac & Cardiovascular Systems
Pamela L. Lutsey, Neil A. Zakai
Summary: Venous thromboembolism is an under-appreciated vascular disease with significant health disparities in incidence and outcomes. In addition to understanding the epidemiological characteristics and risk factors of this disease, attention should also be given to prevention measures and reducing disparities.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Hematology
Brian T. Steffen, James S. Pankow, Faye L. Norby, Pamela L. Lutsey, Ryan T. Demmer, Weihua Guan, Nathan Pankratz, Aixin Li, Guning Liu, Kunihiro Matsushita, Adrienne Tin, Weihong Tang
Summary: This study identified proteomic signatures and pathways related to 23 gene loci associated with abdominal aortic aneurysm (AAA). The results suggest that low levels of neogenin and kit ligand may be novel risk factors for AAA development.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Arun Kumar, Pamela L. Lutsey, Wendy L. St. Peter, Jon C. Schommer, Jeremy R. Van't Hof, Abhijeet Rajpurohit, Joel F. Farley
Summary: In acute coronary syndrome following percutaneous coronary intervention, newer P2Y12 inhibitors (ticagrelor and prasugrel) reduce cardiovascular outcomes compared to clopidogrel, but have a higher bleeding risk. This study examines the safety of each inhibitor in a real-world population.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Arun Kumar, Pamela L. Lutsey, Wendy L. St Peter, Jon C. Schommer, Jeremy R. Van't Hof, Abhijeet Rajpurohit, Joel F. Farley
Summary: This study compared the effectiveness of newer P2Y12 inhibitors (prasugrel and ticagrelor) with clopidogrel in real-world US populations. The results showed that ticagrelor reduced the risk of cardiovascular events by 10% at 90 days compared to clopidogrel. There were no significant differences for other comparisons. This study provides valuable information for clinicians in selecting P2Y12 inhibitors after ACS.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biochemical Research Methods
Bruno Bohn, Pamela L. Lutsey, Weihong Tang, James S. Pankow, Faye L. Norby, Bing Yu, Christie M. Ballantyne, Eric A. Whitsel, Kunihiro Matsushita, Ryan T. Demmer
Summary: This study compared the proteome of statin users and nonusers and found differences in proteins unrelated to lipid metabolism. Further investigation into these differences may help elucidate the pleiotropic effects of statins.
JOURNAL OF PROTEOMICS
(2023)
Article
Medicine, General & Internal
Bruno Bohn, Pamela L. Lutsey, Jeffrey R. Misialek, Keenan A. Walker, Charles H. Brown, Timothy M. Hughes, Junichi Ishigami, Kunihiro Matsushita, Ryan T. Demmer
Summary: This study found an association between hospitalization with infection and incident dementia, suggesting that infections are risk factors for dementia.
Article
Nutrition & Dietetics
Linzi Li, Pamela L. Lutsey, Lin Yee Chen, Elsayed Z. Soliman, Mary R. Rooney, Alvaro Alonso
Summary: Higher serum magnesium is associated with a lower risk of cardiovascular events, especially myocardial infarction, in patients with atrial fibrillation.
Article
Hematology
Pamela L. Lutsey
Summary: The case-control design is an observational study design that compares the exposure prevalence between individuals with and without disease. Proper control selection is crucial for case-control study design, and optimizing control selection can maximize causal inference and enhance the scientific rigor of hematologic case-control studies.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Respiratory System
David M. MacDonald, Yuekai Ji, Selcuk Adabag, Alvaro Alonso, Lin Yee Chen, Benjamin E. Henkle, Stephen P. Juraschek, Faye L. Norby, Pamela L. Lutsey, Ken M. Kunisaki
Summary: This study found that better cardiovascular autonomic function was associated with a lower risk of COPD hospitalization, while worse autonomic function was associated with a higher risk of COPD hospitalization. This relationship was more significant in participants without airflow obstruction.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
