Article
Medicine, General & Internal
Jennifer Fontaine, Evelyn Chin, Jean-Francois Provencher, Anthony Rainone, Dana Wazzan, Carmella Roy, Soham Rej, Marie Lordkipanidze, Vincent Dagenais-Beaule
Summary: This study reveals suboptimal baseline cardiometabolic monitoring of patients taking antipsychotic drugs in a Canadian hospital. Improving collaboration within a multidisciplinary team may enhance cardiometabolic monitoring.
Article
Nutrition & Dietetics
Seo Young Kang, Tae Hee Jeon, Keun-Sang Yum, Sung Sunwoo, Hyun-Young Shin, Dae Hyun Kim, Kiduk Kim, Jong Lull Yoon, Jae-Kyung Choi, Young Sik Kim
Summary: This study found that patients with dyslipidemia can better control their lipid profiles by reducing cholesterol intake, increasing consumption of dairy and protein-rich foods, and following a regular eating schedule.
Review
Pharmacology & Pharmacy
Weilin Chen, Qi Wang, Bin Zhou, Lihua Zhang, Honglin Zhu
Summary: Rheumatic diseases are chronic autoimmune disorders with poorly understood mechanisms, but recent research suggests that cell metabolism plays a crucial role in their pathogenesis. By focusing on lipid metabolism profiles and mechanisms, new insights for clinical treatment of rheumatic diseases can be gained.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Environmental Sciences
Yi Zhang, Jiaqi Shi, Ying Ma, Nairui Yu, Pai Zheng, Zhangjian Chen, Tiancheng Wang, Guang Jia
Summary: Air pollution is associated with dyslipidemia and may also lead to the development of metabolic diseases.
Article
Immunology
Shao-rui Hao, Yuan-yue Zhou, Xue Zhang, Hai-yin Jiang
Summary: This study explored the changes in the gut bacterial microbiome in AP-exposed children with obesity. The findings showed that AP users, regardless of their body mass index, had decreased microbial richness and diversity compared to the control group. The AP-exposed children also had differences in microbial functions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Maike Scherf-Clavel, Amelie Frantz, Andreas Eckert, Heike Weber, Stefan Unterecker, Juergen Deckert, Andreas Reif, Martina Hahn
Summary: Retrospective analysis of clinical routine data shows that the functional enzyme status of CYP2D6 affects serum concentrations and metabolite-to-parent ratios of seven common psychotropic drugs, providing important information for patient care.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2023)
Article
Endocrinology & Metabolism
Zhihao Liu, Zezhong Tian, Dan Zhao, Ying Liang, Suming Dai, Meitong Liu, Shanshan Hou, Xiaoxi Dong, Zhaxinima, Yan Yang
Summary: The study found that CoQ(10) supplementation can lower total cholesterol, LDL-C, and triglycerides levels and increase HDL-C levels in adults. Additionally, a dosage of 400 to 500 mg/day had the greatest effect on total cholesterol.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Chemistry, Medicinal
Nicole Moschny, Gudrun Hefner, Renate Grohmann, Gabriel Eckermann, Hannah B. Maier, Johanna Seifert, Johannes Heck, Flverly Francis, Stefan Bleich, Sermin Toto, Catharina Meissner
Summary: Inflammation and smoking can impact drug metabolism and alter treatment responses, requiring close clinical monitoring. Antipsychotic drugs should be carefully monitored due to various factors, such as narrow therapeutic windows, chronic mental illnesses, and common polypharmacotherapy in psychiatry. Therapeutic drug monitoring (TDM), particularly for drugs like clozapine and olanzapine, is crucial for optimizing drug safety and providing personalized treatment.
Article
Environmental Sciences
Hai Duc Nguyen, Hojin Oh, Min-Sun Kim
Summary: This study investigates the effects of exposure to a combination of chemicals on lipid profiles and the molecular mechanisms related to dyslipidemia. The results show that heavy metals, volatile organic compound metabolites, and phthalate metabolites are associated with lipid profiles, and several key molecular mechanisms are identified.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Clinical Neurology
Ole Koehler-Forsberg, Christiane Gasse, Fredrik Hieronymus, Liselotte Petersen, Rune H. Christensen, Andrew A. Nierenberg, Soren D. Ostergaard
Summary: The study described the trends in pre-diagnostic and post-diagnostic psychopharmacological treatment of bipolar disorder over the past two decades in Denmark. The use of two or more antidepressants increased before diagnosis, while the use of lithium decreased and the use of atypical antipsychotics, valproate, and lamotrigine increased after diagnosis. A significant proportion of patients received psychotropic medication post-diagnosis, but a concerning percentage received antidepressants without overlapping mood-stabilizing treatment.
Article
Endocrinology & Metabolism
Fei Guo, Zhentao Gong, Taniya Fernando, Lingshan Zhang, Xiaoyong Zhu, Yingli Shi
Summary: This retrospective study examined lipid profiles in women with polycystic ovary syndrome (PCOS) and assessed the correlation between changes in key lipid parameters and PCOS characteristics. The study found a high prevalence of dyslipidemia in Chinese PCOS patients, with different lipid profiles observed in individuals with different PCOS characteristics. The findings suggest a complex relationship between lipid metabolism and PCOS characteristics, which may explain the increased risk of long-term cardiovascular disease. Regular screening of blood lipids is important for PCOS women, and further research is needed to identify optimal subgroups for lipid-lowering treatment and assess therapeutic effectiveness.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Shuidong Feng, Mengyue Cao, Peng Tang, Shuxiang Deng, Limou Chen, Yan Tang, Lemei Zhu, Xiang Chen, Zhijun Huang, Minxue Shen, Fei Yang
Summary: Increasing experimental evidence suggests a link between exposure to microcystins (MCs) and lipid metabolism disorder. This population-based study in China examined the association between MCs exposure and dyslipidemia risk. The results showed that higher levels of MCs exposure were significantly associated with an increased risk of dyslipidemia, elevated triglyceride levels, and reduced high-density lipoprotein cholesterol levels. The study also found an additive antagonistic effect between MCs and a metal called Zn on dyslipidemia.
Review
Psychiatry
Sara Bertolin, Pino Alonso, Cinto Segalas, Eva Real, Maria Alemany-Navarro, Virginia Soria, Susana Jimenez-Murcia, Jose Manuel Crespo, Jose M. Menchon
Summary: High doses of antidepressants, particularly clomipramine and SSRIs, are a well-established treatment for OCD, but manic/hypomanic episodes can be a potential adverse event. A systematic literature review found that these switching episodes often occurred within the first 12 weeks of starting antidepressants, with SSRIs, especially fluoxetine, being most commonly associated with these episodes.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Medicine, General & Internal
Barbara Nussbaumer-Streit, Kylie Thaler, Andrea Chapman, Thomas Probst, Dietmar Winkler, Andreas Soennichsen, Bradley N. Gaynes, Gerald Gartlehner
Summary: Evidence on the effectiveness of second-generation antidepressants (SGAs) in treating seasonal affective disorder (SAD) is limited, with only one small trial showing a non-significant effect compared with placebo. Further research, including larger randomized controlled trials (RCTs), is needed to strengthen the evidence base in this area. Data on adverse events were sparse, making it difficult to draw firm conclusions about the safety of SGAs for SAD.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Psychology, Developmental
Hua Chen, Ning Lyu, Wenyaw Chan, Austin De La Cruz, Chadi Calarge
Summary: This study examines the utilization and predictors of adjuvant metformin among pediatric recipients of second-generation antipsychotics. The findings suggest that the utilization of adjuvant metformin is uncommon among pediatric SGA recipients, and early introduction of the medication among nonobese children is rare.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
