Article
Cell Biology
Himani Thakkar, Vinnyfred Vincent, Ambuj Roy, Ajay Kumar Gautam, Rintu Kutum, Lakshmy Ramakrishnan, Sandeep Singh, Archna Singh
Summary: Impairments in high-density lipoprotein (HDL) function are linked to coronary artery disease development. This study found distinct lipid and protein profiles in HDL from ACS patients, suggesting a potential contribution to HDL dysfunction beyond inflammatory conditions.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Herman E. Popeijus, Willem Zwaan, Jehad Z. Tayyeb, Jogchum Plat
Summary: ApoA-I plays a crucial role in HDL metabolism and RCT. Lower serum ApoA-I concentrations during inflammation may lead to dysfunctional HDL particles. Modulating hepatic lipoprotein metabolism with compounds like SCFAs shows promise in increasing ApoA-I concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Paula de Albuquerque, Viviani De Marco, Thiago Henrique Annibale Vendramini, Andressa Rodrigues Amaral, Sergio Catanozi, Kelly Gomes Santana, Valeria Sutti Nunes, Edna Regina Nakandakare, Marcio Antonio Brunetto
Summary: The study evaluated the therapeutic efficacy of omega-3 fatty acids associated with different fat content diets in Schnauzer with primary hyperlipidaemia. Both low-fat and moderate-fat diet combined with omega-3 fatty acids effectively reduced triglyceride and cholesterol levels without altering lipoprotein profile in Schnauzer with primary hyperlipidaemia.
Article
Biochemistry & Molecular Biology
Gediz Dogay Us, Sohail Mushtaq
Summary: The study demonstrates that high-dose intake of omega-3 fatty acids in combination with statins has a positive effect on improving lipid profiles in hyperlipidemic patients, particularly in reducing LDL III, non-HDL-C, TG, and VLDL-C. Further research is needed to validate these findings.
LIPIDS IN HEALTH AND DISEASE
(2022)
Review
Nutrition & Dietetics
Elif Ulug, Reyhan Nergiz-Unal
Summary: The CD36 receptor plays a crucial role in cholesterol homeostasis, with dietary fatty acids influencing its levels and cholesterol metabolism. The effects of saturated fatty acids and trans-fatty acids on CD36-mediated cholesterol homeostasis may be detrimental, while monounsaturated fatty acids could be beneficial. The role of polyunsaturated fatty acids in CD36-mediated cholesterol homeostasis is controversial and depends on the ratio of n-3 to n-6 PUFA.
NUTRITION RESEARCH REVIEWS
(2021)
Article
Nutrition & Dietetics
Jhih-Han Yeh, Yu-Tang Tung, Yu-Sheng Yeh, Yi-Wen Chien
Summary: Postmenopausal obesity is a serious issue and a high-fat diet may worsen lipid metabolism abnormalities. However, this study found that a specific ratio of experimental oil mixture can ameliorate these imbalances.
Article
Agriculture, Multidisciplinary
Jiaheng Xia, Ping Yu, Zheling Zeng, Maomao Ma, Guohua Zhang, Dongman Wan, Deming Gong, Shuguang Deng, Jun Wang
Summary: The study revealed that high-dose lauric triglycerides affected cholesterol metabolism in obese rats by downregulating cholesterol biosynthesis and improving lipid transfer, but also accelerated LDL receptor degradation, impaired VLDL/LDL transport, ultimately leading to elevated levels of TC and LDL-c.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Nutrition & Dietetics
Wei Zeng, Qingzhe Jin, Xingguo Wang
Summary: There is a significant correlation between dietary fat consumption and cardiovascular disease in China over the past 30 years. Changes in fat intake have been closely related to the incidence of cardiovascular disease. Therefore, it is important for the government to raise awareness about dietary fat intake and educate the public to avoid high-fat diets.
Article
Nutrition & Dietetics
Teresa Padro, Anallely Lopez-Yerena, Antonio Perez, Gemma Vilahur, Lina Badimon
Summary: High-density lipoproteins (HDLs) are complex particles that have multiple cardiovascular protective properties. Diet, specifically supplementation with ?3 and phytosterols, has been shown to improve the lipid profile of HDL. This study found that ?3 supplementation had greater effects on HDL lipidome compared to phytosterols, particularly in cholesteryl esters (CEs). Furthermore, the HDL lipidome was found to be sex-dependent. Overall, this study highlights the importance of diet and sex in modulating the HDL lipid profile.
Article
Endocrinology & Metabolism
Shuang Zhang, Shitong Cheng, Xue He, Wei Wang, Ke Yun, Dongliang Man, Haibo Ding, Ping Li, Zhenxing Chu, Xiaotao Yang, Hong Shang, Xiaoxu Han
Summary: The study found a significant positive correlation between RLP-C and both the occurrence and severity of FLD, which may assist clinicians in identifying individuals at high risk for FLD and implementing interventions to reduce FLD prevalence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Iman Moussa, Rena S. Day, Ruosha Li, Ahmed Kaseb, Prasun K. Jalal, Carrie Daniel-MacDougall, Rikita I. Hatia, Ahmed Abdelhakeem, Asif Rashid, Yun Shin Chun, Donghui Li, Manal M. Hassan
Summary: This study found an inverse association between monounsaturated fatty acid intake and hepatocellular carcinoma (HCC) risk, and a direct association between total polyunsaturated fatty acid intake and HCC risk. Omega-6 PUFA intake was directly associated with HCC risk, while long-chain omega-3 PUFA intake was inversely associated with HCC risk. No significant association was observed for saturated fat and HCC risk.
Article
Biochemistry & Molecular Biology
Pere Rehues, Marina Rodriguez, Judith Alvarez, Marta Jimenez, Alba Melia, Mar Sempere, Clara Balsells, Gemma Castillejo, Montse Guardiola, Antoni Castro, Josep Ribalta
Summary: Atherosclerosis is a chronic inflammatory disease caused by the accumulation of LDL particles in the intima, leading to immune cell activation and inflammation. This study investigated the distribution of LPS and its immunogenic portion (3OHFAs) among different lipoprotein types in healthy men. The results showed that LDL and HDL fractions had the highest concentration of LPS, while VLDL particles carried more LPS molecules per particle. The distribution of LPS and 3OHFAs among lipoprotein fractions showed high variability, suggesting their potential as biomarkers for atherosclerosis.
Article
Biochemistry & Molecular Biology
Lin Xiao, Gang Luo, Hongxia Li, Ping Yao, Yuhan Tang
Summary: The study found that dietary iron overload did not exacerbate atherosclerosis in ApoE KO mice, but instead led to a reduction in lesion area by 65.3%. The research identified impaired fatty acid uptake and trafficking mediated by hepatic CD36 and fatty acid binding proteins as key mechanisms by which iron overload diminishes atherosclerotic lesions.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Cardiac & Cardiovascular Systems
Xiao Lin, Ping Ma, Chun Yang, Jinjie Wang, Kunxiang He, Gonglie Chen, Wei Huang, Jianglin Fan, Xunde Xian, Yuhui Wang, George Liu
Summary: LDLR-/- Syrian golden hamsters exhibit high levels of triglycerides and cholesterol in plasma when fed a high cholesterol high-fat diet, with increased serum TRLs and ApoB100 and 48 in these particles. Treatment with ezetimibe decreases large particles but not LDL, suggesting the importance of LDL receptor in chylomicron remnant clearance in hamsters.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Nutrition & Dietetics
Glen D. Lawrence
Summary: PUFAs regulate cholesterol synthesis and uptake through various mechanisms, while genetic variations in proteins involved in cholesterol homeostasis can affect serum cholesterol levels. PUFAs are susceptible to lipid peroxidation, leading to oxidative stress, inflammation, and various diseases.
ADVANCES IN NUTRITION
(2021)