Article
Clinical Neurology
Yuan Wang, Gang Liu, Haiqing Song, Catherine Cao, Xunming Ji, Guodong Cao
Summary: This study found that elevated levels of Lp-PLA2 were associated with intracranial artery stenosis in patients with acute ischemic stroke, suggesting it may serve as a promising biomarker and potential therapeutic target for intracranial artery stenosis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Varnavas D. Mouchlis, Daiki Hayashi, Alexis M. Vasquez, Jian Cao, J. Andrew McCammon, Edward A. Dennis
Summary: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) associates with lipoproteins in human plasma and hydrolyzes oxidized phospholipids. The mechanism of enzyme-membrane association and substrate specificity were studied using lipidomics and mass spectrometry techniques.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Jingjin Li, Xiaoping Zhang, Mengxi Yang, Hang Yang, Ning Xu, Xueqiang Fan, Gang Liu, Xintong Jiang, Jiasai Fan, Lifang Zhang, Hu Zhang, Ying Zhou, Rui Li, Si Gao, Jiangli Jin, Zening Jin, Jingang Zheng, Qiang Tu, Jingyi Ren
Summary: Through genome-wide analysis of DNA methylation, it was found that hypomethylation in vulnerable atherosclerotic plaques is associated with genes involved in inflammation, indicating a potential role in driving the progression and destabilization of atherosclerotic cardiovascular disease.
CLINICAL EPIGENETICS
(2021)
Review
Integrative & Complementary Medicine
Lu-ming Wang, Wen-lan Zhang, Nuan Lyu, Yan-rong Suo, Lin Yang, Bin Yu, Xi-juan Jiang
Summary: This paper reviews the research on Chinese medicine in treating atherosclerosis, focusing on reducing levels of lipoprotein-associated phospholipase A2 to guide future experimental studies and clinical applications related to atherosclerosis.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Clinical Neurology
Yuan Liu, Jinhua Zhu, Xuhui Deng, Zhi Yang, Chunchun Chen, Shuxuan Huang, Lue Chen, Ying Ma, Weifeng Lin, Feiqi Zhu
Summary: This study found that the serum marker Lp-PLA2 is an independent risk factor for the occurrence and progression of VBD to posterior circulation ischemic stroke. Age and serum level of Lp-PLA2 were significantly associated with VBD and VBD with ischemic stroke.
NEUROLOGICAL SCIENCES
(2021)
Article
Immunology
Xue Jiang, Jie Xu, Xiwa Hao, Jing Xue, Ke Li, Aoming Jin, Jinxi Lin, Xia Meng, Lemin Zheng, Yongjun Wang
Summary: The study found that elevated levels of Lp(a) are associated with unfavorable functional outcomes in patients with ischemic stroke. Furthermore, the combination of high Lp(a) and high Lp-PLA(2) levels showed the highest incidence of unfavorable functional outcomes at 3 months and 1 year after ischemic stroke.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Giovanni Zuliani, Judit Marsillach, Alessandro Trentini, Valentina Rosta, Carlo Cervellati
Summary: A wealth of evidence suggests that Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays a relevant role in atherogenesis and inflammation, which in turn are associated with the risk of developing dementia. The aim of this study was to evaluate whether serum Lp-PLA2 activity might be an early and/or late biomarker for different forms of dementia. We found that VAD patients had significantly higher levels of Lp-PLA2 activity compared to other groups, and MCI patients who converted to VAD also had higher levels of Lp-PLA2 activity. After adjusting for potential confounders, high levels of Lp-PLA2 activity were associated with the diagnosis of VAD, but not with other types of dementia.
Article
Medicine, General & Internal
Yan Zhai, Xudong Cao, Shuye Liu, Yanna Shen
Summary: The aim of this study was to investigate the diagnosis of lipoprotein-associated phospholipase A2 (Lp-PLA2) in early diabetic nephropathy (DN). The results showed that Lp-PLA2 level was significantly higher in the DN groups compared to the DM group, and it was positively correlated with disease progression. Lp-PLA2 can be used as an independent factor for the evaluation and monitoring of early DN.
ANNALS OF MEDICINE
(2023)
Article
Immunology
Adrianos Nezos, Charalampos Skarlis, Anna Psarrou, Konstantinos Markakis, Panagiotis Garantziotis, Asimina Papanikolaou, Fotini Gravani, Michael Voulgarelis, Athanasios G. Tzioufas, Michael Koutsilieris, Haralampos M. Moutsopoulos, Eleni Kotsifaki, Clio P. Mavragani
Summary: The study aimed to investigate the contributory role of Lp-PLA2 in B-NHL development in primary SS patients. Results showed that serum Lp-PLA2 activity was significantly increased in SS-L patients, and Lp-PLA2 expression in MSG tissues was also higher in SS-L patients compared to SS-nL patients and healthy controls. These findings suggest that Lp-PLA2 could potentially serve as a new biomarker and therapeutic target for B-cell lymphoproliferation in the context of SS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kendall Clark, Sydney Sharp, Christopher J. Womack, Stephanie P. Kurti, Trent A. Hargens
Summary: This study aimed to investigate the impact of physical activity and sedentary time on the level of Lp-PLA(2) mass. The results showed a positive correlation between sedentary minutes per day and Lp-PLA(2), and a negative correlation between light intensity physical activity and Lp-PLA(2). Subjects with higher Lp-PLA(2) mass had more sedentary time and less light intensity physical activity. The study suggests that overall physical activity habits, including sedentary time and lower intensity physical activity, affect the levels of Lp-PLA2, an important inflammatory marker and marker of cardiovascular disease risk.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Biochemical Research Methods
Xindong Chen, Kewen Zhou, Zhongyi Xiang, Xiumei Zhou, Yigang Wang, Jianfeng Hong, Biao Huang, Yuan Qin, Hongming Fang
Summary: The study established a highly sensitive method for the detection of Lp-PLA2 and found that serum Lp-PLA2 levels in breast cancer patients were significantly higher than in healthy subjects, suggesting a potential association between serum Lp-PLA2 and dyslipidemia in breast cancer.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Immunology
Yi-Hsuan Chen, Wen-Cheng Li, Yi-Chuan Chen, Wei-Chung Yeh, Wei Yu, Hsiung Ying Hung, Xiong-Xue Jie, Jau-Yuan Chen
Summary: This study investigated the association between Lp-PLA(2) and overweight status, finding that male subjects had higher Lp-PLA(2) levels than female subjects. Those with central overweight status had higher Lp-PLA(2) levels compared to those with normal weight or peripheral overweight status.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Medical Laboratory Technology
Hongling Qu, Guangjun Zhang, Jianyi Pan, Yuli Huang, Weibiao Lv
Summary: The study identified Lp-PLA(2) as a potential prognostic and diagnostic biomarker for CKD-CAS, which can be used as an assessment indicator for patient risk factors.
CLINICAL LABORATORY
(2021)
Article
Biochemistry & Molecular Biology
Pin-Hsuan Ke, Jau-Yuan Chen, Yi-Hsuan Chen, Wei-Chung Yeh, Wen-Cheng Li
Summary: This study investigated the correlation between cardiometabolic risk factors and Lp-PLA2 levels. It found that Lp-PLA2 was significantly related to lipoproteins and GPT, and its correlation with other factors such as fasting glucose, obesity-related parameters, and mean arterial pressure varied with age and sex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Zhenli Cheng, Haobo Weng, Jing Zhang, Qijian Yi
Summary: This study found that Lp-PLA2 may be related to Kawasaki disease (KD) and the formation of coronary artery aneurysms (CAAs), and may serve as a potential diagnostic biomarker for KD.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cardiac & Cardiovascular Systems
Matthias Bossard, Shahar Lavi, Sunil V. Rao, David J. Cohen, Warren J. Cantor, Kevin R. Bainey, Nicholas Valettas, Sanjit S. Jolly, Shamir R. Mehta
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2018)
Review
Cardiac & Cardiovascular Systems
Samual Hayman, Aashish Goela, Shahar Lavi
HEART LUNG AND CIRCULATION
(2019)
Article
Cardiac & Cardiovascular Systems
Tawfiq Choudhury, Tim G. Schaeufele, Shahar Lavi, Katsutoshi Makino, Miguel Nobre Menezes, Amir Solomonica, Olivier F. Bertrand, Ian C. Gilchrist, Mamas A. Mamas, Rodrigo Bagur
CANADIAN JOURNAL OF CARDIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Jacqueline Saw, Andrew Starovoytov, Karin Humphries, Tej Sheth, Derek So, Kunal Minhas, Neil Brass, Andrea Lavoie, Helen Bishop, Shahar Lavi, Colin Pearce, Suzanne Renner, Mina Madan, Robert C. Welsh, Sohrab Lutchmedial, Ram Vijayaraghavan, Eve Aymong, Bryan Har, Reda Ibrahim, Heather L. Gornik, Santhi Ganesh, Christopher Buller, Alexis Matteau, Giuseppe Martucci, Dennis Ko, Giovanni Battista John Mancini
EUROPEAN HEART JOURNAL
(2019)
Article
Cardiac & Cardiovascular Systems
Amir Solomonica, Rodrigo Bagur, Tawfiq Choudhury, Shahar Lavi
AMERICAN JOURNAL OF CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Robert C. Welsh, Robinder S. Sidhu, John A. Cairns, Shahar Lavi, Sasko Kedev, Raul Moreno, Warren J. Cantor, Goran Stankovic, Brandi Meeks, Fei Yuan, Vladimir Dzavik, Sanjit S. Jolly
CANADIAN JOURNAL OF CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Warren J. Cantor, Shahar Lavi, Vladimir Dzavik, John Cairns, Asim N. Cheema, Anthony Della Siega, Raul Moreno, Goran Stankovic, Sasko Kedev, Madhu K. Natarajan, Yaniv Levi, Fei Yuan, Sanjit S. Jolly
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2020)
Article
Medicine, General & Internal
Shamir R. Mehta, David A. Wood, Robert F. Storey, Roxana Mehran, Kevin R. Bainey, Helen Nguyen, Brandi Meeks, Giuseppe Di Pasquale, Jose Lopez-Sendon, David P. Faxon, Laura Mauri, Sunil V. Rao, Laurent Feldman, P. Gabriel Steg, Alvaro Avezum, Tej Sheth, Natalia Pinilla-Echeverri, Raul Moreno, Gianluca Campo, Benjamin Wrigley, Sasko Kedev, Andrew Sutton, Richard Oliver, Josep Rodes-Cabau, Goran Stankovic, Robert Welsh, Shahar Lavi, Warren J. Cantor, Jia Wang, Juliet Nakamya, Shrikant I. Bangdiwala, John A. Cairns
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Article
Cardiac & Cardiovascular Systems
Tawfiq Choudhury, Philipp Lurz, Tim G. Schaufele, Miguel Nobre Menezes, Shahar Lavi, Nikolaos Tzemos, Philipp Hartung, Thomas Stiermaier, Katsutoshi Makino, Olivier F. Bertrand, Ian C. Gilchrist, Mamas A. Mamas, Rodrigo Bagur
Review
Medicine, General & Internal
Karla Solo, Shahar Lavi, Conrad Kabali, Glenn N. Levine, Alexander Kulik, Ava A. John-Baptiste, Stephen E. Fremes, Janet Martin, John W. Eikelboom, Marc Ruel, Ashlay A. Huitema, Tawfiq Choudhury, Deepak L. Bhatt, Nikolaos Tzemos, A. Mamas Mamas, Rodrigo Bagur
BMJ-BRITISH MEDICAL JOURNAL
(2019)
Article
Cardiac & Cardiovascular Systems
Ali Hage, Vincenzo Giambruno, Philip Jones, Michael W. Chu, Stephanie Fox, Patrick Teefy, Shahar Lavi, Daniel Bainbridge, Christopher Harle, Ivan Iglesias, Woijtecj Dobkowski, Bob Kiaii
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Article
Cardiac & Cardiovascular Systems
Shahar Lavi, Shamir R. Mehta, Rehana Bajwa, Hussein Taleb, Shahrukh N. Bakar, Ayaaz Sachedina, Cassandra Wagner, Amir Solomonica, Kokab Awan, Klajdi Puka, Pallav Garg, Pantelis Diamantouros, Rodrigo Bagur
Summary: The study showed that among individuals receiving small sheath sizes with no adjunctive heparin, the incidence of RAO is low. Shortening the duration of RHD time did not further reduce the risk of complications.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Letter
Medicine, General & Internal
Peter Bogaty, James M. Brophy
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Review
Cardiac & Cardiovascular Systems
Mohamed O. Mohamed, Mamas A. Mamas, Vinayak Nagaraja, M. Chadi Alraies, Pablo Lamelas, Nikolaos Tzemos, Diana Ayan, Shahar Lavi, Rodrigo Bagur
JOURNAL OF INVASIVE CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Yaniv Levi, Shahar Lavi, Amir Solomonica, Zeev Israeli, Rodrigo Bagur
JOURNAL OF INVASIVE CARDIOLOGY
(2019)
