期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 278, 期 -, 页码 112-122出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2014.12.009
关键词
Multiple sclerosis (MS); Experimental autoimmune encephalomyelitis (EAE); Meninges; CNS demyelinating disease; Blood brain barrier (BBB); Relapsing-remitting EAE
资金
- National Multiple Sclerosis Society [RG-4684A5]
- NRSA [5F31NS068031, 5F31NS076225]
Inflammation in the meninges, tissues surrounding the brain and spinal cord that enclose the cerebrospinal fluid, closely parallels clinical exacerbations in relapsing-remitting experimental autoimmune encephalomyelitis (EAE). In preclinical disease, an influx of innate immune cells precedes loss of blood brain barrier (BBB) integrity and large-scale inflammation in the central nervous system (CNS). T cell infiltration into the meninges is observed in acute disease as well as during relapse, when neither BBB permeability nor significant increases in peripherally-derived immune cell numbers in the CNS are observed. These findings support the idea that the meninges are a gateway for immune cell access into the CNS, a finding that has important therapeutic implications. (C) 2014 Elsevier B.V. All rights reserved.
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