Article
Biochemistry & Molecular Biology
David Vogrinc, Milica Gregoric Kramberger, Andreja Emersic, Sasa Cucnik, Katja Goricar, Vita Dolzan
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease with a complex genetic background. Genome-wide association studies (GWAS) have identified numerous AD risk loci. This study aims to assess the associations between SNPs in well-established GWAS AD risk loci and CSF biomarker levels or cognitive test results in Slovenian patients with cognitive decline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Sofia Sanchez-de-Lara-Sanchez, Ana Maria Sanchez-Perez
Summary: Recent studies have shown that the use of probiotics can improve cognitive function in individuals with mild cognitive impairment and help slow down the progression of cognitive decline.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Clinical Neurology
Abdul Gofir, Samekto Wibowo, Muhammad Hakimi, David Dwi Putera, Irawan Satriotomo, Mustofa Mustofa
Summary: This study conducted a systematic review and meta-analysis on folic acid treatments for vascular cognitive impairment. The findings suggest that folic acid can effectively lower plasma homocysteine concentration, but it has limited impact on cognitive function.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Yu Zheng, Yin Liu, Jiawen Wu, Yi Xie, Siyu Yang, Wanting Li, Huaiqing Sun, Qing He, Ting Wu
Summary: This study aimed to test the feasibility of early decision-tailoring using a hybrid convolutional neural network and long-short-term memory model to predict cognitive conversion in patients with Alzheimer's disease and mild cognitive impairment. The results showed that the hybrid model had good predictive performance and provided the possibility of reassigning recommended treatment for patients.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Julia Doroszkiewicz, Jan Mroczko, Piotr Rutkowski, Barbara Mroczko
Summary: Alzheimer's disease is the most common cause of dementia worldwide. The lack of established pathology makes it challenging to find suitable approaches for treatment. In addition to the known hallmarks of the disease, such as amyloid β peptides and hyperphosphorylated tau, inflammation and diet also play important roles. Adhering to a beneficial diet high in neuroprotective foods and BDNF-boosting substances may improve memory, cognition, and biomarkers, and even reduce the risk of developing Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Rolando Castillo-Passi, Rodrigo C. Vergara, Nicole K. Rogers, Daniela P. Ponce, Magdalena Bennett, Maria Isabel Behrens
Summary: This study characterizes the trajectories of memory loss in individuals with early amnestic cognitive impairment with and without a history of previous cancer. It identifies two subgroups, fast progressors and slow progressors, and suggests that a history of cancer can slow down the decline in memory specifically in a subgroup of subjects with depression at baseline and accelerated deterioration at follow-up.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Pharmacology & Pharmacy
Chloe G. McKee, Madison Hoffos, Haley A. Vecchiarelli, Marie-Eve Tremblay
Summary: As individuals age, microglia, the resident immune cells of the central nervous system (CNS), become less effective at preserving brain circuits. Increases in microglial inflammatory activity are thought to contribute to age-related declines in cognitive functions and to transitions toward mild cognitive impairment (MCI) and Alzheimer's disease (AD). Preclinical and early phase clinical trials investigating the therapeutic effects of pharmacological agents acting on microglia are currently underway, but important questions about target selectivity and microglial heterogeneity remain unanswered.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Alvaro Santos-Ortega, Carmen Alba-Linero, Facundo Urbinati, Carlos Rocha-de-Lossada, Rafael Orti, Jose Antonio Reyes-Bueno, Francisco Javier Garzon-Maldonado, Vicente Serrano, Carmen de Rojas-Leal, Carlos de la Cruz-Cosme, Manuela Espana-Contreras, Marina Rodriguez-Calvo-de-Mora, Natalia Garcia-Casares
Summary: This study analyzed retinal changes in patients with mild cognitive impairment (MCI) using optical coherence tomography angiography (OCT-A) and found that diabetes may exacerbate retinal vascular changes when combined with MCI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Mingyan Guo, Jun Peng, Xiaoyan Huang, Lingjun Xiao, Fenyan Huang, Zhiyi Zuo
Summary: This study revealed that patients newly diagnosed with AD or MCI have gut dysbiosis, characterized by a decrease in potentially protective microbiome and an increase in microbiome promoting inflammation. Furthermore, the degree of gut dysbiosis worsens as the disease progresses from MCI to AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychology, Multidisciplinary
Virgile Clergue-Duval, Thomas Barre, Emmanuel Cognat, Anne-Laure Brichet, Claire Geraud, Julien Azuar, Philippe Michaud, Dorothee Lecallier, Sonia Arfaoui-Geffroy, Eric Hispard, Claire Paquet, Frank Bellivier, Frank Questel, Florence Vorspan, ResAlCog Care Network
Summary: This study compared the cognitive changes of patients with severe alcohol-related cognitive impairment (ARCI) and patients with Alzheimer's disease (AD) during inpatient treatment. The results showed that severe ARCI patients improved in executive functioning, while AD patients experienced worsening memory.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Lucio Marinelli, Carlo Trompetto, Luca Puce, Fiammetta Monacelli, Laura Mori, Carlo Serrati, Francesco Fattapposta, Maria Felice Ghilardi, Antonio Curra
Summary: Paratonia increases with normal aging and cognitive decline progression. Facilitatory paratonia is due to involuntary contraction of the shortening muscle, while oppositional paratonia is primarily due to involuntary contraction of the lengthening muscle. EMG activity during passive movements correlates with paratonia clinical scores and is velocity-dependent.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Michal S. Beeri, Sue E. Leugrans, Osvaldo Delbono, David A. Bennett, Aron S. Buchman
Summary: In this study, poor muscle function, rather than reduced lean muscle mass, was found to be associated with late-life cognitive impairment, including incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline. Further research is needed to identify muscle structure features that may enhance the specificity of sarcopenia in identifying older adults at risk for late-life cognitive impairment.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Clinical Neurology
Jaewon Kim, Hayeon Lee, Jinseok Lee, Sang Youl Rhee, Jae Il Shin, Seung Won Lee, Wonyoung Cho, Chanyang Min, Rosie Kwon, Jae Gwan Kim, Dong Keon Yon
Summary: This study aimed to investigate the use of olfactory-stimulated functional near-infrared spectroscopy combined with machine learning in the identification of mild cognitive impairment and Alzheimer's disease. Two independent trials showed that the machine learning models were superior to classical statistical models in diagnosing these conditions, and the algorithm demonstrated stability and reproducibility across different patient groups.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Neurosciences
Yorito Hattori, Satoshi Saito, Yuriko Nakaoku, Soshiro Ogata, Masashi Hattori, Mio Nakatsuji, Kunihiro Nishimura, Masafumi Ihara
Summary: This retrospective study investigated the association between TAX intake and cognitive changes. The results showed that TAX intake was significantly associated with changes in visuospatial/executive function, verbal fluency, and total score of MoCA, but not with ADAS-Cog. These findings provide a basis for TAX as a novel strategy for maintaining brain health.
JOURNAL OF ALZHEIMERS DISEASE
(2023)