Article
Clinical Neurology
Yan Cheng, Edward Zamrini, Charles Faselis, Douglas Redd, Yijun Shao, Charity J. Morgan, Helen M. Sheriff, Ali Ahmed, Peter Kokkinos, Qing Zeng-Treitler
Summary: This study found that cardiorespiratory fitness is associated with the incidence of Alzheimer's disease and related dementias. Moderate and high levels of cardiorespiratory fitness are related to a lower risk of dementia.
ALZHEIMERS & DEMENTIA
(2023)
Review
Biochemistry & Molecular Biology
Giovanni Schepici, Valentina Contestabile, Andrea Valeri, Emanuela Mazzon
Summary: Ginger compounds have shown beneficial effects in treating and preventing Alzheimer's Disease and Vascular Dementia, potentially reducing the risk of dementia.
Review
Clinical Neurology
Johanna Thunell, Yi Chen, Geoffrey Joyce, Douglas Barthold, Paul G. Shekelle, Roberta Diaz Brinton, Julie Zissimopoulos
Summary: The study identified 29 drug classes associated with increasing or decreasing ADRD risk, with a need for further research in certain areas. Some areas of study still have limited evidence and require more data to support conclusions.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Sasha A. Philbert, Jingshu Xu, Melissa Scholefield, Stefano Patassini, Stephanie J. Church, Richard D. Unwin, Federico Roncaroli, Garth J. S. Cooper
Summary: Vascular dementia (VaD) is a common type of dementia in the elderly, but its molecular basis is not well understood compared to other age-related dementias. This study used a novel technique to measure urea levels in post-mortem brain tissue and found elevated levels in multiple regions of the brain in VaD cases, suggesting a common urea-mediated disease mechanism present in several types of age-related dementias.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Kimia Shafighi, Sylvia Villeneuve, Pedro Rosa Neto, AmanPreet Badhwar, Judes Poirier, Vaibhav Sharma, Yasser Iturria Medina, Patricia P. Silveira, Laurette Dube, David Glahn, Danilo Bzdok
Summary: Alzheimer's disease and related dementias pose a significant public health burden that will continue to increase due to longer life expectancy. Recent clinical evidence indicates that social isolation may accelerate the onset of dementia. Through the analysis of large population cohorts, we have identified strong associations between individuals' social capital, loneliness, and lack of social support with the risk of Alzheimer's disease and related dementias. The quality and quantity of daily social interactions are deeply connected to key risk factors, highlighting the importance of social lifestyle determinants as potential targets for preventive clinical action.
Article
Neurosciences
Michelle M. Mielke, Jeanine E. Ransom, Jay Mandrekar, Pierpaolo Turcano, Rodolfo Savica, Allen W. Brown
Summary: This study examines the relationship between traumatic brain injury (TBI) and Alzheimer's disease and related dementias (ADRD) using population-based cohort data. The results suggest that TBI is a potential risk factor for developing ADRD.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Coles M. Hoffmann, Roch A. Nianogo, Kristine Yaffe, Amy Rosenwohl-Mack, Anna Carrasco, Deborah E. Barnes
Summary: This study compared the modifiable risk factors of Alzheimer's disease and related dementias (ADRD) between the U.S. and California, and found variations in risk factors among different regions and population groups. The findings emphasize the importance of tailoring dementia risk reduction strategies based on regional, sex, and race/ethnicity factors.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Rebecca F. Gottesman, Sudha Seshadri
Summary: This article summarizes the relationship between traditional cardiovascular risk factors and stroke, while also exploring their impact on brain health. It emphasizes the importance of genes and biomarkers associated with Alzheimer's disease, as well as the influence of social determinants of health on brain health outcomes.
Review
Biochemistry & Molecular Biology
Oliver Cooper, Penny Hallett, Ole Isacson
Summary: Brain health relies on adaptability and resetting after challenges. Neurodegeneration occurs when adaptability is restricted. Accumulation of lipids compromises adaptability in neural circuits. Treatment targeting lipid metabolism can restore adaptive homeostasis in individuals at risk of cognitive decline.
Review
Environmental Sciences
David Mateo, Montse Marques, Margarita Torrente
Summary: The increasing ageing population worldwide raises the risk of cognitive decline and dementia. Metals, particularly environmental toxicants, have been identified as modifiable risk factors for cognitive impairment. Continuous exposure to metals mainly occurs through dietary sources, with older adults being more susceptible. However, dysbiosis in the gut microbiota has also been associated with dementia.
ENVIRONMENTAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jingyuan Ya, Ulvi Bayraktutan
Summary: Ageing is the biggest risk factor for poor health, affecting the integrity and function of cells, tissues, and organs. Vascular ageing, characterized by stiffness, dysfunction, oxidative stress, inflammation, and atherosclerosis, contributes to millions of deaths annually in Europe. Recent studies focus on the accumulation of senescent cells in the vascular system and their role in vascular ageing, as well as the effect of other risk factors like diabetes, hypertension, and smoking. Various interventions have been developed, but specific guidelines for their use are needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Sambhavi Puri, Junming Hu, Zhuorui Sun, Mintao Lin, Thor D. Stein, Lindsay A. Farrer, Benjamin Wolozin, Xiaoling Zhang
Summary: This study investigates the role of circular RNAs (circRNAs) in Alzheimer's disease (AD). It finds that circRNA expression varies between brain regions and is affected by AD-related stress in human neuronal precursor cells (NPCs). The study also shows that circRNAs can be regulated independently from their linear messenger RNAs (mRNAs) by AD-linked neuronal stress.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Eric Jutkowitz, Christopher Halladay, Jack Tsai, Dina Hooshyar, Lien Quach, Thomas O'Toole, James L. Rudolph
Summary: The prevalence of AD/ADRD diagnoses is greater among housing insecure veterans than stably housed veterans.
ALZHEIMERS & DEMENTIA
(2022)
Review
Biochemistry & Molecular Biology
Lynne H. Shinto, Jacob Raber, Anusha Mishra, Natalie Roese, Lisa C. Silbert
Summary: The majority of modifiable risk factors for Alzheimer's disease and related dementia are vascular in nature. Oxylipins may have both protective and detrimental effects on brain structure, cognitive performance, and disease progression.
Article
Geriatrics & Gerontology
Andrew J. Potter, Brad Wright, Jill Akiyama, Grace G. Stehlin, Amal N. Trivedi, Fredric D. Wolinsky
Summary: This study found that Medicare-Medicaid dual-eligibles with Alzheimer's disease and related dementias primarily received primary care in nursing facilities or physician offices. However, there has been a shift in recent years towards receiving care in Federally Qualified Health Centers and other settings.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)