Article
Clinical Neurology
Sung Hoon Kang, Monica Eunseo Kim, Hyemin Jang, Hojeong Kwon, Hyejoo Lee, Hee Jin Kim, Sang Won Seo, Duk L. Na
Summary: The study found that the prevalence of Aβ positivity increased with the severity of cognitive impairment, but decreased with the severity of white matter hyperintensities. Aβ positivity was associated with higher education, absence of diabetes, and presence of APOE ε4.
Article
Geriatrics & Gerontology
Lin Tan, Jian Xing, Zhenqi Wang, Xiao Du, Ruidi Luo, Jianhang Wang, Jinyi Zhao, Weina Zhao, Changhao Yin
Summary: This study investigates the structural imaging changes in patients with subcortical ischemic vascular disease (SIVD)-vascular cognitive impairment no dementia (VCIND) and their correlation with cognitive impairment, aiming to provide new targets for early diagnosis and treatment.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Woori Moon, Ji Won Han, Jong Bin Bae, Seung Wan Suh, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim
Summary: This study investigated the disease burden of various dementias and mild cognitive impairment in a representative South Korean population, predicting a significant increase in disability-adjusted life-years and years lived with disability due to these conditions by 2065.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Jin Myoung Seok, Wanzee Cho, Doo-Hwan Son, Jong Hwa Shin, Eun Bin Cho, Sung Tae Kim, Byoung Joon Kim, Joon-Kyung Seong, Ju-Hong Min
Summary: This study explored the relationship between fatigue and subcortical structures in patients with neuromyelitis optica spectrum disorder (NMOSD). The results showed that atrophy in the right thalamus is strongly correlated with fatigue severity, indicating that the local shape volume of the right thalamus may serve as a biomarker of fatigue in NMOSD.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Michael K. Yeung, Anson Kwok-yun Chau, Jason Yin-chuen Chiu, Jay Tsz-lok Shek, Jody Po-yi Leung, Toby Chun-ho Wong
Summary: The study found significant differences in neuroimaging abnormalities between amnestic mild cognitive impairment (aMCI) and nonamnestic mild cognitive impairment (naMCI), with aMCI showing more and more significant abnormalities, while naMCI showing more limited abnormalities, with shared features but unique neuroimaging abnormalities in aMCI.
AGEING RESEARCH REVIEWS
(2022)
Article
Clinical Neurology
Tommaso Romagnoli, Beatrice Ortolani, Juana Maria Sanz, Alessandro Trentini, Davide Seripa, Edoardo Dalla Nora, Eleonora Capatti, Carlo Cervellati, Angelina Passaro, Giovanni Zuliani, Gloria Brombo
Summary: This study evaluated serum ApoJ levels in 196 MCI subjects and found that low ApoJ levels may be associated with an increased risk of developing dementia. The risk of dementia conversion doubled in subjects with lower ApoJ levels compared to those with higher levels, especially after two years of follow up.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Paul C. C. Donaghy, Calum Hamilton, Rory Durcan, Sarah Lawley, Sally Barker, Joanna Ciafone, Nicola Barnett, Kirsty Olsen, Michael Firbank, Gemma Roberts, Jim Lloyd, Louise M. M. Allan, Ranjan Saha, Ian G. G. McKeith, John T. T. O'Brien, John-Paul Taylor, Alan J. J. Thomas
Summary: Through the investigation of patients with mild cognitive impairment with Lewy bodies (MCI-LB), it was found that MCI-LB patients have more symptoms, and a 10-point symptom scale can effectively differentiate MCI-LB and MCI-AD. These findings are important for clinicians to diagnose and treat MCI.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Hong-Chun Wei, Bing Li, Kok Pin Ng, Qing-Xi Fu, Sheng-Jie Dong, Mao-Wen Ba, Min Kong
Summary: This study compared clinical and biomarker features between A+T+MCI individuals progressing to pMCI and those remaining stable sMCI, identifying CSF and cognitive measures at baseline predictive of dementia progression within 2 years. Subset differences in biomarkers, cognitive assessment, and MRI imaging were observed, with CSF t-tau levels and cognitive scores serving as potential risk factors for dementia progression in A+T+MCI individuals.
CHINESE MEDICAL JOURNAL
(2021)
Article
Clinical Neurology
Olivia Gannon, Sarah M. Tremble, Conor Mcginn, Ruby Guth, Nadia Scoppettone, Ryan D. Hunt, Kirtika Prakash, Abbie C. Johnson
Summary: The study found that memory impairment in late-stage hypertensive rats was associated with hippocampal arteriole endothelial dysfunction, hyperconstriction, and reduced hippocampal blood flow. Captopril improved arteriole function, restored perfusion, and rescued memory in aged SHR, highlighting the therapeutic potential of hippocampal arterioles in maintaining neurocognitive health.
ALZHEIMERS & DEMENTIA
(2023)
Article
Environmental Sciences
Teresa Urbano, Annalisa Chiari, Carlotta Malagoli, Andrea Cherubini, Roberta Bedin, Sofia Costanzini, Sergio Teggi, Giuseppe Maffeis, Marco Vinceti, Tommaso Filippini
Summary: Exposure to outdoor air pollutants, particularly PM10, may nonlinearly increase the risk of conversion from MCI to dementia. Higher PM10 levels were associated with increased concentrations of cerebrospinal fluid tau proteins and decreased beta-amyloid levels. The risk of dementia was positively associated with mean PM10 levels above 10 μg/m3 and maximum PM10 levels above 35 μg/m3.
ENVIRONMENTAL RESEARCH
(2023)
Article
Neuroimaging
Sung Hoon Kang, Yu Hyun Park, Jun Pyo Kim, Ji-Sun Kim, Chi Hun Kim, Hyemin Jang, Hee Jin Kim, Seong-Beom Koh, Duk L. Na, Juhee Chin, Sang Won Seo
Summary: The study found that cognitive dysfunction in A beta (-) SVCI patients is associated with cortical atrophy in specific brain regions, irrespective of the presence of white matter hyperintensity. Memory impairment is mainly linked to cortical atrophy in the frontal and posterior cingulate regions, while poor performance in animal fluency and visuospatial memory tests is associated with cortical atrophy in the left and right hemispheres respectively.
NEUROIMAGE-CLINICAL
(2021)
Review
Clinical Neurology
Jonathan Blackman, Marta Swirski, James Clynes, Sam Harding, Yue Leng, Elizabeth Coulthard
Summary: Suboptimal sleep can lead to cognitive decline and accelerate Alzheimer's Disease progression. Early intervention in MCI and mild AD is necessary, but there is a lack of evidence for sleep interventions in these stages, highlighting the need for high quality experimental studies exploring alternative interventions.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Clinical Neurology
Abbie C. Johnson
Summary: With the increase in aging population and lack of effective treatments for dementia, the incidence of age-related dementia is on the rise. Vascular factors contributing to cognitive impairment and dementia are also increasing due to the prevalence of cerebrovascular diseases such as chronic hypertension, diabetes, and ischemic stroke. This review focuses on the role of the hippocampal vasculature in maintaining neurocognitive health, its contribution to vascular cognitive impairment and dementia, and its potential as a therapeutic target to slow cognitive decline.
Article
Clinical Neurology
Erik Kaestner, Anny Reyes, Austin Chen, Jun Rao, Anna Christina Macari, Joon Yul Choi, Deqiang Qiu, Kelsey Hewitt, Zhong Irene Wang, Daniel L. Drane, Bruce Hermann, Robyn M. Busch, Vineet Punia, Carrie R. McDonald
Summary: Older adults with temporal lobe epilepsy show patterns of cortical atrophy and cognitive impairment similar to those with amnestic mild cognitive impairment, with both groups exhibiting memory and language impairments. Late-onset temporal lobe epilepsy patients have more consistent cortical thinning compared to early-onset patients.
Review
Biochemistry & Molecular Biology
Kyoungjoo Cho
Summary: Cognitive impairment is a serious condition associated with aging and disruption of inflammation and innate immunity. Recent studies have shown that the innate immune system is prevalent in patients with Alzheimer's disease, and peripheral neutrophil markers can predict a decline in cognitive function in patients with mild cognitive impairment. Furthermore, altered levels of pro-inflammatory interleukins have been reported in patients with mild cognitive impairment, potentially playing a role in the progression from early cognitive impairment to dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Maria Gabriella Vita, Dorina Tiple, Alessandra Bizzarro, Anna Ladogana, Elisa Colaizzo, Sabina Capellari, Marcello Rossi, Piero Parchi, Carlo Masullo, Maurizio Pocchiari
Article
Clinical Neurology
Mariachiara Sensi, Giovanni Cossu, Francesca Mancini, Manuela Pilleri, Maurizio Zibetti, Nicola Modugno, Rocco Quatrale, Filippo Tamma, Angelo Antonini
PARKINSONISM & RELATED DISORDERS
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simona Gaudino, Emma Gangemi, Raffaella Colantonio, Annibale Botto, Emanuela Ruberto, Rosalinda Calandrelli, Matia Martucci, Maria Gabriella Vita, Carlo Masullo, Alfonso Cerase, Cesare Colosimo
Article
Clinical Neurology
Davide Quaranta, Guido Gainotti, Daniela Di Giuda, Maria Gabriella Vita, Fabrizio Cocciolillo, Giordano Lacidogna, Valeria Guglielmi, Carlo Masullo, Alessandro Giordano, Camillo Marra
PSYCHIATRY RESEARCH-NEUROIMAGING
(2018)
Article
Geriatrics & Gerontology
Valeria Guglielmi, Camillo Marra, Pasqualina M. Picciotti, Giovanna Masone Iacobucci, Silvia Giovannini, Davide Quaranta, Roberta Anzivino, Gaetano Paludetti, Guido Conti
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2020)
Article
Clinical Neurology
Valerio Brunetti, Aurora D'Atri, Giacomo Della Marca, Catello Vollono, Camillo Marra, Maria Gabriella Vita, Serena Scarpelli, Luigi De Gennaro, Paolo Maria Rossini
CLINICAL NEUROPHYSIOLOGY
(2020)
Article
Genetics & Heredity
Alessandro Vaisfeld, Giorgia Bruno, Martina Petracca, Anna Rita Bentivoglio, Serenella Servidei, Maria Gabriella Vita, Francesco Bove, Giulia Straccia, Clemente Dato, Giuseppe Di Iorio, Simone Sampaolo, Silvio Peluso, Anna De Rosa, Giuseppe De Michele, Melissa Barghigiani, Daniele Galatolo, Alessandra Tessa, Filippo Santorelli, Pietro Chiurazzi, Mariarosa Anna Beatrice Melone
Summary: Neuroacanthocytosis (NA) syndromes are genetically defined diseases characterized by red blood cell acanthocytosis, basal ganglia degeneration, and neuromuscular features. Italian patients with specific neurological phenotypes were studied, with most diagnosed with ChAc and having biallelic changes in the VPS13A gene. The low incidence of ChAc and MLS cases worldwide suggests high genetic variability in ChAc among the Italian population.
Article
Neurosciences
Christoffer Hatlestad-Hall, Ricardo Bruna, Aksel Erichsen, Vebjorn Andersson, Marte Roa Syvertsen, Annette Holth Skogan, Hanna Renvall, Camillo Marra, Fernando Maestu, Kjell Heuser, Erik Tauboll, Anne-Kristin Solbakk, Ira H. Haraldsen
Summary: Research shows that cognitive impairment in epilepsy patients is not directly linked to seizure activity, but rather a manifestation of broader brain pathology. Different cognitive domains were associated with specific intrinsic functional connectivity networks, highlighting the relevance of brain network dysfunction in cognitive impairment.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Clinical Neurology
Tommaso F. Nicoletti, Salvatore Rossi, Maria Gabriella Vita, Alessia Perna, Gisella Guerrera, Federica Lino, Chiara Iacovelli, Daniele Di Natale, Anna Modoni, Luca Battistini, Gabriella Silvestri
Summary: This study found that serum Neurofilament light chain (NfL) may serve as a potential biomarker for CNS damage in DM1. This is of importance for assessing the severity and progression of brain diseases.
JOURNAL OF NEUROLOGY
(2022)
Review
Neurosciences
Vittorio Riso, Tommaso Filippo Nicoletti, Salvatore Rossi, Maria Gabriella Vita, Perna Alessia, Daniele Di Natale, Gabriella Silvestri
Summary: Neurological involvement is common in Erdheim-Chester disease, a rare clonal disorder characterized by multisystem involvement. The disease may present with cerebellar symptoms, mimicking degenerative or immune-mediated ataxia. Diagnosis can be challenging, but certain features are helpful in addressing it.
Article
Clinical Neurology
Valeria Guglielmi, Davide Quaranta, Giovanna Masone Iacobucci, Salvatore Citro, Irene Scala, Danilo Genovese, Valerio Brunetti, Camillo Marra, Paolo Calabresi, Giacomo Della Marca
Summary: This study aimed to assess the cognitive impairment within 1 week after mechanical thrombectomy. It was found that some patients experienced cognitive impairment after the procedure, which may lead to worse neurological and functional outcomes.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Massimo Filippi, Giordano Cecchetti, Annachiara Cagnin, Camillo Marra, Flavio Nobili, Lucilla Parnetti, Federica Agosta
Summary: Currently, no disease-modifying therapies are available for Alzheimer's disease (AD) in Europe. However, evidence from clinical trials suggests that anti-beta amyloid (Aβ) monoclonal antibodies (mAbs) may be authorized for marketing in the near future. A group of prominent AD clinical experts in Italy met to discuss patient selection and management strategies, recognizing the need for significant changes in dementia care to implement disease-modifying therapies. They emphasized the importance of a biological diagnosis using amyloid- and tau-related biomarkers, as well as specialized diagnostic work-up and exclusion criteria assessment by neurology specialists. The experts also proposed a reorganization of dementia and cognitive decline centers into three levels with defined tasks and requirements.
JOURNAL OF NEUROLOGY
(2023)
Article
Behavioral Sciences
Davide Quaranta, Naike Caraglia, Federica L'Abbate, Guido Maria Giuffre, Valeria Guglielmi, Giovanna Masone Iacobucci, Paolo Maria Rossini, Paolo Calabresi, Camillo Marra
Summary: Early impairment of semantic memory could predict the progression to Alzheimer's disease before the onset of memory disorders, and the discrepancy between phonological and semantic verbal fluency tests could be able to detect this impairment in advance.
BRAIN AND BEHAVIOR
(2023)
Article
Endocrinology & Metabolism
Sabrina Chiloiro, Antonella Giampietro, Antonio Bianchi, Tommaso Tartaglione, Chiara Bima, Maria Gabriella Vita, Maurizio Spinello, Alfredo Pontecorvi, Laura De Marinis
Letter
Clinical Neurology
Maria Gabriella Vita, Francesco Bove, Paolo Mariotti, Maria Elena Riccioni, Vincenzo Leuzzi, Anna Rita Bentivoglio
MOVEMENT DISORDERS CLINICAL PRACTICE
(2017)