Article
Nutrition & Dietetics
Bridgette Wilson, Oezge Eyice, Ioannis Koumoutsos, Miranda C. Lomer, Peter M. Irving, James O. Lindsay, Kevin Whelan
Summary: Prebiotics may not reduce clinical scores or inflammation in patients with active ulcerative colitis, but can normalize stools. The increase in proportions of Bifidobacterium and Christensenellaceae only occurred in patients with less active diseases, suggesting that the prebiotic effect may depend on disease activity.
Article
Biochemistry & Molecular Biology
Mengfan Luo, Qiaoyue Yuan, Mingzhen Liu, Xingye Song, Yingjie Xu, Tao Zhang, Xiaoqun Zeng, Zhen Wu, Daodong Pan, Yuxing Guo
Summary: This study aimed to develop a novel astaxanthin nanoparticle using gum arabic (GA) and whey protein powder enriched with milk fat globule membranes (MFGM-WPI) as carriers and investigated its effect and alleviation mechanism on colitis in mice. Results showed that MFGM-GA-astaxanthin effectively improved bioaccessibility of astaxanthin, reduced oxidative stress, alleviated colitis symptoms, repaired intestinal barrier function, and restored abnormalities of gut flora. This study provides a promising therapeutic approach for colon diseases using astaxanthin nanoparticles.
Review
Infectious Diseases
Sara Federici, Denise Kviatcovsky, Rafael Valdes-Mas, Eran Elinav
Summary: Inflammatory bowel disease (IBD) is a group of auto-inflammatory disorders affecting the gastrointestinal tract and other organs. The gut microbiome and specifically bacteriophages, which can infect bacteria, play a role in IBD pathology. Phage therapy shows potential in eradicating pathobionts associated with IBD, but further research is needed.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Microbiology
Jasminka Talapko, Aleksandar Vcev, Tomislav Mestrovic, Emina Pustijanac, Melita Jukic, Ivana Skrlec
Summary: The gut microbiota plays a crucial role in human health by participating in various physiological functions and acting as a metabolic organ. Changes in the composition of the intestinal microbiota have been linked to the pathogenesis of inflammatory bowel disease. The development of biological and immunomodulatory therapy has shown promising results in treating this condition, and lifestyle changes and novel approaches offer solutions for dysbiosis management.
Article
Multidisciplinary Sciences
Maureen M. Leonard, Francesco Valitutti, Hiren Karathia, Meritxell Pujolassos, Victoria Kenyon, Brian Fanelli, Jacopo Troisi, Poorani Subramanian, Stephanie Camhi, Angelo Colucci, Gloria Serena, Salvatore Cucchiara, Chiara Maria Trovato, Basilio Malamisura, Ruggiero Francavilla, Luca Elli, Nur A. Hasan, Ali R. Zomorrodi, Rita Colwell, Alessio Fasano
Summary: This study analyzed the gut microbiome and metabolites of infants at risk of CD, revealing shifts in microbiota before CD onset. Some microbial species were linked to autoimmune and inflammatory conditions, while others had anti-inflammatory effects. Previously unreported microbes/pathways/metabolites were also identified as potential CD-specific biomarkers, pointing towards new therapeutic targets.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Dimitri Poddighe, Almagul Kushugulova
Summary: The salivary microbiota in patients with Celiac Disease (CD) differs from that in healthy individuals, but current clinical studies have not provided conclusive evidence. Further research is needed to understand the role of the salivary microbiome in the pathogenesis of CD.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Qiongyun Chen, Yanyun Fan, Bangzhou Zhang, Changsheng Yan, Qiang Zhang, Yuhao Ke, Zhangran Chen, Lin Wang, Huaxiu Shi, Yiqun Hu, Qingwen Huang, Jingling Su, Chenxi Xie, Xu Zhang, Lixiang Zhou, Jianlin Ren, Hongzhi Xu
Summary: Fecal microbiota transplantation (FMT) can induce clinical remission in ulcerative colitis (UC) patients. In this study, capsulized FMT was successfully administered to UC patients, resulting in clinical remission in 57.1% of patients and clinical response in 76.2%.
MICROBIOLOGY SPECTRUM
(2023)
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Review
Food Science & Technology
Sevda Zoghi, Amin Abbasi, Fatemah Sadeghpour Heravi, Mohammad Hossein Somi, Zeinab Nikniaz, Seyed Yaghoub Moaddab, Hamed Ebrahimzadeh Leylabadlo
Summary: This article discusses the association between the development of celiac disease and gut microbiota, the effects of infectious agents, especially the recent Covid-19 infection in celiac disease patients, and the efficacy of potential therapeutic approaches. Scientific literature suggests that microbiome-based therapy can improve the symptoms and quality of life of celiac disease patients, but the full potential of microbiota-based techniques requires further research.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Ecology
Rachel S. Fitzgerald, Ian R. Sanderson, Marcus J. Claesson
Summary: Paediatric inflammatory bowel disease is a chronic inflammatory disorder of the digestive tract, with increasing global incidence. Genetics, environment, and microbiota are believed to contribute to the development of the disease. Studies have found significant differences in the microbiome of paediatric IBD patients compared to healthy children, with changes in response to treatments and disease severity. Further research into biome differences in paediatric IBD patients may enhance our understanding of the disease's etiology.
Article
Nutrition & Dietetics
Vaios Svolos, Konstantinos Gkikas, Konstantinos Gerasimidis
Summary: The etiology of IBD involves multiple factors, with diet and gut microbiota playing crucial roles in disease management. Clinical trials focusing on the effects of EEN on gut microbiota in children with CD offer insights into disease pathogenesis, while evidence linking food-based dietary therapies for IBD with gut microbiota mechanisms remains inconclusive.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2021)
Article
Gastroenterology & Hepatology
Yu-Fei Lin, Chang Mu Sung, Huei-Mien Ke, Chia-Jung Kuo, Wei-an Liu, Wen-Sy Tsai, Cheng-Yu Lin, Hao-Tsai Cheng, Meiyeh J. Lu, Isheng J. Tsai, Sen-Yung Hsieh
Summary: This study investigated the mucosal tissue microbiomes in distinguishing patients with subclinical UC from healthy individuals, finding that rectal tissue microbiome was more effective than cecal tissue and fecal samples. Specific microbial compositions and functional pathways were identified in subclinical UC patients, suggesting the potential of rectal biopsy microbiome assessment in predicting disease progression and relapse in UC.
Article
Biochemistry & Molecular Biology
Mengfan Luo, Qiaoyue Yuan, Mingzhen Liu, Xingye Song, Yingjie Xu, Tao Zhang, Xiaoqun Zeng, Zhen Wu, Daodong Pan, Yuxing Guo
Summary: This study aimed to develop a novel astaxanthin nanoparticle using gum arabic and whey protein powder enriched with milk fat globule membranes as carriers, and investigate its effect and alleviation mechanism on colitis in mice. The study demonstrated that the nanoparticle could improve astaxanthin bioaccessibility and cope with oxidative stress more effectively. In vivo studies showed that the nanoparticle alleviated colitis symptoms, repaired intestinal barrier function, and restored the abnormalities of flora caused by dextran sulfate sodium. This study provides a basis for the therapeutic effect of astaxanthin nanoparticles on colon diseases.
Article
Gastroenterology & Hepatology
Mahasish Shome, Lusheng Song, Stacy Williams, Yunro Chung, Vel Murugan, Jin G. Park, William Faubion, Shabana F. Pasha, Jonathan A. Leighton, Joshua LaBaer, Ji Qiu
Summary: By analyzing the anti-microbial antibody response in patients with inflammatory bowel disease (IBD), we have identified antibody signatures for Crohn's disease (CD) and ulcerative colitis (UC), as well as discovered the associated microorganisms. These findings contribute to our understanding of the role specific microorganisms play in the pathogenesis of IBD and could potentially aid in early and accurate diagnosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Zi-xiao Zhao, Xi Yuan, Yan-yan Cui, Jun Liu, Jing Shen, Bi-ying Jin, Bing-cheng Feng, Yun-jiao Zhai, Meng-qi Zheng, Guan-jun Kou, Ru-chen Zhou, Li-xiang Li, Xiu-li Zuo, Shi-yang Li, Yan-qing Li
Summary: This study reveals that melatonin can alleviate type 2 immune response-associated colitis by suppressing inflammation, improving intestinal permeability, and modulating gut microbiota composition.
FRONTIERS IN IMMUNOLOGY
(2022)
