期刊
CURRENT ALLERGY AND ASTHMA REPORTS
卷 11, 期 5, 页码 388-394出版社
CURRENT MEDICINE GROUP
DOI: 10.1007/s11882-011-0210-y
关键词
Interleukin-17; IL-17; T cells; Asthma
资金
- National Institute of Allergy and Infectious Diseases [R01 AI090129-01, RO1HL067736, RO1AIO83315]
- American Lung Association/American Academy of Allergy, Asthma and Immunology Foundation
Asthma has long been characterized as a disease of dysregulated T-helper type 2 immune responses to environmental allergens. Clinical studies suggest that asthma is a heterogeneous disorder with distinct types of inflammatory processes. Accumulating evidence suggests that aberrant interleukin (IL)-17 production is a key determinant of severe forms of asthma. However, the identity of IL-17-producing cells and the factors regulating IL-17 production during the course of allergic inflammation remain elusive. In this review, we summarize the potential IL-17-producing cells and their involvement in the inflammatory responses that mediate distinct features of asthma. The role of proinflammatory cytokines and the complement pathway in regulating the generation of IL-17-producing T cells is also discussed. Understanding the biology of IL-17 in the context of allergic inflammation may be informative in the development of novel approaches to the diagnosis and treatment of asthma.
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