Review
Developmental Biology
Avery C. Kramer, Thomas Jansson, Tracy L. Bale, Theresa L. Powell
Summary: Altered placental function may mediate the link between the maternal environment and fetal growth and development, through nutrient sensing, modulation of transporters, and changes in extracellular vesicles. Maternal diet and stress can also influence fetal development and metabolism, and fetal growth restriction may increase the risk of chronic disease later in life.
Article
Biochemistry & Molecular Biology
Danielewicz Hanna, Gurgul Artur, Debinska Anna, Myszczyszyn Grzegorz, Szmatola Tomasz, Myszkal Anna, Jasielczuk Igor, Drabik-Chamerska Anna, Hirnle Lidia, Boznanski Andrzej
Summary: The prevalence of allergic diseases may be predicted by DNA methylation patterns, with maternal atopy being associated with methylation patterns in newborns' cord blood. The unique intrauterine environment provided by maternal atopy may lead to alterations in methylation patterns, as shown in this study.
Article
Developmental Biology
Evangelina Capobianco, Irune Pirrone
Summary: The alarming increase in the prevalence of metabolic pathologies has raised worldwide concerns. Recent studies have focused on the programming of metabolic diseases by paternal exposure. This review aims to explore the evidence of fetoplacental developmental alterations and metabolic pathologies in offspring, considering paternal metabolic disorders and unhealthy exposures, as well as identifying potential paternal interventions to reduce negative health outcomes in the offspring.
Article
Obstetrics & Gynecology
Brian J. Koos, Jeffrey A. Gornbein
Summary: This metabolomics study identified a high-accuracy model for predicting gestational diabetes mellitus in early pregnancy. The research showed that certain metabolites were independently associated with gestational diabetes mellitus and could be used as predictive markers. This finding contributes to future studies on early therapeutic interventions for gestational diabetes mellitus.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Allergy
Gayan Bowatte, Dinh S. Bui, Sajith Priyankara, Adrian J. Lowe, Jennifer L. Perret, Caroline J. Lodge, Garun S. Hamilton, Bircan Erbas, Paul Thomas, Bruce Thompson, Vivi Schlunssen, David Martino, John W. Holloway, Cecilie Svanes, Michael J. Abramson, E. Haydn Walters, Shyamali C. Dharmage
Summary: This study found an association between fathers' high BMI trajectories before conception and an increased risk of asthma in their offspring, especially allergic asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Matheus Ajackson, Brenda A. Nagagata, Ilitch A. Marcondes-de-Castro, Carlos A. Mandarim-de-Lacerda, Marcia Barbosa Aguila
Summary: The aim of this study was to investigate the effects of melatonin supplementation in the liver of adult offspring from obese mothers during pregnancy and lactation. The results showed that supplementation of melatonin reduced body weight and liver lipid levels in offspring from high-fat diet-fed mothers. Additionally, melatonin supplementation improved lipid metabolism, inflammation, oxidative stress, and endoplasmic reticulum stress in the offspring's liver.
Article
Toxicology
Lulu Xie, Zhexiao Jiao, Haiju Zhang, Tingting Wang, Jiaxin Qin, Shuai Zhang, Mingcui Luo, Mengxi Lu, Baozhen Yao, Hui Wang, Dan Xu
Summary: This study confirms that prenatal dexamethasone exposure can cause susceptibility to convulsions in male offspring, and explores the epigenetic programming mechanism related to intrauterine KCC2. It was found that male offspring showed convulsion susceptibility, increased GABA and chloride ions levels, and decreased GABA receptor expression. There was also a decrease in H3K14ac levels and KCC2 expression. The abnormal epigenetic modification may be the mechanism underlying offspring convulsion susceptibility.
TOXICOLOGY LETTERS
(2022)
Review
Cell Biology
Mariana Schroeder, Gina Badini, Amanda N. Sferruzzi-Perri, Christiane Albrecht
Summary: The use of assisted reproductive technologies (ART) has increased over the years, but pregnancies achieved by ART still carry risks for the mother and unborn child. The long-term effects of ART are currently unknown, and more research is needed in this area. This review aims to summarize the latest findings on the effects of ART on various outcomes and explore the factors that may contribute to the developmental outcomes of ART offspring, particularly focusing on placental intrinsic factors. Although current knowledge suggests better long-term outcomes for ART-conceived individuals than previously predicted, further investigation is necessary to fully understand the potential consequences of ART.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
G. M. Silva, C. D. Chalk, J. Ranches, T. M. Schulmeister, D. D. Henry, N. DiLorenzo, J. D. Arthington, P. Moriel, P. A. Lancaster
Summary: This study investigated the effect of metabolizable methionine supply to lactating beef cows during the periconception period on the performance of cows, calves, and subsequent offspring. Results showed that maternal methionine supply plays an important role in programming future performance of the offspring, potentially affecting the growth rate and feed efficiency of subsequent calves.
Review
Endocrinology & Metabolism
Niharika Sinha, Gretchen Lydia Walker, Aritro Sen
Summary: Exposure to adverse conditions during fetal development can lead to epigenetic changes that predispose offspring to diseases later in life. For example, offspring exposed to gestational diabetes have an increased risk of developing obesity and metabolic disorders in adulthood. Reproductive dysfunction and infertility later in life may be linked to epigenetic reprogramming of genes.
Article
Biology
Yuping Zhou, Baoxia Gu, Geraldine Brichant, Jay Prakash Singh, Huan Yang, Hao Chang, Yanding Zhao, Chao Cheng, Zhong-Wu Liu, Myles H. Alderman, Lingeng Lu, Xiaoyong Yang, Xiao-Bing Gao, Hugh S. Taylor
Summary: A study found that mice offspring exposed to estriol (E-3) during pregnancy had increased fertility and better pregnancy outcomes. These offspring also showed decreased anxiety and increased exploratory behavior. E-3 acts on estrogen receptors, recruiting epigenetic modifiers to alter gene expression and affect organ development and brain function.
Review
Biochemistry & Molecular Biology
S. Rao Sirasanagandla, Isehaq Al-Huseini, R. G. Sumesh Sofin, Srijit Das
Summary: Bisphenol A (BPA) is a commonly used industrial compound, and evidence suggests that perinatal exposure to BPA increases the risk of cardiovascular diseases. Developmental programming and epigenetic modifications of genes may play a role in this impact.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoli Zhang, Ahmed A. Hasan, Hongwei Wu, Mohamed M. S. Gaballa, Suimin Zeng, Liping Liu, Li Xie, Tobias Jung, Tilman Grune, Bernhard K. Kramer, Burkhard Kleuser, Jian Li, Berthold Hocher
Summary: The effects of feeding male rats a high-fat, high-sucrose and high-salt diet during spermatogenesis on renal outcomes in two generations (F0 and F1) are unclear. This study found that female offspring of F0HD+F1HD rats showed increased urinary albumin excretion and developed glomerulosclerosis and renal interstitial fibrosis. RNA sequencing revealed differential regulation of four genes in the kidneys of female F2 offspring. Epigenetic alterations, such as decreased expression of lncRNA XR-146683.1 and increased methylation of the Cd300lf promoter region, were found in the F0HD+F1HD female F2 offspring. These alterations were associated with decreased Cd300lf mRNA expression and increased urinary albumin excretion in F2 female offspring. The findings suggest that an unhealthy diet in paternal pre-conception may predispose female offspring to chronic kidney disease through epigenetic changes in renal gene expression.
Article
Physiology
Gina N. Calco, Yem J. Alharithi, Kayla R. Williams, David B. Jacoby, Allison D. Fryer, Alina Maloyan, Zhenying Nie
Summary: Children born to obese mothers have a greater risk of developing asthma and airway hyperresponsiveness. This study used a mouse model to show that offspring of dams fed a high-fat diet develop metabolic abnormalities and increased bronchoconstriction. The researchers also found that maternal high-fat diet increases airway sensory innervation in offspring, leading to reflex airway hyperresponsiveness.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Immunology
Jose M. Rodrigo-Munoz, Marta Gil-Martinez, Clara Lorente-Sorolla, Raquel Garcia-Latorre, Marcela Valverde-Monge, Santiago Quirce, Joaquin Sastre, Victoria del Pozo
Summary: MicroRNA miR-144-3p is identified as a potential diagnostic biomarker for severe asthma, as its expression is associated with the severity of the disease and corticosteroid treatment. It is increased in asthmatic lungs and serum, correlating with blood eosinophilia and genes involved in asthma pathophysiology. This miRNA shows promise as a novel biomarker for severe asthma previously treated with higher doses of corticosteroids.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Malia Su-Qin Murphy, Egle Bytautiene, George Saade, Graeme Neil Smith
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2015)
Article
Obstetrics & Gynecology
Egle Bytautiene Prewit, Talar Kechichian, Deborah Okunade, Huaizhi Yin, Alison M. Stuebe
REPRODUCTIVE SCIENCES
(2018)
Article
Public, Environmental & Occupational Health
E. Bytautiene Prewit, C. Porter, M. La Rosa, N. Bhattarai, H. Yin, P. Gamble, T. Kechichian, L. S. Sidossis
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2018)
Article
Obstetrics & Gynecology
Egle Bytautiene, Esther Tamayo, Talar Kechichian, Nathan Drever, Phyllis Gamble, Gary D. V. Hankins, George R. Saade
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2011)
Article
Obstetrics & Gynecology
Karin A. Fox, Monica Longo, Esther Tamayo, Talar Kechichian, Egle Bytautiene, Gary D. V. Hankins, George R. Saade, Maged M. Costantine
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2011)
Article
Obstetrics & Gynecology
Nathan Drever, Huaizhi Yin, Talar Kechichian, Maged Costantine, Monica Longo, George R. Saade, Egle Bytautiene
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2012)
Article
Obstetrics & Gynecology
Arshag Kalanderian, Nicola Abate, Igor Patrikeev, Jingna Wei, Kathleen Listiak Vincent, Massoud Motamedi, George Robert Saade, Egle Bytautiene
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2013)
Article
Obstetrics & Gynecology
Egle Bytautiene, Nataliya Bulayeva, Geeta Bhat, Li Li, Kevin P. Rosenblatt, George R. Saade
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2013)
Article
Obstetrics & Gynecology
Alexandria J. Hill, Nathan Drever, Huaizhi Yin, Esther Tamayo, George Saade, Egle Bytautiene
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2014)
Article
Obstetrics & Gynecology
Aaron T. Poole, Kathleen L. Vincent, Gayle L. Olson, Igor Patrikeev, George R. Saade, Alison Stuebe, Egle Bytautiene
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2014)
Article
Obstetrics & Gynecology
Giuseppe Chioss, Maged M. Costantine, Egle Bytautiene, Ancizar Betancourt, Gary D. V. Hankins, George R. Saade, Monica Longo
AMERICAN JOURNAL OF PERINATOLOGY
(2012)
Article
Obstetrics & Gynecology
Giuseppe Chiossi, Maged M. Costantine, Egle Bytautiene, Talar Kechichian, Gary D. V. Hankins, Elena Sbrana, George R. Saade, Monica Longo
AMERICAN JOURNAL OF PERINATOLOGY
(2012)
Article
Obstetrics & Gynecology
Sandra R. Herrera, Kathleen L. Vincent, Aaron Poole, Gayle Olson, Igor Patrikeev, Jamal Saada, Phyllis Gamble, Massoud Motamedi, George R. Saade, Alison M. Stuebe, Egle Bytautiene Prewit
AMERICAN JOURNAL OF PERINATOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Julio Mateus, Egle Bytautiene, Fangxian Lu, Esther H. Tamayo, Ancizar Betancourt, Gary D. V. Hankins, Monica Longo, George R. Saade
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2011)
Article
Obstetrics & Gynecology
Mauricio La Rosa, Talar Kechichian, Gayle Olson, George Saade, Egle Bytautiene Prewit
REPRODUCTIVE SCIENCES
(2020)
