Article
Allergy
Freda Yang, John Busby, Liam G. Heaney, Andrew Menzies-Gow, Paul E. Pfeffer, David J. Jackson, Adel H. Mansur, Salman Siddiqui, Christopher E. Brightling, Robert Niven, Neil C. Thomson, Rekha Chaudhuri
Summary: This study aimed to identify factors associated with frequent exacerbations in severe asthma patients, and found that factors included ACQ-6 score, smoking history, and fractional exhaled nitric oxide levels. A high ACQ-6 score had the strongest association with frequent exacerbations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Review
Allergy
Agamemnon Bakakos, Zoi Sotiropoulou, Angelos Vontetsianos, Stavroula Zaneli, Andriana Papaioannou, Petros Bakakos
Summary: Asthma is a common airway disease that affects millions of people globally. Viral infections are the most common trigger of asthma exacerbations. Asthmatics are more susceptible to severe viral infections due to their unique inflammatory response. Although targeted therapies for viral infections in asthma have been studied in the laboratory, none have been approved for clinical use.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Article
Respiratory System
Seyi Soremekun, Liam G. Heaney, Derek Skinner, Lakmini Bulathsinhala, Victoria Carter, Isha Chaudhry, Naeimeh Hosseini, Neva Eleangovan, Ruth Murray, Trung N. Tran, Benjamin Emmanuel, Esther Garcia Gil, Andrew Menzies-Gow, Matthew Peters, Njira Lugogo, Rupert Jones, David B. Price
Summary: This study, based on a large nationwide cohort of asthma patients, found that asthma exacerbations are associated with faster decline in lung function, especially in younger patients.
Review
Biotechnology & Applied Microbiology
Ghalya H. Banafea, Sherin Bakhashab, Huda F. Alshaibi, Peter Natesan Pushparaj, Mahmood Rasool
Summary: Mast cells play a crucial role in inflammatory diseases of the airway tract, releasing various mediators that contribute to immune cell accumulation and tissue remodeling.
Article
Allergy
Marleen P. Bokern, Annelies L. Robijn, Megan E. Jensen, Daniel Barker, Leonie Callaway, Vicki Clifton, Peter Wark, Warwick Giles, Joerg Mattes, Michael Peek, John Attia, Sean Seeho, Alistair Abbott, Peter G. Gibson, Vanessa E. Murphy
Summary: This study identified factors associated with asthma exacerbations during pregnancy, with medium to high dose of ICS treatment being the most strongly correlated. Poor asthma control, possession of a written action plan, and a history of asthma exacerbations prior to pregnancy were also found to be associated with an increased rate of exacerbations during pregnancy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
James G. Krings, Charles W. Goss, Daphne Lew, Maanasi Samant, Mary Clare McGregor, Jonathan Boomer, Leonard B. Bacharier, Ajay Sheshadri, Chase Hall, Joshua Brownell, Ken B. Schechtman, Samuel Peterson, Stephen McEleney, David T. Mauger, John V. Fahy, Sean B. Fain, Loren C. Denlinger, Elliot Israel, George Washko, Eric Hoffman, Sally E. Wenzel, Mario Castro
Summary: For patients with asthma, qCT measurements show that more severe airway remodeling, small airway disease and hyperinflation, as well as less pointwise regional change in lung volumes at baseline are associated with future decline in lung function and exacerbations of asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Jonathan M. Gaffin, Carter R. Petty, Ronald L. Sorkness, Loren C. Denlinger, Brenda R. Phillips, Ngoc P. Ly, Benjamin Gaston, Kristie Ross, Anne Fitzpatrick, Leonard B. Bacharier, Mark D. DeBoer, W. Gerald Teague, Sally E. Wenzel, Sima Ramratnam, Elliot Israel, David T. Mauger, Wanda Phipatanakul
Summary: This study aimed to identify phenotypic factors associated with FEV1 in children with asthma. The results showed that baseline FENO, response to triamcinolone acetonide, and bronchodilator reversibility were associated with FEV1. Additionally, age, obesity, and exacerbation frequency predicted FEV1 over time. There was also a significant interaction between age and sex, with boys experiencing more significant effects of exacerbation frequency on FEV1 compared to girls.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Kathryn E. McCauley, Kaitlin Flynn, Agustin Calatroni, Vincent DiMassa, Brandon LaMere, Douglas W. Fadrosh, Kole Lynch, Michelle A. Gill, Jacqueline A. Pongracic, Gurjit K. Khurana Hershey, Carolyn M. Kercsmar, Andrew H. Liu, Christine C. Johnson, Haejin Kim, Meyer Kattan, George T. O'Connor, Leonard B. Bacharier, Stephen J. Teach, Peter J. Gergen, Lisa M. Wheatley, Alkis Togias, Petra LeBeau, Scott Presnell, Homer A. Boushey, William W. Busse, James E. Gern, Daniel J. Jackson, Matthew C. Altman, Susan Lynch
Summary: This study found that respiratory illnesses and asthma exacerbations are associated with seasonal variation in upper airway microbiota. Seasonally adjusted analysis revealed specific bacteria-host interactions that significantly increase the risk of asthma exacerbation in children.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Ka Pang Chan, Fanny Wai San Ko, Kwun Cheung Ling, Pik Shan Cheung, Lee Veronica Chan, Yu Hong Chan, Yi Tat Lo, Chun Kong Ng, Macy Mei-sze Lui, Kwok Sang Wilson Yee, Cee Zhung Steven Tseng, Pak Yiu Tse, Mo Lin Maureen Wong, Kah Lin Choo, Wai Kei Lam, Chun Man Wong, Sheng Sheng Ho, Chung Tat Lun, Christopher Kei Wai Lai
Summary: This retrospective study in Hong Kong examined the real-world relationships between demographic and clinical characteristics of asthma patients, their prehospitalization management, and hospitalization frequency due to asthma exacerbation. The study identified advancing age, history of emergency department visits or hospitalizations for asthma exacerbation, and presence of neuropsychiatric and gastrointestinal comorbidities as risk factors for increasing admissions for asthma exacerbation. Optimal management and early identification of patients at risk may help prevent recurrent exacerbations and subsequent hospitalizations.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Allergy
Xingnan Li, Stephanie A. Christenson, Brian Modena, Huashi Li, William W. Busse, Mario Castro, Loren C. Denlinger, Serpil C. Erzurum, John V. Fahy, Benjamin Gaston, Annette T. Hastie, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, Wendy C. Moore, Prescott G. Woodruff, Naftali Kaminski, Sally E. Wenzel, Eugene R. Bleecker, Deborah A. Meyers
Summary: Multiple SNPs in the gasdermin B (GSDMB) gene are associated with asthma severity and longitudinal asthma exacerbations. Higher expression levels of GSDMB correlate with asthma exacerbations and pathways related to IFN signaling and immune system. GSDMB is identified as a functional gene for both asthma susceptibility and severity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Paul M. O'Byrne, J. Mark FitzGerald, Eric D. Bateman, Peter J. Barnes, Jinping Zheng, Per Gustafson, Rosa Lamarca, Margareta Puu, Christina Keen, Vijay K. T. Alagappan, Helen K. Reddel
Summary: In patients with mild asthma, as-needed budesonide-formoterol reduces the short-term risk of severe exacerbations after a single day of higher use. The use of an anti-inflammatory reliever may reduce the risk of short-term severe exacerbations by providing increased doses of inhaled corticosteroids and formoterol when symptoms occur.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ludovic de Gabory, Sabine Amet, Annelore Le Maux, Jean-Pierre Meunier, Antoine Chartier, Cecile Chenivesse
Summary: The study aimed to quantify and describe flare-ups of house dust mite allergic rhinitis (HDM-AR) that occurred during the last 12 months in a population of candidates for Allergen ImmunoTherapy (AIT), and to identify associated clinical features. The results showed that AR flare-ups are common and have an impact on the quality of life of patients.
Editorial Material
Immunology
Alexandre Boissonnas, Christophe Combadiere
Summary: The study shows that targeting the post-translational modification enzyme QPCTL can prevent the protection of CCL2 and CCL7, leading to the inactivation of their chemotactic function and limiting the recruitment of pro-tumoral macrophages.
Article
Multidisciplinary Sciences
Takehiro Hasegawa, Maho Yoshida, Shunsuke Watanabe, Takami Kondo, Hideo Asada, Atsushi Nakagawa, Keisuke Tomii, Masami Kameda, Mitsuo Otsuka, Koji Kuronuma, Hirofumi Chiba, Shinji Katayanagi, Yasunari Miyazaki, Akio Mori
Summary: In this study, we evaluated a new CXCL9 reagent for a fully automated immunoassay device. The results showed that the assay had good accuracy and stability in detecting T1 inflammation in plasma or serum. Elevated CXCL9 levels were observed in patients with COVID-19, bird-related hypersensitivity pneumonitis, asthma, and ILDs compared to healthy individuals. The automated CXCL9 immunoassay has potential clinical utility and reflects its role in T1 inflammation.
SCIENTIFIC REPORTS
(2023)
Article
Allergy
Christian J. Carlsson, Morten A. Rasmussen, Susanne B. Pedersen, Ni Wang, Jakob Stokholm, Bo L. Chawes, Klaus Bonnelykke, Hans Bisgaard
Summary: The study found that upper airway immune mediator levels were altered during episodes of asthma-like symptoms, and levels of TNF-alpha, CCL22, and IL-10 may predict the response to azithromycin treatment.