Review
Medicine, Research & Experimental
Yi Qin, Zhong-hua Chen, Jun-Jie Wu, Zhen-Yu Zhang, Zheng-Dong Yuan, Dan-Yang Guo, Meng-Nan Chen, Xia Li, Feng-Lai Yuan
Summary: The circadian clock plays a crucial role in regulating bone metabolism, including bone loss. Clock-related genes control signaling pathways and transcription factors in osteoblasts and osteoclasts, while also regulating osteocytes and endothelial cells. Furthermore, the regulation of circadian clock genes by novel modulators presents a potential strategy for preventing and treating bone diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Behavioral Sciences
Max de Leeuw, Sanne I. Verhoeve, Nic J. A. van der Wee, Albert M. van Hemert, Erno Vreugdenhil, Claudia P. Coomans
Summary: Circadian rhythms are closely related to depression, and disruption of circadian rhythms may contribute to the development of depression. A better understanding of the connection between disturbed circadian rhythms and the etiology of depression could lead to novel therapeutic and preventative strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Maria Savino, Claudio Carmine Guida, Maria Nardella, Emanuele Murgo, Bartolomeo Augello, Giuseppe Merla, Salvatore De Cosmo, Antonio Fernando Savino, Roberto Tarquini, Francesco Cei, Filippo Aucella, Gianluigi Mazzoccoli
Summary: This article investigates the relationship between heme biosynthesis disorders and altered expression of circadian genes, finding that changes in circadian gene expression may be associated with the symptoms and signs of porphyria patients.
Review
Neurosciences
Elizabeth A. Schroder, Makoto Ono, Sidney R. Johnson, Ezekiel R. Rozmus, Don E. Burgess, Karyn A. Esser, Brian P. Delisle
Summary: This article focuses on the impact of circadian rhythms, environmental and behavioral changes on 24-hour rhythms in heart rate and ventricular repolarization. The circadian clock in cardiomyocytes regulates the expression of cardiac ion channels, influences the sinoatrial node excitability and the duration of the ventricular action potential waveform. However, autonomic signaling primarily drives the 24-hour rhythms. Changing rhythmic behaviors can significantly affect heart rate and ventricular repolarization. Targeting endogenous circadian mechanisms and modifying rhythmic behaviors may emerge as therapeutic strategies for regulating cardiac electrophysiology.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Review
Biochemistry & Molecular Biology
Masanori Ono, Hitoshi Ando, Takiko Daikoku, Tomoko Fujiwara, Michihiro Mieda, Yasunari Mizumoto, Takashi Iizuka, Kyosuke Kagami, Takashi Hosono, Satoshi Nomura, Natsumi Toyoda, Naomi Sekizuka-Kagami, Yoshiko Maida, Naoaki Kuji, Hirotaka Nishi, Hiroshi Fujiwara
Summary: The circadian rhythm, controlled by clock genes, is crucial for reproduction. In the mouse uterus, the oscillation of circadian clock gene has been observed. CLOCK-BMAL1 heterodimer promotes the transcription of Per1/2 and Cry1/2 genes by binding to their promoters' E-box sequences. The endometrial clock plays an important role in pregnancy, and disruptions in the uterine clock can lead to complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Peripheral Vascular Disease
Hannah M. Costello, Michelle L. Gumz
Summary: The molecular circadian clock is crucial in blood pressure control, with central and peripheral clocks playing a key role. Dysregulation of the circadian rhythm of blood pressure is associated with adverse cardiorenal outcomes and increased risk of cardiovascular mortality. Understanding peripheral clock function in regulating the circadian rhythm of blood pressure will pave the way for targeted therapeutics in circadian blood pressure dysregulation and hypertension.
Review
Biochemistry & Molecular Biology
Ana Beatriz Aguiar Sanford, Leidivan Sousa da Cunha, Caio Bezerra Machado, Flavia Melo Cunha de Pinho Pessoa, Abigail Nayara dos Santos Silva, Rodrigo Monteiro Ribeiro, Fabiano Cordeiro Moreira, Manoel Odorico de Moraes Filho, Maria Elisabete Amaral de Moraes, Lucas Eduardo Botelho de Souza, Andre Salim Khayat, Caroline Aquino Moreira-Nunes
Summary: The circadian clock is a system that regulates physiological processes and responds to the external environment, while its disruption can lead to various diseases. Leukemia is a malignancy of the blood and bone marrow caused by alterations in cellular regulatory processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ryota Nakazato, Yuki Matsuda, Faryal Ijaz, Koji Ikegami
Summary: Clock genes regulate the length of primary cilia through circadian dynamics, which affects fibroblast migration. The length of primary cilia exhibits circadian oscillation and controls the migration of fibroblasts.
Article
Cell Biology
Waleed Hassan Almalki, Mohammed M. Ghoneim, Sultan Alshehri, Syed Sarim Imam, Imran Kazmi, Gaurav Gupta
Summary: Sleep and circadian rhythm disturbance are common in individuals with sepsis-related neurodegenerative illness, which may be caused by alteration in genomic expression linked with the immune-directed oxidative stress-inflammatory axis. Rare ailments often have connections with aberrant sleep and disturbance in the sleep-wake cycle.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Takashi Maejima, Yusuke Tsuno, Shota Miyazaki, Yousuke Tsuneoka, Emi Hasegawa, Md Tarikul Islam, Ryosuke Enoki, Takahiro J. Nakamura, Michihiro Mieda
Summary: The study found that specific deletion of vesicular GABA transporter in AVP neurons led to significant impairment of circadian rhythm and disruption of GABA-mediated synaptic transmission in SCN neurons. While molecular circadian oscillations among SCN neurons did not significantly change, there were significant alterations in the phase relationships between molecular clocks and circadian behavioral activities.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Victoria M. Alvord, Elizabeth J. Kantra, Julie S. Pendergast
Summary: Circadian rhythms are 24-hour cycles of behavior and physiology generated by molecular clocks in various tissues. The suprachiasmatic nucleus (SCN) serves as the main circadian clock in mammals, receiving light information and coordinating tissue clocks. Estrogens play a role in regulating biological processes and behavior by interacting with circadian genes. This review focuses on the interplay between estrogens and the circadian system in female rodents, summarizing current understanding of their effects.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tingting Li, Shihua Zhang, Yuxuan Yang, Lingli Zhang, Yu Yuan, Jun Zou
Summary: This paper reviews the progress of research on the co-regulation of bone metabolism by circadian clock genes and microRNAs, aiming to provide new ideas for the prevention and treatment of bone metabolic diseases such as osteoporosis.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Microbiology
Zala Zuzek, Lucija Raspor Dall'Olio, Katka Pohar, Alojz Ihan, Miha Moskon, Damjana Rozman, Ursa Kovac, Marjanca Starcic Erjavec
Summary: Research has shown that dysbiosis of gut microbiota can affect the circadian clock of mammalian hosts, highlighting the importance of genetic background of E. coli in influencing the host's circadian clock genes.
Article
Gastroenterology & Hepatology
Daniel Granados-Fuentes, Kevin Cho, Gary J. Patti, Rodolfo Costa, Erik D. Herzog, Sara Montagnese
Summary: Hyperammonaemia affects circadian regulation of rest-activity behavior by increasing extracellular glutamate levels in the suprachiasmatic nuclei.
LIVER INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Annika F. Barber, Shi Yi Fong, Anna Kolesnik, Michael Fetchko, Amita Sehgal
Summary: Regulation of circadian behavior and physiology by the Drosophila brain clock requires communication from central clock neurons to downstream output regions. Morning and evening clock neurons have time-of-day-dependent connectivity to the pars intercerebralis, which is regulated by specific peptides and fast neurotransmitters. This study provides insights into mechanisms by which clock neurons signal to nonclock cells to drive rhythms of behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Daniel DeWoskin, Jihwan Myung, Mino D. C. Belle, Hugh D. Piggins, Toru Takumi, Daniel B. Forger
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Neurosciences
Mino D. C. Belle, Hugh D. Piggins
EUROPEAN JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Sven Wegner, Mino D. C. Belle, Alun T. L. Hughes, Casey O. Diekman, Hugh D. Piggins
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Mino D. C. Belle, Casey O. Diekman
EUROPEAN JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Mino D. C. Belle, Alun T. L. Hughes, David A. Bechtold, Peter Cunningham, Massimo Pierucci, Denis Burdakov, Hugh D. Piggins
JOURNAL OF NEUROSCIENCE
(2014)
Article
Neurosciences
Kanwal Sakhi, Mino D. C. Belle, Nicole Gossan, Philippe Delagrange, Hugh D. Piggins
JOURNAL OF PHYSIOLOGY-LONDON
(2014)
Article
Neurosciences
Joseph W. S. Timothy, Natasza Klas, Harshmeena R. Sanghani, Taghreed Al-Mansouri, Alun T. L. Hughes, Greer S. Kirshenbaum, Vincent Brienza, Mino D. C. Belle, Martin R. Ralph, Steven J. Clapcote, Hugh D. Piggins
BIOLOGICAL PSYCHIATRY
(2018)
Article
Endocrinology & Metabolism
Tansi Khodai, Nicolas Nunn, Amy A. Worth, Claire H. Feetham, Mino D. C. Belle, Hugh D. Piggins, Simon M. Luckman
FRONTIERS IN ENDOCRINOLOGY
(2018)
Article
Neurosciences
Ben Collins, Sara Pierre-Ferrer, Christine Muheim, David Lukacsovich, Yuchen Cai, Andrea Spinnler, Carolina Gutierrez Herrera, Shao'Ang Wen, Jochen Winterer, Mino D. C. Belle, Hugh D. Piggins, Michael Hastings, Andrew Loudon, Jun Yan, Csaba Foldy, Antoine Adamantidis, Steven A. Brown
Article
Biochemistry & Molecular Biology
Jessica Rodgers, Beatriz Bano-Otalora, Mino D. C. Belle, Sarika Paul, Rebecca Hughes, Phillip Wright, Richard McDowell, Nina Milosavljevic, Patrycja Orlowska-Feuer, Franck P. Martial, Jonathan Wynne, Edward R. Ballister, Riccardo Storchi, Annette E. Allen, Timothy Brown, Robert J. Lucas
Summary: There is no consensus on the best inhibitory optogenetic tool. Gi/o signalling is a native mechanism of neuronal inhibition, and Lamprey Parapinopsin (Lamplight) can be used for optogenetic silencing by switching between stable signalling active and inactive states with different wavelengths. The properties of Lamplight can be applied to achieve switchable neuronal hyperpolarisation and suppression of spontaneous spike firing in specific brain regions. Expressing Lamplight in ON bipolar cells can photosensitise retinas following advanced photoreceptor degeneration, showing potential for scalable, sustained, and reversible optogenetic inhibition.
Article
Multidisciplinary Sciences
Beatriz Bano-Otalora, Franck Martial, Court Harding, David A. Bechtold, Annette E. Allen, Timothy M. Brown, Mino D. C. Belle, Robert J. Lucas
Summary: The study reveals an impact of daytime light intensity on SCN physiology and the amplitude of circadian rhythms, with lower daytime irradiance leading to a marked reduction in the amplitude of spontaneous activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Alun Thomas Lloyd Hughes, Rayna Eve Samuels, Beatriz Bano-Otalora, Mino David Charles Belle, Sven Wegner, Clare Guilding, Rebecca Catrin Northeast, Andrew Stewart Irvine Loudon, John Gigg, Hugh David Piggins
Summary: Studies have shown that daily scheduled voluntary exercise promotes suprachiasmatic nuclei (SCN) clock cell synchrony and robust 24-hour rhythms in behavior in mice. This suggests the potential utility of regular exercise as a non-invasive intervention for the elderly or mentally ill individuals with poorly aligned circadian rhythms.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biology
Beatriz Bano-Otalora, Matthew J. Moye, Timothy Brown, Robert J. Lucas, Casey O. Diekman, Mino D. C. Belle
Summary: The study revealed that SCN neurons in the diurnal rodent Rhabdomys pumilio are more excited during daytime hours, but their evoked activity includes a suppressive response not present in nocturnal rodents. By investigating the evoked electrical activity, researchers confirmed the key role of transient subthreshold A-type potassium channels in this response.
Review
Physiology
Mino D. C. Belle, Charles N. Allen
CURRENT OPINION IN PHYSIOLOGY
(2018)