Article
Medicine, Research & Experimental
Jack P. Antel, Timothy E. Kennedy, Tanja Kuhlmann
Summary: In this study, the authors investigate the potential of targeting the neuron-oligodendrocyte potassium shuttling as a neuroprotective strategy in multiple sclerosis. They examine disease models, evaluate the impact of pharmacologic intervention, and assess the status in tissues from MS patients. These findings serve as a template for defining a potential protective pathway.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Urology & Nephrology
Suzanne M. Biers, Chris Harding, Mo Belal, Nikesh Thiruchelvam, Rizwan Hamid, Arun Sahai, Richard Parkinson, Rachel Barratt, Ased Ali, Sheilagh Reid
Summary: The BAUS has issued guidelines on the assessment and management of female voiding dysfunction, covering a wide range of conditions that can cause this issue. The aim is to optimize assessment and treatment pathways for patients with voiding dysfunction, providing guidance in the absence of a known underlying neurological condition.
Review
Biochemistry & Molecular Biology
Alexander V. Blagov, Vasily N. Sukhorukov, Alexander N. Orekhov, Margarita A. Sazonova, Alexandra A. Melnichenko
Summary: This article reviews the role of mitochondrial dysfunction in the pathogenesis of multiple sclerosis and proposes new therapeutic strategies to restore mitochondrial function in this disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Rose Khavari, Khue Tran, Santosh A. Helekar, Zhaoyue Shi, Christof Karmonik, Hamida Rajab, Blessy John, Ali Jalali, Timothy Boone
Summary: This study investigated the therapeutic effects and safety of Transcranial Rotating Permanent Magnet Stimulator (TRPMS) in treating urinary retention in female patients with multiple sclerosis (MS). The results showed that TRPMS effectively improved bladder emptying function in MS patients, which was supported by both neuroimaging and clinical data.
JOURNAL OF UROLOGY
(2022)
Review
Clinical Neurology
Vasileios Giannopapas, Dimitrios Kitsos, Anthi Tsogka, John S. Tzartos, Georgios Paraskevas, Georgios Tsivgoulis, Konstantinos Voumvourakis, Sotirios Giannopoulos, Daphne Bakalidou
Summary: This review explores possible therapeutic options for managing sexual dysfunction in people with multiple sclerosis (MS). A thorough search of the PubMed Medline database was conducted and 9 relevant records were identified. Pharmacological approaches investigated the effectiveness of sildenafil, tadalafil and onabotulinumtoxinA, while non-pharmacological interventions examined aquatic exercises, pelvic floor exercises, and the use of assistive devices, among others.
NEUROLOGICAL SCIENCES
(2023)
Article
Urology & Nephrology
Floriane Michel, Fabiana Cancrini, Henri Bensadoun, Olivier Cussenot, Cyrille Guillot-Tantay, Morgan Roupret, Gilles Karsenty, Veronique Phe
Summary: This study evaluated the incidence of bladder cancer (BCa) in patients with neurological diseases that cause neurogenic lower urinary tract dysfunction (multiple sclerosis, spinal cord injury, and spina bifida). The study found that the incidence of BCa was highest in patients with spinal cord injury, with an overall incidence of 174.9/100,000 persons/year in France.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Zhaoyue Shi, Khue Tran, Christof Karmonik, Timothy Boone, Rose Khavari
Summary: This study evaluated the feasibility of using resting state fMRI to study bladder-related networks and found that voiding process is achieved through similar network connections in all subjects. The resting-state network closely resembles the task-based bladder-related network during voiding, but not in other states.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Medicine, General & Internal
Hueih-Ling Ong, Hann-Chorng Kuo
Summary: This study evaluated the long-term effectiveness of transurethral incision of the bladder neck (TUI-BN) with or without an additional procedure for female voiding dysfunction. The success rate of the first TUI-BN was 29.4% and increased to 66.7% after combining TUI-BN and an additional procedure. TUI-BN alone or in combination with an additional procedure was safe, effective, and durable in patients with detrusor underactivity to resume spontaneous voiding.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
James F. Sumowski, Sam Horng, Rachel Brandstadter, Stephen Krieger, Victoria M. Leavitt, Ilana Katz Sand, Michelle Fabian, Sylvia Klineova, Robin Graney, Claire S. Riley, Fred D. Lublin, Aaron E. Miller, Andrew W. Varga
Summary: The study found that about 40% of early MS patients experience sleep disturbance, which is associated with memory dysfunction.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Clinical Neurology
Jenny A. Nij Bijvank, Sam N. Hof, Stefanos E. Prouskas, Menno M. Schoonheim, Bernard M. J. Uitdehaag, Laurentius J. van Rijn, Axel Petzold
Summary: Double-step saccades can serve as a robust metric for evaluating clinical, cognitive, and visual functioning, as well as global and local grey matter atrophy in multiple sclerosis, making it a potential new outcome measure for remyelination trials.
Article
Clinical Neurology
Bisecco Alvino, Fornasiero Arianna, Bianco Assunta, Cortese Antonio, D'Amico Emanuele, Mataluni Giorgia, Sinisi Leonardo, Spitaleri Daniele, Docimo Renato, Maria Chiara Buscarinu, Mirabella Massimiliano, Sebastiano Giuseppe Crisafulli, Zanghi Aurora, Carolina Gabri Nicoletti, Salvetti Marco, Baione Viola, Patti Francesco, Alessandra Girolama Marfia, Sibilia Grazia, Scarano Valentina, Orlando Davide, Stabile Giovanni, Tedeschi Gioacchino, Antonio Gallo
Summary: This study confirms a relatively high prevalence of moderate/severe bowel dysfunction in a large, multicenter, unselected outpatient multiple sclerosis population, mainly associated with female sex and MS-related disability.
JOURNAL OF NEUROLOGY
(2022)
Article
Urology & Nephrology
Zhaoyue Shi, Christof Karmonik, Amelia Soltes, Khue Tran, John A. Lincoln, Timothy Boone, Rose Khavari
Summary: This study aims to identify the altered brain network associated with bladder function in multiple sclerosis (MS) women with voiding dysfunction through comparisons with healthy subjects. The study found that healthy individuals showed stronger functional connectivity in regions involved in bladder filling and suppression of voiding compared to MS patients. Moreover, healthy subjects exhibited stronger functional connectivity in the right inferior frontal gyrus during (attempt at) voiding initiation compared to MS patients.
NEUROUROLOGY AND URODYNAMICS
(2022)
Article
Clinical Neurology
Seyed Massood Nabavi, Maryam Dastoorpoor, Nastaran Majdinasab, Narges Khodadadi, Narges Khanjani, Zohreh Sekhavatpour, Maryam Zamanian, Sasan Kazemian, Amir Ebrahim Eftekhari, Fereshteh Ashtari, Roya Abolfazli, Mahdi Jalili, Gholamhossein Ghaedi, Hamid Reza Ghalianchi
Summary: This study aimed to assess the prevalence of sexual dysfunction (SD) and its related risk factors in men with multiple sclerosis (MS) in Iran. The results revealed a relatively high prevalence of SD in these male MS patients, with age, MSISQ-19, and SQOL-M identified as the only independent predictive factors for SD. Patients with MS in Iran should be screened, diagnosed, and treated for SD and influencing factors based on these findings.
NEUROLOGY AND THERAPY
(2021)
Article
Neurosciences
Yu Shao, Chen Chen, Tao Zhu, Zengxian Sun, Shufen Li, Lifen Gong, Xinyan Dong, Weida Shen, Linghui Zeng, Yicheng Xie, Peifang Jiang
Summary: A recent study demonstrates the protective role of TRPM2 gene in progressive multiple sclerosis, showing that it improves disease symptoms by regulating NLRP3 inflammasome activation, which suggests a potential therapeutic target for MS.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Luigi Fiondella, Francesco Cavallieri, Elena Canali, Maria Paola Cabboi, Alessandro Marti, Francesca Sireci, Alena Fiocchi, Gloria Montanari, Sara Montepietra, Franco Valzania
Summary: The simultaneous occurrence of relapsing remitting multiple sclerosis (RRMS) and amyotrophic lateral sclerosis (ALS) is rare. This case report describes a 49-year-old woman with a history of RRMS who developed progressive weakness in her left arm. The patient's father had ALS, and her paternal uncle had Parkinson's disease. Imaging and electromyography confirmed the co-occurrence of RRMS and ALS in this patient.
