Evaluation of the Cardiac Safety of Long-Acting Endectocide Moxidectin in a Randomized Concentration-QT Study

Single dose moxidectin versus ivermectin for Onchocerca volvulus infection in Ghana, Liberia, and the Democratic Republic of the Congo: a randomised, controlled, double-blind phase 3 trial

(2018) Nicholas O Opoku et al.   LANCET

How do the macrocyclic lactones kill filarial nematode larvae?

(2016) Adrian J. Wolstenholme et al.   INVERTEBRATE NEUROSCIENCE

Results From the IQ-CSRC Prospective Study Support Replacement of the Thorough QT Study by QT Assessment in the Early Clinical Phase

(2015) B Darpo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Implications of the IQ-CSRC Prospective Study: Time to Revise ICH E14

(2015) Borje Darpo et al.   DRUG SAFETY

Cardiac Safety Research Consortium: Can the thorough QT/QTc study be replaced by early QT assessment in routine clinical pharmacology studies? Scientific update and a research proposal for a path forward

(2014) Borje Darpo et al.   AMERICAN HEART JOURNAL

Detection of QTc Effects in Small Studies-Implications for Replacing the Thorough QT Study

(2014) Georg Ferber et al.   ANNALS OF NONINVASIVE ELECTROCARDIOLOGY

The role of concentration−effect relationships in the assessment of QTcinterval prolongation

(2014) Nicholas P. France et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A Randomized, Single-Ascending-Dose, Ivermectin-Controlled, Double-Blind Study of Moxidectin in Onchocerca volvulus Infection

(2014) Kwablah Awadzi et al.   PLoS Neglected Tropical Diseases

The IQ-CSRC Prospective Clinical Phase 1 Study: “Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?”

(2013) Borje Darpo et al.   ANNALS OF NONINVASIVE ELECTROCARDIOLOGY

The Effect of a High-Fat Breakfast on the Pharmacokinetics of Moxidectin in Healthy Male Subjects: A Randomized Phase I Trial

(2012) Joan M. Korth-Bradley et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Relative Bioavailability of Liquid and Tablet Formulations of the Antiparasitic Moxidectin

(2012) J. M. Korth-Bradley et al.   Clinical Pharmacology in Drug Development

Excretion of Moxidectin into Breast Milk and Pharmacokinetics in Healthy Lactating Women

(2011) Joan M. Korth-Bradley et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Concentration-QT Relationships Play a Key Role in the Evaluation of Proarrhythmic Risk During Regulatory Review

(2007) Christin E. Garnett et al.   JOURNAL OF CLINICAL PHARMACOLOGY