The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease
出版年份 2015 全文链接
标题
The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease
作者
关键词
-
出版物
JOURNAL OF NEUROCHEMISTRY
Volume 135, Issue 1, Pages 4-18
出版商
Wiley
发表日期
2015-07-02
DOI
10.1111/jnc.13234
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Efficient Modification of Alpha-Synuclein Serine 129 by Protein Kinase CK1 Requires Phosphorylation of Tyrosine 125 as a Priming Event
- (2014) Jonas Kosten et al. ACS Chemical Neuroscience
- Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment
- (2014) Anne-Maria Poehler et al. Autophagy
- LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis
- (2014) A. Raquel Esteves et al. EXPERIMENTAL NEUROLOGY
- Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells
- (2014) Rita Perfeito et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner
- (2014) Guowei Yin et al. NEUROBIOLOGY OF DISEASE
- Transgenic mice expressing S129 phosphorylation mutations in α-synuclein
- (2014) Valerie Drews Escobar et al. NEUROSCIENCE LETTERS
- Modelling Ser129 Phosphorylation Inhibits Membrane Binding of Pore-Forming Alpha-Synuclein Oligomers
- (2014) Georg Sebastian Nübling et al. PLoS One
- Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease
- (2014) Sandra Tenreiro et al. PLoS Genetics
- Tenuigenin Attenuatesα-Synuclein-Induced Cytotoxicity by Down-Regulating Polo-Like Kinase 3
- (2013) Jin-Xia Zhou et al. CNS Neuroscience & Therapeutics
- Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
- (2013) David J. Irwin et al. NATURE REVIEWS NEUROSCIENCE
- Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease
- (2013) Fabia Febbraro et al. NEUROBIOLOGY OF DISEASE
- In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 α-synuclein phosphorylation in mouse brain
- (2013) M. Bergeron et al. NEUROSCIENCE
- Large -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
- (2013) B.-K. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context
- (2012) Vicente Sancenon et al. HUMAN MOLECULAR GENETICS
- Phosphorylation of α-Synuclein Protein at Ser-129 Reduces Neuronal Dysfunction by Lowering Its Membrane Binding Property inCaenorhabditis elegans
- (2012) Tomoki Kuwahara et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human -Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease
- (2012) A. Oueslati et al. JOURNAL OF NEUROSCIENCE
- Accumulation of Toxic -Synuclein Oligomer within Endoplasmic Reticulum Occurs in -Synucleinopathy In Vivo
- (2012) E. Colla et al. JOURNAL OF NEUROSCIENCE
- Elucidating the Role of C-Terminal Post-Translational Modifications Using Protein Semisynthesis Strategies: α-Synuclein Phosphorylation at Tyrosine 125
- (2012) Mirva Hejjaoui et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The many faces of α-synuclein: from structure and toxicity to therapeutic target
- (2012) Hilal A. Lashuel et al. NATURE REVIEWS NEUROSCIENCE
- Impaired neurotransmission caused by overexpression of -synuclein in nigral dopamine neurons
- (2012) M. Lundblad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphorylated -Synuclein in Parkinson's Disease
- (2012) Y. Wang et al. Science Translational Medicine
- Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra
- (2012) A L McCormack et al. Cell Death & Disease
- Phosphorylation of α-Synuclein at Y125 and S129 Alters Its Metal Binding Properties: Implications for Understanding the Role of α-Synuclein in the Pathogenesis of Parkinson’s Disease and Related Disorders
- (2011) Yu Lu et al. ACS Chemical Neuroscience
- Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson’s disease
- (2011) Jinxia Zhou et al. ACTA NEUROPATHOLOGICA
- Autophagy in Dementias
- (2011) Christine Lund Kragh et al. BRAIN PATHOLOGY
- Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease
- (2011) Penelope G. Foulds et al. FASEB JOURNAL
- Effect of Ser-129 Phosphorylation on Interaction of α-Synuclein with Synaptic and Cellular Membranes
- (2011) Naomi P. Visanji et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of -Synuclein
- (2011) D. Ebrahimi-Fakhari et al. JOURNAL OF NEUROSCIENCE
- Explaining the Structural Plasticity of α-Synuclein
- (2011) Orly Ullman et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Low-resolution structure of a vesicle disrupting -synuclein oligomer that accumulates during fibrillation
- (2011) L. Giehm et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Pathologic Cascade Leading to Synaptic Dysfunction in -Synuclein-Induced Neurodegeneration
- (2010) D. A. Scott et al. JOURNAL OF NEUROSCIENCE
- Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits -Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions
- (2010) K. E. Paleologou et al. JOURNAL OF NEUROSCIENCE
- Characterization of kinases involved in the phosphorylation of aggregated α-synuclein
- (2010) Elisa A. Waxman et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
- (2010) Venu M. Nemani et al. NEURON
- Phosphorylation of α-synuclein upregulates tyrosine hydroxylase activity in MN9D cells
- (2009) Bo Wu et al. ACTA HISTOCHEMICA
- Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications
- (2009) Hong Qing et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Phosphorylation of Synucleins by Members of the Polo-like Kinase Family
- (2009) Martial K. Mbefo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson’s disease pathogenesis
- (2009) Kai-Yin Chau et al. JOURNAL OF NEUROCHEMISTRY
- α-Synuclein S129 Phosphorylation Mutants Do Not Alter Nigrostriatal Toxicity in a Rat Model of Parkinson Disease
- (2009) Nikolaus R. McFarland et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in -Synuclein Models of Parkinson's and Lewy Body Diseases
- (2009) B. Spencer et al. JOURNAL OF NEUROSCIENCE
- Exogenous -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
- (2009) K. C. Luk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphorylation, lipid raft interaction and traffic of α-synuclein in a yeast model for Parkinson
- (2008) Piotr Zabrocki et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Semi-quantitative analysis of α-synuclein in subcellular pools of rat brain neurons: An immunogold electron microscopic study using a C-terminal specific monoclonal antibody
- (2008) Ling Zhang et al. BRAIN RESEARCH
- Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration
- (2008) Brit Mollenhauer et al. EXPERIMENTAL NEUROLOGY
- Serine 129 Phosphorylation of α-Synuclein Induces Unfolded Protein Response-mediated Cell Death
- (2008) Naoto Sugeno et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein
- (2008) Katerina E. Paleologou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System
- (2008) Kelly J. Inglis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Specificity and Regulation of Casein Kinase-Mediated Phosphorylation of α-Synuclein
- (2008) Elisa A. Waxman et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Proteomics Analysis Identifies Phosphorylation-dependent α-Synuclein Protein Interactions
- (2008) Melinda A. McFarland et al. MOLECULAR & CELLULAR PROTEOMICS
- Phosphorylation of tau and α-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer’s disease, and in Parkinson’s disease and related α-synucleinopathies
- (2008) G. Muntané et al. NEUROSCIENCE
- Cerebrospinal fluid α-synuclein in neurodegenerative disorders—A marker of synapse loss?
- (2008) Annika Öhrfelt et al. NEUROSCIENCE LETTERS
- The phosphorylation state of Ser-129 in human -synuclein determines neurodegeneration in a rat model of Parkinson disease
- (2008) O. S. Gorbatyuk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now