Prostaglandin E2 and IL-23 plus IL-1β Differentially Regulate the Th1/Th17 Immune Response of Human CD161+CD4+ Memory T Cells

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC

(2010) Laura Maggi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

(2010) Philip P. Ahern et al.   IMMUNITY

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment

(2010) K. Nistala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-γ production by memory CD4+ T cells

(2009) Giorgio Napolitani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differential regulation of interleukin 17 and interferon   production in inflammatory bowel disease

(2009) L. Rovedatti et al.   GUT

Interleukin-23/Th17 pathways and inflammatory bowel disease

(2009) Clara Abraham et al.   INFLAMMATORY BOWEL DISEASES

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

(2009) Melanie A. Kleinschek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

(2009) Katia Boniface et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion

(2009) Chengcan Yao et al.   NATURE MEDICINE

Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion

(2008) C. Chizzolini et al.   BLOOD

Human interleukin 17–producing cells originate from a CD161+CD4+T cell precursor

(2008) Lorenzo Cosmi et al.   JOURNAL OF EXPERIMENTAL MEDICINE