期刊
ANNALES D ENDOCRINOLOGIE
卷 76, 期 6, 页码 650-657出版社
MASSON EDITEUR
DOI: 10.1016/j.ando.2015.10.009
关键词
Osteoporosis; Denosumab; Fracture risk; Renal insufficiency; Safety
Denosumab is an anti-RANK ligand (RANKL) monoclonal antibody approved for the treatment of postmenopausal osteoporosis and prevention of skeletal metastasis complications. Administered subcutaneously every 6 months, it reduces the risk of vertebral fracture by 70% and of hip fracture by 40%. Its safety profile is acceptable. Denosumab may be used to treat patients with moderate to severe renal insufficiency. It has anti-fracture activity equivalent to that of zoledronic acid, but no residual effect, and no action at all beyond 6 months. In France, denosumab is reimbursed as a second-line treatment after a first attempt with bisphosphonate. (C) 2015 Elsevier Masson SAS. All rights reserved.
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