Article
Polymer Science
Xiaowen Xu, Valentin Victor Jerca, Richard Hoogenboom
Summary: This manuscript reports the fabrication of metallo-supramolecular hydrogels using btp-functionalized star PEG precursors. Compared to previous linear systems, this method is more easily accessible and yields stronger hydrogels. The gelation is induced by Ni2+ ions and strongly depends on the metal-ligand ratio and polymer concentration.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Physical
Mariya Chernobryva, Majid Motevalli, Chris S. Hawes, Michael Watkinson
Summary: The steric influences of triazole side chains in two tripodal chelating ligands were explored through structural studies of four new d-block metal complexes. The structural analysis provides new insights into the breadth of coordination geometries and intermolecular packing modes available to this important class of chelating ligand.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Ivy L. Librando, Abdallah G. Mahmoud, Sonia A. C. Carabineiro, M. Fatima C. Guedes da Silva, Carlos F. G. C. Geraldes, Armando J. L. Pombeiro
Summary: A group of Cu(I) complexes with DAPTA phosphine ligands were immobilized on activated carbon and multi-walled carbon nanotubes for efficient catalysis in the one-pot synthesis of 1,2,3-triazoles via azide-alkyne cycloaddition reaction. The immobilized catalysts showed high catalytic activity and could be easily recovered and reused up to four consecutive cycles.
Article
Chemistry, Multidisciplinary
Puneet Singh Gahlaut, Deepak Gautam, Prem Lama, Barun Jana
Summary: A modified click reaction between 2-azidopyridine and di(prop-2-yn-1-yl)phthalate produces a novel bis(1,2,3-triazolyl-pyridine) ligand on an ortho-phthalic acid platform. The ligand can form transition metal complexes through selective N-3 coordination. The formed PdCl2[bptmp] complex acts as a highly effective catalyst for the Suzuki-Miyaura coupling reaction in a water/ethanol solvent combination.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Pavel S. Gribanov, Anna N. Philippova, Maxim A. Topchiy, Lidiya Minaeva, Andrey F. Asachenko, Sergey N. Osipov
Summary: An efficient method for accessing novel 5-(het)arylamino-1,2,3-triazole derivatives has been developed using Buchwald-Hartwig cross-coupling reaction. The most active catalyst for the process, palladium complex [(THP-Dipp)Pd(cinn)Cl] with expanded-ring N-heterocyclic carbene ligand, affords the target molecules in high yields.
Review
Chemistry, Inorganic & Nuclear
Konrad Kowalski
Summary: Cancer is a leading cause of death worldwide. This review emphasizes the significance of metal-catalyzed azide-alkyne cycloaddition reactions in synthesizing ferrocenyl-x-1,2,3-triazolyl-R compounds with anticancer activity. The review discusses over 160 ferrocenyl-triazoles and their classification into four categories based on their chemical properties. The study demonstrates that copper-catalyzed azide-alkyne cycloaddition reactions are particularly important in yielding the highest number of ferrocenyl-x-1,2,3-triazolyl compounds with anticancer activity. Oxidative stress and reactive oxygen species generation are identified as common mechanisms through which the ferrocenyl moiety contributes to the anticancer activity of 1,2,3-triazolyl derivatives. The review contains 23 figures, 24 schemes, and 208 references.(c) 2022 Elsevier B.V. All rights reserved.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Organic
Avetik G. Gevondian, Yury N. Kotovshchikov, Gennadij Latyshev, Nikolay Lukashev, Irina P. Beletskaya
Summary: A straightforward domino approach has been developed for the assembly of benzoxazole-derived sulfonamides, based on the in situ generation of diazo compounds from readily available starting material followed by denitrogenative transformation. The method is operationally simple, with a broad substrate scope and generally good yields, providing a library of target compounds.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Zita G. Rios-Malvaez, Ma-Angeles Cano-Herrera, Juan Carlos Davila-Becerril, Gustavo Mondragon-Solorzano, Maria Teresa Ramirez-Apan, David Morales-Morales, Joaquin Barroso-Flores, Jonnathan G. Santillan-Benitez, M. V. Basavanag Unnamatla, Marco Antonio Garcia-Eleno, Nelly Gonzalez-Rivas, Erick Cuevas-Yanez
Summary: A novel series of 4-(1,2,3-triazol-1-yl) salicylic acid derivatives were synthesized and their selective activity against various tumoral cell lines was explored in vitro. Molecular docking studies suggested a strong interaction between some compounds and ARG-154 in STAT3.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Review
Chemistry, Inorganic & Nuclear
Emmanuel B. Patricio-Rangel, Veronica Salazar-Pereda, Omar Cortezano-Arellano, Daniel Mendoza-Espinosa
Summary: The chemistry of multinuclear metal complexes supported by N-heterocyclic carbene (NHC) ligands, especially those supported by mesoionic (MIC) 1,2,3-triazolylidenes, has attracted significant attention due to their postulated superior donor capacity compared to classical NHC ligands. Despite the availability of synthetic routes for MIC-based ligands with various substitution levels, the coordination chemistry of triazolylidenes is still mainly dominated by mononuclear complexes. Recent progress on the design and synthesis of multinuclear triazolylidene complexes, ranging from di- to tetranuclear species, is discussed with emphasis on their structural features, electronic properties, and catalytic applications.
DALTON TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Francesca Begini, Renata A. Balaguez, Allya Larroza, Eric F. Lopes, Eder Joao Lenardao, Claudio Santi, Diego Alves
Summary: This study presents a simple method to synthesize 4-arylselanyl-1H-1,2,3-triazoles from selenium-containing carbinols in a one-pot strategy, with moderate to good yields including quinoline and Zidovudine derivatives. One-pot protocols are essential for addressing concerns about waste production and solvent consumption, while also producing interesting by-products with alkynylselenium moieties connected to the triazole.
Review
Chemistry, Multidisciplinary
Lozan Todorov, Irena Kostova
Summary: The urgent need for innovative antimicrobial therapeutics is emphasized by the emergence of drug-resistant bacterial and fungal pathogens. Transition metal complexes with biologically active ligands have long been investigated for their antimicrobial activity. However, there has been surprisingly little research and experimentation reported in scientific literature regarding potential antimicrobial 1,2,3-triazole complexes with transition metals. This mini-review aims to highlight the current research efforts and emphasize the untapped potential for novel and effective medicinal substances in this field.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Nasrin Moeini-Eghbali, Hossein Eshghi
Summary: In this study, a new and selective nanocatalyst (Fe3O4@S-TiO2/Cu) was synthesized by incorporating sulfur heteroatoms onto Fe3O4@TiO2 substrate as a ligand to stabilize copper nanoparticles. The Fe3O4@S-TiO2/Cu nanorods were characterized using various techniques and showed high catalytic activity in preparing triazole derivatives. The nanocatalyst exhibited advantages such as high regioselectivity, short reaction times, easy separation, and recyclability.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Aman Kumar, Kashmiri Lal, Nisha Poonia, Ashwani Kumar, Anil Kumar
Summary: A diverse series of imine linked 1,2,3-triazole hybrids were synthesized via Cu(I)-promoted click reaction, and their structures were characterized using various spectral techniques. Among them, 7d exhibited the highest antimicrobial activity against R. oryzae and S. aureus. Docking studies revealed that some triazole hybrids showed high potency towards E. coli DNA gyrase and C. albicans sterol 14-alpha demethylase.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Chemistry, Medicinal
Nayera W. Hassan, Ahmed Sabt, Maryam A. Z. El-Attar, Mikko Ora, Alaa El-Din A. Bekhit, Kikuko Amagase, Adnan A. Bekhit, Ahmed S. F. Belal, Perihan A. Elzahhar
Summary: According to WHO statistics, leishmaniasis is a neglected tropical disease that affects 700,000 to 1 million people annually. Researchers have designed and synthesized a new series of coumarin-1,2,3-triazole hybrid compounds that exhibit higher activity against L. major parasites than miltefosine. These compounds showed strong anti-leishmanial effects, with three of them demonstrating submicromolar potencies. Mechanistic studies revealed that folic and folinic acids reduced the anti-leishmanial effects of these compounds. Docking simulation studies supported the observed biological activities and highlighted the selectivity of these compounds.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Olga V. Ryzhikova, Kseniya N. Sedenkova, Sergey V. Kositov, Victor A. Tafeenko, Yuri K. Grishin, Elena B. Averina
Summary: In this study, a series of hydroxyalkyltriazoles with a cyclooctane core were synthesized by reacting azidoalcohols or diazidodiols with phenylacetylene. It was found that one of the obtained compounds can act as an effective ligand for CuAAC reactions. X-ray diffraction analysis revealed that this compound forms a complex with copper ions by coordinating only one N-atom of the triazole ring.
Article
Chemistry, Multidisciplinary
Abu Talha Aqueel Ahmed, Sankar Sekar, Shubhangi S. Khadtare, Nurul Taufiqu Rochman, Bathula Chinna, Abu Saad Ansari
Summary: In this study, MnCo2S4 nanosheet catalyst was successfully synthesized and found to exhibit superior performance in hydrogen evolution. Compared to MnCo2S4, MnCo2S4 showed low overpotentials, moderate Tafel slope, and excellent sustainability. The outstanding performance can be attributed to the increased number of electrochemically active sites and enhanced electronic conductivity on the catalyst surface.
Article
Chemistry, Multidisciplinary
Victor V. Maltsev, Elena A. Volkova, Elizaveta V. Koporulina, Diana D. Mitina, Vladimir L. Kosorukov, Anna I. Jiliaeva, Daniil A. Naprasnikov, Konstantin N. Gorbachenya, Viktor E. Kisel
Summary: The phase relationships, crystal properties and luminescence kinetics of two complex systems were studied, including unit cell parameters, segregation coefficients of impurities, and lifetimes of energy levels.
Article
Chemistry, Multidisciplinary
Xiaoman Zhang, Wangwang Xu, W. J. Meng, Andrew C. Meng
Summary: This study successfully grew high-quality single crystal AlScN nanowires through ultra-high vacuum reactive sputtering technique and characterized their structure and properties. The nanowires exhibit significantly reduced mosaic spread and predominantly single ferroelectric domains, as well as a high piezoelectric constant.
Article
Chemistry, Multidisciplinary
Tom E. de Vries, Elias Vlieg, Rene de Gelder
Summary: Networks are important for describing relationships between people, roads between cities, reactions between chemicals, and other interactions. Bipartiteness, dividing the network into two groups, can facilitate the study of the network's structure. We have developed an algorithm that can find a near-optimal bipartisation within a reasonable time frame and used it to uncover the hidden structure of the CSD cocrystal network.
Article
Chemistry, Multidisciplinary
Chuchu Han, Jing Yang, Xin Zhang, Aisen Li, Jiang Peng
Summary: An elastic crystal based on a photo-reactive acylhydrazone derivative is reported, which exhibits reversible bending behavior under UV irradiation and heating. The crystal undergoes reversible E<->Z isomerization under light and heating conditions. The crystal demonstrates excellent elastic properties and the bending can be controlled to control the output direction of red light.
Article
Chemistry, Multidisciplinary
Lingfeng Zhang, Yu Wang, Yefeng Wang, Shuai Liu, Na Zhang, Mingmin Yang, Haixia Ma, Zhaoqi Guo
Summary: This study designs and synthesizes a series of high-energy salts compounds without heavy metal ions and azide groups. The molecular structures and stability of the compounds are confirmed through single-crystal X-ray diffraction and intermolecular interaction analysis. Furthermore, the thermal stability, energetic properties, and electrical initiation properties of the compounds are investigated, suggesting their potential as primary explosives.