Article
Dentistry, Oral Surgery & Medicine
Francyenne Maira Castro Goncalves, Alberto Carlos Botazzo Delbem, Leonardo Fernandes Gomes, Nayara Goncalves Emerenciano, Juliano Pelim Pessan, Giovana Dornelas Azevedo Romero, Mark L. Cannon, Marcelle Danelon
Summary: The study demonstrated that the combination treatment of 1100 F-TMP and MI Paste Plus (R) had the best effect on enamel remineralization, significantly increasing subsurface hardness and promoting an increase in calcium and phosphorus concentrations.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Moufida Abufarwa, Amal Noureldin, Phillip M. Campbell, Peter H. Buschang
Summary: The study demonstrated that reapplication of CPP-ACP fluoride varnish every 4-6 weeks is more effective in reducing enamel demineralization compared to every 12 weeks. Significant differences were found in the changes of demineralization area and impact among different time intervals, while intensity remained relatively stable.
JOURNAL OF DENTISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Seok-Min Choi, Hee-Won Jung, Ji Hyun Ryu, Hyung-Keun You
Summary: This study evaluated the remineralization of tooth enamel using one-pot coating with polydopamine and fluoride ions. The results showed that enamel coated with polydopamine and fluoride ions had the highest fluoride content and the lowest reduction in hardness. Scanning electron microscopy further supported the effect of the coating on enamel remineralization.
Article
Nanoscience & Nanotechnology
Youna Paik, Min Joo Kim, Hyeryeong Kim, Sun-Woo Kang, Youn-Kyung Choi, Yong-Il Kim
Summary: The study aimed to evaluate the remineralization effect of calcium phosphate ion clusters (CPICs) on demineralized enamel surfaces and their effects on bracket shear bond strength. The results showed that CPIC treatment led to epitaxial growth of enamel, a decrease in demineralized enamel thickness, an increase in Ca/P ratio, and an improvement in microhardness. The radiolucency gradually decreased with longer CPIC treatment. The shear bond strength and adhesive remnant index results indicated improved bonding stability after CPIC treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mina Biria, Parastoo Iranparvar, Seyyed Mostafa Fatemi, Mostafa Nejadian, Negin Eslamiamirabadi
Summary: The study revealed that CPP-ACP toothpaste significantly increased surface microhardness of enamel. All three toothpastes showed significant remineralization effects on early enamel lesions, with increased microhardness values within 30 days.
PEDIATRIC DENTISTRY
(2021)
Article
Materials Science, Ceramics
Marta Kalbarczyk, Aleksandra Szczes
Summary: Polyphasic calcium phosphates were synthesized using raw non-calcined eggshells as a source of calcium via low-cost precipitation method. The material composition, morphology, calcium release profile, and enamel remineralization potential were influenced by the initial pH value.
CERAMICS INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Ines Cardoso-Martins, Sofia Pessanha, Ana Coelho, Sofia Arantes-Oliveira, Paula F. Marques
Summary: This study evaluated the efficacy of CPP-ACP tooth mousse in remineralizing MIH-affected enamel and found that treatment with CPP-ACP tooth mousse improved the mineral density and organization of hypomineralized enamel.
Article
Crystallography
Go Inoue, Xuefei Chen, Yasushi Shimada
Summary: This study evaluated the effects of phosphoryl-oligosaccharides of calcium (POs-Ca) and/or fluoride-containing toothpaste on enamel. Results showed that high fluoride concentration had a better mineral recovery rate, while low fluoride concentration with POs-Ca showed a higher remineralization effect. The addition of POs-Ca and fluoride to toothpaste may help recover mineral density in enamel subsurface lesions at low fluoride concentrations.
Article
Engineering, Mechanical
Jiapin Peng, Lei Lei, Heng Xiao, Dan Yang, Jing Zheng, Zhongrong Zhou
Summary: Occlusal loading can promote the restoration of enamel anti-wear properties by enhancing remineralization. Remineralization enhancement through occlusal loading-induced nanoparticle fragmentation plays a significant role in preventing human teeth from excessive wear.
Article
Biotechnology & Applied Microbiology
Vincenzo Tosco, Flavia Vitiello, Riccardo Monterubbianesi, Maria Laura Gatto, Giulia Orilisi, Paolo Mengucci, Angelo Putignano, Giovanna Orsini
Summary: This study used SEM-EDX analysis to evaluate the loss of mineral content in early artificial lesions on enamel surfaces and assess the remineralizing potential of different agents. The results showed that all tested materials had a biomimetic ability in remineralizing lesions after 28 days of treatment. The experimental groups treated with remineralizing agents exhibited a structural reorganization of enamel prisms and no significant differences in Ca/P ratios compared to sound enamel.
BIOENGINEERING-BASEL
(2023)
Article
Chemistry, Physical
Yasushi Shimada, Takaaki Sato, Go Inoue, Hisaichi Nakagawa, Tomoko Tabata, Yuan Zhou, Noriko Hiraishi, Tadamu Gondo, Syunsuke Takano, Kei Ushijima, Hirotoshi Iwabuchi, Yukiko Tsuji, Sadr Alireza, Yasunori Sumi, Junji Tagami
Summary: The study evaluated the diagnostic accuracy of 3D swept-source optical coherence tomography (3D SS-OCT) for enamel caries at smooth tooth surface and found that it could clearly depict caries and also differentiate lesion remineralization.
Review
Engineering, Multidisciplinary
Lingyun Zhang, Yunfan Zhang, Tingting Yu, Liying Peng, Qiannan Sun, Bing Han
Summary: This article summarizes the characteristics and challenges of tooth enamel, as well as the research progress and potential applications of enamel-mimetic materials.
Article
Multidisciplinary Sciences
Kun Tian, Chengwei Xiao, Yue Chen, Min Zhou, Jun Guo, Xiaohua Ren, Qin Du
Summary: A proline-rich region was found in the surface antigen I/II of Streptococcus mutans. This region was compared with human amelogenin to explore its role in the cariogenic abilities of S. mutans. The study revealed differences between Ag I/II and amelogenin in terms of protein self-assembly, mineralization induction, and bacterial adhesion ability.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Edona Morina, Marius Dotter, Christoph Doepke, Ilda Kola, Tatjana Spahiu, Andrea Ehrmann
Summary: Nanofiber mats can be produced by electrospinning using different techniques, but the homogeneity of the mats is a concern. In this study, nanofiber mats were prepared using wire-based electrospinning and showed significant variations in thickness, mass per unit area, and porosity even in seemingly homogeneous areas.
Article
Polymer Science
Harshal Gade, Sreevalli Bokka, George G. Chase
Summary: This paper focuses on the polarization of electrospun PVDF fibers using a custom-made heat-stretch-poling method and studies the effects of stretching, heating, and electrical poling on filter characteristics and the beta phase. The results show that most treatments have a significant impact on filter performance, but little impact on the beta phase content.
Article
Chemistry, Multidisciplinary
Zhuping Yin, Liangfei Tian, Avinash J. Patil, Mei Li, Stephen Mann
Summary: This study describes a dynamic alginate/silk coacervate-based protocell model, where membrane-less droplets can be reversibly reconfigured and inflated into semipermeable coacervate vesicles by the spontaneous self-organization of amphiphilic silk polymers at the droplet surface under non-neutral charge conditions. The researchers found that the membranization process can be reversibly controlled endogenously by programming the pH within the protocells using an antagonistic enzyme system.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Ning Gao, Can Xu, Zhuping Yin, Mei Li, Stephen Mann
Summary: In this paper, we developed a caged protocell model that can control the dynamics of protocells by unlocking a stimuli-responsive membrane. The controlled and selective uptake of guest protocells into microdroplets was achieved by tailoring the surface properties of the protocells. The results highlight the potential for programming surface-contact interactions between artificial membrane-bounded compartments.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Multidisciplinary Sciences
Can Xu, Nicolas Martin, Mei Li, Stephen Mann
Summary: This study presents a living material assembly process that utilizes bacterial colonies to construct complex synthetic cells. These synthetic cells inherit diverse biological components and exhibit multifunctional properties. The ability to remodel these cells internally allows for the integration of additional features, providing opportunities for various applications.
Article
Multidisciplinary Sciences
Songyang Liu, Yanwen Zhang, Xiaoxiao He, Mei Li, Jin Huang, Xiaohai Yang, Kemin Wang, Stephen Mann, Jianbo Liu
Summary: The study presents the construction of a tubular prototissue-like vessel by spatially segregating chemically communicating populations of enzyme-decorated protocells in hydrogel modules. The vessel is capable of modulating the output of bioactive nitric oxide (NO) and inhibiting platelet activation and blood clot formation. This research highlights the potential of spatially organized synthetic prototissue modules for applications in anticoagulation.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Paco Lopez-Cuevas, Can Xu, Charlotte E. Severn, Tiah C. L. Oates, Stephen J. Cross, Ashley M. Toye, Stephen Mann, Paul Martin
Summary: This study demonstrates that silencing or knocking out a specific immune cell-expressed miRNA, microRNA-223 (miR223), can reduce cancer progression. By using miniature artificial protocells (PCs) to deliver anti-inflammatory miRNAs, the interactions between immune cells and cancer cells are altered, resulting in reduced tumor burden.
Review
Chemistry, Multidisciplinary
Ning Gao, Stephen Mann
Summary: Complex coacervate microdroplets derived from associative phase separation have shown great potential in constructing membraneless protocells. However, the lack of an enclosing membrane limits their functionality. In this Account, we present chemical strategies for the membranization of coacervate microdroplets and discuss their potential applications as functional materials. We hope that this Account will inspire further research and development in this field.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Qi-Zhi Zhong, Joseph J. J. Richardson, Yuan Tian, Haijiang Tian, Jiwei Cui, Stephen Mann, Frank Caruso
Summary: Metal-quinone networks (MQNs) have been developed as structurally tunable, universally adhesive, hydrophilic, and pH-degradable materials by coordinating metal ions with quinones through metal-acetylacetone coordination bonds. MQNs exhibit bidirectional pH-responsive disassembly and can be assembled into various forms such as particles, tubes, capsules, and films. Leveraging the tunable release ability of MQNs and the medicinal properties of quinones, MQN prodrugs with high drug loading are engineered for anti-cancer therapy and inhibition of the main protease in the SARS-CoV-2 virus.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Omar Rifaie-Graham, Jonathan Yeow, Adrian Najer, Richard Wang, Rujie Sun, Kun Zhou, Tristan N. Dell, Christopher Adrianus, Chalaisorn Thanapongpibul, Mohamed Chami, Stephen Mann, Javier Read de Alaniz, Molly M. Stevens
Summary: This study describes a non-equilibrium nanosystem that utilizes light-gated chemical communication, controllable feedback, and macroscopic oscillations. The system allows for communication between nanoreactors and induces chemical mechanical oscillations in a hydrogel using feedback loops.
Article
Chemistry, Multidisciplinary
Ali Heidari, Oya I. I. Sentuerk, Shuo Yang, Alex Joesaar, Pierangelo Gobbo, Stephen Mann, Tom F. A. de Greef, Seraphine V. V. Wegner
Summary: The authors developed a method to control the communication between sender-receiver pairs in a synthetic cell community through red and blue light illumination. They used photoswitchable membrane adhesion to self-assemble sender and receiver cells into different multicellular structures under red and blue light, allowing specific communication without interference. This work demonstrates the potential for designing orthogonal chemical communication networks in diverse synthetic cell communities.
Article
Chemistry, Multidisciplinary
Hannah Taylor, Ning Gao, Stephen Mann
Summary: We fabricate Janus-like calcium alginate hydrogel microspheres with spatially segregated populations using microfluidics. These microspheres serve as integrated platforms for domain-mediated chemical communication and programmable protocell-matrix dynamics. Our results offer new possibilities for the design and construction of spatially organized cytomimetic consortia capable of endogenous chemical processing and protocell-environment interactivity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yanwen Zhang, Zefeng Wang, Mei Li, Can Xu, Ning Gao, Zhuping Yin, Kemin Wang, Stephen Mann, Jianbo Liu
Summary: The design and construction of synthetic protocells capable of stimuli response and homeostatic regulation is an important challenge for synthetic protobiology. In this study, we demonstrate a reconfigurable model protocell based on osmotic reconfiguration of lipid-coated coacervate droplets into multicompartmentalized coacervate vesicles that can exhibit hypotonic stress-induced volume response and enhance enzyme reactions. The increased nitric oxide (NO) within the swollen vesicles can induce blood vessel vasodilation, showing potential applications in biomedicine, cellular diagnostics, and bioengineering.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Chengying Yin, Xingyu Jiang, Stephen Mann, Liangfei Tian, Bruce W. Drinkwater
Summary: The high throughput deposition of microscale objects with precise spatial arrangement is crucial in microfabrication technology. The utilization of dynamic acoustic fields offers a contactless approach to real-time reconfigurable miniaturized systems, with potential applications in various fields. This article discusses the physical interactions of microscale objects in an acoustic pressure field, the fabrication of acoustic trapping devices, methods to tune the spatial arrangement, and potential applications in different disciplines.
Article
Multidisciplinary Sciences
Zhijun Xu, Jiarui Qi, Shengliang Wang, Xiaoman Liu, Mei Li, Stephen Mann, Xin Huang
Summary: The researchers achieved sustainable hydrogen production for over 200 days by coating algal cells with an ultra-thin Fe(III)-doped polypyrrole inner layer and an outer exoskeleton of CaCO3. This cellular bionic approach enhances green hydrogen production under environmentally benign conditions.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Patrick J. Grimes, Mary Jenkinson-Finch, Henry E. Symons, Wuge H. Briscoe, Sebastien Rochat, Stephen Mann, Pierangelo Gobbo
Summary: The synthesis of a novel photocleavable, poly(ethylene) glycol-based crosslinker enables the realization of light-induced disassembly, pattern generation and membrane permeability modulation in protocells, opening up new avenues for the engineering of organized protocell networks and micro-compartmentalized systems for information storage and release.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Zhuping Yin, Ning Gao, Can Xu, Mei Li, Stephen Mann
Summary: This article describes a self-driven, endosymbiotic-like pathway where proteinosomes are captured within membranized alginate/silk fibroin coacervate vesicles by guest-mediated reconfiguration. The interchange of coacervate vesicle and droplet morphologies through proteinosome-mediated activity produces discrete nested communities with integrated catalytic activity and selective disintegration.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Abu Talha Aqueel Ahmed, Sankar Sekar, Shubhangi S. Khadtare, Nurul Taufiqu Rochman, Bathula Chinna, Abu Saad Ansari
Summary: In this study, MnCo2S4 nanosheet catalyst was successfully synthesized and found to exhibit superior performance in hydrogen evolution. Compared to MnCo2S4, MnCo2S4 showed low overpotentials, moderate Tafel slope, and excellent sustainability. The outstanding performance can be attributed to the increased number of electrochemically active sites and enhanced electronic conductivity on the catalyst surface.
Article
Chemistry, Multidisciplinary
Victor V. Maltsev, Elena A. Volkova, Elizaveta V. Koporulina, Diana D. Mitina, Vladimir L. Kosorukov, Anna I. Jiliaeva, Daniil A. Naprasnikov, Konstantin N. Gorbachenya, Viktor E. Kisel
Summary: The phase relationships, crystal properties and luminescence kinetics of two complex systems were studied, including unit cell parameters, segregation coefficients of impurities, and lifetimes of energy levels.
Article
Chemistry, Multidisciplinary
Xiaoman Zhang, Wangwang Xu, W. J. Meng, Andrew C. Meng
Summary: This study successfully grew high-quality single crystal AlScN nanowires through ultra-high vacuum reactive sputtering technique and characterized their structure and properties. The nanowires exhibit significantly reduced mosaic spread and predominantly single ferroelectric domains, as well as a high piezoelectric constant.
Article
Chemistry, Multidisciplinary
Tom E. de Vries, Elias Vlieg, Rene de Gelder
Summary: Networks are important for describing relationships between people, roads between cities, reactions between chemicals, and other interactions. Bipartiteness, dividing the network into two groups, can facilitate the study of the network's structure. We have developed an algorithm that can find a near-optimal bipartisation within a reasonable time frame and used it to uncover the hidden structure of the CSD cocrystal network.
Article
Chemistry, Multidisciplinary
Chuchu Han, Jing Yang, Xin Zhang, Aisen Li, Jiang Peng
Summary: An elastic crystal based on a photo-reactive acylhydrazone derivative is reported, which exhibits reversible bending behavior under UV irradiation and heating. The crystal undergoes reversible E<->Z isomerization under light and heating conditions. The crystal demonstrates excellent elastic properties and the bending can be controlled to control the output direction of red light.
Article
Chemistry, Multidisciplinary
Lingfeng Zhang, Yu Wang, Yefeng Wang, Shuai Liu, Na Zhang, Mingmin Yang, Haixia Ma, Zhaoqi Guo
Summary: This study designs and synthesizes a series of high-energy salts compounds without heavy metal ions and azide groups. The molecular structures and stability of the compounds are confirmed through single-crystal X-ray diffraction and intermolecular interaction analysis. Furthermore, the thermal stability, energetic properties, and electrical initiation properties of the compounds are investigated, suggesting their potential as primary explosives.