Article
Clinical Neurology
Giuseppe Maria Vincenzo Barbagallo, Francesco Certo, Stefania Di Gregorio, Massimiliano Maione, Marco Garozzo, Simone Peschillo, Roberto Altieri
Summary: This study presents the integration of multiple technologies including neuronavigation, 5-ALA fluorescence, iUS, iCT, C-11-MET-PET, and IOM during microsurgical resection of recurrent glioma. The authors believe that this multimodal protocol is useful in increasing safety, effectiveness, and extent of tumor resection in patients with recurrent HGG and brain alterations.
NEUROSURGICAL FOCUS
(2021)
Review
Oncology
Andrea Bianconi, Marta Bonada, Pietro Zeppa, Stefano Colonna, Fulvio Tartara, Antonio Melcarne, Diego Garbossa, Fabio Cofano, Andreas F. Hottinger, Nimish Mohile
Summary: This systematic review aimed to evaluate the reliability of fluorescence-guided surgery in low-grade gliomas and identify the best fluorophore for highlighting tumor boundaries. The current evidence does not support the routine use of 5-aminolevulinic acid or sodium fluorescein in low-grade glioma surgery. New molecules and techniques show promising results but require further clinical validation.
Article
Oncology
Kazuhide Shimizu, Kaoru Tamura, Shoko Hara, Motoki Inaji, Yoji Tanaka, Daisuke Kobayashi, Takashi Sugawara, Hiroaki Wakimoto, Tadashi Nariai, Kenji Ishii, Ichiro Sakuma, Taketoshi Maehara
Summary: This study aimed to investigate the correlation between preoperative MET-PET signals and intraoperative 5-ALA-induced fluorescence in malignant brain tumor surgery. The results showed that strong tumor fluorescence correlated with high MET-PET uptake and cellular proliferation, providing valuable tumor biology information for surgery in situations where MET-PET is not accessible.
Review
Clinical Neurology
Danielle Golub, Jonathan Hyde, Siddhant Dogra, Joseph Nicholson, Katherine A. Kirkwood, Paulomi Gohel, Stephen Loftus, Theodore H. Schwartz
Summary: The study compared the efficacy of 5-ALA and IMRI in optimizing EOR in HGG, finding both to be superior to conventional neuronavigation. However, no clear difference in effectiveness was found between IMRI and 5-ALA.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Michael Muether, Mohammed Jaber, Timothy D. Johnson, Daniel A. Orringer, Walter Stummer
Summary: Using a logistic regression model, the study found a strong correlation between enhancement on preoperative MRI and the likelihood of visible fluorescence during surgery in patients with intermediate-grade glioma. The research provides a robust method for predicting 5-ALA-induced fluorescence in patients with grade II and grade III gliomas with high accuracy.
Article
Multidisciplinary Sciences
David Black, Sadahiro Kaneko, Anna Walke, Simone Koenig, Walter Stummer, Eric Suero Molina
Summary: This study investigated autofluorescence in different grades of gliomas and identified new spectral features that can enhance the quantitative precision and sensitivity of fluorescence. Additionally, certain indicators such as the ratio (620/634) and the PpIX peak blue-shift were found to be significantly associated with WHO grade, fluorescence visibility, and PpIX contribution, serving as potential quantitative biomarkers for evaluation.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Artem I. Batalov, Sergey A. Goryaynov, Natalya E. Zakharova, Kristina D. Solozhentseva, Alexandra V. Kosyrkova, Alexander A. Potapov, Igor N. Pronin
Summary: The study found that tumor blood flow levels measured by non-contrast ASL perfusion method can predict the fluorescence by 5-ALA, especially in cases with contraindication to contrast. However, the additional value beyond contrast enhancement is not clear. ASL is useful in predicting fluorescence in these cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Shumpei Morisawa, Kohei Jobu, Tomoaki Ishida, Kei Kawada, Hitoshi Fukuda, Yu Kawanishi, Taku Nakayama, Shinkuro Yamamoto, Naohisa Tamura, Mitsuhiro Takemura, Nao Kagimoto, Tsuyoshi Ohta, Noritaka Masahira, Hideo Fukuhara, Shun-ichiro Ogura, Tetsuya Ueba, Keiji Inoue, Mitsuhiko Miyamura
Summary: Administration of 5-aminolevulinic acid is associated with intraoperative hypotension in malignant glioma surgery, with this effect being more pronounced in older patients and those using renin-angiotensin system inhibitors. In vitro experiments suggest that the low blood pressure induced by 5-aminolevulinic acid may be mediated by an increase in intracellular nitric oxide in vascular endothelial cells.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Akihiro Inoue, Takanori Ohnishi, Masahiro Nishikawa, Hideaki Watanabe, Kosuke Kusakabe, Mashio Taniwaki, Hajime Yano, Yoshihiro Ohtsuka, Shirabe Matsumoto, Satoshi Suehiro, Daisuke Yamashita, Seiji Shigekawa, Hisaaki Takahashi, Riko Kitazawa, Junya Tanaka, Takeharu Kunieda
Summary: This study analyzed the relationship between CD44 expression and magnetic resonance imaging (MRI)-based invasiveness of recurrent glioblastoma multiforme (GBM). High-invasive GBM showed significantly higher CD44 expression and was associated with worse survival. In addition, the study investigated the relationship between 5-aminolevulinic acid (5-ALA) spectroscopy-based tumor invasiveness and CD44 expression.
Review
Radiology, Nuclear Medicine & Medical Imaging
Sanjit Shah, Natalie Ivey, Abhijith Matur, Norberto Andaluz
Summary: Recent advances in tumor visualization have improved the extent of resection and reduced morbidity and mortality in central nervous system tumor surgery. This study systematically reviewed and analyzed the use of 5-aminolevulinic acid (5-ala) and sodium fluorescein as intraoperative fluorophores for tumor visualization. The findings suggest that both fluorophores have the potential to enhance tumor visualization and improve the extent of resection.
Article
Medicine, General & Internal
Jiro Akimoto, Shinjiro Fukami, Megumi Ichikawa, Kenta Nagai, Michihiro Kohno
Summary: The surgical eradication of malignant glioma cells is theoretically impossible, so reducing the number of remaining tumor cells around the BTI is crucial for satisfactory clinical outcomes. The effectiveness of fluorescence-guided resection for malignant glioma has been reported, and intraoperative rapid fluorescence cytology may help evaluate tumor cell presence in resection cavity walls for more complete resection.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemical Research Methods
Silvia Noble Anbunesan, Alba Alfonso-Garcia, Xiangnan Zhou, Julien Bec, Han Sung Lee, Lee-Way Jin, Orin Bloch, Laura Marcu
Summary: Intraoperative identification of IDH-mutant glioma using fluorescence lifetime imaging can aid in modifying tumor resection strategies for better survival outcomes.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Clinical Neurology
Cordelia Orillac, Walter Stummer, Daniel A. Orringer
Summary: The central goal in glioma surgery is to safely maximize extent of resection, especially in eloquent cortex, where the goal of maximal resection is balanced with neurological risk. New technologies such as fluorescence-guided surgery, intraoperative magnetic resonance imaging, and microscopic imaging methods have elevated the standards for maximal safe resection.
Article
Oncology
Kathryn Ottolino-Perry, Anam Shahid, Stephanie DeLuca, Viktor Son, Mayleen Sukhram, Fannong Meng, Zhihui ( Amy) Liu, Sara Rapic, Nayana Thalanki Anantha, Shirley C. Wang, Emilie Chamma, Christopher Gibson, Philip J. Medeiros, Safa Majeed, Ashley Chu, Olivia Wignall, Alessandra Pizzolato, Cheryl F. Rosen, Liis Lindvere Teene, Danielle Starr-Dunham, Iris Kulbatski, Tony Panzarella, Susan J. Done, Alexandra M. Easson, Wey L. Leong, Ralph S. DaCosta
Summary: The use of 5-ALA in BCS can lead to specific fluorescence in breast cancer tissue, aiding in the differentiation of tumors from normal tissue and improving intraoperative visualization. In this study, the positive predictive value of 5-ALA at doses of 15mg/kg and 30mg/kg showed high accuracy in detecting tumor locations.
BREAST CANCER RESEARCH
(2021)
Article
Biology
Mikael Marois, Jonathan D. Olson, Dennis J. Wirth, Jonathan T. Elliott, Xiaoyao Fan, Scott C. Davis, Keith D. Paulsen, David W. Roberts
Summary: A system for rapid hyperspectral imaging during neurosurgery has been developed, which can acquire data from 64 spectral channels simultaneously. The system uses a birefringent spectral demultiplexer to split incoming light and redirects it to different sections of a large format microscope sensor. This new device is an important advance in achieving real-time quantitative imaging of fluorophore concentration for guiding surgery.
COMMUNICATIONS BIOLOGY
(2023)