Article
Chemistry, Multidisciplinary
Arun Dhaka, Ie-Rang Jeon, Olivier Jeannin, Emmanuel Aubert, Enrique Espinosa, Marc Fourmigue
Summary: Successful topochemical polymerization of bis(selenocyanatomethyl)butadyine 1 was achieved through the formation of a co-crystal with 1,2-bis(2-pyridyl)ethylene (2-bpen). The co-crystal underwent polymerization upon heating and the ChB acceptor molecules 2-bpen sublimated during the reaction. The polymer showed enhanced conductivity after iodine doping.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Dhrubajyoti Talukdar, Jinti Moni Kumar, Bappaditya Gole
Summary: Molecular self-assembly is an important process in biological systems and has great potential in various applications. Recently, shape-persistent and rigid macrocycles have emerged as potential monomers for self-assembly. This perspective provides an overview of the strategies, noncovalent interactions, applications, and future development of self-assembled macrocycles.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Polymer Science
Bubsung Kim, Mohammed Iqbal Khazi, Jong-Man Kim
Summary: The paper describes a Ni2+-ion-directed reversibly solvatochromic tubular PDA based on macrocyclic diacetylene (MCDA). A dimeric MCDA complex was formed through Ni2+-intercalated coordinative binding with carboxyl groups, which later transform into blue-phase PDA upon UV irradiation. Spectroscopic studies revealed an unusual and unprecedented chromatic switching mechanism due to localized structural disruption at the Ni2+ coordination site, attributed to coordinating water molecules causing structural distortion.
Article
Chemistry, Multidisciplinary
Govind P. Maurya, Deepak Verma, Aloka Sinha, Luc Brunsveld, V Haridas
Summary: This study demonstrates the synthesis of simple and tunable hydrophobically driven chiral functional assemblies of diacetylene cored pseudopeptides. The chiral appended amino acid elements and the hydrophobic dialkyne core play important roles in the self-assembly and aggregation induced emission properties of these materials. Moreover, these supramolecular materials show promising applications in inducing chirality into non-chiral liquid crystal matrices.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Nanoscience & Nanotechnology
Yu-Jin Choi, Seohee Park, Dong-Gue Kang, Seok-In Lim, Jahyeon Koo, Duy Thanh Tran, Sungjune Park, Kwang-Un Jeong
Summary: By synthesizing newly designed amphiphilic molecules containing iodine or iodine ions and optimizing the process, a broadband coatable thin film polarizer has been successfully developed. This polarizer, which is stable, thin, and capable of absorbing light in a specific direction, broadens the polarization light region.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Lei Zhang, Chenyang Zhang, Jing Min, Chenglong Liu, Shizhong Mao, Liyan Wang, Bing Yang, Zeyuan Dong
Summary: This article presents a novel method of region-confined amphiphilic supramolecular polymerization (RASP) in a controllable two-step self-organization pathway, leading to the formation of circularly assembled supramolecular polymers. Water molecule plays a crucial role in RASP, and the water content in nonpolar solvent chloroform is sensitive to trigger controllable amphiphilic self-organization.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2023)
Article
Chemistry, Multidisciplinary
Javed R. Pathan, Subhrajyoti Bhandary, Kana M. Sureshan
Summary: We designed and synthesized a malonamide-derived monomer with azide and alkyne units for topochemical polymerization to produce nylon (n,3). Two polymorphs M1 and M2 were obtained upon crystallization of this monomer. The polymorphs exhibited suitable crystal packings for topochemical azide-alkyne cycloaddition polymerization. Depending on the polymorph, heating resulted in the regiospecific formation of either 1,4-disubstituted-1,2,3-triazolyl-linked polymer (M1) or 1,5-disubstituted-1,2,3-triazolyl-linked polymer (M2). These single-crystal-to-single-crystal polymerizations allowed for atomic resolution structure analysis using single-crystal X-ray diffraction. This is the first reported instance of synthesizing two chemically distinct polymers from a single monomer.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Inorganic & Nuclear
Bozumeh Som, Mark D. Smith, Linda S. Shimizu
Summary: A new flexible multimodal macrocyclic ligand was synthesized and used to form two coordination polymers with different structures. The ligand exhibited conformational flexibility and could adopt different conformations and binding modes depending on the metal ions. The coordination polymers demonstrated potential for diverse topology and functional applications in self-assembly.
Article
Chemistry, Multidisciplinary
Guijun Wang, Dan Wang, Anji Chen, Ifeanyi S. Okafor, Lalith Palitha Samankumara
Summary: Glycolipids with diacetylene functional groups are important compounds that can form photopolymerizable gels with stimuli-responsive properties. By introducing diacetylene functional groups at specific positions, a series of N-acetyl-D-glucosamine derivatives were synthesized and found to form self-assembled gels in various solvents, producing red-colored gels. The chemical structures and UV treatment affected the gelation properties of these compounds.
Article
Chemistry, Multidisciplinary
Sudhakar Ganta, Christoph Drechsler, Yen-Ting Chen, Guido H. Clever
Summary: This study introduces a self-assembled coordination cage as a molecular surfactant to stabilize various oil-in-oil emulsions. The cage can also be used for templated polycondensation reactions and guest molecule encapsulation.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Rishika Rai, Ravichandran Khazeber, Kana M. Sureshan
Summary: A covalent helical polymer was synthesized by biomimicry, which exhibited high strength and load-bearing capacity in its single crystals, making it suitable for various technological applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Janos Wasternack, Tom White, Sebastian Mueller, Christoph A. Schalley
Summary: A new gelator with a diacetylene core and fluorous ponytails was drop-casted to produce porous xerogels as surface coatings. The mechanical stability of these coatings was quantified using a scratch balance, providing a simple and universal method to compare the stability of & mu;m-scale coatings. The pore size in the coatings could be controlled through the breath figure effect. The coatings exhibited omniphobicity with static contact angles of up to 139 & DEG; (water) and 96 & DEG; (n-decane). Polymerization of the coatings through UV irradiation increased their mechanical stability by up to four times. At the same time, the water and n-decane contact angles increased by about 9 & DEG; and 4 & DEG; respectively due to a slight increase in surface roughness.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Polymer Science
Grzegorz Markiewicz, Adrianna Szmulewicz, Lukasz Majchrzycki, Maarten M. J. Smulders, Artur R. Stefankiewicz
Summary: Hydrogen-bonded polymers are highly dynamic supramolecular aggregates that can self-assemble through external or internal stimuli. This study finds that chiral biphenyldiimides derived from amino acids can self-assemble into open-chain 1D supramolecular polymers, and the amino acid side chains play an important role in stabilizing or destabilizing the assemblies. Significant differences in the polymerization process are observed between dynamic liquid and static solid. This work demonstrates the potential of diimide-based organic dyes in the formation of chiral supramolecular assemblies with tunable properties.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Yoo Jin Lee, Mustafa K. Abdelrahman, Manivannan Sivaperuman Kalairaj, Taylor H. Ware
Summary: Materials that can undergo reversible changes typically require top-down processing for microstructure programming, making it difficult to program microscale 3D shape-morphing materials that deform in non-uniaxial ways. However, a new bottom-up approach is described here, using liquid crystal monomers with controlled chirality to create bending microactuators. By adjusting the concentration of chiral dopants, the bending behavior of these microactuators can be controlled. The asymmetric molecular alignment within the 3D structure confirms the effectiveness of this fabrication method.
Article
Chemistry, Multidisciplinary
Lanxin Long, Samara Medina Rivero, Fanxi Sun, Dongsheng Wang, Dimitri Chekulaev, Claire Tonnele, David Casanova, Juan Casado, Yonghao Zheng
Summary: A combined experimental and theoretical study was conducted to elucidate the polymerization mechanism of a bisindenedione compound in the solid state. The study revealed the reaction pathway, starting from the formation of a triplet excimer state to an intermolecularly bonded triplet state that initiates the polymerization. Various spectroscopic techniques and quantum chemical calculations were employed to analyze the process. The presented mechanistic insight is valuable for understanding the complexity of this important reaction and for predicting and diversifying the resulting products.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Ingo Helmers, Muhammad Saddam Hossain, Nils Baumer, Paul Wesarg, Bartolome Soberats, Linda S. Shimizu, Gustavo Fernandez
Summary: By enforcing an anti-cooperative self-assembly, we have achieved a maintained emissive behavior in the self-assembled state and limited the growth of the assembly. This research finding is significant for the study of emissive supramolecular assemblies and controlled supramolecular polymerization.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Dustin W. Goodlett, Ammon J. Sindt, Md Faizul Islam, Mark D. Smith, Linda S. Shimizu
Summary: Supramolecular self-assembly of brominated triphenyl amine bis-urea macrocycles leads to the formation of porous organic crystals with unidirectional pores, which have been applied for the enrichment of xylene isomeric mixtures. The host exhibits selectivity and robustness in multiple separations, providing energy efficient alternatives for separating complex petrochemical feed mixtures.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Leily Daneshian, Isabella Renggli, Ryan Hanaway, Lesa R. Offermann, Caleb R. Schlachter, Shannon Henry, Rahul Prakash, Nicky Wybouw, Wannes Dermauw, Linda S. Shimizu, Thomas M. Makris, Vojislava Grbic, Miodrag Grbic, Maksymilian Chruszcz, Ricardo Hernandez Arriaza, Thomas Van Leeuwen
Summary: This study reveals the structure and function of TuCAS in Tetranychus urticae, showing its involvement in cyanide detoxification and additional enzymatic activities. The findings provide new molecular insights into the xenobiotic metabolism of this species.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Grace C. Thaggard, Gabrielle A. Leith, Daniil Sosnin, Corey R. Martin, Kyoung Chul Park, Margaret K. McBride, Jaewoong Lim, Brandon J. Yarbrough, Buddhima K. P. Maldeni Kankanamalage, Gina R. Wilson, Austin R. Hill, Mark D. Smith, Sophya Garashchuk, Andrew B. Greytak, Ivan Aprahamian, Natalia B. Shustova
Summary: Confinement-imposed photophysics was investigated for hydrazone-based compounds with novel stimuli-responsiveness, showing a conceptual difference in behavior between 2D and 3D porous matrices. The challenges of photoswitch isomerization in 2D scaffolds could be overcome in 3D materials by immobilizing the sterically demanding hydrazone derivatives. This approach enables the synthesis of hydrazone-based materials with fast photoisomerization kinetics in the solid state.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Rahul Prakash, Dustin W. Goodlett, Sheelu Varghese, Justyna Andrys, Fahidat A. Gbadamosi, Ricardo H. Arriaza, Megha Patel, Purushottam B. Tiwari, Tomasz Borowski, Maksymilian Chruszcz, Linda S. Shimizu, Geeta Upadhyay
Summary: The small molecule NSC243928 binds to LY6K and induces cancer cell death, but the mechanism is unclear. We have developed chemical tools to understand the molecular mechanisms of NSC243928-LY6K interaction.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Nattakarn Phromsiri, Sakiru L. Abiodun, Chonnavee Manipuntee, Pannee Leeladee, Andrew B. Greytak, Numpon Insin
Summary: In this study, a new ratiometric mixed-QDs probe for the quantification of Cu2+ in an aqueous solution was reported. This probe combines the concepts of ratiometric and fluorescence resonance energy transfer. The detection method is simple, fast, sensitive, selective, and accurate, with a low detection limit for Cu2+ and high selectivity towards other biological and environmental relevant ions. Additionally, the mixed-QDs probe shows potential for naked-eye detection of Cu2+ in water samples and biological specimens.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Polymer Science
Md Faizul Islam, Emely Adame-Ramirez, Eric R. Williams, Preecha Kittikhunnatham, Andrew Wijesekera, Siteng Zhang, Ting Ge, Morgan Stefik, Mark D. Smith, Perry J. Pellechia, Andrew B. Greytak, Linda S. Shimizu
Summary: In this study, pyrrole and ethylenedioxythiophene monomers are loaded into a self-assembled bis-urea host and polymerized within its nanochannels, dramatically altering the properties of the crystalline complexes. The findings suggest that supramolecular polymerization strategies have the potential to easily modulate the properties of nanostructured materials.
Article
Oncology
Benson Chellakkan Selvanesan, Sheelu Varghese, Justyna Andrys-Olek, Ricardo Hernandez Arriaza, Rahul Prakash, Purushottam Babu Tiwari, Daniel Hupalo, Yuriy Gusev, Megha Nitin Patel, Sara Contente, Miloslav Sanda, Aykut Uren, Matthew D. Wilkerson, Clifton Lee Dalgard, Linda S. Shimizu, Maksymilian Chruszcz, Tomasz Borowski, Geeta Upadhyay
Summary: LY6K is a small GPI-linked protein expressed in testes and its increased expression is associated with poor survival outcomes in various solid cancers. This report reveals a novel role of LY6K in mitosis and cytokinesis through aurora B kinase and histone H3 signaling axis. The interaction of small molecule NSC243928 with LY6K disrupts LY6K-aurora B signaling, resulting in failed cytokinesis, DNA damage, senescence, and apoptosis of cancer cells. Inhibition of LY6K signaling could be a potential therapeutic approach for hard-to-treat cancers.
Article
Chemistry, Multidisciplinary
Rahul Prakash, Md Faizul Islam, Rajeen Madawa Kothalawala, Muhammad Saddam Hossain, Mark D. Smith, Linda S. Shimizu
Summary: In this study, the hydrogen bond-driven self-assembly of a triphenylamine (TPA) bis-urea macrocycle in the presence and absence of guests was investigated. The assembly behavior and structural characteristics were analyzed using various spectroscopic and microscopy techniques. The results indicate that the function and utility of these supramolecular systems can be modulated by the selection of suitable monomers.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Llorenc Rubert, Md Faizul Islam, Andrew B. Greytak, Rahul Prakash, Mark D. Smith, Rosa Maria Gomila, Antonio Frontera, Linda S. Shimizu, Bartolome Soberats
Summary: We reported the self-assembly of a dendronized bis-urea macrocycle into two-dimensional nanosheets via a cooperative mechanism. The self-assembly mode of the macrocycle changed drastically in different solvents, and the formation of two-dimensional networks was promoted by solvent effects and a sophisticated hydrogen-bonding pattern.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Inorganic & Nuclear
Gregory Morrison, Lakshani W. Masachchi, Hunter B. Tisdale, Tieyan Chang, Virginia G. Jones, K. Pilar Zamorano, Logan S. Breton, Mark D. Smith, Yu-Sheng Chen, Hans-Conrad zur Loye
Summary: Single crystals of A(3)MF(6) (A = Rb, Cs; M = Al, Ga) were grown from mixed alkali chloride/fluoride fluxes in sealed silver tubes. Multiple polymorphs were observed at room temperature for Cs3AlF6 and Cs3GaF6, while only one polymorph was observed for the Rb-containing compositions. High temperature behavior of A(3)MF(6) was studied using simultaneous TGA/DSC and high temperature SCXRD/PXRD, revealing structure transitions to the cubic structure type, c-A(3)MF(6), for all four compositions.
DALTON TRANSACTIONS
(2023)
Review
Chemistry, Multidisciplinary
Andrew B. Greytak, Sakiru L. Abiodun, Jennii M. Burrell, Emily N. Cook, Nuwanthaka P. Jayaweera, Md Moinul Islam, Abdulla E. Shaker
Summary: Manipulations of nanocrystal surfaces play a vital role in various applications. This article focuses on the surface chemistry of colloidal nanocrystals and the binding motifs for ligands that coordinate nanocrystal surfaces, particularly for semiconductor quantum dots. The use of isothermal titration calorimetry (ITC) and other techniques to study the thermodynamics of nanocrystal-ligand interactions is discussed, along with different thermodynamic models for interpretation. Understanding the complexity of nanocrystal surface-ligand interactions provides opportunities to tune their properties for desired applications.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Muhammad Saddam Hossain, Fiaz Ahmed, Stavros G. Karakalos, Mark D. Smith, Namrata Pant, Sophya Garashchuk, Andrew B. Greytak, Pablo Docampo, Linda S. Shimizu
Summary: This study reports on the structural, computational, and conductivity studies of urea-directed self-assembled iodinated triphenylamine derivatives. It compares the assembled structures of different derivatives and their charge transport properties, showcasing one derivative with higher conductivity due to urea hydrogen bonding and specific interactions, making it a potential dopant-free p-type hole transporter.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)