Article
Chemistry, Multidisciplinary
Alica C. Keuper, Kevin Fengler, Florian Ostler, Tobias Danelzik, Dariusz G. Piekarski, Olga Garcia Mancheno
Summary: A new approach to achieve highly enantioselective halogen-bonding catalysis has been developed by designing fine-tuned halogen-halogen interactions. This strategy utilizes both the electron cloud and sigma-hole site of the substrate's halogen substituent to form a tight chiral complex, enabling controlled induction of high levels of chirality transfer. Remarkable enantioselectivities of up to 95:5 e.r. (90% ee) have been achieved in a model dearomatization reaction using tetrakis-iodotriazole multidentate anion-binding catalysts.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Subrata Nath, Alexander Kappelt, Matthias Spengler, Bibhisan Roy, Jens Voskuhl, Michael Giese
Summary: The first example of halogen-bonded fluorescent liquid crystals based on the interaction of iodofluorobenzene derivatives with nitro-cyanostilbenes is reported, highlighting the importance of halogen bond strength for inducing liquid crystalline properties. The modular self-assembly approach allows for efficient tuning of the fluorescence behavior and mesomorphic properties of the assemblies.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Crystallography
Dmitriy F. Mertsalov, Rosa M. Gomila, Vladimir P. Zaytsev, Mikhail S. Grigoriev, Eugeniya Nikitina, Fedor Zubkov, Antonio Frontera
Summary: This paper reports the synthesis and X-ray characterization of two derivatives containing the four most abundant halogen atoms, aiming to study Ha···Ha halogen bonding interactions. The heavier halogen atoms exhibit anisotropy of electron density, leading to the formation of multiple Ha···Ha contacts in the solid state. The halogen bonding assemblies in both compounds were analyzed using various methods such as DFT calculations, MEP surfaces, QTAIM, NCIplot, and ELF.
Article
Chemistry, Multidisciplinary
Vasily Sivchik, Aleksandr Kochetov, Toni Eskelinen, Kristina S. Kisel, Anastasia Solomatina, Elena Grachova, Sergey P. Tunik, Pipsa Hirva, Igor O. Koshevoy
Summary: The luminescent cyclometalated complexes decorated with cyanide ligand can serve as nucleophilic building blocks for halogen-bonded adducts, with noncovalent interactions playing a key role in their photoluminescent properties and excited states. The degree of aggregation via metal-metal interactions determines the optoelectronic properties and photoemissive characteristics of the crystalline materials.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Sergey Baykov, Daniil M. Ivanov, Svetlana O. Kasatkina, Bartomeu Galmes, Antonio Frontera, Giuseppe Resnati, Vadim Y. Kukushkin
Summary: The co-crystallization of tetracyanobenzene with haloarenes was studied, and it was found that the stacking interactions and lone pair-pi-hole bonds between the molecules promote the strength of halogen bonding. The stacking interactions increase the ability of haloarenes to act as halogen bonding donors.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Kenneth B. Wiberg
Summary: For methyl halides and phenyl halides, the 90 degrees approach leads to 1-2 kcal/mol stabilization due to halogen hydrogen interactions. The best arrangement for chlorobenzene dimer is with two benzene rings oriented over each other, with meta orientation of the chlorines having a lower energy. The dimerization energy suggests that the effect of the halogen on the electron distribution is more important than Cl center dot center dot center dot Cl interaction.
Article
Chemistry, Physical
Gaber A. M. Mersal, A. A. H. Basry, M. Khodari
Summary: The study investigated the mechanism of interaction between metformin and halogen molecules using experimental and theoretical methods, highlighting the crucial role of orthogonal hydrogen bonds and halogen bonds in stabilizing molecular structures, as well as the significant impact of solvents on the stability of complexes.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Applied
Dhananjoy Pal, Tim Steinke, Lukas Vogel, Elric Engelage, Sascha Heinrich, Dana Kutzinski, Stefan M. Huber
Summary: This article describes the synthesis of a mixed chalcogen- and halogen-bond donor and provides a first indication of its catalytic activity in a benchmark reaction.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Infectious Diseases
Maja Kokot, Doroteja Novak, Irena Zdovc, Marko Anderluh, Martina Hrast, Nikola Minovski
Summary: Novel bacterial topoisomerase inhibitors (NBTIs) are effective antibacterial agents that target bacterial type II topoisomerases. The crystal structure of an NBTI ligand complex with DNA gyrase and DNA showed that halogen atom in the phenyl RHS moiety can establish strong halogen bonds with the enzyme, which contribute to the inhibitory potency and antibacterial activity of NBTIs. Further investigations revealed that hydrogen-bonding interactions are not feasible, while hydrophobic and halogen-bonding interactions are possible.
Article
Chemistry, Physical
Manasa Purushotham, Bishwajit Paul, Divya Maldepalli Govindachar, Ashutosh Kumar Singh, Ganga Periyasamy, Sebastian C. Peter
Summary: Noncovalent interactions are important in stabilizing conformation and creating new structures. In this study, noncovalent interactions between ortho-halogen and backbone tertiary amide carbonyl were discovered in N-aryl glycine peptoid foldamers. These interactions exhibited chiral features and had an impact on the structure and dynamics of peptoid oligomers.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Burcu Topaloglu Aksoy, Burcu Dedeoglu, Yunus Zorlu, Mehmet Menaf Ayhan, Bunyemin Cosut
Summary: In this study, the researchers explored the efficiency of halogen center dot center dot center dot halogen interactions in controlling supramolecular assemblies of boron dipyrromethene (BODIPY) derivatives. By systematically decorating BODIPY scaffolds with iodine groups, they were able to promote halogen center dot center dot center dot halogen interactions and form various supramolecular self-assemblies. Analysis showed that the major source for all halogen-bonded formations were the dispersion and electrostatic components.
Article
Pharmacology & Pharmacy
Hua Huang, Yong Zhang, Yao Liu, Yufei Guo, Chunhui Hu
Summary: This study examines the relationships between drug-polymer interactions, crystallite size, and in vitro dissolution behavior in crystalline solid dispersions (CSDs) using flavonoid drugs and poloxamer 188 as a carrier. The results demonstrate that the strength of drug-polymer interactions increases with the number of hydroxyl groups, leading to a reduced likelihood of drug crystallization in the CSD system. This results in a decrease in crystalline domain size and crystallite size, thereby significantly enhancing drug dissolution.
Article
Chemistry, Inorganic & Nuclear
Mikhail A. Bondarenko, Alexander S. Novikov, Maxim N. Sokolov, Sergey A. Adonin
Summary: Reactions between Zn(II) nitrate, pentaiodobenzoic acid (HPIBA) and different pyridines in DMF result in the formation of two heteroleptic neutral complexes 1 and 2. The structures of both compounds were confirmed by PXRD data. DFT calculations were carried out to investigate the features of specific non-covalent interactions involving halogen atoms.
Article
Chemistry, Multidisciplinary
Andrew J. Peloquin, Jena M. McCollum, Colin D. McMillen, William T. Pennington
Summary: This article discusses a new deep eutectic solvent based on halogen bonding, which is different from the majority of DESs that rely on ionic components. The newly developed deep eutectic solvent remains in liquid form, with a eutectic melting temperature at different 1,3-dithiane mole fractions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Sofia Lindblad, Flora Boroka Nemeth, Tamas Foldes, Daniel von der Heiden, Herh G. Vang, Zakarias L. Driscoll, Emily R. Gonnering, Imre Papai, Nathan Bowling, Mate Erdelyi
Summary: (English Summary)
The study investigates the stability and reactivity of halonium ions stabilized by [bis(pyridine)iodine(I)](+) complexes. Factors such as chelation, strain, steric hindrance, and electrostatic interaction were found to influence the structure and release rate of these ions. Additionally, the presence of an electron-rich moiety nearby the [N-I-N](+) motif was observed to increase the iodenium release rate.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Organic
F. Christopher Pigge
CURRENT ORGANIC CHEMISTRY
(2016)
Article
Chemistry, Inorganic & Nuclear
Moustafa T. Gabr, F. Christopher Pigge
DALTON TRANSACTIONS
(2016)
Article
Chemistry, Multidisciplinary
Moustafa T. Gabr, F. Christopher Pigge
CHEMISTRY-A EUROPEAN JOURNAL
(2018)
Article
Chemistry, Inorganic & Nuclear
Moustafa T. Gabr, F. Christopher Pigge
DALTON TRANSACTIONS
(2018)
Article
Chemistry, Organic
Madhur S. Joshi, F. Christopher Pigge
SYNTHESIS-STUTTGART
(2018)
Article
Crystallography
Moustafa T. Gabr, F. Christopher Pigge
Article
Chemistry, Inorganic & Nuclear
Moustafa T. Gabr, F. Christopher Pigge
INORGANIC CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Moustafa T. Gabr, F. Christopher Pigge
Review
Chemistry, Analytical
Moustafa T. Gabr, F. Christopher Pigge
Summary: Luminogens with aggregation induced emission (AIE) properties are non-emissive in solution but become highly luminescent upon aggregation in poor solvents or solid state, offering superior photostability and sensitivity for bioimaging. They have been successfully applied in cell organelle imaging, ion sensing and biomacromolecule detection.
CURRENT ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Organic
Grant N. Shivers, F. Christopher Pigge
Summary: This experiment presents a straightforward method for the preparation of N-alkenyl-2-pyridones in one pot, utilizing easily available reagents. The reaction displays high diastereoselectivity and tolerance towards a variety of aldehyde reaction partners. Furthermore, the resulting pyridone products are versatile and can be further manipulated to form N-alkyl pyridones and polycyclic ring systems.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Soe L. Tun, S. V. Santhana Mariappan, F. Christopher Pigge
Summary: Aldehyde-derived imidazolidines can act as hydride donors in intramolecular reductive Heck-type reactions. This study demonstrates the regio- and stereoselective palladium-catalyzed hydroarylation of ortho-alkynyl benzaldehydes followed by 1,5-hydride transfer and reductive elimination to generate substituted alkenes and imidazolium moieties. This process provides a convenient method for converting imidazolium moieties to ring-opened benzanilides, simplifying product isolation. Additionally, a styrene derivative with an attached N,N'-dimethylbenzimidazoline hydride donor undergoes a similar hydroarylation/benzimidazoline oxidation reaction.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Grant N. Shivers, Soe L. Tun, Shay L. McLean, F. Christopher Pigge
Summary: 4-Alkylpyridines can be converted into conjugated 1,1-disubstituted alkenyl pyridines under mild conditions using excess ethyl chloroformate, triethylamine, and Eschenmoser's salt via alkylidene dihydropyridine intermediates.
Article
Chemistry, Organic
Soe L. Tun, Grant N. Shivers, F. Christopher Pigge
Summary: 4-Picoline derivatives can be converted to aryl picolyl sulfones by reacting with aryl sulfonyl chlorides and Et3N in the presence of catalytic DMAP. This reaction works well for various alkyl and aryl picolines and a variety of aryl sulfonyl chlorides can be used. It is believed that the reaction involves N-sulfonyl 4-alkylidene dihydropyridine intermediates and results in the formal sulfonylation of unactivated picolyl C-H bonds.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Moustafa T. Gabr, F. Christopher Pigge
DALTON TRANSACTIONS
(2017)
Article
Chemistry, Multidisciplinary
Moustafa T. Gabr, F. Christopher Pigge
MATERIALS CHEMISTRY FRONTIERS
(2017)