Article
Engineering, Chemical
Manuri Brahmayya, Dong-Chiao Yang, Yu-Chun Fu, Si-Yu Li, Shing-Yi Suen
Summary: This study reports the synthesis and characterization of a novel GO-ODA nanomaterial, which exhibits superior antibacterial activity. The results suggest that this nanomaterial has potential applications as a greener and more effective antibacterial material.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2023)
Article
Chemistry, Multidisciplinary
Jian Li, Jin-Xia Wen, Xue-Chen Lu, Guo-Quan Hou, Xu Gao, Yang Li, Li Liu
Summary: An efficient synthesis of a variety of 2,5-disubstituted 1,3,4-oxadiazole derivatives through cyclization reaction by photoredox catalysis between aldehydes and hypervalent iodine(III) reagents is described. The reaction proceeds under mild conditions and affords various target compounds in excellent yields. The commercially available aldehydes without preactivation and a simple visible-light-promoted procedure without any catalysts make this strategy an alternative to the conventional methods.
Article
Chemistry, Medicinal
Sibghat Mansoor Rana, Muhammad Islam, Hamid Saeed, Hummera Rafique, Muhammad Majid, Muhammad Tahir Aqeel, Fariha Imtiaz, Zaman Ashraf
Summary: 1,3,4-oxadiazole derivatives Ox-6a-f were synthesized by incorporating flurbiprofen moiety to decrease oxidative stress. The compounds were prepared by esterification, hydrazide formation, cyclization, and S-alkylation reactions. Molecular docking and dynamics simulation suggested that compound Ox-6f had the highest binding affinity with COX-2. The synthesized compounds showed antioxidant and anti-inflammatory activities, with Ox-6f exhibiting the most promising results.
Article
Polymer Science
Manping Ma, Changjun Gong, Chuan Li, Qiaolong Yuan, Farong Huang
Summary: The silicon-containing arylacetylene resins synthesized with 2,5-diphenyl-[1,3,4]-oxadiazole moieties exhibit good solubility, thermal and mechanical properties, as well as high flexural strength and modulus. The resins can be cured at temperatures below 200 degrees C and show high temperature resistance.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Fatih Tok, Zefine Ugras, Begum Nurpelin Saglik, Yusuf Ozkay, Zafer Asim Kaplancikli, Bedia Kocyigit-Kaymakcioglu
Summary: Thirty novel 2,5-disubstituted-1,3,4-oxadiazole derivatives bearing urea moiety were synthesized and their structures were confirmed. Monoamine oxidase inhibitory activity was determined, showing significant MAO-B inhibition in some compounds. Molecular docking studies were conducted to evaluate the interaction mechanism.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ramesh S. Gani, Avinash K. Kudva, Karabasanagouda Timanagouda, Raghuveer, Salma Begum Hussain Mujawar, Shrinivas D. Joshi, Shamprasad Varija Raghu
Summary: The study synthesized a series of novel oxadiazole-2-thiol derivatives and demonstrated their inhibitory activity against alpha-amylase and alpha-glucosidase in vitro. In vivo experiments on Drosophila melanogaster showed compounds 2b and 2g had better activity, indicating their potential as candidates for further development as novel antidiabetic agents.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Elena A. Nikiforova, Nikolay F. Kirillov, Daniil Baibarodskikh, Sergey N. Shurov, Maksim Dmitriev, Dmitriy P. Zverev
Summary: The reaction between methyl alpha-bromoisobutyrate or 1-bromocycloalkanecarboxylates with zinc and 2,5-diphenyl-1,3,4-oxadiazole produces 5-phenyl-2,4-dihydro-3H-pyrazol-3-one derivatives, with the cycloalkane series forming products of spiro structure. Additionally, in the case of cyclobutane reactant, 3-phenyl-2,4,5,6-tetrahydropyrano[2,3-c]pyrazole is also formed.
MENDELEEV COMMUNICATIONS
(2021)
Article
Crystallography
Sriram Sundaresan, Julian Eppelsheimer, Luca M. Carrella, Eva Rentschler
Summary: A novel synthesis of 2,5-bis[(1,3-thiazol-2-ylmethyl)amino]methyl-1,3,4-oxadiazole (LThiazole) and the preparation of three new dinuclear Fe(II) complexes with different counterions were reported. Characterization of the complexes was conducted using single-crystal X-ray crystallography, SQUID magnetometry, and IR spectroscopy. The magnetic properties of the complexes were measured and found to remain in the high-spin state over the measured temperature range.
Article
Chemistry, Physical
Valentin Karabelyov, Violina T. Angelova, Martin Sharkov, Rositsa Mihaylova, Georgi Popov, Tania Pencheva, Vasil Manov, Miroslav Dangalov, Nadezhda Todorova, Magdalena Kondeva-Burdina
Summary: A series of new 1,3,4-oxadiazole 3a-3k and hydrazone hybrids 5a-5m were synthesized and evaluated for their activity against hMAO-A and hMAO-B in vitro. The results showed that compounds 3a and 3d exhibited effective inhibition of hMAO-B, with compound 3a showing the strongest enzyme-inhibiting effect. The neuroprotective effect of compound 3a was found to be due to hMAO-B inhibition based on in vitro, in vivo, and in silico results.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Abdelhakim Laachir, Ferdaousse Rhoufal, Salaheddine Guesmi, El Mostafa Ketatni, Mohamed Saadi, Lahcen El Ammari, Olivier Mentre, Fouad Bentiss
Summary: The synthesis and crystal structure of a one-dimensional coordination polymer from an angular dipyridyl ligand and copper(I) thiocyanate are reported. The crystallographic study reveals the coordination environment of copper and shows the protonation of the ligand pyridine. The crystal cohesion is ensured by hydrogen bonds, π-π stacking, and coordination bonds. Thermal analysis confirms the thermal stability of the complex, and magnetic measurements indicate its diamagnetic nature.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Manping Ma, Xiaotian Liu, Chuan Li, Zhiyao Qiao, Qiaolong Yuan, Farong Huang
Summary: The introduction of side aromatic groups in silicon-containing arylacetylene resins can effectively improve the processability of the resins, reduce crystallinities, while maintaining high modulus and good heat resistance.
Article
Chemistry, Physical
Iskender Muz, Mustafa Kurban
Summary: In this study, the interaction of 1,3,4-oxadiazole with pristine and B-, Al-, Ga-doped C-60 fullerenes was investigated using density functional theory. The results demonstrate that doping B, Al, Ga atoms on C-60 enhances chemical reactivity and adsorption energy, while reducing electronic sensitivity. The bonding interactions with N or O atoms in the oxadiazole significantly affect charge carrier mobility and electron density.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Xiang-Dong Meng, Li-Xin Gao, Zhi-Jia Wang, Bo Feng, Chun Zhang, Rajendran Satheeshkumar, Jia Li, Yun-Long Zhu, Yu-Bo Zhou, Wen-Long Wang
Summary: SHP2 functions as a convergent node in oncogenic cell-signaling cascades and has emerged as a promising target for anti-cancer agents. A novel type of SHP2 inhibitors with sensitivity to SHP2 mutants has been developed, showing potential for improved pharmacological properties.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Pratima Katiyar, Manjul Pratap Singh
Summary: A series of 2,5-disubstituted-1,3,4 oxadiazole analogues with retaining pyridine moiety were synthesized and evaluated for their antimicrobial activity. Compound 4d and 4f showed promising activity against microbial strains.
LETTERS IN ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
I Nadi, M. Bouanis, F. Benhiba, K. Nohair, A. Nyassi, A. Zarrouk, C. Jama, F. Bentiss
Summary: The study assessed the organic corrosion inhibition properties of 4-PDX on carbon steel in hydrochloric acid solution, showing excellent inhibitory performance and formation of a protective film over the metal surface. The addition of 4-PDX led to a decrease in charge capacitance and improved interface charge/discharge function. Additionally, DFT calculations and MD simulations provided insight into the structural and electronic effects related to the anticorrosion properties of the inhibitors.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Applied
Jia-Yue Tian, Xiaolong Liu, Shuai Zhang, Kun Chen, Lei Zhu, Yingpan Song, Minghua Wang, Zhihong Zhang, Miao Du
Summary: We propose a novel electrochemical aptasensing strategy for efficient detection of staphylococcus aureus (S. aureus) using a copper-based metal-organic framework encapsulated with copper oxide nanocrystals. The developed biosensor exhibits a low limit of detection for S. aureus and demonstrates high stability, reproducibility, and practicality.
Article
Chemistry, Inorganic & Nuclear
Zhengyi Di, Zhao-Fei Liu, Hai-Ruo Li, Zhong Liu, Cheng-Peng Li
Summary: This study proposes an impregnation-coating hierarchical composite strategy to fabricate a ReO4- sorbent that can maintain structural stability under both acidic and alkaline conditions. The material shows high capture efficiency and good performance in removing ReO4- from simulated low-activity waste and high-level radioactive waste. This strategy provides a constructive way to design hierarchical core-shell composites and extends the applications of polyILs@MOF@COF hybrids.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Fenghe Duan, Qiaojuan Jia, Gaolei Liang, Mengfei Wang, Lei Zhu, Kevin J. McHugh, Lihong Jing, Miao Du, Zhihong Zhang
Summary: This study establishes a Schottky junction nanozyme between a manganese-bridged cobalt-phthalocyanines complex and Ti3C2Tx MXene nanosheets, which can serve as an integrative type I and II photosensitizer for enhancing cancer therapeutic efficacy under near-infrared light irradiation. The nanozyme exhibits enhanced electron-hole separation ability and redox potential, and enables improved H2O2 and O-2 supplying performances in vitro.
Article
Engineering, Environmental
Chuanpan Guo, Yiming Ruan, Shuai Zhang, Lun Kan, Heng Bian, Feilong Rong, Linghao He, Dongsheng Li, Miao Du, Zhihong Zhang
Summary: An electrocatalyst based on ultrathin graphene-like mesoporous carbon nanosheets embedded with ultra-small manganese oxide nanocrystals (MnOx@C) was established to improve the selectivity and production rate of H2O2 electrosynthesis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Jing Cui, Baiwei Wu, Zhenzhen Li, Yanhong Bai, Lun Kan, Minghua Wang, Linghao He, Miao Du
Summary: An electrochemical impedimetric immunosensor based on hierarchical nanostructured CoCoPBA@PCN-221 was developed for sensitive detection of deoxynivalenol (DON). The sensor showed high binding interaction, stability, and applicability, making it suitable for food safety applications.
Article
Chemistry, Multidisciplinary
Jiameng Liu, Linghao He, Shuangrun Zhao, Lijun Hu, Sizhuan Li, Zhihong Zhang, Miao Du
Summary: In this study, an n-n type heterojunction with Cu-N and B-N dual active sites was synthesized by in situ growth of a conductive metal-organic framework (MOF) [Cu-3(HITP)(2)] on hexagonal boron nitride (h-BN) nanosheets. The optimized Cu-3(HITP)(2)@h-BN exhibited outstanding electrocatalytic nitrogen reduction performance with NH3 production of 146.2 μg/h mg(cat) and a Faraday efficiency of 42.5% due to its high porosity, abundant oxygen vacancies, and Cu-N/B-N dual active sites. The construction of the n-n heterojunction efficiently modulated the state density of active metal sites, facilitating charge transfer at the catalyst-reactant interface. Additionally, the NH3 production pathway catalyzed by the Cu-3(HITP)(2)@h-BN heterojunction was elucidated by in situ FT-IR spectroscopy and density functional theory calculations. This work presents an alternative approach to designing advanced electrocatalysts based on conductive MOFs.
Article
Nanoscience & Nanotechnology
Meng Liang, Siwen Hu, Yanning Han, Zhongyi Liu, Cheng-Peng Li, Jingjun Hao, Pengchong Xue
Summary: A linear distyrylanthracene derivative with two diaminotriazine groups was synthesized to construct flexible organic porous crystals. The resulting organic framework exhibited stimuli-responsive properties such as a bathochromic shift in fluorescence when in contact with methanol and rapid adsorption and release of water molecules. These HOFs can be used as advanced functional materials in anticounterfeiting applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Lei Zhu, Hai-Ruo Li, Zhao-Fei Liu, Zhengyi Di, Wengui Xu, Libo Zhang, Cheng-Peng Li
Summary: By grafting imidazole-based ionic liquids onto the backbone of covalent organic framework, we developed a COF-polyILs sorbent that efficiently removes TcO4- in high acidity and salinity environments.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Thermodynamics
Jun Zhang, Xiaotian Li, Jili Zheng, Miao Du, Xuehong Wu, Jun Song, Chuanxiao Cheng, Tao Li, Wei Yang
Summary: This review examines the advancements in non-thermal plasma-assisted ammonia synthesis under conditions characterized by low temperature and low pressure. It covers various aspects, including plasma pretreatment of ammonia synthesis catalysts, plasma-activated air-assisted ammonia synthesis, and the influence of different hydrogen sources and plasma sources. An evaluation framework for non-thermal plasma-assisted ammonia synthesis is proposed, and a comparative analysis of different ammonia synthesis methods is conducted to elucidate the role of non-thermal plasma in the ammonia synthesis process. Finally, an outlook and recommendations for non-thermal plasma-assisted ammonia production are provided.
ENERGY CONVERSION AND MANAGEMENT
(2023)
Article
Chemistry, Analytical
Qiaojuan Jia, Yinpeng Zhang, Mengfei Wang, Minghua Wang, Jiayue Tian, Shuai Zhang, Linghao He, Zhihong Zhang, Miao Du
Summary: This study proposes a NIR-assisted dual-modal photoelectrochemical and photo-fuel-cell-driven self-powered biosensor for the sensitive detection of cancer biomarkers in living cancer cells. The developed sensor demonstrates excellent detection capabilities and potential clinical applications.
MICROCHEMICAL JOURNAL
(2023)
Article
Engineering, Environmental
Hongming He, Hao-Ming Wen, Ping Li, Hong-Kai Li, Cheng-Peng Li, Zhihong Zhang, Miao Du
Summary: This study successfully prepared a series of yolk-shell nanostructures of monodispersed Au nanostars within porous organic polymers (POPs) using a self-sacrificing template strategy. These yolk-shell nanocomposites, with highly active Au nanostar cores and permeable POP shells, demonstrate efficient electrocatalytic nitrogen reduction reaction (NRR) for ammonia synthesis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Jiameng Liu, Linghao He, Zheng Tao, Sizhuan Li, Changbao Wang, Yinpeng Zhang, Shuai Zhang, Miao Du, Zhihong Zhang
Summary: A novel semiconductive Co/Fe-MOF embedded with Fe2O3 nanocrystals has been developed as a trifunctional electrocatalyst for urea oxidation reaction, oxygen evolution reaction, and hydrogen evolution reaction, enhancing the efficiency of hydrogen production via urea-assisted overall water splitting.
Article
Chemistry, Multidisciplinary
Zining Qiu, Xiaodan Yang, Bowen Ni, Jiarui Liu, Hongming Sun, Jing Chen, Cheng-Peng Li, Miao Du
Summary: This study develops a new superhydrophilic self-supported Ni/Tb2O3 electrocatalyst with excellent catalytic performance and stability for alkaline HER. Tb2O3 promotes water dissociation and optimizes hydrogen adsorption on Ni, while electronic redistribution enhances the catalyst's activity. The thermodynamically stable Tb2O3 improves its long-term catalytic stability.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Engineering, Chemical
Jia-Yue Tian, Wen-Chao Lv, Ao-Song Shen, Yashen Ma, Minghua Wang, Shuai Zhang, Xiao-Long Liu, Zhihong Zhang, Miao Du
Summary: In this study, a novel two-dimensional (2D)-on-3D metal-organic framework (MOF) heterostructure was developed as a photocatalyst for the efficient removal of Cr(VI) ions in polluted water under visible irradiation. The MOF-on-MOF heterojunction exhibited enhanced separation ability of photocarriers and electron transfer, leading to high photocatalytic reduction efficiency of Cr(VI).
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)