Article
Biochemistry & Molecular Biology
Shiying Wu, Wanxin Cui, Qingqing Zhou, Ying Liang, Danli Wu, Yang Xu, Ping Li, Qing Gu
Summary: In this study, researchers found that phenyl lactic acid (PLA) derived from Lactobacillus plantarum ZJ316 can inhibit the growth and urease activity of Helicobacter pylori and cause a morphological transformation in vitro. In mice, PLA administration improved gastric mucosal damage caused by H. pylori and reduced inflammation and increased beneficial gut bacteria. These findings suggest that PLA can ameliorate H. pylori-induced inflammation and support beneficial gut bacteria, providing a new perspective against H. pylori infection.
Article
Pharmacology & Pharmacy
Jianwei Fan, Lifang Duan, Nan Wu, Xiaofan Xu, Jiaqi Xin, Shengnan Jiang, Cheng Zhang, Hong Zhang
Summary: Baicalin has been shown to inhibit the activation of pancreatic stellate cells (PSCs), reduce pancreatic inflammation and fibrosis, and decrease the levels of various markers associated with fibrosis in the pancreas. It inhibits the TGF-beta 1/TGF-beta R1/TAK1/NF-kappa B signaling pathway, leading to decreased MCP-1 secretion and reduced infiltration of macrophages and inflammation cells in the pancreas. This study provides a basis for the potential use of baicalin in the prevention and treatment of chronic pancreatitis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Zhu-jie Cao, Ying Liu, Zhe Zhang, Pei-ran Yang, Zhao-guo Li, Mei-yue Song, Xian-mei Qi, Zhi-fa Han, Jun-ling Pang, Bai-cun Li, Xin-ri Zhang, Hua-ping Dai, Jing Wang, Chen Wang
Summary: Pirfenidone has been demonstrated to effectively ameliorate silica-induced lung dysfunction, pulmonary inflammation, and fibrosis in mouse models by inhibiting the secretion of IL-17A, showing potential as a treatment for both early and advanced silicosis.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell Biology
Anding Wu, Mao Ye, Tengfei Ma, Zhigang She, Ruyan Li, Hongjie Shi, Ling Yang, Maolin Yi, Huoping Li
Summary: Nonalcoholic fatty liver disease (NAFLD) is a significant contributor to cardiovascular diseases, affecting a quarter of the global population. This study revealed that the expression of TBC1 domain family member 25 (TBC1D25) is upregulated in NAFLD/NASH. TBC1D25 deficiency worsened hepatic steatosis, inflammation, and fibrosis in NASH, while its overexpression inhibited NASH responses.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mingming Han, Shayan Wang, Xuehua Zhou, Pengfei Zhang, Zhengyuan Han, Yang Chen, Haijian Cai, Lina Wu, Xiaoying Huang, Liangxing Wang, Yanfan Chen
Summary: This study demonstrates the protective effects of baicalin in bleomycin-induced pulmonary fibrosis and elucidates the underlying mechanism. The findings suggest that activation of the mitochondrial ATP-sensitive potassium channel can attenuate fibrosis progression and mitigate cell death by reducing mitochondrial ROS, maintaining the mitochondrial membrane potential, and impeding the mitochondrial apoptotic pathway.
Article
Plant Sciences
Xiaodong Li, Xia Wu, Qi Wang, Weilv Xu, Qingwei Zhao, Nana Xu, Xingjiang Hu, Ziqi Ye, Songxia Yu, Jian Liu, Xuelin He, Fushan Shi, Qiao Zhang, Weifen Li
Summary: The study found that sanguinarine (SAN) has a therapeutic effect on ulcerative colitis (UC) by blocking the NLRP3-(Caspase-1)/IL-1 beta pathway and improving intestinal microbial dysbiosis.
Article
Chemistry, Medicinal
Yea-Jin Park, Tae-Young Gil, Bo-Ram Jin, Yun-Yeop Cha, Hyo-Jin An
Summary: This study aimed to investigate the effect of APO on the reduction of weight gain and obesity-induced adipose tissue inflammation. The results showed that APO-treated mice had a significantly lower white adipose tissue mass index compared to orlistat-treated mice. APO also reduced the expression of inflammatory markers and improved local inflammatory response in adipose tissue. These findings provide a foundation for further research on the use of APO as a therapeutic agent for obesity-induced inflammatory diseases.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biology
Sen-Wei Tsai, Jou-Hsuan Wang, Yu-Kang Chang, Chi-Chen Lin
Summary: Erianin, a compound found in Dendrobium sp., has shown promising inhibitory effect on Th17 overactivation and reduces disability in patients with rheumatoid arthritis. It also decreases proinflammatory cytokine levels.
OPEN LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yuhua Liu, Shaofang Wang, Xueqi Gong, Yingshuo Wang, Tonghui Xu
Summary: Research indicates that B7, a B chain of recombinant human relaxin, effectively inhibits bleomycin-induced pulmonary inflammation, improving damaged alveolar structure, reducing collagen deposition, and suppressing primary pathological features of idiopathic pulmonary fibrosis.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Integrative & Complementary Medicine
Di Hua, Jie Yang, Qinghai Meng, Yuanyuan Ling, Qin Wei, Zhigang Wang, Qingyun Wei, Jiao Chen, Juan Ye, Xuan Han, Kelei Su, Weikang Kong, Chao Xu, Peng Cao, Chunping Hu
Summary: This study demonstrates that the Soufeng sanjie formula (SF) has anti-arthritic effects by reducing arthritis symptoms, inflammation levels, and restoring Th17/Treg cell balance in collagen-induced arthritis (CIA) mice.
Article
Biochemistry & Molecular Biology
Sixia Yang, Tingting Pei, Linshuang Wang, Yi Zeng, Wenxu Li, Shihua Yan, Wei Xiao, Weidong Cheng
Summary: The study found that Salidroside has a protective effect in aging-related renal fibrosis. It can reduce renal dysfunction, decrease mesangial hyperplasia, and regulate proteins related to ferroptosis.
Article
Agriculture, Multidisciplinary
Mengdi Guo, Chenhui Zhu, Rongzhan Fu, Xiaoxuan Ma, Zhiguang Duan, Daidi Fan
Summary: The protective effect of ginsenoside Rk3 against non-alcoholic steatohepatitis (NASH) and its mechanism of action were investigated in this study. The results showed that Rk3 administration significantly improved liver inflammation, lipid deposition, and fibrosis caused by a high-fat-high-cholesterol (HFHC) diet and CCl4 injection in mice. Additionally, ginsenoside Rk3 was discovered to inhibit the PI3K/AKT signaling pathway and modify the abundance and composition of short-chain fatty acids, which were associated with beneficial variations to the intestinal microbiota. These findings suggest that ginsenoside Rk3 is a promising drug candidate for NASH treatment.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Immunology
Simin Lu, Kang Zheng, Jianye Wang, Man Xu, Yafeng Xie, Shuai Yuan, Chuan Wang, Yimou Wu
Summary: The study evaluated the response of mice to Treponema pallidum, showing that the pathogen could colonize multiple organs and potentially penetrate the blood-brain barrier in mice. Following infection, bacterial loads were higher in tissues than in blood, and a significant Th1 immune response was recorded.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nana Makiuchi, Shun Takano, Yuki Tada, Kaichi Kasai, Naoya Igarashi, Koudai Kani, Miyuna Kato, Kana Goto, Yudai Matsuura, Mayuko Ichimura-Shimizu, Yukihiro Furusawa, Koichi Tsuneyama, Yoshinori Nagai
Summary: Macrophages play a critical role in the development of NASH, and the accumulation of different subsets of macrophages in the liver is influenced by the composition of the diet and the strain of mice.
Article
Endocrinology & Metabolism
Qingcai Zhen, Qijian Liang, Hongchun Wang, Yan Zheng, Zhongting Lu, Chunyong Bian, Xiulan Zhao, Xin Guo
Summary: Nonalcoholic steatohepatitis (NASH) is a clinical syndrome characterized by liver inflammation and hepatocyte injury, which is closely related to metabolic disorders. This study investigated the effects of theabrownin, a pigment substance in fermented tea, on NASH. The results showed that theabrownin could improve liver injury, reduce liver inflammatory response, alleviate liver oxidative stress and fibrosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)