Article
Biochemistry & Molecular Biology
Shweta Guleria, Rahul Jain, Dharam Singh, Sanjay Kumar
Summary: The research identified a thermostable Fe/Mn SOD enzyme with high catalytic activity and stability, making it suitable for industrial applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Environmental
Qiming Mao, Dongning Wei, Binghua Yan, Shuang Luo, Thomas William Seviour, Zongsu Wei, Xiande Xie, Lin Luo
Summary: Biological approaches using manganese-oxidizing bacteria (MnOB) are cost-effective and environmentally friendly for removing bivalent manganese (Mn(II)). However, these bacteria have poor performance under pH below 5.5. In this study, an acid-tolerant manganese-oxidizing bacterium (Achromobacter sp. strain QBM-4) was isolated from acid mine drainage (AMD) and found to effectively remove Mn(II) at pH 4.0.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2022)
Article
Microbiology
Melissa Bisaccia, Elisa Binda, Elena Rosini, Gabriella Caruso, Ombretta Dell'Acqua, Maurizio Azzaro, Pasqualina Lagana, Gabriella Tedeschi, Elisa M. Maffioli, Loredano Pollegioni, Flavia Marinelli
Summary: Microbial communities in the Antarctic Ocean have adapted to cold and salty environments, producing enzymes with unique properties that can be used in biotechnology and bioremediation. These enzymes offer cost reduction, contaminant reduction, and simplified pretreatment. This study identified a laccase enzyme from a marine Antarctic bacterium that is tolerant to temperature, salt, and organic solvents.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Ruiyong Zhang, Sabrina Hedrich, Decai Jin, Anja Breuker, Axel Schippers
Summary: BGR 140(T), isolated from mine tailings in the Harz Mountains near Goslar, Germany, represents a novel species of the genus Sulfobacillus, named Sulfobacillus harzensis sp. nov., with high acid tolerance and mixotrophic characteristics.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Coralie Pavesi, Victor Flon, Stephane Mann, Stephane Leleu, Soizic Prado, Xavier Franck
Summary: Azaphilones are fungal polyketide pigments with diverse applications, and their biosynthetic pathways are not fully understood. Recent advances in genomic approaches and fungal genome sequencing have contributed to unveiling some of these pathways. This review provides a genomic perspective on the biosynthesis of azaphilonoids.
NATURAL PRODUCT REPORTS
(2021)
Article
Microbiology
Kunal Jani, Swapnil Kajale, Meghana Shetye, Shivani Palkar, Avinash Sharma
Summary: SM7_A14T is a coccus-shaped bacterium isolated from glacier fed sediment sample near India’s Maitri station in Antarctica. It shows distinct phylogenetic positioning within the genus Marisediminicola and has specific growth conditions. Based on polyphasic analysis, it is identified as a novel species of the genus Marisediminicola and named Marisediminicola senii sp. nov.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2021)
Article
Engineering, Environmental
Silisti Karuriya, Sangeeta Choudhary
Summary: A strain of Paenibacillus sp. isolated from a lignite mine waste site in Rajasthan, India, was found to be efficient in simultaneous nitrification and denitrification, with a high nitrogen removal rate. The presence of genetic determinants related to these processes was confirmed, suggesting a potential application of this strain in wastewater treatment.
WATER SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Chao Yuan, Yuhua Guo, Ke Wang, Zhunian Wang, Longfei Li, Huajie Zhu, Gang Li
Summary: Two known azaphilone derivatives, 4,6-dimethylcurvulinic acid (1) and austdiol (2), and their novel heterotrimer, muyophilone A (3), were isolated and identified from an endophytic fungus, Muyocopron laterale 0307-2. The structures and stereochemistry of these compounds were established through extensive spectroscopic analyses and single crystal X-ray diffraction. Compound 3 represents the first example of azaphilone heterotrimers.
FRONTIERS IN CHEMISTRY
(2021)
Article
Microbiology
Jung-Yun Lee, Dong-Hun Lee, Dong-Hun Kim
Summary: Gram-stain-negative bacterial strains NC18(T) and NC20, isolated from sediment near-vertical borehole effluent originating 714 m below the subsurface in Minnesota, USA, belong to the genus Martelella and are proposed as a novel species, Martelella soudanensis sp. nov.
Article
Biochemistry & Molecular Biology
Felipe Torres-Rojas, Pedro Hernandez, Ignacio T. Vargas, Ivan Nancucheo
Summary: A new extremophilic microorganism (USS-CCA7) related to Acidithiobacillus ferrivorans was isolated from an acidic environment in Antarctica. Its electrotrophic capacities were evaluated using a three-electrode electrochemical cell. The microorganism exhibited cathodic peaks for nitrate, oxygen, and perchlorate, and its catalytic role was observed by a decrease in charge transfer resistance. The microorganism also showed efficient perchlorate removal and growth on electrodes, making it a potential candidate for the bioremediation of harsh acidic environments.
BIOELECTROCHEMISTRY
(2023)
Article
Microbiology
Zhen Jiang, Dildar Wu, Zong-Lin Liang, Xiu-Tong Li, Ye Huang, Nan Zhou, Zheng-Hua Liu, Guang-Ji Zhang, Yan Jia, Hua-Qun Yin, Shuang-Jiang Liu, Cheng-Ying Jiang
Summary: Two novel Alicyclobacillus species, Alicyclobacillus curvatus and Alicyclobacillus mengziensis, were isolated from acid mine drainage sediment. These strains are anaerobic, endospore-forming rods capable of growth in acidic and mesophilic conditions, utilizing various carbon sources.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2022)
Article
Environmental Sciences
Tianhao Du, Anna Bogush, Paul Edwards, Peter Stanley, Ana T. Lombardi, Luiza C. Campos
Summary: This study investigated the role of indigenous algae in removing metals from acid mine drainage and found that metals such as Zn, Cu, and Cd can be adsorbed onto and accumulated in the algae, while Pb and Fe are mainly bioaccumulated in the algae. Indigenous algae can serve as a biogeochemical barrier for metal accumulation and can be used as bioindicators for assessing water pollution.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Organic
Wei-Hua Jiao, Jia-Xin Li, Hong-Yan Liu, Xiang-Chao Luo, Tian-Yong Hu, Guo-Hua Shi, Dong-Dong Xie, Hai-Feng Chen, Bao-Hui Cheng, Hou-Wen Lin
Summary: An unusual secomeroterpenoid, dysambiol (1), was isolated from a Dysidea sp. marine sponge collected from the South China Sea. Dysambiol features a rare lactone bridge in its unprecedented secomeroterpenoid scaffold. The structure of 1 was determined through extensive spectroscopic analysis, Mosher's method, and electronic circular dichroism calculation. Dysambiol exhibited potent anti-inflammatory activity in LPS-induced Raw 264.7 macrophages by regulating the NF-κB/MAKP signaling pathway.
Article
Biochemistry & Molecular Biology
Hyerin Jeon, Eunsil Choi, Jihwan Hwang
Summary: Toxin-antitoxin (TA) systems are genetic modules found in bacterial and archaeal genomes, consisting of a toxin and its cognate antitoxin. These systems play a role in helping prokaryotes adapt to unfavorable conditions. A study on the Arctic bacterium Bosea sp. PAMC 26642 revealed the toxic effects of 9 functional TA systems on Escherichia coli.
Article
Environmental Sciences
M. Hermassi, M. Granados, C. Valderrama, C. Ayora, J. L. Cortina
Summary: The study successfully developed a three-stage process to selectively separate and concentrate rare earth elements from other metals, producing a product rich in rare earth elements.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Oncology
Neerav Shukla, Romel Somwar, Roger S. Smith, Sri Ambati, Stanley Munoz, Melinda Merchant, Padraig D'Arcy, Xin Wang, Rachel Kobos, Christophe Antczak, Bhavneet Bhinder, David Shum, Constantin Radu, Guangbin Yang, Barry S. Taylor, Charlotte K. Y. Ng, Britta Weigelt, Inna Khodos, Elisa de Stanchina, Jorge S. Reis-Filho, Ouathek Ouerfelli, Stig Linder, Hakim Djaballah, Marc Ladanyi
Article
Microbiology
Paul Smith, C. Kiong Ho, Yuko Takagi, Hakim Djaballah, Stewart Shuman
Article
Biochemical Research Methods
Glorymar Ibanez, Paul A. Calder, Constantin Radu, Bhavneet Bhinder, David Shum, Christophe Antczak, Hakim Djaballah
Article
Biochemistry & Molecular Biology
Gil Blum, Glorymar Ibanez, Xiangjun Rao, David Shum, Constantin Radu, Hakim Djaballah, Judd C. Rice, Minkui Luo
ACS CHEMICAL BIOLOGY
(2014)
Article
Biochemical Research Methods
Christophe Antczak, Boyoung Wee, Constantin Radu, Bhavneet Bhinder, Eric C. Holland, Hakim Djaballah
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
(2014)
Article
Multidisciplinary Sciences
Boyoung Wee, Alexander Pietras, Tatsuya Ozawa, Elena Bazzoli, Ondrej Podlaha, Christophe Antczak, Bengt Westermark, Sven Nelander, Lene Uhrbom, Karin Forsberg-Nilsson, Hakim Djaballah, Franziska Michor, Eric C. Holland
SCIENTIFIC REPORTS
(2016)
Article
Cell Biology
Abbas Hadji, Paolo Ceppi, Andrea E. Murmann, Sonia Brockway, Abhinandan Pattanayak, Bhavneet Bhinder, Annika Hau, Shirley De Chant, Vamsi Parimi, Piotre Kolesza, JoAnne Richards, Navdeep Chandel, Hakim Djaballah, Marcus E. Peter
Article
Cell Biology
Enrico Derenzini, Patrizia Mondello, Tatiana Erazo, Ana Portelinha, Yuxuan Liu, Mary Scallion, Zahra Asgari, John Philip, Patrick Hilden, Debora Valli, Alessandra Rossi, Hakim Djaballah, Ouathek Ouerfelli, Elisa de Stanchina, Venkatraman E. Seshan, Ronald C. Hendrickson, Anas Younes
Article
Oncology
Christina Angeles, Ana Velez, Jordan Rios, Bernadette Laxa, David Shum, Penelope D. Ruiz, Yawei Shen, Irina Ostrovnaya, Rodrigo Gularte-Merida, Benjamin A. Nacev, Mark A. Dickson, Hakim Djaballah, Tomoyo Okada, Samuel Singer
Summary: This study aims to find potential treatments for dedifferentiated liposarcoma (DDLS) by increasing the expression of C/EBP alpha. The results showed that irinotecan can induce apoptosis in DDLS cells through C/EBP alpha-dependent, p53-independent mechanisms, suggesting its therapeutic potential.
CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Fraser D. Johnson, John Ferrarone, Alvin Liu, Christina Brandstaedter, Ravi Munuganti, Dylan A. Farnsworth, Daniel Lu, Jennifer Luu, Tianna Sihota, Sophie Jansen, Amy Nagelberg, Rocky Shi, Giovanni C. Forcina, Xu Zhang, Grace S. W. Cheng, Sandra E. Spencer Miko, Georgia de Rappard-Yuswack, Poul H. Sorensen, Scott J. Dixon, Udayan Guha, Katja Becker, Hakim Djaballah, Romel Somwar, Harold Varmus, Gregg B. Morin, William W. Lockwood
Summary: Phenotype-based screening led to the identification of a compound called LCS3 that selectively impairs the growth of LUAD cells, induces oxidative stress, and inhibits the activity of disulfide reductases GSR and TXNRD1. The study also reveals that LCS3-sensitive LUAD cells are sensitive to the synergistic inhibition of glutathione and thioredoxin pathways. Furthermore, NQO1 loss is identified as a mechanism of LCS3 resistance through a genome-wide CRISPR knockout screen.
Article
Oncology
Thapi D. Rao, Mengyao Xu, Stephanie Eng, Guangli Yang, Robin Manson, Nestor Rosales, Raj Kumar, Irva E. Veillard, Qin Zhou, Alexia Iasonos, Ouathek Ouerfelli, Hakim Djaballah, David R. Spriggs, Oladapo O. Yeku
Summary: Significant progress has been made in the development of precision therapeutics for cancer, with a focus on aberrantly expressed glycoproteins. Through various screening strategies, compounds that selectively target MUC16(+) cells have been identified. These candidates demonstrate preferential inhibition of invasion in MUC16(+) cells and may have potential for further clinical development.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Ophthalmology
Ursula Winter, Emiliano Buitrago, Hebe A. Mena, Maria Jose Del Sole, Viviana Laurent, Soledad Negrotto, Jasmine Francis, Eloisa Arana, Mariana Sgroi, Juan O. Croxatto, Hakim Djaballah, Guillermo L. Chantada, David Abramson, Paula Schaiquevich
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2015)
Article
Biochemical Research Methods
Zachary D. Stolp, Cameron A. Smurthwaite, Connor Reed, Wesley Williams, Andre Dharmawan, Hakim Djaballah, Roland Wolkowicz
JOURNAL OF BIOMOLECULAR SCREENING
(2015)
Article
Biochemical Research Methods
David Shum, Hakim Djaballah
JOURNAL OF BIOMOLECULAR SCREENING
(2014)