期刊
CRYOBIOLOGY
卷 60, 期 2, 页码 235-237出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cryobiol.2009.10.012
关键词
DNA damage; Human semen; Comet assay
资金
- Universidade de Camas do Sul
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul
Cryopreservation of human semen can cause DNA damages, which compromise the fertilization and normal embryo development The present study showed that the antioxidant resveratrol prevents these damages both in fertile and infertile men The addition of ascorbic acid before cryopreservation can reduce DNA damages only in infertile men Although further Studies are needed, the present work showed that resveratrol Could be considered in human cryopreservation procedures to avoid/minimize DNA damages and preserve sperm integrity (C) 2009 Elsevier Inc All rights reserved.
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