Article
Medicine, General & Internal
Li Liu, Youde Jiang, Jena J. Steinle
Summary: Diabetic retinopathy is associated with increased levels of inflammatory mediators. Prohibitin 1 plays a crucial role in regulating inflammation, and decreased levels of prohibitin 1 can reduce the levels of inflammatory mediators and reactive oxygen species in retinal endothelial cells.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Ana Luisa Perdigoto, Songyan Deng, Katherine C. Du, Manik Kuchroo, Daniel B. Burkhardt, Alexander Tong, Gary Israel, Marie E. Robert, Stuart P. Weisberg, Nancy Kirkiles-Smith, Angeliki M. Stamatouli, Harriet M. Kluger, Zoe Quandt, Arabella Young, Mei-Ling Yang, Mark J. Mamula, Jordan S. Pober, Mark S. Anderson, Smita Krishnaswamy, Kevan C. Herold
Summary: Checkpoint inhibitors targeting PD-1/PD-L1 and CTLA-4 have revolutionized cancer treatment but can lead to autoimmune complications. This study found evidence of pancreatic inflammation and shrinkage in patients with CPI-induced diabetes mellitus (CPI-DM). In mouse models, anti-PD-L1 induced diabetes rapidly, while anti-CTLA-4 did not. RNA sequencing revealed infiltrations of cytolytic IFN-gamma(+)CD8(+) T cells in islets with anti-PD-L1. IFN-gamma and TNF-alpha drove changes in beta cells and apoptosis pathways. Inhibition of inflammatory cytokines prevented CPI-DM, providing a new clinical strategy for preventing this complication.
Article
Immunology
Yanhao He, Guangde Yang, Lijing Sun, Hongqian Gao, Feng Yao, Zhen Jin, Zihan Zheng, Lifang Chen, Weirong Wang, Nanbo Zheng, Rong Lin
Summary: SIRT6 protects against vascular inflammation through its deacetylase activity and the NRF2-dependent signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Salvatore Calogero Gaglio, Marta Donini, Piyachat Evelyn Denbaes, Stefano Dusi, Massimiliano Perduca
Summary: Oxyresveratrol suppresses cytokine production by activated dendritic cells and when loaded into poly(lactic-co-glycolic acid) nanoparticles, it mitigates the pro-inflammatory effects. This suggests that oxyresveratrol could serve as a promising anti-inflammatory and immune-suppressive agent.
Article
Immunology
Xiaobin Fang, Jingyi Li, Xuechao Hao, Weiyi Zhang, Jie Zhong, Tao Zhu, Ren Liao
Summary: Most blood transfusion-related adverse reactions involve the immunologic responses of recipients to exogenous blood components. Extracellular vesicles derived from packed red cells can activate mast cells and induce the production of multiple inflammatory mediators, partly via the TLR-3 and MAPK pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biology
Eirini Dri, Evangelos Lampas, George Lazaros, Emilia Lazarou, Panagiotis Theofilis, Costas Tsioufis, Dimitris Tousoulis
Summary: Endothelial dysfunction (ED) is characterized by imbalanced vasodilation and vasoconstriction, elevated reactive oxygen species (ROS), and inflammatory factors, as well as deficiency of nitric oxide (NO) bioavailability. Inflammatory modulators/biomarkers and adhesion molecules involved in atherosclerosis progression have been shown to predict cardiovascular diseases. Furthermore, several signaling pathways, such as NLRP3 inflammasome, are postulated to be new indicators for endothelial cell inflammation and its associated endothelial dysfunction.
Article
Immunology
Bram M. ter Ellen, Jelmer Niewold, Antine Flikweert, Anneke C. Muller Kobold, Peter Heeringa, Matijs van Meurs, Jolanda M. Smit, Peter H. J. van der Voort, Izabela A. Rodenhuis-Zybert, Jill Moser
Summary: This study found that SARS-CoV-2 virus does not infect endothelial cells and adipokines cannot exacerbate microvascular dysfunction. Instead, endothelial activation associated with COVID-19 is likely a result of inflammatory responses initiated by other cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Peripheral Vascular Disease
Li Liu, Youde Jiang, Jena J. Steinle
Summary: Research indicates that inflammation plays a crucial role in damaging the retinal vasculature. This study investigates the regulation of inflammatory pathways and suggests that semaphorin 7a (Sema7a) is involved in the increased inflammatory mediators and permeability changes in retinal endothelial cells (REC) grown in high glucose. The use of Sema7a siRNA shows promise as a potential treatment avenue.
MICROVASCULAR RESEARCH
(2023)
Article
Immunology
Elisa Weiss, Amanda Vlahos, Bowon Kim, Sachintha Wijegunasekara, Dhanya Shanmuganathan, Thomas Aitken, Ji-Hoon E. Joo, Samira Imran, Rebecca Shepherd, Jeffrey M. Craig, Mark Green, Ursula Hiden, Boris Novakovic, Richard Saffery
Summary: Inflammatory memory involves the reprogramming of innate immune cells to provide non-specific protection. This study found specific transcriptional responses in fetal endothelial cells to initial viral exposure, with both cell types capable of establishing memory. While both cell types showed similar abilities, progenitor ECFCs demonstrated a higher capacity for memory establishment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Song Shen, Lingling Shang, Hongrui Liu, Qianyu Liang, Wei Liang, Shaohua Ge
Summary: AGGF1 expression increased in inflammatory dental pulp tissues. It inhibits the synthesis of inflammatory cytokines through the NF-kappa B signaling pathway and promotes the angiogenesis of dental pulp cells. Further clinical trials are needed to confirm these findings.
CLINICAL ORAL INVESTIGATIONS
(2021)
Review
Biochemistry & Molecular Biology
Daniela Ricci, Marilena Paola Etna, Fabiana Rizzo, Silvia Sandini, Martina Severa, Eliana Marina Coccia
Summary: The vulnerability and unpredictability of humankind to SARS-CoV-2, coupled with its high transmissibility and tissue tropism, pose a major challenge in perpetuating the COVID-19 pandemic. However, researchers have the unique opportunity to study the immune response and its impact on disease severity, highlighting the role of innate immune cells, cytokines, and chemokines in shaping the outcome of SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Takashi Matsuo
Summary: The study found that nobiletin effectively inhibited inflammatory responses in IL-1 beta-stimulated HPDLCs by reducing the expression of inflammatory cytokines, cell adhesion molecules, and MMPs. Additionally, nobiletin treatment also suppressed the activation of NF-kappa B, MAPKs, and Akt pathways.
Article
Biochemistry & Molecular Biology
Markus Pirklbauer, Sebastian Sallaberger, Petra Staudinger, Ulrike Corazza, Johannes Leierer, Gert Mayer, Herbert Schramek
Summary: Research suggests that the SGLT2 inhibitor Empagliflozin may have nephroprotective effects by inhibiting the expression of various inflammatory response genes, providing new insights into the mechanism of action of SGLT2 inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Pelin Erkoc, Michaela Schmitt, Rebecca Ingelfinger, Iris Bischoff-Kont, Larissa Kopp, Helge B. Bode, Susanne Schiffmann, Robert Fuerst
Summary: Xcn2 exhibits significant pharmacological activity in vitro regarding inflammation and angiogenesis, inhibiting pro-inflammatory activation of endothelial cells and hindering pro-angiogenic processes in HUVECs. It also reduces viability, nitric oxide release, and iNOS expression in activated macrophages.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Environmental Sciences
Wendy J. Wilburn, Sara Jamal, Farah Ismail, Dylan Brooks, Margaret Whalen
Summary: Triclosan (TCS) affects the secretion of pro-inflammatory cytokines from human immune cells, increasing levels of IL-1β, IL-6, and TNFα. Additionally, TCS stimulates an increase in IFNγ secretion, with a more consistent effect seen after 48 hours of exposure.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Yasodha Sivasothy, Kok Hoong Leong, Kong Yong Loo, Siti Mariam Adbul Wahab, Muhamad Aqmal Othman, Khalijah Awang
Summary: Malabaricone C and Giganteone A show potential as antidiabetic agents by controlling glycemic levels, inhibiting oxidative stress, and acting as potent alpha-glucosidase inhibitors.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Amelie Rousseliere, Laurence Delbos, Celine Bressollette, Mailys Berthaume, Beatrice Charreau
Summary: This study quantitatively determined the frequency of various anti-HCMV immune cell subsets and qualitatively analyzed their phenotypes using spectral flow cytometry analysis. The results provide insights into the cellular immune responses to HCMV infection or vaccines, and can be used for monitoring and analysis of T-cell and NK cell responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Beatrice Charreau
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Manon Meunier, Dimitri Breard, Khalijah Awang, Severine Boisard, David Guilet, Pascal Richomme, Severine Derbre, Andreas Schinkovitz
Summary: This study presents a simple and efficient approach using matrix-free laser desorption ionization mass spectrometry (LDI-MS) to identify activity markers in complex mixtures of natural products (NPs). The method was successfully applied to predict and isolate NPs with notable anti-AGEs effects from crude bark extracts of Garcinia parvifolia. The results were comparable to those obtained by liquid chromatography coupled to high-resolution tandem mass spectrometry (LC-MS2), and the C-13 NMR dereplication tool MixONat was used to confirm the structures of the activity markers.
Article
Chemistry, Analytical
Norfaizah Osman, Azeana Zahari, Hazrina Hazni, Wan Nurul Nazneem Wan Othman, Nurulfazlina Edayah Rasol, Nor Hadiani Ismail, Pierre Champy, Mehdi A. Beniddir, Marc Litaudon, Khalijah Awang
Summary: Phytochemical investigation of the dichloromethane crude extract from the bark of Ochreinauclea maingayi using LCMS/MS-based molecular networking led to the isolation and identification of known and new indole alkaloids. The molecular networking analysis identified different clusters and nodes representing various compounds. By analyzing each cluster and node, it was determined that indole alkaloids are of interest, particularly those found between F5 and F10. Nine indole alkaloids were successfully purified and their structures confirmed using various analytical techniques. The presence of unannotated ions suggests the possibility of novel compounds yet to be discovered.
Article
Chemistry, Medicinal
Maurizio Mastropasqua Talamo, Thomas Cauchy, Francesco Zinna, Flavia Pop, Narcis Avarvari
Summary: This study reports the synthesis and functionalization of diketopyrrolo[3,4-c]pyrrole (DPP) derivatives containing chiral groups. Four bis([4]helicene)-DPP and bis([4]thiahelicene)-DPP dyes were prepared by condensation and N-alkylation reactions. Compound 12, with sec-phenylethyl groups attached to the nitrogen atoms, was obtained as enantiomers. The chiroptical properties of compound 12 indicate a strong chiral perturbation despite the stereodynamic nature of the flanking units.
Article
Chemistry, Inorganic & Nuclear
Nataliya Plyuta, Thomas Cauchy, Miguel Julve, Narcis Avarvari
Summary: Two new luminescent ligands were successfully synthesized through Suzuki coupling reactions. DFT and TD-DFT calculations were performed to analyze the UV-visible and emission bands. The experimental results revealed the coordination modes and structural characteristics of the ligands with metal ions. The products showed strong luminescence properties in solution and the solid state, and magnetic studies indicated small antiferromagnetic interactions in some of the compounds.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Maurizio Mastropasqua Talamo, Thomas Cauchy, Flavia Pop, Francesco Zinna, Lorenzo Di Bari, Narcis Avarvari
Summary: In this work, the aggregation-enhanced emission (AEE) and circularly polarised light (CPL) emission of achiral and chiral DPPs appended with tetraarylethylene units have been studied. It was found that some chiral DPPs exhibited excellent emissive properties in the solid state by suppressing aggregation-caused quenching, while achiral DPPs showed classical ACQ behavior. Furthermore, the chiroptical properties of DPPs can be enhanced by introducing N-sec-phenethyl groups.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Khaled Youssef, Magali Allain, Thomas Cauchy, Frederic Gohier
Summary: 2-Bromo, 3-bromothiophene, 2,5-dibromothiophene, 3,4-dibromothiophene, and perbrominated thiophene were oxidized under different conditions to form thiophene S,S-dioxide. Depending on the substitution, sulfone was obtained when the hindered thiophene was used. However, monosubstituted thiophenes could not be transformed into sulfone due to the reactivity of the sulfoxide intermediate, which led to dimerization. The structures were confirmed through the obtaining of crystals. The oxidation of 3,4-dibromothiophene could either result in the formation of cycloadduct or the isolation of sulfone, which could further evolve into benzothiophene sulfone.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Food Science & Technology
Julie Miranda, Cecile Miot-Sertier, Laura Olazabal, Warren Albertin, Tristan Richard, Gregory Da Costa, Caroline Rouger, Marguerite Dols-Lafargue
Summary: The growth ability of Brettanomyces bruxellensis yeast strains in different Bordeaux red wines varied. The key factors affecting the permissiveness score of wines were the ethanol content, yeast strain, and wine itself, while pH had little effect. Wine composition analysis could not identify the molecules responsible for wine permissiveness.
Article
Chemistry, Physical
Laure Pichereau, Laure Fillaud, Nikolaos Kostopoulos, Emmanuel Maisonhaute, Thomas Cauchy, Magali Allain, Jean-Marc Noel, Christelle Gautier, Tony Breton
Summary: We have experimentally reassessed the widely accepted concerted reduction mechanism for diazonium electroreduction. We demonstrated the existence of a stepwise pathway using ultrafast cyclic voltammetry, and real-time spectroelectrochemistry experiments allowed us to visualize the spectral signature of an evolution product of the phenyldiazenyl radical intermediate. By trapping the radical and resolving its X-ray structure, we unambiguously identified the diazenyl species. The electrochemical generation of this transient under intermediate energetic conditions questions our understanding of the layer structuration in surface modification achieved via the diazonium electrografting technique, as this azo-containing intermediate may be responsible for the systematic presence of azo bridges in nanometric films.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Parasitology
M. N. Azmi, N. S. Hasmaruddin, N. A. Mat Ali, H. Osman, S. Mohamad, T. Parumasivam, M. Z. Hassan, M. S. Abd Ghani, K. Awang
Summary: A series of new 2,5-disubstituted-1,3,4-oxadiazole derivatives have been synthesized and characterized. Compound 5d exhibited the highest antibacterial activity against M. smegmatis and showed good synergy with isoniazid. Docking simulation suggested its potential as a pantothenate synthetase inhibitor.
TROPICAL BIOMEDICINE
(2022)
Article
Materials Science, Multidisciplinary
Antoine Goujon, Lou Rocard, Hayley Melville, Thomas Cauchy, Clement Cabanetos, Sylvie Dabos-Seignon, Pietrick Hudhomme
Summary: AzaBenzannulated PeryleneDiimides (AzaBPDIs) and their nitrogen, sulphur and selenium bay-functionalized derivatives are introduced as a novel class of n-type semiconductors. Heteroatoms were inserted prior to a visible-light-driven cyclisation strategy, resulting in the formation of a six-membered ring comprising a nitrogen atom on the opposite bay. The electronic and optical properties of these compounds in solution and thin films were investigated, revealing their potential for future applications in complex AzaBPDI-based architectures.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Chemistry, Multidisciplinary
Nabil Mroweh, Thomas Cauchy, Nicolas Vanthuyne, Narcis Avarvari
Summary: Chiral electroactive precursors were synthesized and their structures were characterized by single crystal X-ray diffraction analysis. The results indicate that the axial conformation of the precursors is more stable than the equatorial conformation in both gas phase and solution.
Article
Chemistry, Multidisciplinary
Nur Amirah Saad, Sharifah Mohammad, Mohamad Hafizi Abu Bakar, Mohammad Tasyriq Che Omar, Marc Litaudon, Khalijah Awang, Mohamad Nurul Azmi
Summary: This study isolated 11 cyclic polyketides from the bark of Endiandra kingiana and found that compounds 9 and 2 exhibited potent inhibition towards alpha-amylase, while compounds 10 and 5 demonstrated good inhibition towards alpha-glucosidase. Molecular docking examination confirmed the inhibitory reactions of these compounds with alpha-amylase and alpha-glucosidase enzymes.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
