期刊
JOURNAL OF NATURAL PRODUCTS
卷 78, 期 6, 页码 1446-1450出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00129
关键词
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资金
- Division of Cancer Treatment Diagnosis and Centers, National Cancer Institute, DHHS [RO1CA90441-02-05, 5RO1CA90441-07]
- Arizona Biomedical Research Commission
- J. W. Kieckhefer Foundation
- Margaret T. Morris Foundation
- Robert B. Dalton Endowment Fund
For the purpose of advancing knowledge of the structural variations available in the natural cephalostatins contained in the marine worm Cephalodiscus gilchristi, the isolation and structure of the 20th member (1) has been accomplished (10(-7) % yield). In turn cephalostatin 20 (1) proved to be enough for an initial SAR study comprising six important human cancer cell lines. A parallel objective was aimed at the possible discovery of a natural cephalostatin with a more accessible structure for total synthesis and/or synthetic modifications, but with powerful cancer cell growth inhibition.
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