Article
Gastroenterology & Hepatology
Shashank Garg, Anam Rizvi, Diana Wee, Aditya Sreenivasan, Kelly Suchman, Sheila Louise Thomas, Sumant Inamdar, Arvind J. Trindade
Summary: This study found limited transparency in gastroenterology clinical trials. While most trials had reported results, only a small portion of these results were published.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Veterinary Sciences
Vanessa Ashall, David Morton, Eddie Clutton
Summary: This article explores the ethical principles of the Declaration of Helsinki as a framework for human medical research and suggests its potential application in defining ethical best practices in clinical veterinary research (CVR). It discusses the specific ethical responsibilities of clinicians in protecting patient interests and translates them to the veterinary setting. The article identifies the ethical risks in CVR through examining issues such as risk and harm, unproven interventions, vulnerability, and informed consent.
VETERINARY ANAESTHESIA AND ANALGESIA
(2023)
Article
Economics
Xakousti Chrysanthopoulou, Alexandros Tsioutsios, Dimitrios Dimitriou
Summary: We propose a theoretical framework that uncovers a negative relationship between loan interest rate volatility and central bank transparency. Empirical analysis on G-7 economies supports this theory, and reveals that this relationship is further strengthened under tight macroprudential regulations.
Article
Health Care Sciences & Services
Anna Kearney, Anna Rosala-Hallas, Naomi Rainford, Jane M. Blazeby, Mike Clarke, Athene J. Lane, Carrol Gamble
Summary: This study aims to explore the transparency of reporting primary outcome data within randomized controlled trials in the presence of missing data. The study finds that the reporting of imputed primary outcome data is poor and that participant flow diagrams do not necessarily reflect data availability. The authors recommend explicitly reporting the number of imputed values in the CONSORT flow diagrams to increase transparency.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Anesthesiology
David Ferreira, Pierre-Olivier Ludes, Pierre Diemunsch, Eric Noll, Klaus D. Torp, Nicolas Meyer
Summary: By simulating a sequential analysis of a clinical trial, this paper illustrates the use of PredP in Bayesian methods. The results demonstrate that the equivalence determined by PredP is more accurate than that from frequentist analysis, allowing for early termination of the trial.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Editorial Material
Health Care Sciences & Services
Daniel Kotz, Robert West
Summary: Randomized controlled trials are considered the most robust design for evaluating clinical interventions. The revised Cochrane risk-of-bias tool (RoB 2) helps researchers mitigate bias and ensure transparency in reporting.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Social Sciences, Interdisciplinary
Tariq H. Malik, Chunhui Huo
Summary: The study reveals that sponsors with more experience are more likely to disclose results, industrial enterprises are more willing to disclose than universities, and foreign clinical trial projects in China tend to disclose more than domestic projects. These findings are linked to informing the academic community on risk-taking behavior in the biopharmaceutical industry and addressing general audiences concerned about ethical and socioeconomic wellbeing.
Article
Health Care Sciences & Services
Priya Satalkar, Stuart McLennan, Bernice S. Elger, Erik von Elm, Briel Matthias
Summary: When a clinical trial is prematurely discontinued, stakeholders need to take appropriate actions to maintain trust in clinical research and learn from the experience. However, barriers to transparency continue to exist, with many investigators failing to notify stakeholders or publish the trial's results. Investigators' sense of failure and associated negative emotions were identified as key reasons for this lack of transparency.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Oncology
Ren-Qian Huang, You Zhou, Hai-Xia Zheng, Dan Wang, Xiao-Yi Zheng, Zhao-Shen Li, Liang-Hao Hu
Summary: Pancreatic cancer is a highly malignant tumor, and the transparency of its clinical trial data is a concern. This study examined clinical trials on pancreatic cancer and found that 30% of trials did not report any results, and the reporting rate on ClinicalTrial.gov was low. Overall, there is room for improvement in the transparency of pancreatic cancer clinical trials.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gerontology
Brad P. Taylor, George W. Rebok, Michael Marsiske
Summary: Clinical trials are guided by GCP principles to enhance rigor, reproducibility, and transparency in scientific research. Single-laboratory studies can mimic GCP principles used in large clinical trials.
PSYCHOLOGY AND AGING
(2022)
Article
Computer Science, Cybernetics
Chris Snijders, Rianne Conijn, Evie de Fouw, Kilian van Berlo
Summary: Algorithms have become an integral part of our daily lives, but people are often reluctant to follow algorithmic advice due to lack of trust. This study analyzes the influence of individual and contextual factors on people's willingness to request and follow algorithmic advice, and validates these influences in the context of fake news detection.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
(2023)
Review
Medicine, General & Internal
Anastasios Kyriazoglou, Michalis Liontos, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou
Summary: Uterine leiomyosarcomas are rare malignant mesenchymal tumors, and there are various treatment options including chemotherapy, targeted therapy, and immunotherapy. However, the optimal therapeutic algorithm has yet to be determined despite efforts by clinicians.
Article
Immunology
Yumiko Nomura, Kiyohito Noda, Yuusuke Oohashi, Shin Okuda, Jun Matsumoto, Takashi Nakano, Nao Tsuchida, Ken J. Ishii, Kunihiko Hayashi, Tatsuo Iiyama, Hiroshi Onodera, Koji Ishii, Mayumi Shikano, Nobuhiko Okabe
Summary: The study identifies current challenges in vaccine development through a questionnaire-based survey and review of vaccine approval reports in Japan. The challenges include the requirement for protective efficacy trials, evaluation of combination vaccines, development of multiregional and foreign clinical trials, and immunization of specific populations. The study proposes the use of multiregional clinical trials for assessing protective efficacy and suggests strategies for evaluating vaccine efficacy in specific populations.
Article
Health Care Sciences & Services
Norah Anthony, Antoine Tisseaux, Florian Naudet
Summary: This study aimed to describe randomized controlled trials (RCTs) in the clinical field published as registered reports (RR). Results showed that RR RCTs were rare in the clinical field, mostly originating from a single journal group, and did not comply with the basic features of this format.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Orthopedics
Laura Theresa Fischer, Markus Heinecke, Eric Roehner, Peter Schlattmann, Georg Matziolis
Summary: This paper provides a comparative meta-analysis on the fixation performance of metaphyseal cones and sleeves in revision total knee arthroplasties. The results show that cones had higher complication rates in short- and long-term follow-up compared to sleeves. However, the higher infection rate after cone fixation remains a concern.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Review
Medicine, General & Internal
Lesley A. Stewart, Mike Clarke, Maroeska Rovers, Richard D. Riley, Mark Simmonds, Gavin Stewart, Jayne F. Tierney
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2015)
Editorial Material
Medicine, General & Internal
Scott Y. H. Kim, Trudo Lemmens
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2016)
Article
Ethics
Shannon G. Gibson, Renata E. Axler, Trudo Lemmens
JOURNAL OF EMPIRICAL RESEARCH ON HUMAN RESEARCH ETHICS
(2017)
Article
Medicine, General & Internal
Christian Ohmann, Rita Banzi, Steve Canham, Serena Battaglia, Mihaela Matei, Christopher Ariyo, Lauren Becnel, Barbara Bierer, Sarion Bowers, Luca Clivio, Monica Dias, Christiane Druml, Helene Faure, Martin Fenner, Jose Galvez, Davina Ghersi, Christian Gluud, Trish Groves, Paul Houston, Ghassan Karam, Dipak Kalra, Rachel L. Knowles, Karmela Krleza-Jeric, Christine Kubiak, Wolfgang Kuchinke, Rebecca Kush, Ari Lukkarinen, Pedro Silverio Marques, Andrew Newbigging, Jennifer O'Callaghan, Philippe Ravaud, Irene Schluender, Daniel Shanahan, Helmut Sitter, Dylan Spalding, Catrin Tudur-Smith, Peter van Reusel, Evert-Ben van Veen, Gerben Rienk Visser, Julia Wilson, Jacques Demotes-Mainard
Article
Medical Laboratory Technology
Mersiha Mahmic-Kaknjo, Josip Simic, Karmela Krleza-Jeric
Editorial Material
Medicine, General & Internal
Trudo Lemmens, Carlos Herrera Vacaflor
BMJ-BRITISH MEDICAL JOURNAL
(2018)
Editorial Material
Medicine, General & Internal
Trudo Lemmens, Carlos Herrera Vacaflor
BMJ-BRITISH MEDICAL JOURNAL
(2018)
Editorial Material
Ethics
Trudo Lemmens, Bernadette J. Richards
JOURNAL OF BIOETHICAL INQUIRY
(2014)
Article
Medicine, General & Internal
Cinzia Colombo, Anna Roberto, Karmela Krleza-Jeric, Elena Parmelli, Rita Banzi
Editorial Material
Ethics
Trudo Lemmens
AMERICAN JOURNAL OF BIOETHICS
(2019)
Article
Law
Trudo Lemmens, Kanksha Mahadevia Ghimire
REVISTA DE DIREITO SANITARIO-JOURNAL OF HEALTH LAW
(2018)
Article
Medical Laboratory Technology
Karmela Krleza-Jeric, Mirko Gabelica, Rita Banzi, Marina Krnic-Martinic, Bibiana Pulido, Mersiha Mahmic-Kaknjo, Ludovic Reveiz, Josip Simic, Ana Utrobicic, Irena Hrgovic
Article
Law
Shannon Gibson, Trudo Lemmens
MCGILL JOURNAL OF LAW AND HEALTH
(2015)
Article
Public, Environmental & Occupational Health
Shannon Gibson, Hamid R. Raziee, Trudo Lemmens
WORLD MEDICAL & HEALTH POLICY
(2015)
Article
Environmental Studies
Renata E. Axler, Fiona A. Miller, Pascale Lehoux, Trudo Lemmens
SCIENCE AND PUBLIC POLICY
(2018)
